Lawson
Richard
James
penny.noble@dpag.ox.ac.uk
50000
0.001
2007-07-18T12:59:52+12:00
Department of Physiology, Anatomy & Genetics, University of Oxford
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Stretch Model)
Changed stim_end in stimulus protocol from 10.1 to 1,000,000 seconds
This model has been curated by Penny Noble
guinea-pig
cardiac
excitation-contraction coupling
Penny
Noble
J
James
Lawson
Richard
Varghese
A
Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.
calcium dynamics
ventricular myocyte
diadic space
electrophysiology
This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 3 is parameterised for the 'stretch' model.
Penny
Noble
J
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
Noble
P
James Lawson
14(1)
123
134
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes
James
Richard
Lawson
Noble
Penny
J
2007-02-06T13:00:00+13:00
Noble
Penny
0.001
bdf15
100000
2007-09-06T13:01:21+12:00
9487284
James Lawson
keyword
Units checked, curated.
2007-06-22T13:59:26+12:00
Canadian Journal of Cardiology
Oxford University
Department of Physiology, Anatomy & Genetics
2006-05-03T00:00:00+00:00
Several variables have been given cmeta:id's to allow creation of a PCEnv session file.
2007-12-04T15:11:55+13:00
Noble
D
This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is the STRETCH model, which includes acetylcholine dependent modulation and the electromechanical processes simulated by Variant 02, and also includes simulation of stretch and fibroblasts. This model is parameterised the same as the BASIC model, with all additional variables set to zero.
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.
1998-01-00 00:00
2008-05-14T03:16:52+12:00
P
Kohl