function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =12; end % There are a total of 5 entries in each of the rate and state variable arrays. % There are a total of 31 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('t in component interface (ms)'); LEGEND_CONSTANTS(:,1) = strpad('Cm in component interface (uFpmmsq)'); LEGEND_CONSTANTS(:,2) = strpad('Am in component interface (pmm)'); LEGEND_ALGEBRAIC(:,1) = strpad('Istim in component interface (uApmmcu)'); LEGEND_STATES(:,1) = strpad('Vm in component membrane (mV)'); LEGEND_STATES(:,2) = strpad('Vt in component Ttubular_current_Vt_var (mV)'); LEGEND_STATES(:,3) = strpad('m in component sodium_current_m_gate (dimensionless)'); LEGEND_STATES(:,4) = strpad('h in component sodium_current_h_gate (dimensionless)'); LEGEND_STATES(:,5) = strpad('n in component potassium_current_n_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('INa in component sodium_current (uApmmsq)'); LEGEND_ALGEBRAIC(:,10) = strpad('IK in component potassium_current (uApmmsq)'); LEGEND_ALGEBRAIC(:,11) = strpad('IL in component leak_current (uApmmsq)'); LEGEND_ALGEBRAIC(:,12) = strpad('IT in component Ttubular_current (uApmmsq)'); LEGEND_ALGEBRAIC(:,6) = strpad('IStimC in component interface (uApmmcu)'); LEGEND_CONSTANTS(:,31) = strpad('AmC in component interface (pmm)'); LEGEND_CONSTANTS(:,3) = strpad('IstimStart in component interface (ms)'); LEGEND_CONSTANTS(:,4) = strpad('IstimEnd in component interface (ms)'); LEGEND_CONSTANTS(:,5) = strpad('IstimAmplitude in component interface (uApmmcu)'); LEGEND_CONSTANTS(:,6) = strpad('IstimPeriod in component interface (ms)'); LEGEND_CONSTANTS(:,7) = strpad('IstimPulseDuration in component interface (ms)'); LEGEND_CONSTANTS(:,8) = strpad('gNa_max in component sodium_current (mSpmmsq)'); LEGEND_CONSTANTS(:,9) = strpad('ENa in component sodium_current (mV)'); LEGEND_ALGEBRAIC(:,2) = strpad('alpha_m in component sodium_current_m_gate (pms)'); LEGEND_ALGEBRAIC(:,7) = strpad('beta_m in component sodium_current_m_gate (pms)'); LEGEND_CONSTANTS(:,10) = strpad('alpha_m_max in component sodium_current_m_gate (pms)'); LEGEND_CONSTANTS(:,11) = strpad('beta_m_max in component sodium_current_m_gate (pms)'); LEGEND_CONSTANTS(:,12) = strpad('Em in component sodium_current_m_gate (mV)'); LEGEND_CONSTANTS(:,13) = strpad('v_alpha_m in component sodium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,14) = strpad('v_beta_m in component sodium_current_m_gate (mV)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha_h in component sodium_current_h_gate (pms)'); LEGEND_ALGEBRAIC(:,8) = strpad('beta_h in component sodium_current_h_gate (pms)'); LEGEND_CONSTANTS(:,15) = strpad('alpha_h_max in component sodium_current_h_gate (pms)'); LEGEND_CONSTANTS(:,16) = strpad('beta_h_max in component sodium_current_h_gate (pms)'); LEGEND_CONSTANTS(:,17) = strpad('Eh