205
163
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms
230 1259
0.001
5
200000
James
Lawson
Richard
D
W
Hilgemann
added cmeta:id's to some variables to facilitate creation of PCEnv session file
Department of Physiology, Anatomy & Genetics
Oxford University
atrial myocyte
calcium dynamics
electrophysiology
mouse
excitation-contraction coupling
James Lawson
D
Noble
This is a CellML representation of Hilgeman et al.'s 1987 model of the basic cellular mechanisms of excitation-contraction coupling and Ca++ handling in the rabbit atrial myocyte.
unknown
Made 2 new variables - dCaCalmoddt and dCaTropdt in component "intracellular_calcium_concentration," equated these variables to d(CaCalmod)/d(time) and d(CaTrop)/d(time), respectively. This was done to allow PCEnv 0.2 to run the model.
keyword
Department of Physiology, Anatomy & Genetics, University of Oxford
Noble
J
Penny
James
Lawson
Richard
Added stimulus protocol to allow simulation of trains of action potentials.
James Lawson
2008-01-10T13:06:42+13:00
This version was created by Penny Noble of Oxford University and is known to run in both COR and PCEnv. The integration problems experienced with Version 03 are fixed in this version. A predefined operator diff error produced by PCEnv in the component intracellular_calcium_concentration of Penny Noble's version was fixed by James Lawson on 19/04/07. Due to the small stimulus duration, for this model to produce a train of action potentials, the max step size must be set at 0.001 or below and the number of points per graph must be over 10k.
2007-06-20T15:15:35+12:00
2006-08-08T00:00:00+00:00
penny.noble@dpag.ox.ac.uk
1987-03-23
2884668
Lawson
Richard
James
2007-09-20T12:40:08+12:00
Proceedings of the Royal Society of London - Series B