function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =13; end % There are a total of 2 entries in each of the rate and state variable arrays. % There are a total of 30 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (millisecond)'); LEGEND_ALGEBRAIC(:,11) = strpad('P_CE in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,6) = strpad('P_PE in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('P_SE in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('Ca in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,13) = strpad('C_2 in component equations (per_millisec)'); LEGEND_ALGEBRAIC(:,2) = strpad('phi_A_1 in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,12) = strpad('pi_n in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,9) = strpad('A in component equations (dimensionless)'); LEGEND_STATES(:,1) = strpad('A_1 in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('S in component equations (um)'); LEGEND_ALGEBRAIC(:,10) = strpad('n in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('n_1 in component equations (dimensionless)'); LEGEND_STATES(:,2) = strpad('n_2 in component equations (dimensionless)'); LEGEND_CONSTANTS(:,28) = strpad('G_V in component equations (dimensionless)'); LEGEND_CONSTANTS(:,27) = strpad('q_V in component equations (per_millisec)'); LEGEND_CONSTANTS(:,26) = strpad('V in component equations (um_per_millisec)'); LEGEND_CONSTANTS(:,29) = strpad('F_V in component equations (dimensionless)'); LEGEND_CONSTANTS(:,30) = strpad('p_V in component equations (dimensionless)'); LEGEND_CONSTANTS(:,1) = strpad('alpha_1 in component equations (per_um)'); LEGEND_CONSTANTS(:,2) = strpad('alpha_2 in component equations (per_um)'); LEGEND_CONSTANTS(:,3) = strpad('beta_1 in component equations (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('beta_2 in component equations (dimensionless)'); LEGEND_CONSTANTS(:,5) = strpad('lambda in component equations (per_um)'); LEGEND_CONSTANTS(:,6) = strpad('V_max in component equations (um_per_millisec)'); LEGEND_CONSTANTS(:,7) = strpad('Ca_m in component equations (dimensionless)'); LEGEND_CONSTANTS(:,8) = strpad('t_d in component equations (millisecond)'); LEGEND_CONSTANTS(:,9) = strpad('a_c in component equations (per_millisec2)'); LEGEND_CONSTANTS(:,10) = strpad('b_c in component equations (per_millisec2)'); LEGEND_CONSTANTS(:,11) = strpad('C_1 in component equations (per_millisec)'); LEGEND_CONSTANTS(:,12) = strpad('C_20 in component equations (per_millisec)'); LEGEND_CONSTANTS(:,13) = strpad('q_k in component equations (dimensionless)'); LEGEND_CONSTANTS(:,25) = strpad('V_1 in component equations (um_per_millisec)'); LEGEND_CONSTANTS(:,14) = strpad('a in component equations (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('m_0 in component equations (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('g_1 in component equations (per_um)'); LEGEND_CONSTANTS(:,17) = strpad('g_2 in component equations (dimensionless)'); LEGEND_CONSTANTS(:,18) = strpad('pi_min in component equations (dimensionless)'); LEGEND_CONSTANTS(:,19) = strpad('S_0 in component equations (um)'); LEGEND_CONSTANTS(:,20) = strpad('q_1 in component equations (per_millisec)'); LEGEND_CONSTANTS(:,21) = strpad('q_2 in component equations (per_millisec)'); LEGEND_CONSTANTS(:,22) = strpad('q_3 in component equations (per_millisec)'); LEGEND_CONSTANTS(:,23) = strpad('TnC in component equations (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('l_1 in component user_defined (um)'); LEGEND_ALGEBRAIC(:,5) = strpad('l_2 in component user_defined (um)'); LEGEND_CONSTANTS(:,24) = strpad('dl_1_dt in component user_defined (um_per_millisec)'); LEGEND_RATES(:,1) = strpad('d/dt A_1 in component equations (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt n_2 in component equations (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 0; STATES(:,2) = 0; CONSTANTS(:,1) = 14.6; CONSTANTS(:,2) = 14.6; CONSTANTS(:,3) = 1; CONSTANTS(:,4) = 0.0012; CONSTANTS(:,5) = 30; CONSTANTS(:,6) = 0.0043; CONSTANTS(:,7) = 45e-3; CONSTANTS(:,8) = 170; CONSTANTS(:,9) = 2.4e-4; CONSTANTS(:,10) = 5e-4; CONSTANTS(:,11) = 2.9e-2; CONSTANTS(:,12) = 0.2; CONSTANTS(:,13) = 4; CONSTANTS(:,14) = 0.25; CONSTANTS(:,15) = 0.87; CONSTANTS(:,16) = 0.4; CONSTANTS(:,17) = 0.6; CONSTANTS(:,18) = 5e-2; CONSTANTS(:,19) = 0.77; CONSTANTS(:,20) = 0.017; CONSTANTS(:,21) = 0.26; CONSTANTS(:,22) = 0.03; CONSTANTS(:,23) = 1; CONSTANTS(:,24) = 0.00000; CONSTANTS(:,25) = 0.100000.