/* There are a total of 11 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 23 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is C in component membrane (picofarad). * ALGEBRAIC[7] is I_Ca in component I_Ca (picoampere). * ALGEBRAIC[0] is I_K in component I_K (picoampere). * ALGEBRAIC[8] is I_SK in component I_SK (picoampere). * ALGEBRAIC[10] is I_DA in component I_DA (picoampere). * CONSTANTS[1] is gK in component I_K (nanosiemens). * CONSTANTS[2] is VK in component model_parameters (millivolt). * STATES[1] is n in component n (dimensionless). * ALGEBRAIC[1] is n_infinity in component n (dimensionless). * CONSTANTS[3] is lambda in component n (dimensionless). * CONSTANTS[4] is tau_n in component n (millisecond). * CONSTANTS[5] is vn in component n (millivolt). * CONSTANTS[6] is sn in component n (millivolt). * CONSTANTS[7] is gCa in component I_Ca (nanosiemens). * CONSTANTS[8] is VCa in component model_parameters (millivolt). * ALGEBRAIC[2] is m_infinity in component m (dimensionless). * CONSTANTS[9] is vm in component m (millivolt). * CONSTANTS[10] is sm in component m (millivolt). * CONSTANTS[11] is gSK in component I_SK (nanosiemens). * ALGEBRAIC[3] is s_infinity in component I_SK (dimensionless). * CONSTANTS[12] is ks in component I_SK (micromolar). * STATES[2] is Ca in component Ca (micromolar). * ALGEBRAIC[9] is I_A in component I_DA (picoampere). * CONSTANTS[13] is gA in component I_DA (nanosiemens). * ALGEBRAIC[4] is a_infinity in component a (dimensionless). * STATES[3] is h in component h (dimensionless). * CONSTANTS[14] is va in component a (millivolt). * CONSTANTS[15] is sa in component a (millivolt). * ALGEBRAIC[5] is h_infinity in component h (dimensionless). * CONSTANTS[16] is tau_h in component h (millisecond). * CONSTANTS[17] is vh in component h (millivolt). * CONSTANTS[18] is sh in component h (millivolt). * CONSTANTS[19] is fc in component Ca (dimensionless). * CONSTANTS[20] is alpha in component Ca (micromolar_femtocoulomb). * CONSTANTS[21] is kc in component Ca (first_order_rate_constant). * ALGEBRAIC[6] is PRL in component PRL (dimensionless). * CONSTANTS[22] is kPRL in component PRL (micromolar_4). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt n in component n (dimensionless). * RATES[3] is d/dt h in component h (dimensionless). * RATES[2] is d/dt Ca in component Ca (micromolar). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -60; CONSTANTS[0] = 10; CONSTANTS[1] = 4; CONSTANTS[2] = -75; STATES[1] = 0.1; CONSTANTS[3] = 0.7; CONSTANTS[4] = 30; CONSTANTS[5] = -5; CONSTANTS[6] = 10; CONSTANTS[7] = 2; CONSTANTS[8] = 50; CONSTANTS[9] = -20; CONSTANTS[10] = 12; CONSTANTS[11] = 1.7; CONSTANTS[12] = 0.5; STATES[2] = 0.1; CONSTANTS[13] = 25; STATES[3] = 0.1; CONSTANTS[14] = -20; CONSTANTS[15] = 10; CONSTANTS[16] = 20; CONSTANTS[17] = -60; CONSTANTS[18] = 5; CONSTANTS[19] = 0.01; CONSTANTS[20] = 0.0015; CONSTANTS[21] = 0.16; CONSTANTS[22] = 1; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[3] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - (ALGEBRAIC[7]+ALGEBRAIC[0]+ALGEBRAIC[8]+ALGEBRAIC[10])/CONSTANTS[0]; resid[1] = RATES[1] - ( CONSTANTS[3]*(ALGEBRAIC[1] - STATES[1]))/CONSTANTS[4]; resid[2] = RATES[3] - (ALGEBRAIC[5] - STATES[3])/CONSTANTS[16]; resid[3] = RATES[2] - - CONSTANTS[19]*( CONSTANTS[20]*ALGEBRAIC[7]+ CONSTANTS[21]*STATES[2]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[6] = CONSTANTS[22]*pow(STATES[2], 4.00000); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[1]*STATES[1]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[5] - STATES[0])/CONSTANTS[6])); ALGEBRAIC[5] = 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[17])/CONSTANTS[18])); ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[9] - STATES[0])/CONSTANTS[10])); ALGEBRAIC[7] = CONSTANTS[7]*ALGEBRAIC[2]*(STATES[0] - CONSTANTS[8]); ALGEBRAIC[3] = pow(STATES[2], 2.00000)/(pow(STATES[2], 2.00000)+pow(CONSTANTS[12], 2.00000)); ALGEBRAIC[8] = CONSTANTS[11]*ALGEBRAIC[3]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[4] = 1.00000/(1.00000+exp((CONSTANTS[14] - STATES[0])/CONSTANTS[15])); ALGEBRAIC[9] = CONSTANTS[13]*ALGEBRAIC[4]*STATES[3]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[10] = ALGEBRAIC[9]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }