/* There are a total of 11 entries in the algebraic variable array. There are a total of 10 entries in each of the rate and state variable arrays. There are a total of 27 entries in the constant variable array. */ /* * VOI is time in component environment (second). * ALGEBRAIC[0] is Rate_Ca_influx_across_the_SR in component Ca_influx_across_the_SR (flux). * CONSTANTS[0] is Ca_e in component extracellular_calcium (molar). * STATES[0] is Ca_f in component fuzzy_space_calcium (molar). * CONSTANTS[1] is k1 in component Ca_influx_across_the_SR (first_order_rate_constant). * STATES[1] is Ca_2_S1 in component Ca_bound_to_the_SRRC_fast_activating_binding_site (molar). * STATES[2] is Ca_S2 in component Ca_bound_to_the_SRRC_slow_inactivating_binding_site (molar). * STATES[3] is S1 in component SRRC_fast_activating_binding_site (molar). * STATES[4] is S2 in component SRRC_slow_inactivating_binding_site (molar). * STATES[5] is Ca_s in component SR_calcium (molar). * ALGEBRAIC[1] is dCa2_S1_dt in component Ca_movement_through_the_SRRC (flux). * ALGEBRAIC[2] is dCa_S2_dt in component Ca_movement_through_the_SRRC (flux). * CONSTANTS[2] is k_on1 in component Ca_movement_through_the_SRRC (second_order_rate_constant). * CONSTANTS[3] is k_off1 in component Ca_movement_through_the_SRRC (first_order_rate_constant). * CONSTANTS[4] is k_on2 in component Ca_movement_through_the_SRRC (second_order_rate_constant). * CONSTANTS[5] is k_off2 in component Ca_movement_through_the_SRRC (first_order_rate_constant). * CONSTANTS[6] is k_s in component Ca_movement_through_the_SRRC (first_order_rate_constant). * STATES[6] is cas1 in component Ca_movement_through_the_SRRC (dimensionless). * STATES[7] is cas2 in component Ca_movement_through_the_SRRC (dimensionless). * ALGEBRAIC[4] is dcas1_dt in component Ca_movement_through_the_SRRC (first_order_rate_constant). * ALGEBRAIC[5] is dcas2_dt in component Ca_movement_through_the_SRRC (first_order_rate_constant). * ALGEBRAIC[3] is r_o in component Ca_movement_through_the_SRRC (dimensionless). * ALGEBRAIC[6] is Rate_Ca_movement_through_the_SRRC in component Ca_movement_through_the_SRRC (flux). * CONSTANTS[7] is Km_NaCaX in component Ca_efflux_across_the_SR_by_NaCa_exchange (molar). * CONSTANTS[8] is Vmax_NaCaX in component Ca_efflux_across_the_SR_by_NaCa_exchange (flux). * ALGEBRAIC[7] is Rate_Ca_efflux_across_the_SR_by_NaCa_exchange in component Ca_efflux_across_the_SR_by_NaCa_exchange (flux). * STATES[8] is Ca_c in component cytosolic_calcium (molar). * CONSTANTS[9] is kf in component Ca_movement_between_the_fuzzy_space_and_cytosol (first_order_rate_constant). * ALGEBRAIC[8] is Rate_Ca_movement_between_the_fuzzy_space_and_cytosol in component Ca_movement_between_the_fuzzy_space_and_cytosol (flux). * CONSTANTS[10] is Km_s in component Ca_uptake_by_SR_Ca_ATPase (molar). * CONSTANTS[11] is Vmax_s in component Ca_uptake_by_SR_Ca_ATPase (flux). * ALGEBRAIC[9] is Rate_Ca_uptake_by_SR_Ca_ATPase in component Ca_uptake_by_SR_Ca_ATPase (flux). * STATES[9] is Ca_CSQ in component calsequestrin_bound_calcium (molar). * CONSTANTS[12] is K_ons in component Ca_buffering_in_the_SR (second_order_rate_constant). * CONSTANTS[13] is K_offs in component Ca_buffering_in_the_SR (first_order_rate_constant). * CONSTANTS[14] is Bmax_s in component Ca_buffering_in_the_SR (molar). * ALGEBRAIC[10] is Rate_Ca_buffering_in_the_SR in component Ca_buffering_in_the_SR (flux). * CONSTANTS[15] is Rt in component fuzzy_space_calcium (molar). * CONSTANTS[16] is Bmax_f1 in component fuzzy_space_calcium (molar). * CONSTANTS[17] is Bmax_f2 in component fuzzy_space_calcium (molar). * CONSTANTS[18] is Kb_f1 in component fuzzy_space_calcium (molar). * CONSTANTS[19] is Kb_f2 in component fuzzy_space_calcium (molar). * CONSTANTS[20] is V_f in component fuzzy_space_calcium (dimensionless). * CONSTANTS[21] is Bmax_c in component cytosolic_calcium (molar). * CONSTANTS[22] is dye_c in component cytosolic_calcium (molar). * CONSTANTS[23] is Kb_c in component cytosolic_calcium (molar). * CONSTANTS[24] is Kb_dye in component cytosolic_calcium (molar). * CONSTANTS[25] is V_c in component cytosolic_calcium (dimensionless). * CONSTANTS[26] is V_s in component SR_calcium (dimensionless). * RATES[6] is d/dt cas1 in component Ca_movement_through_the_SRRC (dimensionless). * RATES[7] is d/dt cas2 in component Ca_movement_through_the_SRRC (dimensionless). * RATES[0] is d/dt Ca_f in component fuzzy_space_calcium (molar). * RATES[8] is d/dt Ca_c in component cytosolic_calcium (molar). * RATES[5] is d/dt Ca_s in component SR_calcium (molar). * RATES[9] is d/dt Ca_CSQ in component calsequestrin_bound_calcium (molar). * RATES[3] is d/dt S1 in component SRRC_fast_activating_binding_site (molar). * RATES[4] is d/dt S2 in component SRRC_slow_inactivating_binding_site (molar). * RATES[1] is d/dt Ca_2_S1 in component Ca_bound_to_the_SRRC_fast_activating_binding_site (molar). * RATES[2] is d/dt Ca_S2 in component Ca_bound_to_the_SRRC_slow_inactivating_binding_site (molar). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.002; STATES[0] = 0.12e-6; CONSTANTS[1] = 0.2; STATES[1] = 0; STATES[2] = 0; STATES[3] = 0; STATES[4] = 0; STATES[5] = 201e-6; CONSTANTS[2] = 2000000000; CONSTANTS[3] = 1400; CONSTANTS[4] = 13000000; CONSTANTS[5] = 3.9; CONSTANTS[6] = 9; STATES[6] = 0; STATES[7] = 0; CONSTANTS[7] = 0.000036; CONSTANTS[8] = 0.0012; STATES[8] = 1e-7; CONSTANTS[9] = 2500; CONSTANTS[10] = 0.00000025; CONSTANTS[11] = 0.000525; STATES[9] = 0; CONSTANTS[12] = 8772; CONSTANTS[13] = 5.596536; CONSTANTS[14] = 0.008; CONSTANTS[15] = 0.00000015; CONSTANTS[16] = 0.0002; CONSTANTS[17] = 0.0011; CONSTANTS[18] = 0.000017; CONSTANTS[19] = 0.000013; CONSTANTS[20] = 0.0013; CONSTANTS[21] = 0.00012; CONSTANTS[22] = 0; CONSTANTS[23] = 0.00000096; CONSTANTS[24] = 2e-7; CONSTANTS[25] = 0.9287; CONSTANTS[26] = 0.07; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[0] = 0.1001; RATES[8] = 0.1001; RATES[5] = 0.1001; RATES[9] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[6] - ALGEBRAIC[4]; resid[1] = RATES[7] - ALGEBRAIC[5]; resid[2] = RATES[0] - ((ALGEBRAIC[6] - ( CONSTANTS[15]*(ALGEBRAIC[4]+ALGEBRAIC[5])+ALGEBRAIC[8]+ALGEBRAIC[7]))+ALGEBRAIC[0])/(( CONSTANTS[16]*CONSTANTS[18])/pow(STATES[0]+CONSTANTS[18], 2.00000)+( CONSTANTS[17]*CONSTANTS[19])/pow(STATES[0]+CONSTANTS[19], 2.00000)+CONSTANTS[20]); resid[3] = RATES[8] - (ALGEBRAIC[8] - ALGEBRAIC[9])/(( CONSTANTS[21]*CONSTANTS[23])/pow(STATES[8]+CONSTANTS[23], 2.00000)+( CONSTANTS[22]*CONSTANTS[24])/pow(STATES[8]+CONSTANTS[24], 2.00000)+CONSTANTS[25]); resid[4] = RATES[5] - (ALGEBRAIC[9] - ALGEBRAIC[6])/CONSTANTS[26] - ALGEBRAIC[10]; resid[5] = RATES[9] - ALGEBRAIC[10]; resid[6] = RATES[3] - - ALGEBRAIC[1]; resid[7] = RATES[4] - - ALGEBRAIC[2]; resid[8] = RATES[1] - ALGEBRAIC[1]; resid[9] = RATES[2] - ALGEBRAIC[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[1]*(CONSTANTS[0] - STATES[0]); ALGEBRAIC[1] = CONSTANTS[2]*STATES[0]*STATES[3] - (pow(CONSTANTS[3], 2.00000)/( CONSTANTS[2]*STATES[0]))*STATES[1]; ALGEBRAIC[2] = CONSTANTS[4]*STATES[0]*STATES[4] - CONSTANTS[5]*STATES[2]; ALGEBRAIC[4] = CONSTANTS[2]*STATES[0]*(1.00000 - STATES[6]) - (pow(CONSTANTS[3], 2.00000)/( CONSTANTS[2]*STATES[0]))*STATES[6]; ALGEBRAIC[5] = CONSTANTS[4]*STATES[0]*(1.00000 - STATES[7]) - CONSTANTS[5]*STATES[7]; ALGEBRAIC[3] = STATES[6]*(1.00000 - STATES[7]); ALGEBRAIC[6] = CONSTANTS[6]*ALGEBRAIC[3]*(STATES[5] - STATES[0]); ALGEBRAIC[7] = ( CONSTANTS[8]*STATES[0])/(CONSTANTS[7]+STATES[0]); ALGEBRAIC[8] = CONSTANTS[9]*(STATES[0] - STATES[8]); ALGEBRAIC[9] = ( CONSTANTS[11]*(pow(STATES[8], 2.00000) - pow(STATES[5], 2.00000)/pow(7000.00, 2.00000)))/(pow(CONSTANTS[10], 2.00000)+pow(STATES[8], 2.00000)+pow(STATES[5], 2.00000)/pow(7000.00, 2.00000)); ALGEBRAIC[10] = CONSTANTS[12]*STATES[5]*(CONSTANTS[14] - STATES[9]) - CONSTANTS[13]*STATES[9]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }