Gave C1 an initial value of 1.0 - this allows the model to produce a curve, rather than a flat line output. This is still unlikely to be the correct output as the model is supposed to depend on voltage and changing calcium levels.
O1
open state 1
Catherine Lloyd
Cardiac Myocyte
calcium dynamics
ryanodine receptors
Saftenku et al's 2001 markovian model of low activity levels of cardiac ryanodine receptors.
Cardiac Myocyte
Catherine
May
Lloyd
The University of Auckland, Bioengineering Institute
Markovian Models of Low and High Activity Levals of Cardiac Ryanodine Receptors (H1 Model)
2741
2727
Markovian Models of Low and High Activity Levals of Cardiac Ryanodine Receptors
80
c.lloyd@auckland.ac.nz
Catherine
May
Lloyd
closed state 1
C1
J
Williams
Alan
C3
closed state 3
closed state 4
C4
11371448
Richard
James
Lawson
This is the CellML description of Saftenku et al's 2001 markovian
model of low activity levels of cardiac ryanodine receptors.
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model runs in the PCEnv simulator but gives a flat output.
C2
closed state 2
keyword
Rebecca
Sitsapesan
2007-05-25T00:00:00+00:00
The University of Auckland
The Bioengineering Institute
2001-06
O2
open state 2
Saftenku
Elena
2007-08-21T10:20:13+12:00
2007-06-05T10:43:32+12:00
Biophysical Journal