Generated Code
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C
C There are a total of 7 entries in the algebraic variable array.
C There are a total of 20 entries in each of the rate and state variable arrays.
C There are a total of 33 entries in the constant variable array.
C
C
C VOI is time in component environment (minute).
C ALGBRC(1) is x1 in component x1 (molar).
C STATES(1) is x2 in component x2 (molar).
C CONSTS(1) is k1 in component reaction_constants (second_order_rate_constant).
C CONSTS(2) is k_minus1 in component reaction_constants (first_order_rate_constant).
C CONSTS(21) is k4 in component reaction_constants (first_order_rate_constant).
C CONSTS(3) is k_minus4 in component reaction_constants (first_order_rate_constant).
C CONSTS(22) is k_minus3 in component reaction_constants (second_order_rate_constant).
C STATES(2) is x3 in component x3 (molar).
C STATES(3) is x5 in component x5 (molar).
C STATES(4) is x6 in component x6 (molar).
C CONSTS(4) is PTP in component reaction_constants (molar).
C CONSTS(5) is k3 in component reaction_constants (first_order_rate_constant).
C STATES(5) is x4 in component x4 (molar).
C CONSTS(23) is k2 in component reaction_constants (second_order_rate_constant).
C CONSTS(24) is k_minus2 in component reaction_constants (first_order_rate_constant).
C CONSTS(6) is k4b in component reaction_constants (first_order_rate_constant).
C CONSTS(7) is k_minus4b in component reaction_constants (first_order_rate_constant).
C STATES(6) is x7 in component x7 (molar).
C STATES(7) is x8 in component x8 (molar).
C ALGBRC(2) is k5 in component reaction_constants (rate).
C CONSTS(8) is k_minus5 in component reaction_constants (first_order_rate_constant).
C CONSTS(9) is k6 in component reaction_constants (second_order_rate_constant).
C STATES(8) is x9 in component x9 (molar).
C CONSTS(10) is k7 in component reaction_constants (first_order_rate_constant).
C CONSTS(25) is k_minus7 in component reaction_constants (second_order_rate_constant).
C STATES(9) is x10 in component x10 (molar).
C CONSTS(11) is IRp in component reaction_constants (molar).
C CONSTS(26) is k8 in component reaction_constants (second_order_rate_constant).
C CONSTS(12) is k_minus8 in component reaction_constants (first_order_rate_constant).
C STATES(10) is x11 in component x11 (molar).
C STATES(11) is x12 in component x12 (molar).
C STATES(12) is x13 in component x13 (percentage).
C ALGBRC(3) is k9 in component reaction_constants (first_order_rate_constant).
C CONSTS(27) is k_minus9 in component reaction_constants (second_order_rate_constant).
C CONSTS(28) is k10 in component reaction_constants (first_order_rate_constant).
C CONSTS(13) is k_minus10 in component reaction_constants (second_order_rate_constant).
C STATES(13) is x14 in component x14 (percentage).
C STATES(14) is x15 in component x15 (percentage).
C CONSTS(14) is PTEN in component reaction_constants (molar).
C CONSTS(15) is SHIP in component reaction_constants (molar).
C STATES(15) is x16 in component x16 (percentage).
C ALGBRC(4) is k11 in component reaction_constants (first_order_rate_constant).
C CONSTS(29) is k_minus11 in component reaction_constants (first_order_rate_constant).
C STATES(16) is x17 in component x17 (percentage).
C STATES(17) is x18 in component x18 (percentage).
C ALGBRC(5) is k12 in component reaction_constants (first_order_rate_constant).
C CONSTS(30) is k_minus12 in component reaction_constants (first_order_rate_constant).
C STATES(18) is x19 in component x19 (percentage).
C STATES(19) is x20 in component x20 (percentage).
C CONSTS(31) is k13 in component reaction_constants (first_order_rate_constant).
C CONSTS(16) is k_minus13 in component reaction_constants (first_order_rate_constant).
C ALGBRC(7) is k13b in component reaction_constants (first_order_rate_constant).
C CONSTS(32) is k14 in component reaction_constants (first_order_rate_constant).
C CONSTS(17) is k_minus14 in component reaction_constants (first_order_rate_constant).
C STATES(20) is x21 in component x21 (percentage).
C CONSTS(33) is k9_basal in component reaction_constants (first_order_rate_constant).
C CONSTS(18) is k9_stimulated in component reaction_constants (first_order_rate_constant).
C ALGBRC(6) is effect in component reaction_constants (dimensionless).
C CONSTS(19) is APequil in component reaction_constants (dimensionless).
C CONSTS(20) is PI3K in component reaction_constants (molar).
C RATES(1) is d/dt x2 in component x2 (molar).
