/* There are a total of 16 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 32 entries in the constant variable array. */ /* * VOI is time in component environment (ms). * CONSTANTS[0] is epi in component environment (dimensionless). * CONSTANTS[1] is endo in component environment (dimensionless). * CONSTANTS[2] is mcell in component environment (dimensionless). * STATES[0] is u in component membrane (dimensionless). * ALGEBRAIC[1] is Vm in component membrane (mV). * CONSTANTS[3] is V_0 in component membrane (mV). * CONSTANTS[4] is V_fi in component membrane (mV). * ALGEBRAIC[6] is J_fi in component fast_inward_current (per_ms). * ALGEBRAIC[11] is J_so in component slow_outward_current (per_ms). * ALGEBRAIC[12] is J_si in component slow_inward_current (per_ms). * ALGEBRAIC[0] is J_stim in component membrane (per_ms). * ALGEBRAIC[2] is m in component m (dimensionless). * CONSTANTS[5] is u_m in component m (dimensionless). * ALGEBRAIC[3] is p in component p (dimensionless). * CONSTANTS[6] is u_p in component p (dimensionless). * ALGEBRAIC[4] is q in component q (dimensionless). * CONSTANTS[13] is u_q in component q (dimensionless). * ALGEBRAIC[5] is r in component r (dimensionless). * CONSTANTS[15] is u_r in component r (dimensionless). * CONSTANTS[16] is tau_fi in component fast_inward_current (ms). * CONSTANTS[17] is u_u in component fast_inward_current (dimensionless). * STATES[1] is v in component fast_inward_current_v_gate (dimensionless). * ALGEBRAIC[7] is v_inf in component fast_inward_current_v_gate (dimensionless). * ALGEBRAIC[8] is tau_v_minus in component fast_inward_current_v_gate (ms). * CONSTANTS[30] is tau_v1_minus in component fast_inward_current_v_gate (ms). * CONSTANTS[12] is tau_v2_minus in component fast_inward_current_v_gate (ms). * CONSTANTS[7] is tau_v_plus in component fast_inward_current_v_gate (ms). * ALGEBRAIC[9] is tau_o in component slow_outward_current (ms). * CONSTANTS[14] is tau_o1 in component slow_outward_current (ms). * CONSTANTS[31] is tau_o2 in component slow_outward_current (ms). * ALGEBRAIC[10] is tau_so in component slow_outward_current (ms). * CONSTANTS[18] is tau_so1 in component slow_outward_current (ms). * CONSTANTS[19] is tau_so2 in component slow_outward_current (ms). * CONSTANTS[20] is k_so in component slow_outward_current (dimensionless). * CONSTANTS[21] is u_so in component slow_outward_current (dimensionless). * CONSTANTS[22] is tau_si in component slow_inward_current (ms). * STATES[2] is w in component slow_inward_current_w_gate (dimensionless). * STATES[3] is s in component slow_inward_current_s_gate (dimensionless). * ALGEBRAIC[13] is w_inf in component slow_inward_current_w_gate (dimensionless). * CONSTANTS[23] is tau_winf in component slow_inward_current_w_gate (ms). * CONSTANTS[24] is wstar_inf in component slow_inward_current_w_gate (dimensionless). * ALGEBRAIC[14] is