in component sodium_current_h_gate (mV)'); LEGEND_CONSTANTS(:,18) = strpad('v_alpha_h in component sodium_current_h_gate (mV)'); LEGEND_CONSTANTS(:,19) = strpad('v_beta_h in component sodium_current_h_gate (mV)'); LEGEND_CONSTANTS(:,20) = strpad('gK_max in component potassium_current (mSpmmsq)'); LEGEND_CONSTANTS(:,21) = strpad('EK in component potassium_current (mV)'); LEGEND_ALGEBRAIC(:,4) = strpad('alpha_n in component potassium_current_n_gate (pms)'); LEGEND_ALGEBRAIC(:,9) = strpad('beta_n in component potassium_current_n_gate (pms)'); LEGEND_CONSTANTS(:,22) = strpad('alpha_n_max in component potassium_current_n_gate (pms)'); LEGEND_CONSTANTS(:,23) = strpad('beta_n_max in component potassium_current_n_gate (pms)'); LEGEND_CONSTANTS(:,24) = strpad('En in component potassium_current_n_gate (mV)'); LEGEND_CONSTANTS(:,25) = strpad('v_alpha_n in component potassium_current_n_gate (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('v_beta_n in component potassium_current_n_gate (mV)'); LEGEND_CONSTANTS(:,27) = strpad('EL in component leak_current (mV)'); LEGEND_CONSTANTS(:,28) = strpad('gL_max in component leak_current (mSpmmsq)'); LEGEND_CONSTANTS(:,29) = strpad('Rs in component Ttubular_current (mmsqpmS)'); LEGEND_CONSTANTS(:,30) = strpad('Ct in component Ttubular_current_Vt_var (uFpmmsq)'); LEGEND_RATES(:,1) = strpad('d/dt Vm in component membrane (mV)'); LEGEND_RATES(:,3) = strpad('d/dt m in component sodium_current_m_gate (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt h in component sodium_current_h_gate (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt n in component potassium_current_n_gate (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt Vt in component Ttubular_current_Vt_var (mV)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 0.009; CONSTANTS(:,2) = 200.0; STATES(:,1) = -95.0; STATES(:,2) = -95.0; STATES(:,3) = 0.0; STATES(:,4) = 1.0; STATES(:,5) = 0.0; CONSTANTS(:,3) = 10; CONSTANTS(:,4) = 50000; CONSTANTS(:,5) = 0.5; CONSTANTS(:,6) = 1000; CONSTANTS(:,7) = 1; CONSTANTS(:,8) = 1.8; CONSTANTS(:,9) = 50.0; CONSTANTS(:,10) = 0.208; CONSTANTS(:,11) = 2.081; CONSTANTS(:,12) = -42.0; CONSTANTS(:,13) = 10.0; CONSTANTS(:,14) = 18.0; CONSTANTS(:,15) = 0.0156; CONSTANTS(:,16) = 3.382; CONSTANTS(:,17) = -41.0; CONSTANTS(:,18) = 14.7; CONSTANTS(:,19) = 7.6; CONSTANTS(:,20) = 0.415; CONSTANTS(:,21) = -70.0; CONSTANTS(:,22) = 0.0229; CONSTANTS(:,23) = 0.09616; CONSTANTS(:,24) = -40.0; CONSTANTS(:,25) = 7.0; CONSTANTS(:,26) = 40.0; CONSTANTS(:,27) = -95.0; CONSTANTS(:,28) = 0.0024; CONSTANTS(:,29) = 15.0; CONSTANTS(:,30) = 0.04; CONSTANTS(:,31) = CONSTANTS(:,2); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,2) = (STATES(:,1) - STATES(:,2))./( CONSTANTS(:,29).*CONSTANTS(:,30)); ALGEBRAIC(:,2) = ( CONSTANTS(:,10).