/* There are a total of 40 entries in the algebraic variable array. There are a total of 15 entries in each of the rate and state variable arrays. There are a total of 55 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is R in component membrane (joule_per_kilomole_kelvin). * CONSTANTS[1] is T in component membrane (kelvin). * CONSTANTS[2] is F in component membrane (coulomb_per_mole). * CONSTANTS[49] is RTONF in component membrane (millivolt). * CONSTANTS[3] is C_m in component membrane (microF). * ALGEBRAIC[24] is i_K1 in component time_independent_potassium_current (nanoA). * ALGEBRAIC[18] is i_b_Na in component sodium_background_current (nanoA). * ALGEBRAIC[20] is i_b_Ca in component calcium_background_current (nanoA). * ALGEBRAIC[23] is i_b_K in component potassium_background_current (nanoA). * ALGEBRAIC[14] is i_NaK in component sodium_potassium_pump (nanoA). * ALGEBRAIC[21] is i_NaCa in component Na_Ca_exchanger (nanoA). * ALGEBRAIC[12] is i_Na in component fast_sodium_current (nanoA). * ALGEBRAIC[35] is i_si in component second_inward_calcium_current (nanoA). * ALGEBRAIC[3] is i_Stim in component membrane (nanoA). * CONSTANTS[4] is stim_start in component membrane (second). * CONSTANTS[5] is stim_end in component membrane (second). * CONSTANTS[6] is stim_period in component membrane (second). * CONSTANTS[7] is stim_duration in component membrane (second). * CONSTANTS[8] is stim_amplitude in component membrane (nanoA). * CONSTANTS[9] is g_Na in component fast_sodium_current (microS). * ALGEBRAIC[8] is E_mh in component fast_sodium_current (millivolt). * CONSTANTS[10] is Na_o in component extracellular_sodium_concentration (millimolar). * STATES[1] is Na_i in component intracellular_sodium_concentration (millimolar). * CONSTANTS[11] is K_c in component extracellular_potassium_concentration (millimolar). * STATES[2] is K_i in component intracellular_potassium_concentration (millimolar). * STATES[3] is m in component fast_sodium_current_m_gate (dimensionless). * STATES[4] is h in component fast_sodium_current_h_gate (dimensionless). * ALGEBRAIC[5] is alpha_m in component fast_sodium_current_m_gate (per_second). * ALGEBRAIC[10] is beta_m in component fast_sodium_current_m_gate (per_second). * CONSTANTS[12] is delta_m in component fast_sodium_current_m_gate (millivolt). * ALGEBRAIC[0] is E0_m in component fast_sodium_current_m_gate (millivolt). * ALGEBRAIC[1] is alpha_h in component fast_sodium_current_h_gate (per_second). * ALGEBRAIC[6] is beta_h in component fast_sodium_current_h_gate (per_second). * CONSTANTS[13] is i_NaK_max in component sodium_potassium_pump (nanoA). * CONSTANTS[14] is K_mK in component sodium_potassium_pump (millimolar). * CONSTANTS[15] is K_mNa in component sodium_potassium_pump (millimolar). * ALGEBRAIC[16] is E_Na in component sodium_background_current (millivolt). * CONSTANTS[16] is g_b_Na in component sodium_background_current (microS). * ALGEBRAIC[19] is E_Ca in component calcium_background_current (millivolt). * CONSTANTS[17] is g_b_Ca in component calcium_background_current (microS). * STATES[5] is Ca_o in component extracellular_calcium_concentration (millimolar). * STATES[6] is Ca_i in component intracellular_calcium_concentration (millimolar). * CONSTANTS[18] is k_NaCa in component Na_Ca_exchanger (nanoA). * CONSTANTS[19] is n_NaCa in component Na_Ca_exchanger (dimensionless). * CONSTANTS[20] is d_NaCa in component Na_Ca_exchanger (dimensionless). * CONSTANTS[21] is gamma in component Na_Ca_exchanger (dimensionless). * ALGEBRAIC[22] is E_K in component time_independent_potassium_current (millivolt). * CONSTANTS[22] is g_b_K in