C C There are a total of 9 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 37 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is R_T in component Parameters (dimensionless). C CONSTS(2) is K_1 in component Parameters (micromolar). C CONSTS(3) is K_2 in component Parameters (micromolar). C CONSTS(4) is k_r in component Parameters (per_second). C CONSTS(5) is k_p in component Parameters (per_second). C CONSTS(6) is k_e in component Parameters (per_second). C CONSTS(7) is xi in component Parameters (dimensionless). C CONSTS(8) is G_T in component Parameters (dimensionless). C CONSTS(9) is k_deg in component Parameters (per_second). C CONSTS(10) is k_a in component Parameters (per_second). C CONSTS(11) is k_d in component Parameters (per_second). C CONSTS(12) is PIP_2_T in component Parameters (dimensionless). C CONSTS(13) is r_r in component Parameters (per_second). C CONSTS(14) is delta in component Parameters (dimensionless). C CONSTS(15) is K_c in component Parameters (micromolar). C CONSTS(16) is alpha in component Parameters (per_second). C CONSTS(17) is N_a in component Parameters (per_micromole). C CONSTS(18) is v in component Parameters (litre). C CONSTS(19) is epsilon_r in component Parameters (dimensionless). C CONSTS(20) is d_1 in component Parameters (micromolar). C CONSTS(21) is d_2 in component Parameters (micromolar). C CONSTS(22) is d_3 in component Parameters (micromolar). C CONSTS(23) is d_5 in component Parameters (micromolar). C CONSTS(24) is a_2 in component Parameters (per_micromolar_per_second). C CONSTS(25) is B_e in component Parameters (micromolar). C CONSTS(26) is K_e in component Parameters (micromolar). C CONSTS(27) is B_ER in component Parameters (micromolar). C CONSTS(28) is K_ER in component Parameters (micromolar). C CONSTS(29) is B_x in component Parameters (micromolar). C CONSTS(30) is K_x in component Parameters (micromolar). C CONSTS(31) is k_3 in component Parameters (micromolar). C CONSTS(32) is eta_1 in component Parameters (per_second). C CONSTS(33) is eta_2 in component Parameters (per_second). C CONSTS(34) is eta_3 in component Parameters (flux). C CONSTS(35) is C_T in component Parameters (micromolar). C CONSTS(36) is L in component ligand (micromolar). C STATES(1) is RS in component RS (dimensionless). C STATES(2) is RS_p in component RS_p (dimensionless). C STATES(3) is G in component G_GTP (dimensionless). C ALGBRC(1) is rho_r in component rho_r (dimensionless). C STATES(4) is IP_3 in component IP_3 (micromolar). C STATES(5) is PIP_2 in component PIP_2 (dimensionless). C ALGBRC(2) is r_h in component r_h (per_second). C STATES(6) is C in component C (micromolar). C ALGBRC(9) is C_ER in component C_ER (micromolar). C ALGBRC(5) is beta in component beta (dimensionless). C STATES(7) is h in component h (dimensionless). C ALGBRC(3) is m_infinit in component m_infinit (dimensionless). C ALGBRC(8) is h_infinit in component h_infinit (dimensionless). C ALGBRC(6) is tau_h in component tau_h (second). C ALGBRC(4) is zeta in component zeta (micromolar). C ALGBRC(7) is gamma in component gamma (dimensionless). C CONSTS(37) is RS_E in component RS_E (dimensionless). C RATES(1) is d/dt RS in component RS (dimensionless). C RATES(2) is d/dt RS_p in component RS_p (dimensionless). C RATES(3) is d/dt G in component G_GTP (dimensionless). C RATES(4) is d/dt IP_3 in component IP_3 (micromolar). C RATES(5) is d/dt PIP_2 in component PIP_2 (dimensionless). C RATES(6) is d/dt C in component C (micromolar). C