/* There are a total of 10 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 8 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is E_R in component membrane (millivolt). * CONSTANTS[1] is Cm in component membrane (microF_per_cm2). * ALGEBRAIC[4] is i_Na in component sodium_channel (microA_per_cm2). * ALGEBRAIC[8] is i_K in component potassium_channel (microA_per_cm2). * ALGEBRAIC[9] is i_L in component leakage_current (microA_per_cm2). * ALGEBRAIC[0] is i_Stim in component membrane (microA_per_cm2). * CONSTANTS[2] is g_Na in component sodium_channel (milliS_per_cm2). * CONSTANTS[5] is E_Na in component sodium_channel (millivolt). * STATES[1] is m in component sodium_channel_m_gate (dimensionless). * STATES[2] is h in component sodium_channel_h_gate (dimensionless). * ALGEBRAIC[1] is alpha_m in component sodium_channel_m_gate (per_millisecond). * ALGEBRAIC[5] is beta_m in component sodium_channel_m_gate (per_millisecond). * ALGEBRAIC[2] is alpha_h in component sodium_channel_h_gate (per_millisecond). * ALGEBRAIC[6] is beta_h in component sodium_channel_h_gate (per_millisecond). * CONSTANTS[3] is g_K in component potassium_channel (milliS_per_cm2). * CONSTANTS[6] is E_K in component potassium_channel (millivolt). * STATES[3] is n in component potassium_channel_n_gate (dimensionless). * ALGEBRAIC[3] is alpha_n in component potassium_channel_n_gate (per_millisecond). * ALGEBRAIC[7] is beta_n in component potassium_channel_n_gate (per_millisecond). * CONSTANTS[4] is g_L in component leakage_current (milliS_per_cm2). * CONSTANTS[7] is E_L in component leakage_current (millivolt). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt m in component sodium_channel_m_gate (dimensionless). * RATES[2] is d/dt h in component sodium_channel_h_gate (dimensionless). * RATES[3] is d/dt n in component potassium_channel_n_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -75; CONSTANTS[0] = -75; CONSTANTS[1] = 1; CONSTANTS[2] = 120; STATES[1] = 0.05; STATES[2] = 0.6; CONSTANTS[3] = 36; STATES[3] = 0.325; CONSTANTS[4] = 0.3; CONSTANTS[5] = CONSTANTS[0]+115.000; CONSTANTS[6] = CONSTANTS[0] - 12.0000; CONSTANTS[7] = CONSTANTS[0]+10.6130; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( - 0.100000*(STATES[0]+50.0000))/(exp(- (STATES[0]+50.0000)/10.0000) - 1.00000); ALGEBRAIC[5] = 4.00000*exp(- (STATES[0]+75.0000)/18.0000); RATES[1] = ALGEBRAIC[1]*(1.00000 - STATES[1]) - ALGEBRAIC[5]*STATES[1]; ALGEBRAIC[2] = 0.0700000*exp(- (STATES[0]+75.0000)/20.0000); ALGEBRAIC[6] = 1.00000/(exp(- (STATES[0]+45.0000)/10.0000)+1.00000); RATES[2] = ALGEBRAIC[2]*(1.00000 - STATES[2]) - ALGEBRAIC[6]*STATES[2]; ALGEBRAIC[3] = ( - 0.0100000*(STATES[0]+65.0000))/(exp(- (STATES[0]+65.0000)/10.0000) - 1.00000); ALGEBRAIC[7] = 0.125000*exp((STATES[0]+75.0000)/80.0000); RATES[3] = ALGEBRAIC[3]*(1.00000 - STATES[3]) - ALGEBRAIC[7]*STATES[3]; ALGEBRAIC[4] = CONSTANTS[2]*pow(STATES[1], 3.00000)*STATES[2]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[8] = CONSTANTS[3]*pow(STATES[3], 4.00000)*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[9] = CONSTANTS[4]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[0] = (VOI>=10.0000&&VOI<=10.5000 ? 20.0000 : 0.00000); RATES[0] = - (- ALGEBRAIC[0]+ALGEBRAIC[4]+ALGEBRAIC[8]+ALGEBRAIC[9])/CONSTANTS[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( - 0.100000*(STATES[0]+50.0000))/(exp(- (STATES[0]+50.0000)/10.0000) - 1.00000); ALGEBRAIC[5] = 4.00000*exp(- (STATES[0]+75.0000)/18.0000); ALGEBRAIC[2] = 0.0700000*exp(- (STATES[0]+75.0000)/20.0000); ALGEBRAIC[6] = 1.00000/(exp(- (STATES[0]+45.0000)/10.0000)+1.00000); ALGEBRAIC[3] = ( - 0.0100000*(STATES[0]+65.0000))/(exp(- (STATES[0]+65.0000)/10.0000) - 1.00000); ALGEBRAIC[7] = 0.125000*exp((STATES[0]+75.0000)/80.0000); ALGEBRAIC[4] = CONSTANTS[2]*pow(STATES[1], 3.00000)*STATES[2]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[8] = CONSTANTS[3]*pow(STATES[3], 4.00000)*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[9] = CONSTANTS[4]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[0] = (VOI>=10.0000&&VOI<=10.5000 ? 20.0000 : 0.00000); }