C C There are a total of 34 entries in the algebraic variable array. C There are a total of 14 entries in each of the rate and state variable arrays. C There are a total of 51 entries in the constant variable array. C C C VOI is time in component Time (time_units). C CONSTS(1) is Ach in component Neural_input (millimolar). C CONSTS(2) is Gcouple in component Gap_junction (conductance_units). C CONSTS(3) is T in component Environment (Temperature_units). C CONSTS(4) is T_exp in component Environment (Temperature_units). C CONSTS(5) is F in component Environment (F_units). C CONSTS(6) is R in component Environment (R_units). C CONSTS(7) is Q10Ca in component Environment (dimensionless). C CONSTS(8) is Q10K in component Environment (dimensionless). C CONSTS(9) is Q10Na in component Environment (dimensionless). C CONSTS(10) is Ca_o in component Environment (millimolar). C CONSTS(11) is Na_o in component Environment (millimolar). C CONSTS(12) is K_o in component Environment (millimolar). C CONSTS(13) is Cl_o in component Environment (millimolar). C CONSTS(34) is T_correction_Na in component Environment (dimensionless). C CONSTS(35) is T_correction_K in component Environment (dimensionless). C CONSTS(36) is T_correction_Ca in component Environment (dimensionless). C CONSTS(37) is T_correction_BK in component Environment (conductance_units). C CONSTS(38) is FoRT in component Environment (Inverse_Voltage_units). C CONSTS(39) is RToF in component Environment (voltage_units). C CONSTS(14) is Cm_SM in component SM_Membrane (capacitance_units). C CONSTS(15) is Vol_SM in component SM_Membrane (volume_units). C STATES(1) is Vm_SM in component SM_Membrane (voltage_units). C STATES(2) is Ca_i in component SM_Membrane (millimolar). C CONSTS(16) is Na_i in component SM_Membrane (millimolar). C CONSTS(17) is K_i in component SM_Membrane (millimolar). C ALGBRC(31) is I_Na_SM in component I_Na_SM (current_units). C ALGBRC(23) is I_Ltype_SM in component I_Ltype_SM (current_units). C ALGBRC(26) is I_LVA_SM in component I_LVA_SM (current_units). C ALGBRC(30) is I_kr_SM in component I_kr_SM (current_units). C ALGBRC(32) is I_ka_SM in component I_ka_SM (current_units). C ALGBRC(28) is I_BK_SM in component I_BK_SM (current_units). C ALGBRC(34) is I_NSCC_SM in component I_NSCC_SM (current_units). C ALGBRC(29) is I_bk_SM in component I_bk_SM (current_units). C ALGBRC(24) is J_CaSR_SM in component J_CaSR_SM (millimolar_per_millisecond). C ALGBRC(21) is I_stim in component I_stim (current_units). C ALGBRC(14) is local_time in component I_stim (time_units). C CONSTS(18) is period in component I_stim (time_units). C ALGBRC(1) is stim_start in component I_stim (time_units). C