Hynne, Dano, Sorensen, 2001

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

Glycolysis is a metabolic pathway that has been comprehensively studied and when viewed qualitatively as a series of enzyme catalysed reaction steps, it is relatively well understood. However, when the quantitative aspects of the biochemical pathway are considered, the situation becomes more complex. Mathematical models encompass this complexity and make the pathway easier to understand. Several mathematical models of glycolysis have been published, including:

• Modelling Glycolysis in Trypanosoma brucei, Bakker et al., 1997;

• The Glycolytic Metabolic Pathway in the Yeast Saccharomyces cerevisiae, 1997;

• 2,3-bisphosphoglycerate Metabolism in the Human Erythrocyte, 1999;

• Bakker et al. Glycosomes Protects Trypanosomes From Glycolysis, 2000;

• Teusink et al., Understanding Yeast Glycolysis in Terms of the in vitro Kinetics of the Constituent Enzymes, 2000;

• Effect of Cellular Interaction on Glycolytic Oscillations in Yeast, 2000;

and

• Yeast Glycolytic Oscillations, 2000;

• Lambeth and Kushmerick, Modelling Glycogenolysis in Skeletal Muscle, 2002.

In this article, Hynne et al. present a general method for fitting a mathematical model of a biochemical pathway to experimental data when the mechanisms are known but the kinetic parameters are lacking. Reaction rate constants and maximum velocities (Km and Vmax values, respectively) are calculated from the experimental data using algebraic equations.

Using this method, the authors create a full-scale model of glycolysis and glycolytic oscillations in the yeast Saccharomyces cerevisiae (see the figure below). The results of model simulations were consistent with experimental data.

The raw CellML description of the Hynne et al. model can be downloaded in various formats as described in ).

The complete original paper reference is cited below:

Full-scale model of glycolysis in Saccharomyces cerevisiae , F. Hynne, S. Danø, and P. G. Sørensen , 2001, Biophysical Chemistry , 94, 121-163. (Full text (HTML) and PDF versions of the article are available on the Biophysical Chemistry website.) PubMed ID: 11744196

The glycolysis pathway described by the mathematical model.