component potassium_background_current (microS). * CONSTANTS[23] is g_K1 in component time_independent_potassium_current (microS). * CONSTANTS[24] is K_m_K1 in component time_independent_potassium_current (millimolar). * ALGEBRAIC[30] is i_siCa in component second_inward_calcium_current (nanoA). * ALGEBRAIC[31] is i_siK in component second_inward_calcium_current (nanoA). * ALGEBRAIC[33] is i_siNa in component second_inward_calcium_current (nanoA). * CONSTANTS[25] is P_si in component second_inward_calcium_current (nanoA_per_millimolar). * STATES[7] is d in component second_inward_calcium_current_d_gate (dimensionless). * STATES[8] is f_Ca in component second_inward_calcium_current_f_Ca_gate (dimensionless). * ALGEBRAIC[29] is CaChon in component second_inward_calcium_current_f_Ca_gate (dimensionless). * ALGEBRAIC[7] is alpha_d in component second_inward_calcium_current_d_gate (per_second). * ALGEBRAIC[11] is beta_d in component second_inward_calcium_current_d_gate (per_second). * CONSTANTS[26] is delta_d in component second_inward_calcium_current_d_gate (millivolt). * ALGEBRAIC[2] is E0_d in component second_inward_calcium_current_d_gate (millivolt). * ALGEBRAIC[26] is alpha_f_Ca in component second_inward_calcium_current_f_Ca_gate (per_second). * ALGEBRAIC[27] is beta_f_Ca in component second_inward_calcium_current_f_Ca_gate (per_second). * ALGEBRAIC[28] is CaChoff in component second_inward_calcium_current_f_Ca_gate (dimensionless). * CONSTANTS[27] is delta_f in component second_inward_calcium_current_f_Ca_gate (millivolt). * ALGEBRAIC[25] is E0_f in component second_inward_calcium_current_f_Ca_gate (millivolt). * ALGEBRAIC[34] is i_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * CONSTANTS[51] is K_1 in component sarcoplasmic_reticulum_calcium_pump (dimensionless). * ALGEBRAIC[32] is K_2 in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[28] is K_cyca in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[29] is K_xcs in component sarcoplasmic_reticulum_calcium_pump (dimensionless). * CONSTANTS[30] is K_srca in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[31] is alpha_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * CONSTANTS[32] is beta_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * STATES[9] is Ca_up in component intracellular_calcium_concentration (millimolar). * ALGEBRAIC[36] is i_rel in component calcium_release (millimolar_per_second). * ALGEBRAIC[9] is VoltDep in component calcium_release (dimensionless). * ALGEBRAIC[13] is RegBindSite in component calcium_release (dimensionless). * ALGEBRAIC[15] is ActRate in component calcium_release (per_second). * ALGEBRAIC[17] is InactRate in component calcium_release (per_second). * CONSTANTS[33] is K_leak_rate in component calcium_release (per_second). * CONSTANTS[34] is K_m_rel in component calcium_release (per_second). * ALGEBRAIC[4] is PrecFrac in component calcium_release (dimensionless). * STATES[10] is ActFrac in component calcium_release (dimensionless). * STATES[11] is ProdFrac in component calcium_release (dimensionless). * STATES[12] is Ca_rel in component intracellular_calcium_concentration (millimolar). * ALGEBRAIC[37] is i_trans in component calcium_translocation (millimolar_per_second). * CONSTANTS[35] is alpha_tr in component calcium_translocation (per_second). * CONSTANTS[54] is V_i in component intracellular_calcium_concentration (micrometre3). * CONSTANTS[36] is Cab in component extracellular_calcium_concentration (millimolar). * CONSTANTS[37] is K_diff in component extracellular_calcium_concentration (per_second). * CONSTANTS[53] is Ve in component intracellular_calcium_concentration (micrometre3). * STATES[13] is Ca_Calmod in component intracellular_calcium_concentration (millimolar). * STATES[14] is Ca_Trop in component intracellular_calcium_concentration (millimolar). * CONSTANTS[38] is Calmod in component intracellular_calcium_concentration (millimolar). * CONSTANTS[39] is Trop in component intracellular_calcium_concentration (millimolar). * CONSTANTS[40] is alpha_Calmod in component intracellular_calcium_concentration (per_millimolar_second). * CONSTANTS[41] is beta_Calmod in component intracellular_calcium_concentration (per_second). * CONSTANTS[42] is alpha_Trop in component intracellular_calcium_concentration (per_millimolar_second). * CONSTANTS[43] is beta_Trop in component intracellular_calcium_concentration (per_second). * CONSTANTS[44] is radius in component intracellular_calcium_concentration (micrometre). * CONSTANTS[45] is length in component intracellular_calcium_concentration (micrometre). * CONSTANTS[50] is V_Cell in component intracellular_calcium_concentration (micrometre3). * CONSTANTS[52] is V_i_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[46] is V_rel_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[47] is V_e_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[48] is V_up_ratio in component intracellular_calcium_concentration (dimensionless). * ALGEBRAIC[38] is dCaCalmoddt in component intracellular_calcium_concentration (millimolar_per_second). * ALGEBRAIC[39] is dCaTropdt in component intracellular_calcium_concentration (millimolar_per_second). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[3] is d/dt m in component fast_sodium_current_m_gate (dimensionless). * RATES[4] is d/dt h in component fast_sodium_current_h_gate (dimensionless). * RATES[7] is d/dt d in component second_inward_calcium_current_d_gate (dimensionless). * RATES[8] is d/dt f_Ca in component second_inward_calcium_current_f_Ca_gate (dimensionless). * RATES[10] is d/dt ActFrac in component calcium_release (dimensionless). * RATES[11] is d/dt ProdFrac in component calcium_release (dimensionless). * RATES[1] is d/dt Na_i in component intracellular_sodium_concentration (millimolar). * RATES[5] is d/dt Ca_o in component extracellular_calcium_concentration (millimolar). * RATES[2] is d/dt K_i in component intracellular_potassium_concentration (millimolar). * RATES[6] is d/dt Ca_i in component intracellular_calcium_concentration (millimolar). * RATES[9] is d/dt Ca_up in component intracellular_calcium_concentration (millimolar). * RATES[12] is d/dt Ca_rel in component intracellular_calcium_concentration (millimolar). * RATES[13] is d/dt Ca_Calmod in component intracellular_calcium_concentration (millimolar). * RATES[14] is d/dt Ca_Trop in component intracellular_calcium_concentration (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -88; CONSTANTS[0] = 8314.472; CONSTANTS[1] = 310; CONSTANTS[2] = 96485.3415; CONSTANTS[3] = 0.006; CONSTANTS[4] = 0.1; CONSTANTS[5] = 10000; CONSTANTS[6] = 1; CONSTANTS[7] = 0.002; CONSTANTS[8] = -200; CONSTANTS[9] = 50; CONSTANTS[10] = 140; STATES[1] = 6.5; CONSTANTS[11] = 4; STATES[2] = 140; STATES[3] = 0.076; STATES[4] = 0.015; CONSTANTS[12] = 1e-5; CONSTANTS[13] = 14; CONSTANTS[14] = 1; CONSTANTS[15] = 40; CONSTANTS[16] = 0.012; CONSTANTS[17] = 0.005; STATES[5] = 2; STATES[6] = 1e-5; CONSTANTS[18] = 0.01; CONSTANTS[19] = 3; CONSTANTS[20] = 0.0001; CONSTANTS[21] = 0.5; CONSTANTS[22] = 0.17; CONSTANTS[23] = 1.7; CONSTANTS[24] = 10; CONSTANTS[25] = 5; STATES[7] = 0.0011; STATES[8] = 0.785; CONSTANTS[26] = 0.0001; CONSTANTS[27] = 0.0001; CONSTANTS[28] = 0.0003; CONSTANTS[29] = 0.4; CONSTANTS[30] = 