Christe
Georges
81
3029
The functional role of cardiac T-tubules explored in a model of rat ventricular myocytes
3051
May
Lloyd
Catherine
Recoded the entire model according to the Matlab to CellML automated conversion. Added structure and units.
rat
T-tubules
ventricular myocyte
cardiac
electrophysiology
Michal
Pasek
Lloyd
Catherine
May
c.lloyd@auckland.ac.nz
16608703
Catherine Lloyd
Auckland Bioengineering Institute
The University of Auckland
CellML 1.1 version of the model
2008-11-26T00:00:00+13:00
keyword
T h i s C e l l M L m o d e l i s k n o w n t o r u n i n b o t h C O R a n d P C E n v t o r e c r e a t e t h e p u b l i s h e d r e s u l t s . T h e u n i t s h a v e b e e n c h e c k e d a n d t h e y a r e c o n s i s t e n t . T h i s p a r t i c u l a r v e r s i o n o f t h e C e l l M L m o d e l w a s t r a n s l a t e d f r o m t h e a u t h o r ' s o r i g i n a l M a t l a b c o d e .
P l e a s e n o t e t h a t t h i s m o d e l i s r e l a t i v e l y s t i f f . I f y o u r u n t h e m o d e l u s i n g t h e d e f a u l t C O R s e t t i n g s , y o u w i l l g e t a m e s s a g e t h a t r e a d s : " P r o b l e m w i t h t h e C V O D E i n t e g r a t o r : a t t = 0 . 0 0 1 7 0 1 7 8 , m x s t e p s t e p s t a k e n b e f o r e r e a c h i n g t o u t . " T h i s b a s i c a l l y m e a n s t h a t y o u h a v e t o i n c r e a s e t h e m a x i m u m n u m b e r o f s t e p s w h i c h i s , b y d e f a u l t , s e t t o 5 0 0 . S u c h a v a l u e i s s u f f i c i e n t f o r m o s t O D E p r o b l e m s , b u t n o t f o r O D E p r o b l e m s t h a t h a v e v e r y s t i f f O D E s , s u c h a s t h e c u r r e n t m o d e l . A n y w a y , y o u w i l l s e e t h a t t h e m o d e l r u n s f i n e i f y o u i n c r e a s e t h e v a l u e t o s o m e t h i n g l i k e 5 0 0 0 . N o t e t h a t y o u a l s o n e e d t o s e t t h e m a x i m u m t i m e s t e p t o a s e n s i b l e v a l u e , i . e . t h e d u r a t i o n o f t h e s t i m u l u s w h i c h i s h e r e 1 m s .
R e g a r d i n g P C E n v , i t u s e s a h i g h e r v a l u e t h a n C O R f o r t h e m a x i m u m n u m b e r o f s t e p s , w h i c h i s w h y t h e m o d e l w i l l r u n i n P C E n v w i t h o u t h a v i n g t o c h a n g e t h i s p a r t i c u l a r s e t t i n g . O t h e r w i s e , l i k e i n C O R t h e r e i s a n e e d t o s e t t h e m a x i m u m t i m e s t e p t o a s e n s i b l e v a l u e . P C E n v u s e s a d e f a u l t v a l u e o f 1 s f o r t h e P a s e k m o d e l , w h i c h i s c l e a r l y n o t s m a l l e n o u g h a s c a n b e s e e n w h e n r u n n i n g t h e m o d e l f o r 1 0 s . I f o n e u s e s 0 . 0 0 1 s , t h e n e v e r y t h i n g i s f i n e
2006-00-00 00:00
Philosophical Transactions of the Royal Society
Simurda
Jiri
2009-02-09T14:57:12+13:00