LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport
C2049
281
C2060
2002-06-17
The Bioengineering Institute
The University of Auckland
rabbit
Ventricular Myocyte
The Puglisi-Bers Model of Rabbit Ventricular Myocyte Ion Channels and Ca
transport, 2001
c.lloyd@auckland.ac.nz
Catherine
Lloyd
May
<apply xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" cmeta:id="calcium_overload"><eq/>
<ci> G_rel </ci>
<apply><times/>
<ci> G_rel_max </ci>
<apply><minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><exp/>
<apply><minus/>
<apply><divide/>
<ci> t </ci>
<ci> tau_on </ci>
</apply>
</apply>
</apply>
</apply>
<apply><exp/>
<apply><minus/>
<apply><divide/>
<ci> t </ci>
<ci> tau_off </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cellml="http://www.cellml.org/cellml/1.0#"><eq/>
<ci> G_rel_max </ci>
<piecewise>
<piece>
<cn cellml:units="per_millisecond"> 0.0 </cn>
<apply><lt/>
<ci> CSQN_buff </ci>
<ci> CSQN_th </ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond"> 4.0 </cn>
</otherwise>
</piecewise>
</apply>
When the cell is under calcium-overload conditions, the equations
for G-rel and G-rel max are altered. Rather than include these
equations as part of the CellML model itself, they are presented
below within the metadata. This is because the calcium-overload
conditions are poorly defined and most modelers will be interested
in a cell under normal calcium conditions.
Lloyd
Catherine
May
L
Jose
Puglisi
Corrected units and initial values.
Corrected alpha_j_calculation equation in fast_sodium_current_j_gate
component and removed I_S_calculation from L_type_Ca_channel
component.
Changed equation 'i_leak_calcualtion' to 'i_leak_calculation'.
Cuellar
Autumn
A
Catherine Lloyd
Although i_Ca_T is not generally detectable in rabbit ventricular
myocytes, Puglisi and Bers include it in the mathematical model to
make it more complete. The equation kinetics here are slightly
different from those in the modified Luo-Rudy II model (based on
Zeng et al's model, 1995), but they reproduce more accurately the
current-voltage relationship for i_Ca_T.
2002-01-31
May
Catherine
Lloyd
Ventricular Myocyte
ventricular myocyte
electrophysiology
rabbit
cardiac
calcium dynamics
Corrected several equations.
This is the CellML description of Puglisi and Bers' mathematical model of rabbit ventricular myocyte ion channels and Ca transport. It is a development of the Luo-Rudy II ventricular model (1994).
The University of Auckland, Bioengineering Institute
Bers
Donald
M
Catherine
Lloyd
May
2003-06-05
A calcium-activated chloride current has been reported in rabbit
Purkinje cells and atrial and ventricular myocytes. The current is
modelled by the equations below, with parameters that were chosen to fit experimental results obtained by Puglisi et al (1999).
11698264
keyword
2002-02-27
2001-12-01
A transient outward potassium current has been reported in rabbit
ventricular myocytes. It can contribute to ventricular
repolarisation. This is not part of the Luo-Rudy II model. The
equations below are taken from Winslow et al (1999).
2002-02-25
American Journal of Cellular Physiology