CONSTS(19) is delta_VICC in component I_stim (voltage_units). C CONSTS(20) is t_ICCpeak in component I_stim (time_units). C CONSTS(21) is t_ICCplateau in component I_stim (time_units). C CONSTS(22) is t_ICC_stimulus in component I_stim (time_units). C CONSTS(23) is V_decay in component I_stim (voltage_units). C ALGBRC(2) is d_inf_Ltype_SM in component d_Ltype_SM (dimensionless). C CONSTS(41) is tau_d_Ltype_SM in component d_Ltype_SM (time_units). C STATES(3) is d_Ltype_SM in component d_Ltype_SM (dimensionless). C ALGBRC(3) is f_inf_Ltype_SM in component f_Ltype_SM (dimensionless). C CONSTS(42) is tau_f_Ltype_SM in component f_Ltype_SM (time_units). C STATES(4) is f_Ltype_SM in component f_Ltype_SM (dimensionless). C ALGBRC(4) is f_ca_inf_Ltype_SM in component f_ca_Ltype_SM (dimensionless). C CONSTS(43) is tau_f_ca_Ltype_SM in component f_ca_Ltype_SM (time_units). C STATES(5) is f_ca_Ltype_SM in component f_ca_Ltype_SM (dimensionless). C ALGBRC(22) is E_Ca in component I_Ltype_SM (voltage_units). C CONSTS(24) is G_max_Ltype in component I_Ltype_SM (conductance_units). C CONSTS(25) is J_max_CaSR in component J_CaSR_SM (millimolar_per_millisecond). C ALGBRC(5) is d_inf_LVA_SM in component d_LVA_SM (dimensionless). C CONSTS(44) is tau_d_LVA_SM in component d_LVA_SM (time_units). C STATES(6) is d_LVA_SM in component d_LVA_SM (dimensionless). C ALGBRC(6) is f_inf_LVA_SM in component f_LVA_SM (dimensionless). C ALGBRC(15) is tau_f_LVA_SM in component f_LVA_SM (time_units). C STATES(7) is f_LVA_SM in component f_LVA_SM (dimensionless). C ALGBRC(25) is E_Ca in component I_LVA_SM (voltage_units). C CONSTS(26) is G_max_LVA in component I_LVA_SM (conductance_units). C ALGBRC(27) is d_BK_SM in component d_BK_SM (dimensionless). C CONSTS(45) is E_K in component I_BK_SM (voltage_units). C CONSTS(27) is G_max_BK in component I_BK_SM (conductance_units). C CONSTS(46) is E_K in component I_bk_SM (voltage_units). C CONSTS(28) is G_max_bk in component I_bk_SM (conductance_units). C ALGBRC(7) is xr1_inf_SM in component xr1_SM (dimensionless). C CONSTS(47) is tau_xr1_SM in component xr1_SM (time_units). C STATES(8) is xr1_SM in component xr1_SM (dimensionless). C ALGBRC(8) is xr2_inf_SM in component xr2_SM (dimensionless). C ALGBRC(16) is tau_xr2_SM in component xr2_SM (time_units). C STATES(9) is xr2_SM in component xr2_SM (dimensionless). C CONSTS(48) is E_K in component I_kr_SM (voltage_units). C CONSTS(29) is G_max_kr_SM in component I_kr_SM (conductance_units). C ALGBRC(9) is m_inf_Na in component m_Na_SM (dimensionless). C ALGBRC(17) is tau_m_Na in component m_Na_SM (time_units). C STATES(10) is m_Na_SM in component m_Na_SM (dimensionless). C ALGBRC(10) is h_inf_Na in