Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 51 entries in the algebraic variable array.
There are a total of 23 entries in each of the rate and state variable arrays.
There are a total of 69 entries in the constant variable array.
*/
/*
* VOI is time in component environment (second).
* CONSTANTS[0] is R in component cell_parameters (millijoule_per_mole_kelvin).
* CONSTANTS[1] is T in component cell_parameters (kelvin).
* CONSTANTS[2] is F in component cell_parameters (coulomb_per_mole).
* CONSTANTS[3] is Cm in component cell_parameters (microF).
* CONSTANTS[4] is v_i in component cell_parameters (microlitre).
* CONSTANTS[5] is v_SR in component cell_parameters (microlitre).
* CONSTANTS[6] is Na_o in component cell_parameters (millimolar).
* CONSTANTS[7] is K_o in component cell_parameters (millimolar).
* CONSTANTS[8] is Ca_o in component cell_parameters (millimolar).
* STATES[0] is V in component membrane_potential (millivolt).
* ALGEBRAIC[21] is i_Na in component fast_sodium_current (nanoA).
* ALGEBRAIC[23] is i_K1 in component time_independent_potassium_current (nanoA).
* ALGEBRAIC[24] is i_to in component transient_outward_current (nanoA).
* ALGEBRAIC[22] is i_K in component time_dependent_rectifier_potassium_current (nanoA).
* ALGEBRAIC[28] is i_Ca_L in component L_type_Ca_channel (nanoA).
* ALGEBRAIC[32] is i_NaK in component sodium_potassium_pump (nanoA).
* ALGEBRAIC[30] is i_NaCa in component sodium_calcium_exchanger (nanoA).
* ALGEBRAIC[39] is i_b_Na in component sodium_background_current (nanoA).
* ALGEBRAIC[36] is i_b_K in component potassium_background_current (nanoA).
* ALGEBRAIC[35] is i_b_Ca in component calcium_background_current (nanoA).
* ALGEBRAIC[0] is i_Stim in component membrane_potential (nanoA).
* CONSTANTS[9] is stim_start in component membrane_potential (second).
* CONSTANTS[10] is stim_end in component membrane_potential (second).
* CONSTANTS[11] is stim_period in component membrane_potential (second).
* CONSTANTS[12] is stim_duration in component membrane_potential (second).
* CONSTANTS[13] is stim_amplitude in component membrane_potential (nanoA).
* ALGEBRAIC[8] is E_Na in component reversal_potentials (millivolt).
* ALGEBRAIC[15] is E_K in component reversal_potentials (millivolt).
* ALGEBRAIC[19] is E_Ca in component reversal_potentials (millivolt).
* ALGEBRAIC[20] is E_mh in component reversal_potentials (millivolt).
* STATES[1] is K_i in component intracellular_potassium_concentration (millimolar).
* STATES[2] is Na_i in component intracellular_sodium_concentration (millimolar).
* STATES[3] is Ca_i in component intracellular_calcium_concentration (millimolar).
* CONSTANTS[14] is g_Na in component fast_sodium_current (microS).
* STATES[4] is m in component fast_sodium_current_m_gate (dimensionless).
* STATES[5] is h in component fast_sodium_current_h_gate (dimensionless).
* ALGEBRAIC[9] is alpha_m in component fast_sodium_current_m_gate (per_second).
* ALGEBRAIC[16] is beta_m in component fast_sodium_current_m_gate (per_second).
* CONSTANTS[15] is delta_m in component fast_sodium_current_m_gate (millivolt).
* ALGEBRAIC[1] is E0_m in component fast_sodium_current_m_gate (millivolt).
* ALGEBRAIC[2] is alpha_h in component fast_sodium_current_h_gate (per_second).
* ALGEBRAIC[10] is beta_h in component fast_sodium_current_h_gate (per_second).
* CONSTANTS[16] is shift_h in component fast_sodium_current_h_gate (millivolt).
* CONSTANTS[17] is i_Kmax in component time_dependent_rectifier_potassium_current (nanoA).
* STATES[6] is x in component time_dependent_rectifier_potassium_current_x_gate (dimensionless).
* ALGEBRAIC[3] is alpha_x in component time_dependent_rectifier_potassium_current_x_gate (per_second).
* ALGEBRAIC[11] is beta_x in component time_dependent_rectifier_potassium_current_x_gate (per_second).
* CONSTANTS[18] is K_mk1 in component time_independent_potassium_current (millimolar).
* CONSTANTS[19] is g_K1 in component time_independent_potassium_current (microS).
* CONSTANTS[20] is g_to in component transient_outward_current (microS).
* STATES[7] is s in component transient_outward_current_s_gate (dimensionless).
* STATES[8] is r in component transient_outward_current_r_gate (dimensionless).
* ALGEBRAIC[4] is alpha_s in component transient_outward_current_s_gate (per_second).
* ALGEBRAIC[12] is beta_s in component transient_outward_current_s_gate (per_second).
* ALGEBRAIC[27] is i_Ca_L_Na in component L_type_Ca_channel (nanoA).
