# Size of variable arrays: sizeAlgebraic = 0 sizeStates = 0 sizeConstants = 10 from math import * from numpy import * def createLegends(): legend_states = [""] * sizeStates legend_rates = [""] * sizeStates legend_algebraic = [""] * sizeAlgebraic legend_voi = "" legend_constants = [""] * sizeConstants legend_constants[0] = "QLO in component heart_rate_and_stroke_volume (L_per_minute)" legend_constants[1] = "AUR in component heart_rate_and_stroke_volume (dimensionless)" legend_constants[2] = "PRA in component heart_rate_and_stroke_volume (mmHg)" legend_constants[3] = "HMD in component heart_rate_and_stroke_volume (dimensionless)" legend_constants[5] = "AUHR in component effect_of_autonomic_stimulation_on_HR (beats_per_minute)" legend_constants[6] = "PRHR in component effect_of_PRA_on_HR (beats_per_minute)" legend_constants[4] = "PR1LL in component parameter_values (mmHg)" legend_constants[7] = "HDHR in component effect_of_heart_deterioration_on_HR (dimensionless)" legend_constants[8] = "HR in component heart_rate (beats_per_minute)" legend_constants[9] = "SVO in component stroke_volume_output (litre)" return (legend_states, legend_algebraic, legend_voi, legend_constants) def initConsts(): constants = [0.0] * sizeConstants; states = [0.0] * sizeStates; constants[0] = 4.9943 constants[1] = 1.30 constants[2] = 0.00852183 constants[3] = 1.0 constants[4] = 0 constants[5] = 72.0000*constants[1] constants[6] = (power(constants[4], 0.500000))*5.00000 constants[7] = (constants[3]-1.00000)*0.500000+1.00000 constants[8] = (constants[5]+constants[6])*constants[7] constants[9] = constants[0]/constants[8] return (states, constants) def computeRates(voi, states, constants): rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic return(rates) def computeAlgebraic(constants, states, voi): algebraic = array([[0.0] * len(voi)] * sizeAlgebraic) states = array(states) voi = array(voi) return algebraic def solve_model(): """Solve model with ODE solver""" from scipy.integrate import ode # Initialise constants and state variables (init_states, constants) = initConsts() # Set timespan to solve over voi = linspace(0, 10, 500) # Construct ODE object to solve r = ode(computeRates) r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1) r.set_initial_value(init_states, voi[0]) r.set_f_params(constants) # Solve model states = array([[0.0] * len(voi)] * sizeStates) states[:,0] = init_states for (i,t) in enumerate(voi[1:]): if r.successful(): r.integrate(t) states[:,i+1] = r.y else: break # Compute algebraic variables algebraic = computeAlgebraic(constants, states, voi) return (voi, states, algebraic) def plot_model(voi, states, algebraic): """Plot variables against variable of integration""" import pylab (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends() pylab.figure(1) pylab.plot(voi,vstack((states,algebraic)).T) pylab.xlabel(legend_voi) pylab.legend(legend_states + legend_algebraic, loc='best') pylab.show() if __name__ == "__main__": (voi, states, algebraic) = solve_model() plot_model(voi, states, algebraic)