*CONSTANTS(:,6); CONSTANTS(:,26) = - CONSTANTS(:,24); CONSTANTS(:,27) = piecewise({CONSTANTS(:,26)<=0.00000, CONSTANTS(:,20) - ( CONSTANTS(:,21).*CONSTANTS(:,26))./CONSTANTS(:,6) }, CONSTANTS(:,22)); CONSTANTS(:,28) = 1.00000+( 0.600000.*CONSTANTS(:,26))./CONSTANTS(:,6); CONSTANTS(:,29) = ( CONSTANTS(:,14).*(1.00000+CONSTANTS(:,26)./CONSTANTS(:,6)))./(CONSTANTS(:,14) - CONSTANTS(:,26)./CONSTANTS(:,6)); CONSTANTS(:,30) = CONSTANTS(:,29)./CONSTANTS(:,28); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,2) = CONSTANTS(:,27).*( CONSTANTS(:,15).*CONSTANTS(:,28) - STATES(:,2)); ALGEBRAIC(:,1) = piecewise({VOI<=CONSTANTS(:,8), CONSTANTS(:,7).*power(1.00000 - exp( - CONSTANTS(:,9).*power(VOI, 2.00000)), 2.00000) }, CONSTANTS(:,7).*power( (1.00000 - exp( - CONSTANTS(:,9).*power(VOI, 2.00000))).*exp( - CONSTANTS(:,10).*power(VOI - CONSTANTS(:,8), 2.00000)), 2.00000)); ALGEBRAIC(:,2) = exp( - CONSTANTS(:,13).*STATES(:,1)); ALGEBRAIC(:,3) = piecewise({200.000<=VOI&VOI<=201.000, 0.00000 }, 0.00000); ALGEBRAIC(:,8) = piecewise({ CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)<0.00000, 0.00000 , 0.00000<= CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)& CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)<=1.00000, CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17) }, 1.00000); ALGEBRAIC(:,10) = ALGEBRAIC(:,8).*STATES(:,2); ALGEBRAIC(:,12) = piecewise({0.750000<=ALGEBRAIC(:,10)&ALGEBRAIC(:,10)<=1.00000, CONSTANTS(:,18) , 0.250000<=ALGEBRAIC(:,10)&ALGEBRAIC(:,10)<0.750000, power(CONSTANTS(:,18), 2.00000.*ALGEBRAIC(:,10) - 0.500000) }, 1.00000); RATES(:,1) = CONSTANTS(:,11).*ALGEBRAIC(:,1).*(CONSTANTS(:,23) - STATES(:,1)) - CONSTANTS(:,12).*ALGEBRAIC(:,12).*ALGEBRAIC(:,2).*STATES(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = piecewise({VOI<=CONSTANTS(:,8), CONSTANTS(:,7).*power(1.00000 - exp( - CONSTANTS(:,9).*power(VOI, 2.00000)), 2.00000) }, CONSTANTS(:,7).*power( (1.00000 - exp( - CONSTANTS(:,9).*power(VOI, 2.00000))).*exp( - CONSTANTS(:,10).*power(VOI - CONSTANTS(:,8), 2.00000)), 2.00000)); ALGEBRAIC(:,2) = exp( - CONSTANTS(:,13).*STATES(:,1)); ALGEBRAIC(:,3) = piecewise({200.000<=VOI&VOI<=201.000, 0.00000 }, 0.00000); ALGEBRAIC(:,8) = piecewise({ CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)<0.00000, 0.00000 , 0.00000<= CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)& CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17)<=1.00000, CONSTANTS(:,16).*ALGEBRAIC(:,3)+CONSTANTS(:,17) }, 1.00000); ALGEBRAIC(:,10) = ALGEBRAIC(:,8).*STATES(:,2); ALGEBRAIC(:,12) = piecewise({0.750000<=ALGEBRAIC(:,10)&ALGEBRAIC(:,10)<=1.00000, CONSTANTS(:,18) , 0.250000<=ALGEBRAIC(:,10)&ALGEBRAIC(:,10)<0.750000, power(CONSTANTS(:,18), 2.00000.*ALGEBRAIC(:,10) - 0.500000) }, 1.00000); ALGEBRAIC(:,4) = 0.500000.*ALGEBRAIC(:,3)+CONSTANTS(:,19); ALGEBRAIC(:,5) = ALGEBRAIC(:,3)+1.87000; ALGEBRAIC(:,6) = CONSTANTS(:,4).*(exp( CONSTANTS(:,2).*ALGEBRAIC(:,5)) - 1.00000); ALGEBRAIC(:,7) = CONSTANTS(:,3).*(exp( CONSTANTS(:,1).*(ALGEBRAIC(:,5) - ALGEBRAIC(:,3))) - 1.00000); ALGEBRAIC(:,9) = ( STATES(:,1).*ALGEBRAIC(:,4))./1.00000; ALGEBRAIC(:,11) = CONSTANTS(:,5).*ALGEBRAIC(:,4).*STATES(:,1).*ALGEBRAIC(:,10).*CONSTANTS(:,30); ALGEBRAIC(:,13) = CONSTANTS(:,12).*ALGEBRAIC(:,12).*ALGEBRAIC(:,2); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end