C C There are a total of 11 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 14 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is S1 in component S1 (millimolar). C CONSTS(1) is Jo in component glucose_influx_rate (flux). C ALGBRC(4) is v1 in component v1 (flux). C STATES(2) is S2 in component S2 (millimolar). C ALGBRC(5) is v2 in component v2 (flux). C ALGBRC(9) is v6 in component v6 (flux). C STATES(3) is S3 in component S3 (millimolar). C ALGBRC(6) is v3 in component v3 (flux). C STATES(4) is S4 in component S4 (millimolar). C ALGBRC(7) is v4 in component v4 (flux). C ALGBRC(11) is J in component S4_flux_rate_across_the_plasma_membrane (flux). C STATES(5) is S4_ex in component S4_ex (millimolar). C CONSTS(2) is phi in component S4_ex (dimensionless). C ALGBRC(10) is v7 in component v7 (flux). C STATES(6) is A3 in component A3 (millimolar). C ALGBRC(8) is v5 in component v5 (flux). C CONSTS(3) is A in component A2 (millimolar). C ALGBRC(1) is A2 in component A2 (millimolar). C STATES(7) is N2 in component N2 (millimolar). C CONSTS(4) is N in component N1 (millimolar). C ALGBRC(2) is N1 in component N1 (millimolar). C CONSTS(5) is K_I in component v1 (millimolar). C CONSTS(6) is k_1 in component v1 (second_order_rate_constant). C CONSTS(7) is q in component v1 (dimensionless). C ALGBRC(3) is f_A3 in component v1 (dimensionless). C CONSTS(8) is k_2 in component v2 (second_order_rate_constant). C CONSTS(9) is k_3 in component v3 (second_order_rate_constant). C CONSTS(10) is k_4 in component v4 (second_order_rate_constant). C CONSTS(11) is k_5 in component v5 (first_order_rate_constant). C CONSTS(12) is k_6 in component v6 (second_order_rate_constant). C CONSTS(13) is k in component v7 (first_order_rate_constant). C CONSTS(14) is kappa in component S4_flux_rate_across_the_plasma_membrane (first_order_rate_constant). C RATES(1) is d/dt S1 in component S1 (millimolar). C RATES(2) is d/dt S2 in component S2 (millimolar). C RATES(3) is d/dt S3 in component S3 (millimolar). C RATES(4) is d/dt S4 in component S4 (millimolar). C RATES(5) is d/dt S4_ex in component S4_ex (millimolar). C RATES(6) is d/dt A3 in component A3 (millimolar). C RATES(7) is d/dt N2 in component N2 (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 5.8 CONSTS(1) = 3.0 STATES(2) = 0.9 STATES(3) = 0.2 STATES(4) = 0.2 STATES(5) = 0.1 CONSTS(2) = 0.1 STATES(6) = 2.4 CONSTS(3) = 4.0 STATES(7) = 0.1 CONSTS(4) = 1.0 CONSTS(5) = 0.52 CONSTS(6) = 100.0 CONSTS(7) = 4.0 CONSTS(8) = 6.0 CONSTS(9) = 16.0 CONSTS(10) = 100.0 CONSTS(11) = 1.28 CONSTS(12) = 12.0 CONSTS(13) = 1.3 CONSTS(14) = 13.0 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000+STATES(6)/CONSTS(5) ** CONSTS(7) ** -1.00000 ALGBRC(4) = CONSTS(6)*STATES(1)*STATES(6)*ALGBRC(3) RATES(1) = CONSTS(1) - ALGBRC(4) ALGBRC(2) = CONSTS(4) - STATES(7) ALGBRC(5) = CONSTS(8)*STATES(2)*ALGBRC(2) ALGBRC(1) = CONSTS(3) - STATES(6) ALGBRC(6) = CONSTS(9)*STATES(3)*ALGBRC(1) RATES(3) = ALGBRC(5) - ALGBRC(6) ALGBRC(8) = CONSTS(11)*STATES(6) RATES(6) = 2.00000*ALGBRC(6) - ( 2.00000*ALGBRC(4)+ALGBRC(8)) ALGBRC(9) = CONSTS(12)*STATES(2)*STATES(7) RATES(2) = 2.00000*ALGBRC(4) - (ALGBRC(5)+ALGBRC(9)) ALGBRC(7) = CONSTS(10)*STATES(4)*STATES(7) RATES(7) = ALGBRC(5) - (ALGBRC(7)+ALGBRC(9)) ALGBRC(11) = CONSTS(14)*(STATES(4) - STATES(5)) RATES(4) = ALGBRC(6) - (ALGBRC(7)+ALGBRC(11)) ALGBRC(10) = CONSTS(13)*STATES(5) RATES(5) = CONSTS(2)*ALGBRC(11) - ALGBRC(10) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000+STATES(6)/CONSTS(5) ** CONSTS(7) ** -1.00000 ALGBRC(4) = CONSTS(6)*STATES(1)*STATES(6)*ALGBRC(3) ALGBRC(2) = CONSTS(4) - STATES(7) ALGBRC(5) = CONSTS(8)*STATES(2)*ALGBRC(2) ALGBRC(1) = CONSTS(3) - STATES(6) ALGBRC(6) = CONSTS(9)*STATES(3)*ALGBRC(1) ALGBRC(8) = CONSTS(11)*STATES(6) ALGBRC(9) = CONSTS(12)*STATES(2)*STATES(7) ALGBRC(7) = CONSTS(10)*STATES(4)*STATES(7) ALGBRC(11) = CONSTS(14)*(STATES(4) - STATES(5)) ALGBRC(10) = CONSTS(13)*STATES(5) RETURN END