C C There are a total of 11 entries in the algebraic variable array. C There are a total of 10 entries in each of the rate and state variable arrays. C There are a total of 27 entries in the constant variable array. C C C VOI is time in component environment (second). C ALGBRC(3) is Rate_Ca_influx_across_the_SR in component Ca_influx_across_the_SR (flux). C CONSTS(1) is Ca_e in component extracellular_calcium (molar). C STATES(1) is Ca_f in component fuzzy_space_calcium (molar). C CONSTS(2) is k1 in component Ca_influx_across_the_SR (first_order_rate_constant). C STATES(2) is Ca_2_S1 in component Ca_bound_to_the_SRRC_fast_activating_binding_site (molar). C STATES(3) is Ca_S2 in component Ca_bound_to_the_SRRC_slow_inactivating_binding_site (molar). C STATES(4) is S1 in component SRRC_fast_activating_binding_site (molar). C STATES(5) is S2 in component SRRC_slow_inactivating_binding_site (molar). C STATES(6) is Ca_s in component SR_calcium (molar). C ALGBRC(1) is dCa2_S1_dt in component Ca_movement_through_the_SRRC (flux). C ALGBRC(2) is dCa_S2_dt in component Ca_movement_through_the_SRRC (flux). C CONSTS(3) is k_on1 in component Ca_movement_through_the_SRRC (second_order_rate_constant). C CONSTS(4) is k_off1 in component Ca_movement_through_the_SRRC (first_order_rate_constant). C CONSTS(5) is k_on2 in component Ca_movement_through_the_SRRC (second_order_rate_constant). C CONSTS(6) is k_off2 in component Ca_movement_through_the_SRRC (first_order_rate_constant). C CONSTS(7) is k_s in component Ca_movement_through_the_SRRC (first_order_rate_constant). C STATES(7) is cas1 in component Ca_movement_through_the_SRRC (dimensionless). C STATES(8) is cas2 in component Ca_movement_through_the_SRRC (dimensionless). C ALGBRC(5) is dcas1_dt in component Ca_movement_through_the_SRRC (first_order_rate_constant). C ALGBRC(6) is dcas2_dt in component Ca_movement_through_the_SRRC (first_order_rate_constant). C ALGBRC(4) is r_o in component Ca_movement_through_the_SRRC (dimensionless). C ALGBRC(7) is Rate_Ca_movement_through_the_SRRC in component Ca_movement_through_the_SRRC (flux). C CONSTS(8) is Km_NaCaX in component Ca_efflux_across_the_SR_by_NaCa_exchange (molar). C CONSTS(9) is Vmax_NaCaX in component Ca_efflux_across_the_SR_by_NaCa_exchange (flux). C ALGBRC(8) is Rate_Ca_efflux_across_the_SR_by_NaCa_exchange in component Ca_efflux_across_the_SR_by_NaCa_exchange (flux). C STATES(9) is Ca_c in component cytosolic_calcium (molar). C CONSTS(10) is kf in component Ca_movement_between_the_fuzzy_space_and_cytosol (first_order_rate_constant). C ALGBRC(9) is Rate_Ca_movement_between_the_fuzzy_space_and_cytosol in component Ca_movement_between_the_fuzzy_space_and_cytosol (flux). C CONSTS(11) is Km_s in component Ca_uptake_by_SR_Ca_ATPase (molar). C CONSTS(12) is Vmax_s in component Ca_uptake_by_SR_Ca_ATPase (flux). C ALGBRC(10) is Rate_Ca_uptake_by_SR_Ca_ATPase in component Ca_uptake_by_SR_Ca_ATPase (flux). C STATES(10) is Ca_CSQ in component calsequestrin_bound_calcium (molar). C CONSTS(13) is K_ons in component Ca_buffering_in_the_SR (second_order_rate_constant). C CONSTS(14) is K_offs in component Ca_buffering_in_the_SR (first_order_rate_constant). C CONSTS(15) is Bmax_s in component Ca_buffering_in_the_SR (molar). C ALGBRC(11) is Rate_Ca_buffering_in_the_SR in component Ca_buffering_in_the_SR (flux). C CONSTS(16) is Rt in component fuzzy_space_calcium (molar). C CONSTS(17) is Bmax_f1 in component fuzzy_space_calcium (molar). C CONSTS(18) is Bmax_f2 in component fuzzy_space_calcium (molar). C CONSTS(19) is Kb_f1 in component fuzzy_space_calcium (molar). C CONSTS(20) is Kb_f2 in component fuzzy_space_calcium (molar). C CONSTS(21) is V_f in component fuzzy_space_calcium (dimensionless). C CONSTS(22) is Bmax_c in component cytosolic_calcium (molar). C CONSTS(23) is dye_c in component cytosolic_calcium (molar). C CONSTS(24) is Kb_c in component cytosolic_calcium (molar). C CONSTS(25) is Kb_dye in component cytosolic_calcium (molar). C CONSTS(26) is V_c in component