* ALGEBRAIC[26] is i_Ca_L_K in component L_type_Ca_channel (nanoA).
* ALGEBRAIC[25] is i_Ca_L_Ca in component L_type_Ca_channel (nanoA).
* CONSTANTS[21] is P_Ca_L_Ca in component L_type_Ca_channel (nanoA_per_millimolar).
* STATES[9] is d in component L_type_Ca_channel_d_gate (dimensionless).
* STATES[10] is f in component L_type_Ca_channel_f_gate (dimensionless).
* ALGEBRAIC[13] is alpha_d in component L_type_Ca_channel_d_gate (per_second).
* ALGEBRAIC[17] is beta_d in component L_type_Ca_channel_d_gate (per_second).
* ALGEBRAIC[5] is E0_d in component L_type_Ca_channel_d_gate (millivolt).
* CONSTANTS[22] is speed_d in component L_type_Ca_channel_d_gate (dimensionless).
* ALGEBRAIC[14] is alpha_f in component L_type_Ca_channel_f_gate (per_second).
* ALGEBRAIC[18] is beta_f in component L_type_Ca_channel_f_gate (per_second).
* CONSTANTS[23] is speed_f in component L_type_Ca_channel_f_gate (dimensionless).
* ALGEBRAIC[6] is E0_f in component L_type_Ca_channel_f_gate (millivolt).
* CONSTANTS[24] is i_NaCa_max in component sodium_calcium_exchanger (nanoA_per_millimolar4).
* CONSTANTS[25] is gamma in component sodium_calcium_exchanger (dimensionless).
* CONSTANTS[26] is i_NaK_max in component sodium_potassium_pump (nanoA).
* CONSTANTS[27] is K_mK in component sodium_potassium_pump (millimolar).
* CONSTANTS[28] is K_mNa in component sodium_potassium_pump (millimolar).
* CONSTANTS[29] is g_b_Ca in component calcium_background_current (microS).
* CONSTANTS[30] is g_b_K in component potassium_background_current (microS).
* CONSTANTS[31] is g_b_Na in component sodium_background_current (microS).
* STATES[11] is F_CaMK in component CaMKII_factor (dimensionless).
* ALGEBRAIC[7] is Inf_CaMK in component CaMKII_factor (dimensionless).
* CONSTANTS[32] is Tau_CaMK in component CaMKII_factor (second).
* STATES[12] is Cmdn_Ca in component calmodulin (millimolar).
* ALGEBRAIC[41] is j_rel in component RyR (millimolar_per_second).
* ALGEBRAIC[40] is K_rel in component RyR (per_second).
* ALGEBRAIC[37] is F_rel in component RyR (dimensionless).
* STATES[13] is Ca_SR in component SR_calcium_concentration (millimolar).
* CONSTANTS[33] is K_rel_max in component RyR (per_second).
* STATES[14] is F_SRCa_RyR in component RyR (millimolar).
* CONSTANTS[34] is Tau_SRCa_RyR in component RyR (second).
* ALGEBRAIC[29] is N_CaMK in component RyR (dimensionless).
* CONSTANTS[35] is gain_k1 in component RyR (dimensionless).
* CONSTANTS[36] is gain_k2 in component RyR (dimensionless).
* CONSTANTS[37] is gain_k3 in component RyR (dimensionless).
* CONSTANTS[38] is gain_k4 in component RyR (dimensionless).
* ALGEBRAIC[31] is k_1 in component RyR (per_second).
* ALGEBRAIC[33] is k_2 in component RyR (per_second).
* ALGEBRAIC[34] is k_3 in component RyR (per_second).
* CONSTANTS[53] is k_4 in component RyR (per_second).
* STATES[15] is F_1 in component RyR (dimensionless).
* STATES[16] is F_2 in component RyR (dimensionless).
* ALGEBRAIC[38] is F_3 in component RyR (dimensionless).
* CONSTANTS[39] is K_leak_rate in component RyR (per_second).
* ALGEBRAIC[44] is j_up in component SERCA (millimolar_per_second).
* CONSTANTS[40] is V_max_f in component SERCA (millimolar_per_second).
* CONSTANTS[41] is V_max_r in component SERCA (millimolar_per_second).
* ALGEBRAIC[42] is f_b in component SERCA (dimensionless).
* ALGEBRAIC[43] is r_b in component SERCA (dimensionless).
* CONSTANTS[42] is Cmdn_tot in component calmodulin (millimolar).
* CONSTANTS[43] is alpha_cmdn in component calmodulin (per_millimolar_per_second).
* CONSTANTS[44] is beta_cmdn in component calmodulin (per_second).
* ALGEBRAIC[45] is dCmdn_Ca_dtime in component calmodulin (millimolar_per_second).
* STATES[17] is Trpn_Ca in component troponin (millimolar).
* CONSTANTS[45] is Trpn_tot in component troponin (millimolar).
* CONSTANTS[46] is alpha_trpn in component troponin (per_millimolar_per_second).
* CONSTANTS[47] is beta_trpn in component troponin (per_second).
* ALGEBRAIC[48] is Force_norm in component Force (dimensionless).
* ALGEBRAIC[49] is dTrpn_Ca_dtime in component troponin (millimolar_per_second).
* ALGEBRAIC[50] is Force in component Force (N_per_mm2).
* CONSTANTS[48] is zeta in component Force (N_per_mm2).
* CONSTANTS[68] is Force_max in component Force (dimensionless).
* CONSTANTS[54] is phi_SL in component Force (dimensionless).
* CONSTANTS[65] is P_1_max in component Force (dimensionless).
* CONSTANTS[66] is P_2_max in component Force (dimensionless).
* CONSTANTS[67] is P_3_max in component Force (dimensionless).
* CONSTANTS[64] is sigma_paths in component Force (dimensionless).
* STATES[18] is N_0 in component Force (dimensionless).
* STATES[19] is P_0 in component Force (dimensionless).
* STATES[20] is P_1 in component Force (dimensionless).
* STATES[21] is P_2 in component Force (dimensionless).
* STATES[22] is P_3 in component Force (dimensionless).
* ALGEBRAIC[47] is N_1 in component Force (dimensionless).
* ALGEBRAIC[46] is alpha_tm in component Force (per_second).
* CONSTANTS[49] is beta_tm in component Force (per_second).
* CONSTANTS[57] is K_tm in component Force (dimensionless).
* CONSTANTS[58] is N_tm in component Force (dimensionless).
* CONSTANTS[50] is SL in component Force (micrometre).
* CONSTANTS[55] is SL_norm in component Force (dimensionless).
* CONSTANTS[56] is f_01 in component Force (per_second).
* CONSTANTS[59] is f_12 in component Force (per_second).
* CONSTANTS[63] is f_23 in component Force (per_second).
* CONSTANTS[60] is g_01 in component Force (per_second).
* CONSTANTS[61] is g_12 in component Force (per_second).
* CONSTANTS[62] is g_23 in component Force (per_second).
* CONSTANTS[51] is f_XB in component Force (per_second).
* CONSTANTS[52] is g_XB in component Force (per_second).
* RATES[0] is d/dt V in component membrane_potential (millivolt).
* RATES[4] is d/dt m in component fast_sodium_current_m_gate (dimensionless).
* RATES[5] is d/dt h in component fast_sodium_current_h_gate (dimensionless).
* RATES[6] is d/dt x in component time_dependent_rectifier_potassium_current_x_gate (dimensionless).
* RATES[7] is d/dt s in component transient_outward_current_s_gate (dimensionless).
* RATES[8] is d/dt r in component transient_outward_current_r_gate (dimensionless).
* RATES[9] is d/dt d in component L_type_Ca_channel_d_gate (dimensionless).
* RATES[10] is d/dt f in component L_type_Ca_channel_f_gate (dimensionless).
* RATES[11] is d/dt F_CaMK in component CaMKII_factor (dimensionless).
* RATES[15] is d/dt F_1 in component RyR (dimensionless).
* RATES[16] is d/dt F_2 in component RyR (dimensionless).
* RATES[14] is d/dt F_SRCa_RyR in component RyR (millimolar).
* RATES[12] is d/dt Cmdn_Ca in component calmodulin (millimolar).
* RATES[17] is d/dt Trpn_Ca in component troponin (millimolar).
* RATES[3] is d/dt Ca_i in component intracellular_calcium_concentration (millimolar).
* RATES[13] is d/dt Ca_SR in component SR_calcium_concentration (millimolar).
* RATES[2] is d/dt Na_i in component intracellular_sodium_concentration (millimolar).
* RATES[1] is d/dt K_i in component intracellular_potassium_concentration (millimolar).
* RATES[18] is d/dt N_0 in component Force (dimensionless).
* RATES[19] is d/dt P_0 in component Force (dimensionless).
* RATES[20] is d/dt P_1 in component Force (dimensionless).
* RATES[21] is d/dt P_2 in component Force (dimensionless).