tau_w_minus in component slow_inward_current_w_gate (ms). * CONSTANTS[25] is tau_w1_minus in component slow_inward_current_w_gate (ms). * CONSTANTS[26] is tau_w2_minus in component slow_inward_current_w_gate (ms). * CONSTANTS[27] is k_w_minus in component slow_inward_current_w_gate (dimensionless). * CONSTANTS[28] is u_w_minus in component slow_inward_current_w_gate (dimensionless). * CONSTANTS[29] is tau_w_plus in component slow_inward_current_w_gate (ms). * ALGEBRAIC[15] is tau_s in component slow_inward_current_s_gate (ms). * CONSTANTS[8] is tau_s1 in component slow_inward_current_s_gate (ms). * CONSTANTS[11] is tau_s2 in component slow_inward_current_s_gate (ms). * CONSTANTS[9] is k_s in component slow_inward_current_s_gate (dimensionless). * CONSTANTS[10] is u_s in component slow_inward_current_s_gate (dimensionless). * RATES[0] is d/dt u in component membrane (dimensionless). * RATES[1] is d/dt v in component fast_inward_current_v_gate (dimensionless). * RATES[2] is d/dt w in component slow_inward_current_w_gate (dimensionless). * RATES[3] is d/dt s in component slow_inward_current_s_gate (dimensionless). * There are a total of 7 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1; CONSTANTS[1] = 0; CONSTANTS[2] = 0; STATES[0] = 0; CONSTANTS[3] = -83; CONSTANTS[4] = 2.7; CONSTANTS[5] = 0.3; CONSTANTS[6] = 0.13; STATES[1] = 1; CONSTANTS[7] = 1.45; STATES[2] = 1; STATES[3] = 0; CONSTANTS[8] = 2.7342; CONSTANTS[9] = 2.0994; CONSTANTS[10] = 0.9087; CONSTANTS[11] = (CONSTANTS[0]==1.00000 ? 16.0000 : CONSTANTS[1]==1.00000 ? 2.00000 : 4.00000); CONSTANTS[12] = (CONSTANTS[0]==1.00000 ? 1150.00 : CONSTANTS[1]==1.00000 ? 10.0000 : 1.45000); CONSTANTS[13] = (CONSTANTS[0]==1.00000 ? 0.00600000 : CONSTANTS[1]==1.00000 ? 0.0240000 : 0.100000); CONSTANTS[14] = (CONSTANTS[0]==1.00000 ? 400.000 : CONSTANTS[1]==1.00000 ? 470.000 : 410.000); CONSTANTS[15] = (CONSTANTS[0]==1.00000 ? 0.00600000 : CONSTANTS[1]==1.00000 ? 0.00600000 : 0.00500000); CONSTANTS[16] = (CONSTANTS[0]==1.00000 ? 0.110000 : CONSTANTS[1]==1.00000 ? 0.104000 : 0.0780000); CONSTANTS[17] = (CONSTANTS[0]==1.00000 ? 1.55000 : CONSTANTS[1]==1.00000 ? 1.56000 : 1.61000); CONSTANTS[18] = (CONSTANTS[0]==1.00000 ? 30.0200 : CONSTANTS[1]==1.00000 ? 40.0000 : 91.0000); CONSTANTS[19] = (CONSTANTS[0]==1.00000 ? 0.996000 : CONSTANTS[1]==1.00000 ? 1.20000 : 0.800000); CONSTANTS[20] = (CONSTANTS[0]==1.00000 ? 2.04600 : CONSTANTS[1]==1.00000 ? 2.00000 : 2.10000); CONSTANTS[21] = (CONSTANTS[0]==1.00000 ? 0.650000 : CONSTANTS[1]==1.00000 ? 0.650000 : 0.600000); CONSTANTS[22] = (CONSTANTS[0]==1.00000 ? 1.88750 : CONSTANTS[1]==1.00000 ? 2.90130 : 3.38490); CONSTANTS[23] = (CONSTANTS[0]==1.00000 ? 0.0700000 : CONSTANTS[1]==1.00000 ? 0.0273000 : 0.0100000); CONSTANTS[24] = (CONSTANTS[0]==1.00000 ? 0.940000 : CONSTANTS[1]==1.00000 ? 0.780000 : 0.500000); CONSTANTS[25] = (CONSTANTS[0]==1.00000 ? 