*(STATES(:,1) - CONSTANTS(:,12)))./(1.00000 - exp((CONSTANTS(:,12) - STATES(:,1))./CONSTANTS(:,13))); ALGEBRAIC(:,7) = CONSTANTS(:,11).*exp((CONSTANTS(:,12) - STATES(:,1))./CONSTANTS(:,14)); RATES(:,3) = ALGEBRAIC(:,2).*(1.00000 - STATES(:,3)) - ALGEBRAIC(:,7).*STATES(:,3); ALGEBRAIC(:,3) = CONSTANTS(:,15).*exp((CONSTANTS(:,17) - STATES(:,1))./CONSTANTS(:,18)); ALGEBRAIC(:,8) = CONSTANTS(:,16)./(1.00000+exp((CONSTANTS(:,17) - STATES(:,1))./CONSTANTS(:,19))); RATES(:,4) = ALGEBRAIC(:,3).*(1.00000 - STATES(:,4)) - ALGEBRAIC(:,8).*STATES(:,4); ALGEBRAIC(:,4) = ( CONSTANTS(:,22).*(STATES(:,1) - CONSTANTS(:,24)))./(1.00000 - exp((CONSTANTS(:,24) - STATES(:,1))./CONSTANTS(:,25))); ALGEBRAIC(:,9) = CONSTANTS(:,23).*exp((CONSTANTS(:,24) - STATES(:,1))./CONSTANTS(:,26)); RATES(:,5) = ALGEBRAIC(:,4).*(1.00000 - STATES(:,5)) - ALGEBRAIC(:,9).*STATES(:,5); ALGEBRAIC(:,1) = piecewise({VOI>=CONSTANTS(:,3)&VOI<=CONSTANTS(:,4)&(VOI - CONSTANTS(:,3)) - floor((VOI - CONSTANTS(:,3))./CONSTANTS(:,6)).*CONSTANTS(:,6)<=CONSTANTS(:,7), CONSTANTS(:,5) }, 0.00000); ALGEBRAIC(:,5) = CONSTANTS(:,8).*STATES(:,3).*STATES(:,3).*STATES(:,3).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,9)); ALGEBRAIC(:,10) = CONSTANTS(:,20).*STATES(:,5).*STATES(:,5).*STATES(:,5).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,21)); ALGEBRAIC(:,11) = CONSTANTS(:,28).*(STATES(:,1) - CONSTANTS(:,27)); ALGEBRAIC(:,12) = (STATES(:,1) - STATES(:,2))./CONSTANTS(:,29); RATES(:,1) = (ALGEBRAIC(:,1) - (ALGEBRAIC(:,5)+ALGEBRAIC(:,10)+ALGEBRAIC(:,11)+ALGEBRAIC(:,12)))./CONSTANTS(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,2) = ( CONSTANTS(:,10).*(STATES(:,1) - CONSTANTS(:,12)))./(1.00000 - exp((CONSTANTS(:,12) - STATES(:,1))./CONSTANTS(:,13))); ALGEBRAIC(:,7) = CONSTANTS(:,11).*exp((CONSTANTS(:,12) - STATES(:,1))./CONSTANTS(:,14)); ALGEBRAIC(:,3) = CONSTANTS(:,15).*exp((CONSTANTS(:,17) - STATES(:,1))./CONSTANTS(:,18)); ALGEBRAIC(:,8) = CONSTANTS(:,16)./(1.00000+exp((CONSTANTS(:,17) - STATES(:,1))./CONSTANTS(:,19))); ALGEBRAIC(:,4) = ( CONSTANTS(:,22).*(STATES(:,1) - CONSTANTS(:,24)))./(1.00000 - exp((CONSTANTS(:,24) - STATES(:,1))./CONSTANTS(:,25))); ALGEBRAIC(:,9) = CONSTANTS(:,23).*exp((CONSTANTS(:,24) - STATES(:,1))./CONSTANTS(:,26)); ALGEBRAIC(:,1) = piecewise({VOI>=CONSTANTS(:,3)&VOI<=CONSTANTS(:,4)&(VOI - CONSTANTS(:,3)) - floor((VOI - CONSTANTS(:,3))./CONSTANTS(:,6)).*CONSTANTS(:,6)<=CONSTANTS(:,7), CONSTANTS(:,5) }, 0.00000); ALGEBRAIC(:,5) = CONSTANTS(:,8).*STATES(:,3).*STATES(:,3).*STATES(:,3).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,9)); ALGEBRAIC(:,10) = CONSTANTS(:,20).*STATES(:,5).*STATES(:,5).*STATES(:,5).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,21)); ALGEBRAIC(:,11) = CONSTANTS(:,28).*(STATES(:,1) - CONSTANTS(:,27)); ALGEBRAIC(:,12) = (STATES(:,1) - STATES(:,2))./CONSTANTS(:,29); ALGEBRAIC(:,6) = ALGEBRAIC(:,1); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end