C RATES(2) is d/dt x3 in component x3 (molar).
C RATES(5) is d/dt x4 in component x4 (molar).
C RATES(3) is d/dt x5 in component x5 (molar).
C RATES(4) is d/dt x6 in component x6 (molar).
C RATES(6) is d/dt x7 in component x7 (molar).
C RATES(7) is d/dt x8 in component x8 (molar).
C RATES(8) is d/dt x9 in component x9 (molar).
C RATES(9) is d/dt x10 in component x10 (molar).
C RATES(10) is d/dt x11 in component x11 (molar).
C RATES(11) is d/dt x12 in component x12 (molar).
C RATES(12) is d/dt x13 in component x13 (percentage).
C RATES(13) is d/dt x14 in component x14 (percentage).
C RATES(14) is d/dt x15 in component x15 (percentage).
C RATES(15) is d/dt x16 in component x16 (percentage).
C RATES(16) is d/dt x17 in component x17 (percentage).
C RATES(17) is d/dt x18 in component x18 (percentage).
C RATES(18) is d/dt x19 in component x19 (percentage).
C RATES(19) is d/dt x20 in component x20 (percentage).
C RATES(20) is d/dt x21 in component x21 (percentage).
C
SUBROUTINE initConsts(CONSTS, RATES, STATES)
REAL CONSTS(*), RATES(*), STATES(*)
STATES(1) = 9e-13
CONSTS(1) = 6e7
CONSTS(2) = 0.2
CONSTS(3) = 0.003
STATES(2) = 0
STATES(3) = 0
STATES(4) = 1e-13
CONSTS(4) = 1
CONSTS(5) = 2500
STATES(5) = 0
CONSTS(6) = 2.1e-3
CONSTS(7) = 2.1e-4
STATES(6) = 0
STATES(7) = 0
CONSTS(8) = 1.67e-18
CONSTS(9) = 0.461
STATES(8) = 1e-13
CONSTS(10) = 4.16
STATES(9) = 1e-13
CONSTS(11) = 8.97e-13
CONSTS(12) = 10
STATES(10) = 1e-13
STATES(11) = 0
STATES(12) = 0.31
CONSTS(13) = 2.77
STATES(13) = 99.4
STATES(14) = 0.29
CONSTS(14) = 1
CONSTS(15) = 1
STATES(15) = 100
STATES(16) = 0
STATES(17) = 100
STATES(18) = 0
STATES(19) = 96
CONSTS(16) = 0.167
CONSTS(17) = 0.001155
STATES(20) = 4
CONSTS(18) = 1.39
CONSTS(19) = 9.09
CONSTS(20) = 5e-15
CONSTS(21) = CONSTS(3)/9.00000
CONSTS(22) = CONSTS(2)/1.00000
CONSTS(23) = CONSTS(1)
CONSTS(24) = 100.000*CONSTS(2)
CONSTS(25) = (2.50000/7.45000)*CONSTS(10)
CONSTS(26) = (( CONSTS(12)*5.00000)/70.7750)*1.00000e+12
CONSTS(27) = (94.0000/3.10000)*CONSTS(18)
CONSTS(28) = (3.10000/2.90000)*CONSTS(13)
CONSTS(29) = 10.0000*log(2.00000)*1.00000
CONSTS(30) = 10.0000*log(2.00000)*1.00000
CONSTS(31) = (4.00000/96.0000)*CONSTS(16)
CONSTS(32) = CONSTS(17)/96.0000
CONSTS(33) = (0.310000/99.4000)*CONSTS(27)
RETURN
END
SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
RATES(6) = CONSTS(6)*STATES(5) - ( CONSTS(7)*STATES(6)+ CONSTS(9)*CONSTS(4)*STATES(6))
RATES(7) = CONSTS(6)*STATES(3) - ( CONSTS(7)*STATES(7)+ CONSTS(9)*CONSTS(4)*STATES(7))
RATES(8) = CONSTS(25)*CONSTS(4)*STATES(9) - ( CONSTS(10)*STATES(8)*(STATES(5)+STATES(3)))/CONSTS(11)
RATES(9) = (( CONSTS(10)*STATES(8)*(STATES(5)+STATES(3)))/CONSTS(11)+ CONSTS(12)*STATES(11)) - ( CONSTS(25)*CONSTS(4)+ CONSTS(26)*STATES(10))*STATES(9)