* RATES[22] is d/dt P_3 in component Force (dimensionless).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 8314.472;
CONSTANTS[1] = 310;
CONSTANTS[2] = 96485.3415;
CONSTANTS[3] = 9.5e-5;
CONSTANTS[4] = 1.6404e-5;
CONSTANTS[5] = 3.3477e-6;
CONSTANTS[6] = 140;
CONSTANTS[7] = 4;
CONSTANTS[8] = 2;
STATES[0] = -92.849333;
CONSTANTS[9] = 0;
CONSTANTS[10] = 1000;
CONSTANTS[11] = 0.5;
CONSTANTS[12] = 0.002;
CONSTANTS[13] = -4;
STATES[1] = 138.22;
STATES[2] = 5.8041;
STATES[3] = 9.91e-6;
CONSTANTS[14] = 2.5;
STATES[4] = 0.0013809;
STATES[5] = 0.99569;
CONSTANTS[15] = 1e-5;
CONSTANTS[16] = 0;
CONSTANTS[17] = 1;
STATES[6] = 5.1127e-2;
CONSTANTS[18] = 10;
CONSTANTS[19] = 1;
CONSTANTS[20] = 0.005;
STATES[7] = 0.95854;
STATES[8] = 1.5185e-8;
CONSTANTS[21] = 0.25;
STATES[9] = 1.7908e-8;
STATES[10] = 1;
CONSTANTS[22] = 3;
CONSTANTS[23] = 0.5;
CONSTANTS[24] = 0.0005;
CONSTANTS[25] = 0.5;
CONSTANTS[26] = 1.36;
CONSTANTS[27] = 1;
CONSTANTS[28] = 21.7;
CONSTANTS[29] = 0.00025;
CONSTANTS[30] = 0.0006;
CONSTANTS[31] = 0.0006;
STATES[11] = 1.028;
CONSTANTS[32] = 0.8;
STATES[12] = 3.9636e-6;
STATES[13] = 0.24886;
CONSTANTS[33] = 500;
STATES[14] = 0.25089;
CONSTANTS[34] = 0.05;
CONSTANTS[35] = 1;
CONSTANTS[36] = 1;
CONSTANTS[37] = 1;
CONSTANTS[38] = 1;
STATES[15] = 0.5268;
STATES[16] = 8.7508e-6;
CONSTANTS[39] = 0;
CONSTANTS[40] = 0.292;
CONSTANTS[41] = 0.391;
CONSTANTS[42] = 0.02;
CONSTANTS[43] = 10000;
CONSTANTS[44] = 500;
STATES[17] = 2.7661e-4;
CONSTANTS[45] = 0.07;
CONSTANTS[46] = 80000;
CONSTANTS[47] = 200;
CONSTANTS[48] = 0.1;
STATES[18] = 0.99917;
STATES[19] = 9.8593e-5;
STATES[20] = 1.3331e-4;
STATES[21] = 2.3505e-4;
STATES[22] = 1.5349e-4;
CONSTANTS[49] = 40;
CONSTANTS[50] = 2.15;
CONSTANTS[51] = 10;
CONSTANTS[52] = 30;
CONSTANTS[53] = CONSTANTS[38]*1.80000;
CONSTANTS[54] = (CONSTANTS[50]>=1.70000&&CONSTANTS[50]<=2.00000 ? (CONSTANTS[50] - 0.600000)/1.40000 : CONSTANTS[50]>2.00000&&CONSTANTS[50]<=2.20000 ? 1.00000 : CONSTANTS[50]>2.20000&&CONSTANTS[50]<=2.30000 ? (3.60000 - CONSTANTS[50])/1.40000 : 0.0/0.0);
CONSTANTS[55] = (CONSTANTS[50] - 1.70000)/0.700000;
CONSTANTS[56] = 3.00000*CONSTANTS[51];
CONSTANTS[57] = 1.00000/(1.00000+(CONSTANTS[47]/CONSTANTS[46])/(0.00170000 - 0.000900000*CONSTANTS[55]));
CONSTANTS[58] = 3.50000+ 2.50000*CONSTANTS[55];
CONSTANTS[59] = 10.0000*CONSTANTS[51];
CONSTANTS[60] = CONSTANTS[52]*(2.00000 - CONSTANTS[55]);
CONSTANTS[61] = 2.00000*CONSTANTS[52]*(2.00000 - CONSTANTS[55]);
CONSTANTS[62] = 3.00000*CONSTANTS[52]*(2.00000 - CONSTANTS[55]);
CONSTANTS[63] = 7.00000*CONSTANTS[51];
CONSTANTS[64] = 1.00000*CONSTANTS[52]*2.00000*CONSTANTS[52]*3.00000*CONSTANTS[52]+ 1.00000*CONSTANTS[56]*2.00000*CONSTANTS[52]*3.00000*CONSTANTS[52]+ 1.00000*CONSTANTS[56]*1.00000*CONSTANTS[59]*3.00000*CONSTANTS[52]+ 1.00000*CONSTANTS[56]*1.00000*CONSTANTS[59]*1.00000*CONSTANTS[63];
CONSTANTS[65] = ( 1.00000*CONSTANTS[56]*2.00000*CONSTANTS[52]*3.00000*CONSTANTS[52])/CONSTANTS[64];
CONSTANTS[66] = ( 1.00000*CONSTANTS[56]*1.00000*CONSTANTS[59]*3.00000*CONSTANTS[52])/CONSTANTS[64];
CONSTANTS[67] = ( 1.00000*CONSTANTS[56]*1.00000*CONSTANTS[59]*1.00000*CONSTANTS[63])/CONSTANTS[64];
CONSTANTS[68] = CONSTANTS[65]+ 2.00000*CONSTANTS[66]+ 3.00000*CONSTANTS[67];
