C
C There are a total of 3 entries in the algebraic variable array.
C There are a total of 3 entries in each of the rate and state variable arrays.
C There are a total of 18 entries in the constant variable array.
C
C
C VOI is time in component environment (day).
C ALGBRC(3) is S in component population_pharmacodynamics_model (units).
C CONSTS(1) is S0 in component population_pharmacodynamics_model (units).
C CONSTS(2) is alpha in component population_pharmacodynamics_model (units_per_day).
C CONSTS(3) is epsilon in component population_pharmacodynamics_model (units).
C ALGBRC(1) is ADAS_Cog_p in component placebo_response_model (units).
C CONSTS(15) is PD_CeA in component drug_response_model (units).
C CONSTS(4) is beta_P in component placebo_response_model (units).
C CONSTS(16) is Keq_p in component placebo_response_model (per_day).
C CONSTS(17) is Kel_p in component placebo_response_model (per_day).
C CONSTS(5) is t_half_el_p in component placebo_response_model (day).
C CONSTS(6) is t_half_eq_p in component placebo_response_model (day).
C CONSTS(18) is CL in component pharmacokinetic_model (litre_per_day).
C CONSTS(7) is smk in component pharmacokinetic_model (dimensionless).
C CONSTS(8) is age in component pharmacokinetic_model (year).
C ALGBRC(2) is Sv in component drop_out_model (dimensionless).
C CONSTS(9) is beta_a in component drug_response_model (units_ml_per_ng).
C CONSTS(10) is CeA in component drug_response_model (ng_per_ml).
C STATES(1) is CC in component drug_clearance (mg_per_litre).
C STATES(2) is PC in component drug_clearance (mg_per_litre).
C CONSTS(11) is Vc in component drug_clearance (litre).
C CONSTS(12) is Vp in component drug_clearance (litre).
C STATES(3) is A_in in component drug_clearance (mg).
C CONSTS(13) is k_ab in component drug_clearance (per_day).
C CONSTS(14) is CL_ic in component drug_clearance (litre_per_day).
C RATES(1) is d/dt CC in component drug_clearance (mg_per_litre).
C RATES(2) is d/dt PC in component drug_clearance (mg_per_litre).
C RATES(3) is d/dt A_in in component drug_clearance (mg).
C
      SUBROUTINE initConsts(CONSTS, RATES, STATES)
      REAL CONSTS(*), RATES(*), STATES(*)
      CONSTS(1) = 30
      CONSTS(2) = 0.0164
      CONSTS(3) = 0.0
      CONSTS(4) = -3
      CONSTS(5) = 7
      CONSTS(6) = 6
      CONSTS(7) = 1
      CONSTS(8) = 40
      CONSTS(9) = -0.047
      CONSTS(10) = 25
      STATES(1) = 0
      STATES(2) = 0
      CONSTS(11) = 172
      CONSTS(12) = 222
      STATES(3) = 25
      CONSTS(13) = 115.44
      CONSTS(14) = 763.2
      CONSTS(15) =  CONSTS(9)*CONSTS(10)
      CONSTS(16) = log(2.00000)/CONSTS(6)
      CONSTS(17) = log(2.00000)/CONSTS(5)
      CONSTS(18) =  2268.00*EXP( - 0.0135000*(CONSTS(8) - 40.0000))*CONSTS(7)
      RETURN
      END
      SUBROUTINE computeRates(VOI, CONSTS,  RATES, STATES, ALGBRC)
      REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
      RATES(1) = ( CONSTS(13)*STATES(3) - ( CONSTS(18)*STATES(1)+ CONSTS(14)*(STATES(1) - STATES(2))))/CONSTS(11)
      RATES(2) = ( CONSTS(14)*(STATES(1) - STATES(2)))/CONSTS(12)
      RATES(3) =  - 115.440*STATES(3)
      RETURN
      END
      SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC)
      REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
      ALGBRC(1) =  (( CONSTS(4)*CONSTS(16))/(CONSTS(16) - CONSTS(17)))*(EXP( - CONSTS(17)*VOI) - EXP( - CONSTS(16)*VOI))
      ALGBRC(2) = EXP( - 0.00145000*VOI)
      ALGBRC(3) = CONSTS(1)+ CONSTS(2)*VOI+ALGBRC(1)+CONSTS(15)+CONSTS(3)
      RETURN
      END