component h_Na_SM (dimensionless). C ALGBRC(18) is tau_h_Na in component h_Na_SM (time_units). C STATES(11) is h_Na_SM in component h_Na_SM (dimensionless). C CONSTS(49) is E_Na in component I_Na_SM (voltage_units). C CONSTS(30) is G_max_Na_SM in component I_Na_SM (conductance_units). C ALGBRC(11) is xa1_inf_SM in component xa1_SM (dimensionless). C ALGBRC(19) is tau_xa1_SM in component xa1_SM (time_units). C STATES(12) is xa1_SM in component xa1_SM (dimensionless). C ALGBRC(12) is xa2_inf_SM in component xa2_SM (dimensionless). C CONSTS(50) is tau_xa2_SM in component xa2_SM (time_units). C STATES(13) is xa2_SM in component xa2_SM (dimensionless). C CONSTS(51) is E_K in component I_ka_SM (voltage_units). C CONSTS(31) is G_max_ka_SM in component I_ka_SM (conductance_units). C ALGBRC(13) is m_inf_NSCC_SM in component m_NSCC_SM (dimensionless). C ALGBRC(20) is tau_m_NSCC_SM in component m_NSCC_SM (time_units). C STATES(14) is m_NSCC_SM in component m_NSCC_SM (dimensionless). C CONSTS(32) is E_NSCC in component I_NSCC_SM (voltage_units). C CONSTS(33) is G_max_NSCC_SM in component I_NSCC_SM (conductance_units). C ALGBRC(33) is f_ca_NSCC_SM in component I_NSCC_SM (dimensionless). C CONSTS(40) is rach_NSCC_SM in component I_NSCC_SM (dimensionless). C RATES(1) is d/dt Vm_SM in component SM_Membrane (voltage_units). C RATES(2) is d/dt Ca_i in component SM_Membrane (millimolar). C RATES(3) is d/dt d_Ltype_SM in component d_Ltype_SM (dimensionless). C RATES(4) is d/dt f_Ltype_SM in component f_Ltype_SM (dimensionless). C RATES(5) is d/dt f_ca_Ltype_SM in component f_ca_Ltype_SM (dimensionless). C RATES(6) is d/dt d_LVA_SM in component d_LVA_SM (dimensionless). C RATES(7) is d/dt f_LVA_SM in component f_LVA_SM (dimensionless). C RATES(8) is d/dt xr1_SM in component xr1_SM (dimensionless). C RATES(9) is d/dt xr2_SM in component xr2_SM (dimensionless). C RATES(10) is d/dt m_Na_SM in component m_Na_SM (dimensionless). C RATES(11) is d/dt h_Na_SM in component h_Na_SM (dimensionless). C RATES(12) is d/dt xa1_SM in component xa1_SM (dimensionless). C RATES(13) is d/dt xa2_SM in component xa2_SM (dimensionless). C RATES(14) is d/dt m_NSCC_SM in component m_NSCC_SM (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.00001 CONSTS(2) = 1.3 CONSTS(3) = 310 CONSTS(4) = 297 CONSTS(5) = 96486 CONSTS(6) = 8314.4 CONSTS(7) = 2.1 CONSTS(8) = 1.365 CONSTS(9) = 2.45 CONSTS(10) = 2.5 CONSTS(11) = 137 CONSTS(12) = 5.9 CONSTS(13) = 134 CONSTS(14) = 77 CONSTS(15) = 3500 STATES(1) = -69.75 STATES(2) = 0.00008 CONSTS(16) = 10 CONSTS(17) = 164 CONSTS(18) = 20000 CONSTS(19) = 59 CONSTS(20) = 98 CONSTS(21) = 7582 CONSTS(22) = 10000 CONSTS(23) = 37.25 STATES(3) = 0.0 STATES(4) = 0.95 STATES(5) = 1.0 CONSTS(24) = 65 CONSTS(25) = 0.31705 STATES(6) = 0.02 STATES(7) = 0.99 CONSTS(26) = 0.18 CONSTS(27) = 45.7 CONSTS(28) = 0.0144 STATES(8) = 0.0 STATES(9) = 0.82 CONSTS(29) = 35 STATES(10) = 0.005 STATES(11) = 0.05787 CONSTS(30) = 3 STATES(12) = 0.00414 STATES(13) = 0.72 CONSTS(31) = 9 STATES(14) = 0.0 CONSTS(32) = -28 CONSTS(33) = 50 CONSTS(34) = CONSTS(9) ** (CONSTS(3) - CONSTS(4))/10.0000 CONSTS(35) = CONSTS(8) ** (CONSTS(3) - CONSTS(4))/10.0000 CONSTS(36) = CONSTS(7) ** (CONSTS(3) - CONSTS(4))/10.0000 CONSTS(37) = 1.10000*(CONSTS(3) - CONSTS(4)) CONSTS(38) = CONSTS(5)/( CONSTS(6)*CONSTS(3)) CONSTS(39) = ( CONSTS(6)*CONSTS(3))/CONSTS(5) CONSTS(40) = 1.00000/(1.00000+0.0100000/CONSTS(1)) CONSTS(41) = CONSTS(36)*0.470000 CONSTS(42) = CONSTS(36)*86.0000 CONSTS(43) = CONSTS(36)*2.00000 CONSTS(44) = CONSTS(36)*3.00000 CONSTS(45) = CONSTS(39)*log(CONSTS(12)/CONSTS(17)) CONSTS(46) = CONSTS(39)*log(CONSTS(12)/CONSTS(17)) CONSTS(47) = CONSTS(35)*80.0000 CONSTS(48) = CONSTS(39)*log(CONSTS(12)/CONSTS(17)) CONSTS(49) = CONSTS(39)*log(CONSTS(11)/CONSTS(16)) CONSTS(50) = CONSTS(35)*90.0000 CONSTS(51) = CONSTS(39)*log(CONSTS(12)/CONSTS(17)) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 1.00000/(1.00000+EXP((STATES(1)+17.0000)/-4.30000)) RATES(3) = (ALGBRC(2) - STATES(3))/CONSTS(41) ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+43.0000)/8.90000)) RATES(4) = (ALGBRC(3) - STATES(4))/CONSTS(42) ALGBRC(4) = 1.00000 - 1.00000/(1.00000+EXP(((STATES(2) - 8.99900e-05) - 0.000214000)/-1.31000e-05)) RATES(5) = (ALGBRC(4) - STATES(5))/CONSTS(43) ALGBRC(5) = 1.00000/(1.00000+EXP((STATES(1)+27.5000)/-10.9000)) RATES(6) = (ALGBRC(5) - STATES(6))/CONSTS(44) ALGBRC(7) = 1.00000/(1.00000+EXP((STATES(1)+27.0000)/-5.00000)) RATES(8) = (ALGBRC(7) - STATES(8))/CONSTS(47) ALGBRC(12) = 0.100000+0.900000/(1.00000+EXP((STATES(1)+65.0000)/6.20000)) RATES(13) = (ALGBRC(12) - STATES(13))/CONSTS(50) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+15.8000)/7.00000)) ALGBRC(15) = CONSTS(36)*( 7.58000*EXP( STATES(1)*0.00817000)) RATES(7) = (ALGBRC(6) - STATES(7))/ALGBRC(15) ALGBRC(8) = 0.200000+0.800000/(1.00000+EXP((STATES(1)+58.0000)/10.0000)) ALGBRC(16) = CONSTS(35)*(-707.000+ 1481.00*EXP((STATES(1)+36.0000)/95.0000)) RATES(9) = (ALGBRC(8) - STATES(9))/ALGBRC(16) ALGBRC(9) = 1.00000/(1.00000+EXP((STATES(1)+47.0000)/-4.80000)) ALGBRC(17) = CONSTS(34)*( STATES(1)*-0.0170000*1.00000+0.440000) RATES(10) = (ALGBRC(9) - STATES(10))/ALGBRC(17) ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+78.0000)/3.00000)) ALGBRC(18) = CONSTS(34)*( STATES(1)*-0.250000*1.00000+5.50000) RATES(11) = (ALGBRC(10) - STATES(11))/ALGBRC(18) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+26.5000)/-7.90000)) ALGBRC(19) = CONSTS(35)*(31.8000+ 