P
M
Nash
The non-dimensional and scaled threshold potential value.
501
Electromechanical model of excitable tissue to study reentrant
cardiac arrhythmias
85
522
This is a CellML version of the modified FitzHugh-Nagumo model,
published by Aliev and Panfilov in 1996. While the
original two-variable model described a non-dimensional activation
variable (u) and a non-dimensional recovery variable (v),
here we formulate the model in terms of the `real' action potential
given by the time course of the transmembrane potential (Vm). In so
doing, the time rate of change of the activation variable describes
the total `ionic current' through the membrane with the original
model parameters adjusted to give the correct dimensionality.
This model has been further modified by Nash and Panfilov 2004 to
include the simplest model of active tension development.
martyn.nash@auckland.ac.nz
The Bioengineering Institute
The University of Auckland
The Bioengineering Institute
The University of Auckland
keyword
electromechanical
myofilament mechanics
excitable tissue
electrophysiology
Modified FitzHugh-Nagumo model
We'll use this component as the "interface" to the model, all
other components are hidden via encapsulation in this component.
Here we define the non-dimensional recovery variable, r. The kinetics
of the recovery variable have been reworked by Aliev and Panfilov to
provide more realistic restitution properties.
The component which defines the kinetics of the transmembrane potential.
A
Panfilov
V
The kinetics of the active tension.
d.nickerson@auckland.ac.nz
2004
Here we define the total ionic current through the cellular
membrane - equivalent to the temporal derivative of the original
activation variable. One modification of Aliev and Panfilov is
in this equation, with the additional multiplication of the recovery
variable with the normalised potential and removal of the scalar
multiplier.
The calcuation of the total ionic current.
This equation describes the kinetics of the transmembrane,
potential - the action potential.
This is the active tension relation from the Nash and Panfilov
article.
The non-dimensional and scaled potential value.
This is a dummy equation that we simply use to make grabbing the
value in CMISS much easier.
2004-07-22
Martyn
Nash
Nickerson
David
The kinetics of the recovery variable.
Prog. Biophys. Molec. Biol.