RATES(10) = CONSTS(12)*STATES(11) - CONSTS(26)*STATES(9)*STATES(10)
RATES(11) = CONSTS(26)*STATES(9)*STATES(10) - CONSTS(12)*STATES(11)
RATES(14) = CONSTS(13)*CONSTS(15)*STATES(12) - CONSTS(28)*STATES(14)
ALGBRC(1) = TERNRY(VOI.LT.15.0000, 1.00000e-07, 0.00000)
RATES(1) = ( CONSTS(2)*STATES(2)+ CONSTS(22)*CONSTS(4)*STATES(3)+ CONSTS(3)*STATES(4)) - ( CONSTS(1)*ALGBRC(1)*STATES(1)+ CONSTS(21)*STATES(1))
RATES(2) = CONSTS(1)*ALGBRC(1)*STATES(1) - ( CONSTS(2)*STATES(2)+ CONSTS(5)*STATES(2))
RATES(5) = ( CONSTS(23)*ALGBRC(1)*STATES(3)+ CONSTS(7)*STATES(6)) - ( CONSTS(24)*STATES(5)+ CONSTS(6)*STATES(5))
RATES(3) = ( CONSTS(5)*STATES(2)+ CONSTS(24)*STATES(5)+ CONSTS(7)*STATES(7)) - ( CONSTS(23)*ALGBRC(1)*STATES(3)+ CONSTS(22)*CONSTS(4)*STATES(3)+ CONSTS(6)*STATES(3))
ALGBRC(2) = TERNRY(STATES(4)+STATES(6)+STATES(7).GT.1.00000e-13, 10.0000*CONSTS(8), 60.0000*CONSTS(8))
RATES(4) = (ALGBRC(2)+ CONSTS(9)*CONSTS(4)*(STATES(6)+STATES(7))+ CONSTS(21)*STATES(1)) - ( CONSTS(8)*STATES(4)+ CONSTS(3)*STATES(4))
ALGBRC(3) = ( (CONSTS(18) - CONSTS(33))*STATES(11))/CONSTS(20)+CONSTS(33)
RATES(12) = ( ALGBRC(3)*STATES(13)+ CONSTS(28)*STATES(14)) - ( CONSTS(27)*CONSTS(14)+ CONSTS(13)*CONSTS(15))*STATES(12)
RATES(13) = CONSTS(27)*CONSTS(14)*STATES(12) - ALGBRC(3)*STATES(13)
ALGBRC(4) = ( 0.100000*CONSTS(29)*(STATES(12) - 0.310000))/(3.10000 - 0.310000)
RATES(15) = CONSTS(29)*STATES(16) - ALGBRC(4)*STATES(15)
RATES(16) = ALGBRC(4)*STATES(15) - CONSTS(29)*STATES(16)
ALGBRC(5) = ( 0.100000*CONSTS(30)*(STATES(12) - 0.310000))/(3.10000 - 0.310000)
RATES(17) = CONSTS(30)*STATES(18) - ALGBRC(5)*STATES(17)
RATES(18) = ALGBRC(5)*STATES(17) - CONSTS(30)*STATES(18)
ALGBRC(6) = ( 0.200000*STATES(16)+ 0.800000*STATES(18))/CONSTS(19)
ALGBRC(7) = (40.0000/60.0000 - 4.00000/96.0000)*CONSTS(16)*ALGBRC(6)
RATES(19) = ( CONSTS(16)*STATES(20)+CONSTS(32)) - ( (CONSTS(31)+ALGBRC(7))*STATES(19)+ CONSTS(17)*STATES(19))
RATES(20) = - CONSTS(16)*STATES(20)+ (CONSTS(31)+ALGBRC(7))*STATES(19)
RETURN
END
SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC)
REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
ALGBRC(1) = TERNRY(VOI.LT.15.0000, 1.00000e-07, 0.00000)
ALGBRC(2) = TERNRY(STATES(4)+STATES(6)+STATES(7).GT.1.00000e-13, 10.0000*CONSTS(8), 60.0000*CONSTS(8))
ALGBRC(3) = ( (CONSTS(18) - CONSTS(33))*STATES(11))/CONSTS(20)+CONSTS(33)
ALGBRC(4) = ( 0.100000*CONSTS(29)*(STATES(12) - 0.310000))/(3.10000 - 0.310000)
ALGBRC(5) = ( 0.100000*CONSTS(30)*(STATES(12) - 0.310000))/(3.10000 - 0.310000)
ALGBRC(6) = ( 0.200000*STATES(16)+ 0.800000*STATES(18))/CONSTS(19)
ALGBRC(7) = (40.0000/60.0000 - 4.00000/96.0000)*CONSTS(16)*ALGBRC(6)
RETURN
END
REAL FUNCTION TERNRY(TEST, VALA, VALB)
LOGICAL TEST
REAL VALA, VALB
IF (TEST) THEN
TERNRY = VALA
ELSE
TERNRY = VALB
ENDIF
RETURN
END