C C There are a total of 3 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 12 entries in the constant variable array. C C C VOI is time in component environment (day). C CONSTS(1) is s in component uninfected (per_day_mm3). C CONSTS(2) is r in component uninfected (per_day). C CONSTS(3) is T_max in component uninfected (per_mm3). C CONSTS(4) is mu_T in component uninfected (per_day). C CONSTS(5) is theta in component uninfected (per_mm3). C CONSTS(6) is k_1 in component latently_infected (mm3_per_day). C STATES(1) is T_1 in component latently_infected (per_mm3). C STATES(2) is T_2 in component actively_infected (per_mm3). C STATES(3) is V in component free_virus_particle (per_mm3). C ALGBRC(1) is s_V in component uninfected (per_day_mm3). C STATES(4) is T in component uninfected (per_mm3). C CONSTS(7) is k_2 in component actively_infected (per_day). C CONSTS(8) is mu_b in component actively_infected (per_day). C CONSTS(9) is mu_V in component free_virus_particle (per_day). C ALGBRC(2) is N in component AZT (dimensionless). C ALGBRC(3) is T_tot in component T_cell_population (per_mm3). C CONSTS(10) is tau in component AZT (day). C CONSTS(11) is N_initial in component AZT (dimensionless). C CONSTS(12) is N_AZT in component AZT (dimensionless). C RATES(4) is d/dt T in component uninfected (per_mm3). C RATES(1) is d/dt T_1 in component latently_infected (per_mm3). C RATES(2) is d/dt T_2 in component actively_infected (per_mm3). C RATES(3) is d/dt V in component free_virus_particle (per_mm3). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 10 CONSTS(2) = 0.03 CONSTS(3) = 1500 CONSTS(4) = 0.02 CONSTS(5) = 1 CONSTS(6) = 2.4E-5 STATES(1) = 0 STATES(2) = 0 STATES(3) = 1.0E-3 STATES(4) = 1000 CONSTS(7) = 3E-3 CONSTS(8) = 0.24 CONSTS(9) = 2.4 CONSTS(10) = 1096 CONSTS(11) = 1400 CONSTS(12) = 1050 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( CONSTS(6)*STATES(3)*STATES(4) - CONSTS(4)*STATES(1)) - CONSTS(7)*STATES(1) RATES(2) = CONSTS(7)*STATES(1) - CONSTS(8)*STATES(2) ALGBRC(1) = ( CONSTS(5)*CONSTS(1))/(CONSTS(5)+STATES(3)) RATES(4) = ((ALGBRC(1) - CONSTS(4)*STATES(4))+ CONSTS(2)*STATES(4)*(1.00000 - (STATES(4)+STATES(1)+STATES(2))/CONSTS(3))) - CONSTS(6)*STATES(3)*STATES(4) ALGBRC(2) = TERNRY(VOI.LT.CONSTS(10), CONSTS(11), TERNRY(VOI.GE.CONSTS(10), CONSTS(12), 0.0/0.0) RATES(3) = ( ALGBRC(2)*CONSTS(8)*STATES(2) - CONSTS(6)*STATES(3)*STATES(4)) - CONSTS(9)*STATES(3) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( CONSTS(5)*CONSTS(1))/(CONSTS(5)+STATES(3)) ALGBRC(2) = TERNRY(VOI.LT.CONSTS(10), CONSTS(11), TERNRY(VOI.GE.CONSTS(10), CONSTS(12), 0.0/0.0) ALGBRC(3) = STATES(4)+STATES(1)+STATES(2) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END