/* There are a total of 11 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 21 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is C in component membrane (nanoF). * CONSTANTS[1] is i_app in component membrane (nanoA). * ALGEBRAIC[10] is i_tonic_e in component tonic_current (nanoA). * ALGEBRAIC[3] is i_Na in component fast_sodium_current (nanoA). * ALGEBRAIC[8] is i_NaP in component persistent_sodium_current (nanoA). * ALGEBRAIC[6] is i_K in component potassium_current (nanoA). * ALGEBRAIC[9] is i_leak in component leakage_current (nanoA). * CONSTANTS[2] is E_Na in component fast_sodium_current (millivolt). * CONSTANTS[3] is g_Na in component fast_sodium_current (nanoS). * ALGEBRAIC[0] is m_infinity in component fast_sodium_current_m_gate (dimensionless). * STATES[1] is n in component potassium_current_n_gate (dimensionless). * CONSTANTS[4] is theta_m in component fast_sodium_current_m_gate (millivolt). * CONSTANTS[5] is omega_m in component fast_sodium_current_m_gate (millivolt). * CONSTANTS[6] is g_K in component potassium_current (nanoS). * CONSTANTS[7] is E_K in component potassium_current (millivolt). * ALGEBRAIC[1] is n_infinity in component potassium_current_n_gate (dimensionless). * ALGEBRAIC[4] is tau_n in component potassium_current_n_gate (millisecond). * CONSTANTS[8] is tau_n_max in component potassium_current_n_gate (millisecond). * CONSTANTS[9] is theta_n in component potassium_current_n_gate (millivolt). * CONSTANTS[10] is omega_n in component potassium_current_n_gate (millivolt). * CONSTANTS[11] is g_NaP in component persistent_sodium_current (nanoS). * ALGEBRAIC[7] is m_infinity in component persistent_sodium_current_m_gate (dimensionless). * STATES[2] is h in component persistent_sodium_current_h_gate (dimensionless). * CONSTANTS[12] is theta_m in component persistent_sodium_current_m_gate (millivolt). * CONSTANTS[13] is omega_m in component persistent_sodium_current_m_gate (millivolt). * ALGEBRAIC[2] is h_infinity in component persistent_sodium_current_h_gate (dimensionless). * ALGEBRAIC[5] is tau_h in component persistent_sodium_current_h_gate (millisecond). * CONSTANTS[14] is tau_h_max in component persistent_sodium_current_h_gate (millisecond). * CONSTANTS[15] is theta_h in component persistent_sodium_current_h_gate (millivolt). * CONSTANTS[16] is omega_h in component persistent_sodium_current_h_gate (millivolt). * CONSTANTS[17] is g_leak in component leakage_current (nanoS). * CONSTANTS[18] is E_leak in component leakage_current (millivolt). * CONSTANTS[19] is g_tonic_e in component tonic_current (nanoS). * CONSTANTS[20] is E_syn_e in component tonic_current (millivolt). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt n in component potassium_current_n_gate (dimensionless). * RATES[2] is d/dt h in component persistent_sodium_current_h_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -50.0; CONSTANTS[0] = 0.021; CONSTANTS[1] = 0; CONSTANTS[2] = 50; CONSTANTS[3] = 28; STATES[1] = 0.01; CONSTANTS[4] = -34; CONSTANTS[5] = -5; CONSTANTS[6] = 11.2; CONSTANTS[7] = -85; CONSTANTS[8] = 10; CONSTANTS[9] = -29; CONSTANTS[10] = -4; CONSTANTS[11] = 1.5; STATES[2] = 0.92; CONSTANTS[12] = -45.1; CONSTANTS[13] = -6; CONSTANTS[14] = 10000; CONSTANTS[15] = -53; CONSTANTS[16] = 6; CONSTANTS[17] = 2.2; CONSTANTS[18] = -57.5; CONSTANTS[19] = 0.2; CONSTANTS[20] = 0; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[9])/CONSTANTS[10])); ALGEBRAIC[4] = CONSTANTS[8]/cosh((STATES[0] - CONSTANTS[9])/( 2.00000*CONSTANTS[10])); RATES[1] = (ALGEBRAIC[1] - STATES[1])/ALGEBRAIC[4]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[15])/CONSTANTS[16])); ALGEBRAIC[5] = CONSTANTS[14]/cosh((STATES[0] - CONSTANTS[15])/( 2.00000*CONSTANTS[16])); RATES[2] = (ALGEBRAIC[2] - STATES[2])/ALGEBRAIC[5]; ALGEBRAIC[10] = CONSTANTS[19]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[20]); ALGEBRAIC[0] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[4])/CONSTANTS[5])); ALGEBRAIC[3] = CONSTANTS[3]*pow(ALGEBRAIC[0], 3.00000)*(1.00000 - STATES[1])*(1.00000/1000.00)*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[12])/CONSTANTS[13])); ALGEBRAIC[8] = CONSTANTS[11]*ALGEBRAIC[7]*STATES[2]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[6] = CONSTANTS[6]*pow(STATES[1], 4.00000)*(1.00000/1000.00)*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[9] = CONSTANTS[17]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[18]); RATES[0] = (- (ALGEBRAIC[3]+ALGEBRAIC[8]+ALGEBRAIC[6]+ALGEBRAIC[9])+ALGEBRAIC[10]+CONSTANTS[1])/CONSTANTS[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[9])/CONSTANTS[10])); ALGEBRAIC[4] = CONSTANTS[8]/cosh((STATES[0] - CONSTANTS[9])/( 2.00000*CONSTANTS[10])); ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[15])/CONSTANTS[16])); ALGEBRAIC[5] = CONSTANTS[14]/cosh((STATES[0] - CONSTANTS[15])/( 2.00000*CONSTANTS[16])); ALGEBRAIC[10] = CONSTANTS[19]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[20]); ALGEBRAIC[0] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[4])/CONSTANTS[5])); ALGEBRAIC[3] = CONSTANTS[3]*pow(ALGEBRAIC[0], 3.00000)*(1.00000 - STATES[1])*(1.00000/1000.00)*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[12])/CONSTANTS[13])); ALGEBRAIC[8] = CONSTANTS[11]*ALGEBRAIC[7]*STATES[2]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[6] = CONSTANTS[6]*pow(STATES[1], 4.00000)*(1.00000/1000.00)*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[9] = CONSTANTS[17]*(1.00000/1000.00)*(STATES[0] - CONSTANTS[18]); }