0.5; CONSTANTS[31] = 3; CONSTANTS[32] = 0.23; STATES[9] = 0.3; CONSTANTS[33] = 0; CONSTANTS[34] = 250; STATES[10] = 0; STATES[11] = 0; STATES[12] = 0.3; CONSTANTS[35] = 50; CONSTANTS[36] = 2; CONSTANTS[37] = 0.0005; STATES[13] = 0.0005; STATES[14] = 0.0015; CONSTANTS[38] = 0.02; CONSTANTS[39] = 0.15; CONSTANTS[40] = 100000; CONSTANTS[41] = 50; CONSTANTS[42] = 100000; CONSTANTS[43] = 200; CONSTANTS[44] = 0.08; CONSTANTS[45] = 0.08; CONSTANTS[46] = 0.1; CONSTANTS[47] = 0.4; CONSTANTS[48] = 0.01; CONSTANTS[49] = ( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2]; CONSTANTS[50] = 3.14159*pow(CONSTANTS[44], 2.00000)*CONSTANTS[45]; CONSTANTS[51] = ( CONSTANTS[28]*CONSTANTS[29])/CONSTANTS[30]; CONSTANTS[52] = ((1.00000 - CONSTANTS[47]) - CONSTANTS[48]) - CONSTANTS[46]; CONSTANTS[53] = CONSTANTS[50]*CONSTANTS[47]; CONSTANTS[54] = CONSTANTS[50]*CONSTANTS[52]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[13] = CONSTANTS[40]*STATES[6]*(CONSTANTS[38] - STATES[13]) - CONSTANTS[41]*STATES[13]; RATES[14] = CONSTANTS[42]*STATES[6]*(CONSTANTS[39] - STATES[14]) - CONSTANTS[43]*STATES[14]; ALGEBRAIC[1] = 20.0000*exp( - 0.125000*(STATES[0]+75.0000)); ALGEBRAIC[6] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*(STATES[0]+75.0000))); RATES[4] = ALGEBRAIC[1]*(1.00000 - STATES[4]) - ALGEBRAIC[6]*STATES[4]; ALGEBRAIC[0] = STATES[0]+41.0000; ALGEBRAIC[5] = (fabs(ALGEBRAIC[0])=CONSTANTS[4]&&VOI<=CONSTANTS[5]&&(VOI - CONSTANTS[4]) - floor((VOI - CONSTANTS[4])/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[7] ? CONSTANTS[8] : 0.00000); RATES[0] = - (ALGEBRAIC[3]+ALGEBRAIC[24]+ALGEBRAIC[18]+ALGEBRAIC[20]+ALGEBRAIC[23]+ALGEBRAIC[14]+ALGEBRAIC[21]+ALGEBRAIC[12]+ALGEBRAIC[35])/CONSTANTS[3]; ALGEBRAIC[32] = STATES[6]+ STATES[9]*CONSTANTS[51]+ CONSTANTS[28]*CONSTANTS[29]+CONSTANTS[28]; ALGEBRAIC[34] = (STATES[6]/ALGEBRAIC[32])*CONSTANTS[31] - (( STATES[9]*CONSTANTS[51])/ALGEBRAIC[32])*CONSTANTS[32]; ALGEBRAIC[37] = (STATES[9] - STATES[12])*CONSTANTS[35]; RATES[9] = (CONSTANTS[52]/CONSTANTS[48])*ALGEBRAIC[34] - ALGEBRAIC[37]; ALGEBRAIC[36] = ( pow(STATES[10]/(STATES[10]+0.250000), 2.00000)*CONSTANTS[34]+CONSTANTS[33])*STATES[12]; RATES[12] = (CONSTANTS[48]/CONSTANTS[46])*ALGEBRAIC[37] - ALGEBRAIC[36]; ALGEBRAIC[38] = CONSTANTS[40]*STATES[6]*(CONSTANTS[38] - STATES[13]) - CONSTANTS[41]*STATES[13]; ALGEBRAIC[39] = CONSTANTS[42]*STATES[6]*(CONSTANTS[39] - STATES[14]) - CONSTANTS[43]*STATES[14]; RATES[6] = ((( (- 1.00000/( 2.00000*1.00000*CONSTANTS[54]*CONSTANTS[2]))*((ALGEBRAIC[30]+ALGEBRAIC[20]) - 2.00000*ALGEBRAIC[21])+( ALGEBRAIC[36]*CONSTANTS[46])/CONSTANTS[52]) - ALGEBRAIC[38]) - ALGEBRAIC[39]) - ALGEBRAIC[34]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 20.0000*exp( - 0.125000*(STATES[0]+75.0000)); ALGEBRAIC[6] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*(STATES[0]+75.0000))); ALGEBRAIC[0] = STATES[0]+41.0000; ALGEBRAIC[5] = (fabs(ALGEBRAIC[0])=CONSTANTS[4]&&VOI<=CONSTANTS[5]&&(VOI - CONSTANTS[4]) - floor((VOI - CONSTANTS[4])/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[7] ? CONSTANTS[8] : 0.00000); ALGEBRAIC[32] = STATES[6]+ STATES[9]*CONSTANTS[51]+ CONSTANTS[28]*CONSTANTS[29]+CONSTANTS[28]; ALGEBRAIC[34] = (STATES[6]/ALGEBRAIC[32])*CONSTANTS[31] - (( STATES[9]*CONSTANTS[51])/ALGEBRAIC[32])*CONSTANTS[32]; ALGEBRAIC[37] = (STATES[9] - STATES[12])*CONSTANTS[35]; ALGEBRAIC[36] = ( pow(STATES[10]/(STATES[10]+0.250000), 2.00000)*CONSTANTS[34]+CONSTANTS[33])*STATES[12]; ALGEBRAIC[38] = CONSTANTS[40]*STATES[6]*(CONSTANTS[38] - STATES[13]) - CONSTANTS[41]*STATES[13]; ALGEBRAIC[39] = CONSTANTS[42]*STATES[6]*(CONSTANTS[39] - STATES[14]) - CONSTANTS[43]*STATES[14]; }