C C There are a total of 4 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 15 entries in the constant variable array. C C C VOI is time in component environment (min). C STATES(1) is Z in component Ca (uM). C STATES(2) is Y in component Ca (uM). C STATES(3) is X in component Ca (uM). C CONSTS(15) is V_in in component V_in (uM_per_min). C ALGBRC(1) is V_2i in component V_2i (uM_per_min). C ALGBRC(2) is V_3i in component V_3i (uM_per_min). C ALGBRC(3) is V_2s in component V_2s (uM_per_min). C ALGBRC(4) is V_3s in component V_3s (uM_per_min). C CONSTS(1) is K_f in component Ca (per_min). C CONSTS(2) is K in component Ca (per_min). C CONSTS(3) is beta in component Ca_flux (dimensionless). C CONSTS(4) is v_0 in component V_in (uM_per_min). C CONSTS(5) is v_1 in component V_in (uM_per_min). C CONSTS(6) is V_M2i in component V_2i (uM_per_min). C CONSTS(7) is K_2i in component V_2i (uM). C CONSTS(8) is V_M3i in component V_3i (uM_per_min). C CONSTS(9) is K_3z in component V_3i (uM). C CONSTS(10) is K_3y in component V_3i (uM). C CONSTS(11) is V_M2s in component V_2s (uM_per_min). C CONSTS(12) is K_2s in component V_2s (uM). C CONSTS(13) is V_M3s in component V_3s (uM_per_min). C CONSTS(14) is K_3s in component V_3s (uM). C RATES(1) is d/dt Z in component Ca (uM). C RATES(2) is d/dt Y in component Ca (uM). C RATES(3) is d/dt X in component Ca (uM). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.0 STATES(2) = 0.0 STATES(3) = 0.5 CONSTS(1) = 0.5 CONSTS(2) = 1 CONSTS(3) = 1 CONSTS(4) = 0.015 CONSTS(5) = 0.012 CONSTS(6) = 3.1 CONSTS(7) = 0.005 CONSTS(8) = 25 CONSTS(9) = 0.022 CONSTS(10) = 0.065 CONSTS(11) = 1.5 CONSTS(12) = 0.0265 CONSTS(13) = 0.169 CONSTS(14) = 0.1 CONSTS(15) = CONSTS(4)+ CONSTS(5)*CONSTS(3) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(6)*(STATES(1) ** 2.00000/(CONSTS(7) ** 2.00000+STATES(1) ** 2.00000)) ALGBRC(2) = CONSTS(8)*(STATES(2) ** 2.00000/(CONSTS(10) ** 2.00000+STATES(2) ** 2.00000))*(STATES(1) ** 2.00000/(CONSTS(9) ** 2.00000+STATES(1) ** 2.00000)) RATES(2) = ALGBRC(1)+- ALGBRC(2)+- ( CONSTS(1)*STATES(2)) ALGBRC(3) = CONSTS(11)*(STATES(1) ** 2.00000/(CONSTS(12) ** 2.00000+STATES(1) ** 2.00000)) ALGBRC(4) = CONSTS(3)*CONSTS(13)*(STATES(3) ** 2.00000/(CONSTS(14) ** 2.00000+STATES(3) ** 2.00000)) RATES(1) = CONSTS(15)+- ALGBRC(1)+ALGBRC(2)+ CONSTS(1)*STATES(2)+- ALGBRC(3)+ALGBRC(4)+ CONSTS(1)*STATES(3)+- ( CONSTS(2)*STATES(1)) RATES(3) = ALGBRC(3)+- ALGBRC(4)+- ( CONSTS(1)*STATES(3)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(6)*(STATES(1) ** 2.00000/(CONSTS(7) ** 2.00000+STATES(1) ** 2.00000)) ALGBRC(2) = CONSTS(8)*(STATES(2) ** 2.00000/(CONSTS(10) ** 2.00000+STATES(2) ** 2.00000))*(STATES(1) ** 2.00000/(CONSTS(9) ** 2.00000+STATES(1) ** 2.00000)) ALGBRC(3) = CONSTS(11)*(STATES(1) ** 2.00000/(CONSTS(12) ** 2.00000+STATES(1) ** 2.00000)) ALGBRC(4) = CONSTS(3)*CONSTS(13)*(STATES(3) ** 2.00000/(CONSTS(14) ** 2.00000+STATES(3) ** 2.00000)) RETURN END