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
RATES[8] = 333.000*(1.00000/(1.00000+exp(- (STATES[0]+4.00000)/5.00000)) - STATES[8]);
RATES[14] = (STATES[13] - STATES[14])/CONSTANTS[34];
RATES[12] = CONSTANTS[43]*(CONSTANTS[42] - STATES[12])*STATES[3] - CONSTANTS[44]*STATES[12];
RATES[21] = - (CONSTANTS[63]+CONSTANTS[61])*STATES[21]+ CONSTANTS[59]*STATES[20]+ CONSTANTS[62]*STATES[22];
RATES[22] = - CONSTANTS[62]*STATES[22]+ CONSTANTS[63]*STATES[21];
ALGEBRAIC[7] = STATES[12]/5.00000e-05;
RATES[11] = (ALGEBRAIC[7] - STATES[11])/CONSTANTS[32];
ALGEBRAIC[2] = 20.0000*exp( - 0.125000*((STATES[0]+75.0000) - CONSTANTS[16]));
ALGEBRAIC[10] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*((STATES[0]+75.0000) - CONSTANTS[16])));
RATES[5] = ALGEBRAIC[2]*(1.00000 - STATES[5]) - ALGEBRAIC[10]*STATES[5];
ALGEBRAIC[3] = ( 0.500000*exp( 0.0826000*(STATES[0]+50.0000)))/(1.00000+exp( 0.0570000*(STATES[0]+50.0000)));
ALGEBRAIC[11] = ( 1.30000*exp( - 0.0600000*(STATES[0]+20.0000)))/(1.00000+exp( - 0.0400000*(STATES[0]+20.0000)));
RATES[6] = ALGEBRAIC[3]*(1.00000 - STATES[6]) - ALGEBRAIC[11]*STATES[6];
ALGEBRAIC[4] = 0.0330000*exp(- STATES[0]/17.0000);
ALGEBRAIC[12] = 33.0000/(1.00000+exp( - 0.125000*(STATES[0]+10.0000)));
RATES[7] = ALGEBRAIC[4]*(1.00000 - STATES[7]) - ALGEBRAIC[12]*STATES[7];
ALGEBRAIC[1] = STATES[0]+41.0000;
ALGEBRAIC[9] = (fabs(ALGEBRAIC[1])<CONSTANTS[15] ? 2000.00 : ( 200.000*ALGEBRAIC[1])/(1.00000 - exp( - 0.100000*ALGEBRAIC[1])));
ALGEBRAIC[16] = 8000.00*exp( - 0.0560000*(STATES[0]+66.0000));
RATES[4] = ALGEBRAIC[9]*(1.00000 - STATES[4]) - ALGEBRAIC[16]*STATES[4];
ALGEBRAIC[5] = (STATES[0]+24.0000) - 5.00000;
ALGEBRAIC[13] = (fabs(ALGEBRAIC[5])<1.00000e-05 ? CONSTANTS[22]*120.000 : ( CONSTANTS[22]*30.0000*ALGEBRAIC[5])/(1.00000 - exp(- ALGEBRAIC[5]/4.00000)));
ALGEBRAIC[17] = (fabs(ALGEBRAIC[5])<1.00000e-05 ? CONSTANTS[22]*120.000 : ( CONSTANTS[22]*- 12.0000*ALGEBRAIC[5])/(1.00000 - exp(ALGEBRAIC[5]/10.0000)));
RATES[9] = ALGEBRAIC[13]*(1.00000 - STATES[9]) - ALGEBRAIC[17]*STATES[9];
ALGEBRAIC[6] = STATES[0]+34.0000;
ALGEBRAIC[14] = (fabs(ALGEBRAIC[6])<1.00000e-05 ? CONSTANTS[23]*25.0000 : ( CONSTANTS[23]*6.25000*ALGEBRAIC[6])/(- 1.00000+exp(ALGEBRAIC[6]/4.00000)));
ALGEBRAIC[18] = ( CONSTANTS[23]*50.0000)/(1.00000+exp(- ALGEBRAIC[6]/4.00000));
RATES[10] = ALGEBRAIC[14]*(1.00000 - STATES[10]) - ALGEBRAIC[18]*STATES[10];
ALGEBRAIC[27] = (( 0.0100000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[2]*exp(( 50.0000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[6]*exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[26] = (( 0.00200000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[1]*exp(( 50.0000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[7]*exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[25] = (( 4.00000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - 2.00000*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[3]*exp(( 100.000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[8]*exp(( - 2.00000*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[28] = ALGEBRAIC[25]+ALGEBRAIC[26]+ALGEBRAIC[27];
ALGEBRAIC[31] = CONSTANTS[35]*( 3.06250e+07*pow(STATES[3], 2.00000) - 245.000*ALGEBRAIC[28]);
