TnC
Troponin C
2001
Mlcek et al's 2001 mathematical model of the elctromechanical heart
contractile system
Cardiac Myocyte
Homo sapiens
cardiac myocyte
myofilament mechanics
electrophysiology
Cardiac Myocyte
Molecular Mechanisms
cardiac
432
50
425
Mathematical Model of the Electromechanical Heart Contractile System - Regulatory Subsystem Physiological Considerations
The University of Auckland, Bioengineering Institute
Actin
A
sarcoplasmic reticulum calcium
CaF
A_M_ADP_Pi
Actin-Myosin-ADP-Pi
May
Catherine
Lloyd
AM_ADP
Actomyosin-ADP
11551150
Myosin-ATP
M_ATP
AM
Actomyosin
2007-05-23T00:00:00+00:00
keyword
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model does not run in the PCEnv simulator because it is underconstrained. I have contacted the authors of the original publication and I have requested the parameter values.
A_M_ATP
Actin-Myosin-ATP
Mlcek
M
c.lloyd@auckland.ac.nz
V
Novak
O
Kittnar
Neumann
J
Lloyd
May
Catherine
M_ADP_Pi
Myosin-ADP-Pi
2007-06-05T09:45:51+12:00
intracellular free calcium
Cai
Below is a CellML description of Mlcek et al's mathematical model of
the elctromechanical heart contractile system.
Rate constants for the reactions were not specified in the original
paper, therefore in the CellML description they have been set at a
default value of 1.0. Similarly, initial concentrations were not
defined so these have been set at a default value of 1 micromolar.
The University of Auckland
The Bioengineering Institute
Physiological Research