RATES(7) is d/dt h in component h (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 2e4 CONSTS(2) = 5 CONSTS(3) = 100 CONSTS(4) = 1.75e-4 CONSTS(5) = 0.03 CONSTS(6) = 6e-3 CONSTS(7) = 0.85 CONSTS(8) = 1e5 CONSTS(9) = 1.25 CONSTS(10) = 0.017 CONSTS(11) = 0.15 CONSTS(12) = 5e7 CONSTS(13) = 10 CONSTS(14) = 1.238e-3 CONSTS(15) = 0.4 CONSTS(16) = 2.781e-5 CONSTS(17) = 6.02252e17 CONSTS(18) = 5e-13 CONSTS(19) = 0.185 CONSTS(20) = 0.13 CONSTS(21) = 1.05 CONSTS(22) = 0.943 CONSTS(23) = 0.0823 CONSTS(24) = 0.2 CONSTS(25) = 150 CONSTS(26) = 10 CONSTS(27) = 120000 CONSTS(28) = 1200 CONSTS(29) = 50 CONSTS(30) = 0.2 CONSTS(31) = 0.4 CONSTS(32) = 575 CONSTS(33) = 5.2 CONSTS(34) = 45 CONSTS(35) = 67 CONSTS(36) = 1000 STATES(1) = 1.7e4 STATES(2) = 0 STATES(3) = 0 STATES(4) = 0.01 STATES(5) = 49997000 STATES(6) = 0.0961 STATES(7) = 0.6155 CONSTS(37) = (( CONSTS(4)*(1.00000+( (CONSTS(5)/CONSTS(6))*(CONSTS(3)+CONSTS(36)))/(CONSTS(2)+CONSTS(36))))/(CONSTS(4)+( CONSTS(5)*CONSTS(36))/(CONSTS(2)+CONSTS(36))+( (( CONSTS(4)*CONSTS(5))/CONSTS(6))*(CONSTS(3)+CONSTS(36)))/(CONSTS(2)+CONSTS(36))))*CONSTS(7)*CONSTS(1)+ (1.00000 - CONSTS(7))*CONSTS(1) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( CONSTS(4)*CONSTS(1) - (CONSTS(4)+( CONSTS(5)*CONSTS(36))/(CONSTS(2)+CONSTS(36)))*STATES(1)) - CONSTS(4)*STATES(2) RATES(2) = CONSTS(36)*(( CONSTS(5)*STATES(1))/(CONSTS(2)+CONSTS(36)) - ( CONSTS(6)*STATES(2))/(CONSTS(3)+CONSTS(36))) ALGBRC(1) = ( CONSTS(36)*STATES(1))/( CONSTS(7)*CONSTS(1)*(CONSTS(2)+CONSTS(36))) RATES(3) = CONSTS(10)*(CONSTS(14)+ALGBRC(1))*(CONSTS(8) - STATES(3)) - CONSTS(11)*STATES(3) ALGBRC(2) = (( CONSTS(16)*STATES(6))/(CONSTS(15)+STATES(6)))*STATES(3) RATES(4) = ( ALGBRC(2)*STATES(5))/( CONSTS(17)*CONSTS(18)) - CONSTS(9)*STATES(4) RATES(5) = ( - (ALGBRC(2)+CONSTS(13))*STATES(5) - CONSTS(13)*CONSTS(17)*CONSTS(18)*STATES(4))+ CONSTS(13)*CONSTS(12) ALGBRC(4) = ( CONSTS(21)*(STATES(4)+CONSTS(20)))/(STATES(4)+CONSTS(22)) ALGBRC(8) = ALGBRC(4)/(ALGBRC(4)+STATES(6)) ALGBRC(6) = CONSTS(24)*(ALGBRC(4)+STATES(6)) ** - 1.00000 RATES(7) = (ALGBRC(8) - STATES(7))/ALGBRC(6) ALGBRC(7) = 1.00000+CONSTS(25)/(CONSTS(26)+STATES(6))+CONSTS(29)/(CONSTS(30)+STATES(6)) ** - 1.00000 ALGBRC(9) = (CONSTS(28)/( CONSTS(27)*CONSTS(19)))*(CONSTS(35) - STATES(6)/ALGBRC(7)) ALGBRC(5) = 1.00000+( CONSTS(26)*CONSTS(25))/CONSTS(26)+STATES(6) ** 2.00000+( CONSTS(30)*CONSTS(29))/CONSTS(30)+STATES(6) ** 2.00000 ** - 1.00000 ALGBRC(3) = ( (STATES(4)/(CONSTS(20)+STATES(4)))*STATES(6))/(CONSTS(23)+STATES(6)) RATES(6) = ALGBRC(5)*( CONSTS(19)*( CONSTS(32)*ALGBRC(3) ** 3.00000*STATES(7) ** 3.00000+CONSTS(33))*(ALGBRC(9) - STATES(6)) - ( CONSTS(34)*STATES(6) ** 2.00000)/(CONSTS(31) ** 2.00000+STATES(6) ** 2.00000)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( CONSTS(36)*STATES(1))/( CONSTS(7)*CONSTS(1)*(CONSTS(2)+CONSTS(36))) ALGBRC(2) = (( CONSTS(16)*STATES(6))/(CONSTS(15)+STATES(6)))*STATES(3) ALGBRC(4) = ( CONSTS(21)*(STATES(4)+CONSTS(20)))/(STATES(4)+CONSTS(22)) ALGBRC(8) = ALGBRC(4)/(ALGBRC(4)+STATES(6)) ALGBRC(6) = CONSTS(24)*(ALGBRC(4)+STATES(6)) ** - 1.00000 ALGBRC(7) = 1.00000+CONSTS(25)/(CONSTS(26)+STATES(6))+CONSTS(29)/(CONSTS(30)+STATES(6)) ** - 1.00000 ALGBRC(9) = (CONSTS(28)/( CONSTS(27)*CONSTS(19)))*(CONSTS(35) - STATES(6)/ALGBRC(7)) ALGBRC(5) = 1.00000+( CONSTS(26)*CONSTS(25))/CONSTS(26)+STATES(6) ** 2.00000+( CONSTS(30)*CONSTS(29))/CONSTS(30)+STATES(6) ** 2.00000 ** - 1.00000 ALGBRC(3) = ( (STATES(4)/(CONSTS(20)+STATES(4)))*STATES(6))/(CONSTS(23)+STATES(6)) RETURN END