ALGEBRAIC[33] = ( CONSTANTS[36]*450.000)/(1.00000+0.360000/STATES[13]);
RATES[16] = ALGEBRAIC[31]*STATES[15] - ALGEBRAIC[33]*STATES[16];
ALGEBRAIC[29] = pow(STATES[11]/0.700000, 2.00000);
ALGEBRAIC[34] = CONSTANTS[37]*1.88500*pow(STATES[14]/0.220000, ALGEBRAIC[29]);
ALGEBRAIC[38] = 1.00000 - (STATES[15]+STATES[16]);
RATES[15] = ( ALGEBRAIC[34]*ALGEBRAIC[38] - CONSTANTS[53]*STATES[15]) - ALGEBRAIC[31]*STATES[15];
ALGEBRAIC[15] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[7]/STATES[1]);
ALGEBRAIC[23] = ( (( CONSTANTS[19]*CONSTANTS[7])/(CONSTANTS[7]+CONSTANTS[18]))*(STATES[0] - ALGEBRAIC[15]))/(1.00000+exp(( 2.00000*CONSTANTS[2]*((STATES[0] - ALGEBRAIC[15]) - 10.0000))/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[24] = CONSTANTS[20]*STATES[7]*STATES[8]*(STATES[0] - ALGEBRAIC[15]);
ALGEBRAIC[22] = ( CONSTANTS[17]*STATES[6]*(STATES[1] - CONSTANTS[7]*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))))/140.000;
ALGEBRAIC[32] = ( (( (( CONSTANTS[26]*CONSTANTS[7])/(CONSTANTS[27]+CONSTANTS[7]))*STATES[2])/(CONSTANTS[28]+STATES[2]))*1.00000)/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[36] = CONSTANTS[30]*(STATES[0] - ALGEBRAIC[15]);
RATES[1] = - ((ALGEBRAIC[23]+ALGEBRAIC[22]+ALGEBRAIC[24]+ALGEBRAIC[36]+ALGEBRAIC[26]) - 2.00000*ALGEBRAIC[32])/( CONSTANTS[4]*CONSTANTS[2]);
ALGEBRAIC[20] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[6]+ 0.120000*CONSTANTS[7])/(STATES[2]+ 0.120000*STATES[1]));
ALGEBRAIC[21] = CONSTANTS[14]*pow(STATES[4], 3.00000)*STATES[5]*(STATES[0] - ALGEBRAIC[20]);
ALGEBRAIC[30] = ( CONSTANTS[24]*( exp(( CONSTANTS[25]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[8] - exp(( (CONSTANTS[25] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[6], 3.00000)*STATES[3]))/(1.00000+STATES[3]/0.00690000);
ALGEBRAIC[8] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[6]/STATES[2]);
ALGEBRAIC[39] = CONSTANTS[31]*(STATES[0] - ALGEBRAIC[8]);
ALGEBRAIC[19] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[3]);
ALGEBRAIC[35] = CONSTANTS[29]*(STATES[0] - ALGEBRAIC[19]);
ALGEBRAIC[0] = (VOI>=CONSTANTS[9]&&VOI<=CONSTANTS[10]&&(VOI - CONSTANTS[9]) - floor((VOI - CONSTANTS[9])/CONSTANTS[11])*CONSTANTS[11]<=CONSTANTS[12] ? CONSTANTS[13] : 0.00000);
RATES[0] = (- 1.00000/CONSTANTS[3])*(ALGEBRAIC[21]+ALGEBRAIC[39]+ALGEBRAIC[23]+ALGEBRAIC[22]+ALGEBRAIC[24]+ALGEBRAIC[36]+ALGEBRAIC[28]+ALGEBRAIC[35]+ALGEBRAIC[30]+ALGEBRAIC[32]+ALGEBRAIC[0]);
RATES[2] = - (ALGEBRAIC[21]+ALGEBRAIC[39]+ALGEBRAIC[27]+ 3.00000*ALGEBRAIC[30]+ 3.00000*ALGEBRAIC[32])/( CONSTANTS[4]*CONSTANTS[2]);
ALGEBRAIC[40] = ( CONSTANTS[33]*STATES[14])/(STATES[14]+0.200000);
ALGEBRAIC[37] = pow(STATES[16]/(STATES[16]+0.250000), 2.00000);
ALGEBRAIC[41] = ( ALGEBRAIC[40]*ALGEBRAIC[37]+CONSTANTS[39])*(STATES[13] - STATES[3]);
ALGEBRAIC[42] = pow(STATES[3]/0.000240000, 2.00000);
ALGEBRAIC[43] = pow(STATES[13]/1.64000, 2.00000);
ALGEBRAIC[44] = ( STATES[11]*CONSTANTS[40]*ALGEBRAIC[42] - CONSTANTS[41]*ALGEBRAIC[43])/(1.00000+ALGEBRAIC[42]+ALGEBRAIC[43]);
RATES[13] = ( ALGEBRAIC[44]*CONSTANTS[4])/CONSTANTS[5] - ALGEBRAIC[41];
ALGEBRAIC[46] = CONSTANTS[49]*pow(STATES[17]/( CONSTANTS[45]*CONSTANTS[57]), CONSTANTS[58]);
RATES[19] = - (CONSTANTS[49]+CONSTANTS[56])*STATES[19]+ ALGEBRAIC[46]*STATES[18]+ CONSTANTS[60]*STATES[20];