60.0000 : CONSTANTS[1]==1.00000 ? 6.00000 : 70.0000); CONSTANTS[26] = (CONSTANTS[0]==1.00000 ? 15.0000 : CONSTANTS[1]==1.00000 ? 140.000 : 8.00000); CONSTANTS[27] = (CONSTANTS[0]==1.00000 ? 65.0000 : CONSTANTS[1]==1.00000 ? 200.000 : 200.000); CONSTANTS[28] = (CONSTANTS[0]==1.00000 ? 0.0300000 : CONSTANTS[1]==1.00000 ? 0.0160000 : 0.0160000); CONSTANTS[29] = (CONSTANTS[0]==1.00000 ? 200.000 : CONSTANTS[1]==1.00000 ? 280.000 : 280.000); CONSTANTS[30] = (CONSTANTS[0]==1.00000 ? 60.0000 : CONSTANTS[1]==1.00000 ? 75.0000 : 80.0000); CONSTANTS[31] = (CONSTANTS[0]==1.00000 ? 6.00000 : CONSTANTS[1]==1.00000 ? 6.00000 : 7.00000); RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - (ALGEBRAIC[6]+ALGEBRAIC[11]+ALGEBRAIC[12]+ALGEBRAIC[0]); resid[1] = RATES[1] - ( (1.00000 - ALGEBRAIC[2])*(ALGEBRAIC[7] - STATES[1]))/ALGEBRAIC[8] - ( ALGEBRAIC[2]*STATES[1])/CONSTANTS[7]; resid[2] = RATES[2] - ( (1.00000 - ALGEBRAIC[5])*(ALGEBRAIC[13] - STATES[2]))/ALGEBRAIC[14] - ( ALGEBRAIC[5]*STATES[2])/CONSTANTS[29]; resid[3] = RATES[3] - ((1.00000+ tanh( CONSTANTS[9]*(STATES[0] - CONSTANTS[10])))/2.00000 - STATES[3])/ALGEBRAIC[15]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[3]+ STATES[0]*(CONSTANTS[4] - CONSTANTS[3]); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>=0.00000&&CONDVAR[1]<=0.00000 ? - 1.00000 : 0.00000); ALGEBRAIC[2] = (CONDVAR[2]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[5] = (CONDVAR[5]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[6] = ( - ALGEBRAIC[2]*STATES[1]*(STATES[0] - CONSTANTS[5])*(CONSTANTS[17] - STATES[0]))/CONSTANTS[16]; ALGEBRAIC[7] = (CONDVAR[6]<0.00000 ? 1.00000 : 0.00000); ALGEBRAIC[4] = (CONDVAR[4]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[8] = ALGEBRAIC[4]*CONSTANTS[12]+ (1.00000 - ALGEBRAIC[4])*CONSTANTS[30]; ALGEBRAIC[3] = (CONDVAR[3]<0.00000 ? 0.00000 : 1.00000); ALGEBRAIC[9] = (1.00000 - ALGEBRAIC[5])*CONSTANTS[14]+ ALGEBRAIC[5]*CONSTANTS[31]; ALGEBRAIC[10] = CONSTANTS[18]+( (CONSTANTS[19] - CONSTANTS[18])*(1.00000+ tanh( CONSTANTS[20]*(STATES[0] - CONSTANTS[21]))))/2.00000; ALGEBRAIC[11] = ( STATES[0]*(1.00000 - ALGEBRAIC[3]))/ALGEBRAIC[9]+ALGEBRAIC[3]/ALGEBRAIC[10]; ALGEBRAIC[12] = ( - ALGEBRAIC[3]*STATES[2]*STATES[3])/CONSTANTS[22]; ALGEBRAIC[13] = (1.00000 - ALGEBRAIC[5])*(1.00000 - ( STATES[0]*1.00000)/CONSTANTS[23])+ ALGEBRAIC[5]*CONSTANTS[24]; ALGEBRAIC[14] = CONSTANTS[25]+( (CONSTANTS[26] - CONSTANTS[25])*(1.00000+ tanh( CONSTANTS[27]*(STATES[0] - CONSTANTS[28]))))/2.00000; ALGEBRAIC[15] = (1.00000 - ALGEBRAIC[3])*CONSTANTS[8]+ ALGEBRAIC[3]*CONSTANTS[11]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - 100.000; CONDVAR[1] = VOI - 101.000; CONDVAR[2] = STATES[0] - CONSTANTS[5]; CONDVAR[3] = STATES[0] - CONSTANTS[6]; CONDVAR[4] = STATES[0] - CONSTANTS[13]; CONDVAR[5] = STATES[0] - CONSTANTS[15]; CONDVAR[6] = STATES[0] - CONSTANTS[13]; }