Journal of Physiology
Mammalia
The Adrian-Chandler-Hodgkin Model of the Skeletal Myocyte Action
Potential, 1970
Skeletal Myocyte
This component defines the variables that are externally set and
passed into the model along with the variables within the model that
are to be available externally.
5499787
R
H
Adrian
10000
0.001
100000
bdf15
4778131
James
Richard
Lawson
The T-tubular Vt component calculates the voltage in the membrane
of the T-tubular system.
Buist
L
Martin
The definition of the voltage-dependent activation gating
kinetics for the sodium ion channel (the m gate).
Updated curation status
Bioengineering Institute, The University of Auckland
Hodgkin
A
L
This model has had a stimulus protocol added to it to allow simulation of action potentials. Unfortunately, the details of the stimulation defined in the original paper are not known and as such, the parameters of the stimulus (magnitude, duration, dimensions,) may not be appropriate. Currently, however, the model runs in PCEnv 0.2 and is able to simulate a train of action potentials. COR will not currently run this model.
D
Chandler
W
The leak current component contains the differential equations
governing the time independent current leakage from the cell.
May
Catherine
Lloyd
131
235
Reconstruction of the action potential of frog sartorius muscle
103
Journal of Physiology
cardiac
electrophysiology
myofilament mechanics
skeletal muscle
644
Voltage clamp experiments in striated muscle fibres
208
607
This component contains the differential equations
governing the time dependence of the n gate of the potassium channel.
H
Adrian
R
D
L
Peachey
Altered documentation such that the semicolons are now with the correct comments in the list.
The University of Auckland
Bioengineering Institute
1973-01-01
1970-01-01
The potassium current component contains the differential equations
governing this voltage and time dependent outward current.
m.buist@auckland.ac.nz
A stimulus protocol (with the same parameters as the Beeler Reuter 97, as the required parameters are unknown) has been added to this model to allow simulation of action potentials.
James Lawson
This component defines the calculation of dV/dt, the ordinary differential
equation for the transmembrane potential.
Lawson
James
Richard
This is the CellML description of Adrian, Chandler and Hodgkin's mathematical model of membrane action potentials of mammalian striated skeletal muscle. It describes four ionic currents and uses Hodgkin-Huxley type equations.
2003-10-29T00:00:00+00:00
2007-11-12T12:20:00+13:00
The sodium current component contains the differential equations
governing the influx of sodium ions through the cell surface
membrane into the cell.
The T-tubular current component contains the differential equations
governing the current that occurs as the result of a potential difference
between the cell membrane and the T-tubular system.
Martin Buist
The voltage-dependent inactivation gate for the sodium channel (the
h gate).
keyword
2007-06-11T13:17:56+12:00
2009-05-05T11:14:24+12:00