ALGEBRAIC[47] = 1.00000 - (STATES[18]+STATES[19]+STATES[20]+STATES[21]+STATES[22]);
RATES[18] = ( CONSTANTS[49]*STATES[19] - ALGEBRAIC[46]*STATES[18])+ CONSTANTS[60]*ALGEBRAIC[47];
RATES[20] = - (CONSTANTS[49]+CONSTANTS[59]+CONSTANTS[60])*STATES[20]+ ALGEBRAIC[46]*ALGEBRAIC[47]+ CONSTANTS[56]*STATES[19]+ CONSTANTS[61]*STATES[21];
ALGEBRAIC[48] = ( CONSTANTS[54]*(STATES[20]+ALGEBRAIC[47]+ 2.00000*STATES[21]+ 3.00000*STATES[22]))/CONSTANTS[68];
RATES[17] = CONSTANTS[46]*(CONSTANTS[45] - STATES[17])*STATES[3] - (( CONSTANTS[47]*(1.00000+ 2.00000*(1.00000 - ALGEBRAIC[48])))/3.00000)*STATES[17];
ALGEBRAIC[45] = CONSTANTS[43]*(CONSTANTS[42] - STATES[12])*STATES[3] - CONSTANTS[44]*STATES[12];
ALGEBRAIC[49] = CONSTANTS[46]*(CONSTANTS[45] - STATES[17])*STATES[3] - (( CONSTANTS[47]*(1.00000+ 2.00000*(1.00000 - ALGEBRAIC[48])))/3.00000)*STATES[17];
RATES[3] = (((- ((ALGEBRAIC[25]+ALGEBRAIC[35]) - 2.00000*ALGEBRAIC[30])/( 2.00000*CONSTANTS[4]*CONSTANTS[2]) - ALGEBRAIC[44])+( ALGEBRAIC[41]*CONSTANTS[5])/CONSTANTS[4]) - ALGEBRAIC[45]) - ALGEBRAIC[49];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[7] = STATES[12]/5.00000e-05;
ALGEBRAIC[2] = 20.0000*exp( - 0.125000*((STATES[0]+75.0000) - CONSTANTS[16]));
ALGEBRAIC[10] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*((STATES[0]+75.0000) - CONSTANTS[16])));
ALGEBRAIC[3] = ( 0.500000*exp( 0.0826000*(STATES[0]+50.0000)))/(1.00000+exp( 0.0570000*(STATES[0]+50.0000)));
ALGEBRAIC[11] = ( 1.30000*exp( - 0.0600000*(STATES[0]+20.0000)))/(1.00000+exp( - 0.0400000*(STATES[0]+20.0000)));
ALGEBRAIC[4] = 0.0330000*exp(- STATES[0]/17.0000);
ALGEBRAIC[12] = 33.0000/(1.00000+exp( - 0.125000*(STATES[0]+10.0000)));
ALGEBRAIC[1] = STATES[0]+41.0000;
ALGEBRAIC[9] = (fabs(ALGEBRAIC[1])<CONSTANTS[15] ? 2000.00 : ( 200.000*ALGEBRAIC[1])/(1.00000 - exp( - 0.100000*ALGEBRAIC[1])));
ALGEBRAIC[16] = 8000.00*exp( - 0.0560000*(STATES[0]+66.0000));
ALGEBRAIC[5] = (STATES[0]+24.0000) - 5.00000;
ALGEBRAIC[13] = (fabs(ALGEBRAIC[5])<1.00000e-05 ? CONSTANTS[22]*120.000 : ( CONSTANTS[22]*30.0000*ALGEBRAIC[5])/(1.00000 - exp(- ALGEBRAIC[5]/4.00000)));
ALGEBRAIC[17] = (fabs(ALGEBRAIC[5])<1.00000e-05 ? CONSTANTS[22]*120.000 : ( CONSTANTS[22]*- 12.0000*ALGEBRAIC[5])/(1.00000 - exp(ALGEBRAIC[5]/10.0000)));
ALGEBRAIC[6] = STATES[0]+34.0000;
ALGEBRAIC[14] = (fabs(ALGEBRAIC[6])<1.00000e-05 ? CONSTANTS[23]*25.0000 : ( CONSTANTS[23]*6.25000*ALGEBRAIC[6])/(- 1.00000+exp(ALGEBRAIC[6]/4.00000)));
ALGEBRAIC[18] = ( CONSTANTS[23]*50.0000)/(1.00000+exp(- ALGEBRAIC[6]/4.00000));
ALGEBRAIC[27] = (( 0.0100000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[2]*exp(( 50.0000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[6]*exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[26] = (( 0.00200000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[1]*exp(( 50.0000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[7]*exp(( - (STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[25] = (( 4.00000*STATES[9]*STATES[10]*CONSTANTS[21]*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]*(1.00000 - exp(( - 2.00000*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))))*( STATES[3]*exp(( 100.000*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - CONSTANTS[8]*exp(( - 2.00000*(STATES[0] - 50.0000)*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[28] = ALGEBRAIC[25]+ALGEBRAIC[26]+ALGEBRAIC[27];
ALGEBRAIC[31] = CONSTANTS[35]*( 3.06250e+07*pow(STATES[3], 2.00000) - 245.000*ALGEBRAIC[28]);
ALGEBRAIC[33] = ( CONSTANTS[36]*450.000)/(1.00000+0.360000/STATES[13]);
ALGEBRAIC[29] = pow(STATES[11]/0.700000, 2.00000);
ALGEBRAIC[34] = CONSTANTS[37]*1.88500*pow(STATES[14]/0.220000, ALGEBRAIC[29]);
ALGEBRAIC[38] = 1.00000 - (STATES[15]+STATES[16]);
ALGEBRAIC[15] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[7]/STATES[1]);
ALGEBRAIC[23] = ( (( CONSTANTS[19]*CONSTANTS[7])/(CONSTANTS[7]+CONSTANTS[18]))*(STATES[0] - ALGEBRAIC[15]))/(1.00000+exp(( 2.00000*CONSTANTS[2]*((STATES[0] - ALGEBRAIC[15]) - 10.0000))/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[24] = CONSTANTS[20]*STATES[7]*STATES[8]*(STATES[0] - ALGEBRAIC[15]);
ALGEBRAIC[22] = ( CONSTANTS[17]*STATES[6]*(STATES[1] - CONSTANTS[7]*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))))/140.000;
ALGEBRAIC[32] = ( (( (( CONSTANTS[26]*CONSTANTS[7])/(CONSTANTS[27]+CONSTANTS[7]))*STATES[2])/(CONSTANTS[28]+STATES[2]))*1.00000)/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])));
ALGEBRAIC[36] = CONSTANTS[30]*(STATES[0] - ALGEBRAIC[15]);
ALGEBRAIC[20] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[6]+ 0.120000*CONSTANTS[7])/(STATES[2]+ 0.120000*STATES[1]));
ALGEBRAIC[21] = CONSTANTS[14]*pow(STATES[4], 3.00000)*STATES[5]*(STATES[0] - ALGEBRAIC[20]);
ALGEBRAIC[30] = ( CONSTANTS[24]*( exp(( CONSTANTS[25]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[8] - exp(( (CONSTANTS[25] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[6], 3.00000)*STATES[3]))/(1.00000+STATES[3]/0.00690000);
ALGEBRAIC[8] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[6]/STATES[2]);
ALGEBRAIC[39] = CONSTANTS[31]*(STATES[0] - ALGEBRAIC[8]);
ALGEBRAIC[19] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[3]);
ALGEBRAIC[35] = CONSTANTS[29]*(STATES[0] - ALGEBRAIC[19]);
ALGEBRAIC[0] = (VOI>=CONSTANTS[9]&&VOI<=CONSTANTS[10]&&(VOI - CONSTANTS[9]) - floor((VOI - CONSTANTS[9])/CONSTANTS[11])*CONSTANTS[11]<=CONSTANTS[12] ? CONSTANTS[13] : 0.00000);
ALGEBRAIC[40] = ( CONSTANTS[33]*STATES[14])/(STATES[14]+0.200000);
ALGEBRAIC[37] = pow(STATES[16]/(STATES[16]+0.250000), 2.00000);
ALGEBRAIC[41] = ( ALGEBRAIC[40]*ALGEBRAIC[37]+CONSTANTS[39])*(STATES[13] - STATES[3]);
ALGEBRAIC[42] = pow(STATES[3]/0.000240000, 2.00000);
ALGEBRAIC[43] = pow(STATES[13]/1.64000, 2.00000);
ALGEBRAIC[44] = ( STATES[11]*CONSTANTS[40]*ALGEBRAIC[42] - CONSTANTS[41]*ALGEBRAIC[43])/(1.00000+ALGEBRAIC[42]+ALGEBRAIC[43]);
ALGEBRAIC[46] = CONSTANTS[49]*pow(STATES[17]/( CONSTANTS[45]*CONSTANTS[57]), CONSTANTS[58]);
ALGEBRAIC[47] = 1.00000 - (STATES[18]+STATES[19]+STATES[20]+STATES[21]+STATES[22]);
ALGEBRAIC[48] = ( CONSTANTS[54]*(STATES[20]+ALGEBRAIC[47]+ 2.00000*STATES[21]+ 3.00000*STATES[22]))/CONSTANTS[68];
ALGEBRAIC[45] = CONSTANTS[43]*(CONSTANTS[42] - STATES[12])*STATES[3] - CONSTANTS[44]*STATES[12];
ALGEBRAIC[49] = CONSTANTS[46]*(CONSTANTS[45] - STATES[17])*STATES[3] - (( CONSTANTS[47]*(1.00000+ 2.00000*(1.00000 - ALGEBRAIC[48])))/3.00000)*STATES[17];
ALGEBRAIC[50] = CONSTANTS[48]*ALGEBRAIC[48];
}