cytosolic_calcium (dimensionless). C CONSTS(27) is V_s in component SR_calcium (dimensionless). C RATES(7) is d/dt cas1 in component Ca_movement_through_the_SRRC (dimensionless). C RATES(8) is d/dt cas2 in component Ca_movement_through_the_SRRC (dimensionless). C RATES(1) is d/dt Ca_f in component fuzzy_space_calcium (molar). C RATES(9) is d/dt Ca_c in component cytosolic_calcium (molar). C RATES(6) is d/dt Ca_s in component SR_calcium (molar). C RATES(10) is d/dt Ca_CSQ in component calsequestrin_bound_calcium (molar). C RATES(4) is d/dt S1 in component SRRC_fast_activating_binding_site (molar). C RATES(5) is d/dt S2 in component SRRC_slow_inactivating_binding_site (molar). C RATES(2) is d/dt Ca_2_S1 in component Ca_bound_to_the_SRRC_fast_activating_binding_site (molar). C RATES(3) is d/dt Ca_S2 in component Ca_bound_to_the_SRRC_slow_inactivating_binding_site (molar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.002 STATES(1) = 0.12e-6 CONSTS(2) = 0.2 STATES(2) = 0 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 201e-6 CONSTS(3) = 2000000000 CONSTS(4) = 1400 CONSTS(5) = 13000000 CONSTS(6) = 3.9 CONSTS(7) = 9 STATES(7) = 0 STATES(8) = 0 CONSTS(8) = 0.000036 CONSTS(9) = 0.0012 STATES(9) = 1e-7 CONSTS(10) = 2500 CONSTS(11) = 0.00000025 CONSTS(12) = 0.000525 STATES(10) = 0 CONSTS(13) = 8772 CONSTS(14) = 5.596536 CONSTS(15) = 0.008 CONSTS(16) = 0.00000015 CONSTS(17) = 0.0002 CONSTS(18) = 0.0011 CONSTS(19) = 0.000017 CONSTS(20) = 0.000013 CONSTS(21) = 0.0013 CONSTS(22) = 0.00012 CONSTS(23) = 0 CONSTS(24) = 0.00000096 CONSTS(25) = 2e-7 CONSTS(26) = 0.9287 CONSTS(27) = 0.07 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(3)*STATES(1)*STATES(4) - (CONSTS(4) ** 2.00000/( CONSTS(3)*STATES(1)))*STATES(2) RATES(4) = - ALGBRC(1) ALGBRC(2) = CONSTS(5)*STATES(1)*STATES(5) - CONSTS(6)*STATES(3) RATES(5) = - ALGBRC(2) RATES(2) = ALGBRC(1) RATES(3) = ALGBRC(2) ALGBRC(5) = CONSTS(3)*STATES(1)*(1.00000 - STATES(7)) - (CONSTS(4) ** 2.00000/( CONSTS(3)*STATES(1)))*STATES(7) RATES(7) = ALGBRC(5) ALGBRC(6) = CONSTS(5)*STATES(1)*(1.00000 - STATES(8)) - CONSTS(6)*STATES(8) RATES(8) = ALGBRC(6) ALGBRC(3) = CONSTS(2)*(CONSTS(1) - STATES(1)) ALGBRC(4) = STATES(7)*(1.00000 - STATES(8)) ALGBRC(7) = CONSTS(7)*ALGBRC(4)*(STATES(6) - STATES(1)) ALGBRC(8) = ( CONSTS(9)*STATES(1))/(CONSTS(8)+STATES(1)) ALGBRC(9) = CONSTS(10)*(STATES(1) - STATES(9)) RATES(1) = ((ALGBRC(7) - ( CONSTS(16)*(ALGBRC(5)+ALGBRC(6))+ALGBRC(9)+ALGBRC(8)))+ALGBRC(3))/(( CONSTS(17)*CONSTS(19))/STATES(1)+CONSTS(19) ** 2.00000+( CONSTS(18)*CONSTS(20))/STATES(1)+CONSTS(20) ** 2.00000+CONSTS(21)) ALGBRC(10) = ( CONSTS(12)*(STATES(9) ** 2.00000 - STATES(6) ** 2.00000/7000.00 ** 2.00000))/(CONSTS(11) ** 2.00000+STATES(9) ** 2.00000+STATES(6) ** 2.00000/7000.00 ** 2.00000) RATES(9) = (ALGBRC(9) - ALGBRC(10))/(( CONSTS(22)*CONSTS(24))/STATES(9)+CONSTS(24) ** 2.00000+( CONSTS(23)*CONSTS(25))/STATES(9)+CONSTS(25) ** 2.00000+CONSTS(26)) ALGBRC(11) = CONSTS(13)*STATES(6)*(CONSTS(15) - STATES(10)) - CONSTS(14)*STATES(10) RATES(6) = (ALGBRC(10) - ALGBRC(7))/CONSTS(27) - ALGBRC(11) RATES(10) = ALGBRC(11) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(3)*STATES(1)*STATES(4) - (CONSTS(4) ** 2.00000/( CONSTS(3)*STATES(1)))*STATES(2) ALGBRC(2) = CONSTS(5)*STATES(1)*STATES(5) - CONSTS(6)*STATES(3) ALGBRC(5) = CONSTS(3)*STATES(1)*(1.00000 - STATES(7)) - (CONSTS(4) ** 2.00000/( CONSTS(3)*STATES(1)))*STATES(7) ALGBRC(6) = CONSTS(5)*STATES(1)*(1.00000 - STATES(8)) - CONSTS(6)*STATES(8) ALGBRC(3) = CONSTS(2)*(CONSTS(1) - STATES(1)) ALGBRC(4) = STATES(7)*(1.00000 - STATES(8)) ALGBRC(7) = CONSTS(7)*ALGBRC(4)*(STATES(6) - STATES(1)) ALGBRC(8) = ( CONSTS(9)*STATES(1))/(CONSTS(8)+STATES(1)) ALGBRC(9) = CONSTS(10)*(STATES(1) - STATES(9)) ALGBRC(10) = ( CONSTS(12)*(STATES(9) ** 2.00000 - STATES(6) ** 2.00000/7000.00 ** 2.00000))/(CONSTS(11) ** 2.00000+STATES(9) ** 2.00000+STATES(6) ** 2.00000/7000.00 ** 2.00000) ALGBRC(11) = CONSTS(13)*STATES(6)*(CONSTS(15) - STATES(10)) - CONSTS(14)*STATES(10) RETURN END