175.000*EXP( -0.500000*(STATES(1)+44.4000)/22.3000 ** 2.00000)) RATES(12) = (ALGBRC(11) - STATES(12))/ALGBRC(19) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+25.0000)/-20.0000)) ALGBRC(20) = (1.00000/(1.00000+EXP((STATES(1)+66.0000)/-26.0000)))*150.000 RATES(14) = (ALGBRC(13) - STATES(14))/ALGBRC(20) ALGBRC(22) = 0.500000*CONSTS(39)*log(CONSTS(10)/STATES(2)) ALGBRC(23) = CONSTS(24)*( STATES(4)*STATES(3)*STATES(5))*(STATES(1) - ALGBRC(22)) ALGBRC(25) = 0.500000*CONSTS(39)*log(CONSTS(10)/STATES(2)) ALGBRC(26) = CONSTS(26)*( STATES(7)*STATES(6))*(STATES(1) - ALGBRC(25)) ALGBRC(24) = CONSTS(25)* STATES(2)*1.00000 ** 1.34000 RATES(2) = ( -1.00000*ALGBRC(23)+ -1.00000*ALGBRC(26))/( 2.00000*0.00100000*CONSTS(5)*CONSTS(15))+ -1.00000*ALGBRC(24) ALGBRC(31) = CONSTS(30)*( STATES(11)*STATES(10))*(STATES(1) - CONSTS(49)) ALGBRC(30) = CONSTS(29)*( STATES(8)*STATES(9))*(STATES(1) - CONSTS(48)) ALGBRC(32) = CONSTS(31)*( STATES(12)*STATES(13))*(STATES(1) - CONSTS(51)) ALGBRC(27) = 1.00000/(1.00000+EXP(STATES(1)/-17.0000 - 2.00000*log(STATES(2)/0.00100000))) ALGBRC(28) = (CONSTS(27)+CONSTS(37))*ALGBRC(27)*(STATES(1) - CONSTS(45)) ALGBRC(33) = 1.00000/(1.00000+STATES(2)/0.000200000 ** -4.00000) ALGBRC(34) = CONSTS(33)*STATES(14)*ALGBRC(33)*CONSTS(40)*(STATES(1) - CONSTS(32)) ALGBRC(29) = CONSTS(28)*(STATES(1) - CONSTS(46)) ALGBRC(1) = TERNRY(VOI.GT. CONSTS(18)*1.00000.AND.VOI.LE. CONSTS(18)*2.00000, CONSTS(18)*1.00000, TERNRY(VOI.GT. CONSTS(18)*2.00000.AND.VOI.LE. CONSTS(18)*3.00000, CONSTS(18)*2.00000, TERNRY(VOI.GT. CONSTS(18)*3.00000.AND.VOI.LE. CONSTS(18)*4.00000, CONSTS(18)*3.00000, TERNRY(VOI.GT. CONSTS(18)*4.00000.AND.VOI.LE. CONSTS(18)*5.00000, CONSTS(18)*4.00000, 0.00000) ALGBRC(14) = VOI - (ALGBRC(1)+CONSTS(20)) ALGBRC(21) = TERNRY(ALGBRC(14).LT.CONSTS(20), CONSTS(2)*CONSTS(19), TERNRY(ALGBRC(14).GE.CONSTS(20).AND.ALGBRC(14).LE.CONSTS(21), CONSTS(2)*CONSTS(19)*(1.00000/(1.00000+EXP((ALGBRC(14) - 8000.00)/1000.00))), TERNRY(ALGBRC(14).GT.CONSTS(21).AND.ALGBRC(14).LT.CONSTS(22), CONSTS(2)*CONSTS(23)*(1.00000/(1.00000+EXP((ALGBRC(14) - 8000.00)/150.000))), 0.00000) RATES(1) = -1.00000*(1.00000/CONSTS(14))*(ALGBRC(31)+ALGBRC(23)+ALGBRC(26)+ALGBRC(30)+ALGBRC(32)+ALGBRC(28)+ALGBRC(34)+ALGBRC(29)+ -1.00000*ALGBRC(21)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 1.00000/(1.00000+EXP((STATES(1)+17.0000)/-4.30000)) ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+43.0000)/8.90000)) ALGBRC(4) = 1.00000 - 1.00000/(1.00000+EXP(((STATES(2) - 8.99900e-05) - 0.000214000)/-1.31000e-05)) ALGBRC(5) = 1.00000/(1.00000+EXP((STATES(1)+27.5000)/-10.9000)) ALGBRC(7) = 1.00000/(1.00000+EXP((STATES(1)+27.0000)/-5.00000)) ALGBRC(12) = 0.100000+0.900000/(1.00000+EXP((STATES(1)+65.0000)/6.20000)) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+15.8000)/7.00000)) ALGBRC(15) = CONSTS(36)*( 7.58000*EXP( STATES(1)*0.00817000)) ALGBRC(8) = 0.200000+0.800000/(1.00000+EXP((STATES(1)+58.0000)/10.0000)) ALGBRC(16) = CONSTS(35)*(-707.000+ 1481.00*EXP((STATES(1)+36.0000)/95.0000)) ALGBRC(9) = 1.00000/(1.00000+EXP((STATES(1)+47.0000)/-4.80000)) ALGBRC(17) = CONSTS(34)*( STATES(1)*-0.0170000*1.00000+0.440000) ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+78.0000)/3.00000)) ALGBRC(18) = CONSTS(34)*( STATES(1)*-0.250000*1.00000+5.50000) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+26.5000)/-7.90000)) ALGBRC(19) = CONSTS(35)*(31.8000+ 175.000*EXP( -0.500000*(STATES(1)+44.4000)/22.3000 ** 2.00000)) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+25.0000)/-20.0000)) ALGBRC(20) = (1.00000/(1.00000+EXP((STATES(1)+66.0000)/-26.0000)))*150.000 ALGBRC(22) = 0.500000*CONSTS(39)*log(CONSTS(10)/STATES(2)) ALGBRC(23) = CONSTS(24)*( STATES(4)*STATES(3)*STATES(5))*(STATES(1) - ALGBRC(22)) ALGBRC(25) = 0.500000*CONSTS(39)*log(CONSTS(10)/STATES(2)) ALGBRC(26) = CONSTS(26)*( STATES(7)*STATES(6))*(STATES(1) - ALGBRC(25)) ALGBRC(24) = CONSTS(25)* STATES(2)*1.00000 ** 1.34000 ALGBRC(31) = CONSTS(30)*( STATES(11)*STATES(10))*(STATES(1) - CONSTS(49)) ALGBRC(30) = CONSTS(29)*( STATES(8)*STATES(9))*(STATES(1) - CONSTS(48)) ALGBRC(32) = CONSTS(31)*( STATES(12)*STATES(13))*(STATES(1) - CONSTS(51)) ALGBRC(27) = 1.00000/(1.00000+EXP(STATES(1)/-17.0000 - 2.00000*log(STATES(2)/0.00100000))) ALGBRC(28) = (CONSTS(27)+CONSTS(37))*ALGBRC(27)*(STATES(1) - CONSTS(45)) ALGBRC(33) = 1.00000/(1.00000+STATES(2)/0.000200000 ** -4.00000) ALGBRC(34) = CONSTS(33)*STATES(14)*ALGBRC(33)*CONSTS(40)*(STATES(1) - CONSTS(32)) ALGBRC(29) = CONSTS(28)*(STATES(1) - CONSTS(46)) ALGBRC(1) = TERNRY(VOI.GT. CONSTS(18)*1.00000.AND.VOI.LE. CONSTS(18)*2.00000, CONSTS(18)*1.00000, TERNRY(VOI.GT. CONSTS(18)*2.00000.AND.VOI.LE. CONSTS(18)*3.00000, CONSTS(18)*2.00000, TERNRY(VOI.GT. CONSTS(18)*3.00000.AND.VOI.LE. CONSTS(18)*4.00000, CONSTS(18)*3.00000, TERNRY(VOI.GT. CONSTS(18)*4.00000.AND.VOI.LE. CONSTS(18)*5.00000, CONSTS(18)*4.00000, 0.00000) ALGBRC(14) = VOI - (ALGBRC(1)+CONSTS(20)) ALGBRC(21) = TERNRY(ALGBRC(14).LT.CONSTS(20), CONSTS(2)*CONSTS(19), TERNRY(ALGBRC(14).GE.CONSTS(20).AND.ALGBRC(14).LE.CONSTS(21), CONSTS(2)*CONSTS(19)*(1.00000/(1.00000+EXP((ALGBRC(14) - 8000.00)/1000.00))), TERNRY(ALGBRC(14).GT.CONSTS(21).AND.ALGBRC(14).LT.CONSTS(22), CONSTS(2)*CONSTS(23)*(1.00000/(1.00000+EXP((ALGBRC(14) - 8000.00)/150.000))), 0.00000) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END