function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =13; end % There are a total of 5 entries in each of the rate and state variable arrays. % There are a total of 15 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (millisecond)'); LEGEND_STATES(:,1) = strpad('V in component membrane (millivolt)'); LEGEND_ALGEBRAIC(:,1) = strpad('Vs in component membrane (millivolt)'); LEGEND_CONSTANTS(:,1) = strpad('V_I in component membrane (millivolt)'); LEGEND_CONSTANTS(:,2) = strpad('V_K in component membrane (millivolt)'); LEGEND_CONSTANTS(:,3) = strpad('V_L in component membrane (millivolt)'); LEGEND_CONSTANTS(:,4) = strpad('V_H_Na in component membrane (millivolt)'); LEGEND_CONSTANTS(:,5) = strpad('V_H_K in component membrane (millivolt)'); LEGEND_CONSTANTS(:,14) = strpad('g_I in component membrane (milliS_per_microF)'); LEGEND_CONSTANTS(:,6) = strpad('g_K in component membrane (milliS_per_microF)'); LEGEND_CONSTANTS(:,7) = strpad('g_L in component membrane (milliS_per_microF)'); LEGEND_CONSTANTS(:,15) = strpad('g_T in component membrane (milliS_per_microF)'); LEGEND_CONSTANTS(:,8) = strpad('g_P in component membrane (milliS_per_microF)'); LEGEND_CONSTANTS(:,9) = strpad('Kp in component membrane (millimolar)'); LEGEND_STATES(:,2) = strpad('c in component calcium_concentration (millimolar)'); LEGEND_ALGEBRAIC(:,9) = strpad('sI in component sI_gate (dimensionless)'); LEGEND_STATES(:,3) = strpad('yI in component yI_gate (dimensionless)'); LEGEND_STATES(:,4) = strpad('xT in component xT_gate (dimensionless)'); LEGEND_STATES(:,5) = strpad('xK in component xK_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('alpha_m in component sI_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,6) = strpad('beta_m in component sI_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,10) = strpad('ZI in component yI_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha_h in component yI_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,7) = strpad('beta_h in component yI_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,12) = strpad('tau_yI in component yI_gate (millisecond)'); LEGEND_ALGEBRAIC(:,4) = strpad('sT in component xT_gate (dimensionless)'); LEGEND_CONSTANTS(:,10) = strpad('tau_xT in component xT_gate (millisecond)'); LEGEND_CONSTANTS(:,11) = strpad('V_Ca in component calcium_concentration (millivolt)'); LEGEND_CONSTANTS(:,12) = strpad('rho in component calcium_concentration (per_millisecond)'); LEGEND_CONSTANTS(:,13) = strpad('K_c in component calcium_concentration (millimolar_per_millivolt)'); LEGEND_ALGEBRAIC(:,5) = strpad('alpha_n in component xK_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,8) = strpad('beta_n in component xK_gate (per_millisecond)'); LEGEND_ALGEBRAIC(:,13) = strpad('tau_xK in component xK_gate (millisecond)'); LEGEND_ALGEBRAIC(:,11) = strpad('sK in component xK_gate (dimensionless)'); LEGEND_RATES(:,1) = strpad('d/dt V in component membrane (millivolt)'); LEGEND_RATES(:,3) = strpad('d/dt yI in component yI_gate (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt xT in component xT_gate (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt c in component calcium_concentration (millimolar)'); LEGEND_RATES(:,5) = strpad('d/dt xK in component xK_gate (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = -54; CONSTANTS(:,1) = 30.0; CONSTANTS(:,2) = -75.0; CONSTANTS(:,3) = -40.0; CONSTANTS(:,4) = 115.0; CONSTANTS(:,5) = -12.0; CONSTANTS(:,6) = 0.3; CONSTANTS(:,7) = 0.003; CONSTANTS(:,8) = 0.03; CONSTANTS(:,9) = 0.5; STATES(:,2) = 0.1; STATES(:,3) = 0.1; STATES(:,4) = 0.1; STATES(:,5) = 0.1; CONSTANTS(:,10) = 235.0; CONSTANTS(:,11) = 140.0; CONSTANTS(:,12) = 0.0003; CONSTANTS(:,13) = 0.0085; CONSTANTS(:,14) = 1.00000.*((CONSTANTS(:,4) - CONSTANTS(:,5))./(CONSTANTS(:,1) - CONSTANTS(:,2))); CONSTANTS(:,15) = 1.00000.*(( CONSTANTS(:,4).*CONSTANTS(:,2) - CONSTANTS(:,1).*CONSTANTS(:,5))./(CONSTANTS(:,1) - CONSTANTS(:,2))); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,2) = CONSTANTS(:,12).*( CONSTANTS(:,13).*STATES(:,4).*(CONSTANTS(:,11) - STATES(:,1)) - STATES(:,2)); ALGEBRAIC(:,1) = 1.00000.*CONSTANTS(:,14).*STATES(:,1)+ 1.00000.*CONSTANTS(:,15); ALGEBRAIC(:,4) = 1.00000./(exp( 0.150000.*(-50.0000 - ALGEBRAIC(:,1)))+1.00000); RATES(:,4) = (ALGEBRAIC(:,4) - STATES(:,4))./CONSTANTS(:,10); ALGEBRAIC(:,2) = ( 0.100000.*(50.0000 - ALGEBRAIC(:,1)))./ - exp((50.0000 - ALGEBRAIC(:,1))./10.0000); ALGEBRAIC(:,6) = 4.00000.*exp((25.0000 - ALGEBRAIC(:,1))./18.0000); ALGEBRAIC(:,9) = ALGEBRAIC(:,2)./(ALGEBRAIC(:,2)+ALGEBRAIC(:,6)); RATES(:,1) = ( CONSTANTS(:,14).*power(ALGEBRAIC(:,9), 3.00000).*STATES(:,3)+ CONSTANTS(:,15).*STATES(:,4)).*(CONSTANTS(:,1) - STATES(:,1))+ ( CONSTANTS(:,6).*power(STATES(:,5), 4.00000)+ CONSTANTS(:,8).*STATES(:,2).*power(CONSTANTS(:,9)+STATES(:,2), -1.00000)).*(CONSTANTS(:,2) - STATES(:,1))+ CONSTANTS(:,7).*(CONSTANTS(:,3) - STATES(:,1)); ALGEBRAIC(:,3) = 0.0700000.*exp((25.0000 - ALGEBRAIC(:,1))./20.0000); ALGEBRAIC(:,7) = 1.00000./(exp((55.0000 - ALGEBRAIC(:,1))./10.0000)+1.00000); ALGEBRAIC(:,10) = ALGEBRAIC(:,3)./(ALGEBRAIC(:,3)+ALGEBRAIC(:,7)); ALGEBRAIC(:,12) = 12.5000./(ALGEBRAIC(:,3)+ALGEBRAIC(:,7)); RATES(:,3) = (ALGEBRAIC(:,10) - STATES(:,3))./ALGEBRAIC(:,12); ALGEBRAIC(:,5) = ( 0.0100000.*(55.0000 - ALGEBRAIC(:,1)))./(exp((55.0000 - ALGEBRAIC(:,1))./10.0000) - 1.00000); ALGEBRAIC(:,8) = 0.125000.*exp((45.0000 - ALGEBRAIC(:,1))./80.0000); ALGEBRAIC(:,13) = 12.5000./(ALGEBRAIC(:,5)+ALGEBRAIC(:,8)); ALGEBRAIC(:,11) = ALGEBRAIC(:,5)./(ALGEBRAIC(:,5)+ALGEBRAIC(:,8)); RATES(:,5) = (ALGEBRAIC(:,11) - STATES(:,5))./ALGEBRAIC(:,13); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = 1.00000.*CONSTANTS(:,14).*STATES(:,1)+ 1.00000.*CONSTANTS(:,15); ALGEBRAIC(:,4) = 1.00000./(exp( 0.150000.*(-50.0000 - ALGEBRAIC(:,1)))+1.00000); ALGEBRAIC(:,2) = ( 0.100000.*(50.0000 - ALGEBRAIC(:,1)))./ - exp((50.0000 - ALGEBRAIC(:,1))./10.0000); ALGEBRAIC(:,6) = 4.00000.*exp((25.0000 - ALGEBRAIC(:,1))./18.0000); ALGEBRAIC(:,9) = ALGEBRAIC(:,2)./(ALGEBRAIC(:,2)+ALGEBRAIC(:,6)); ALGEBRAIC(:,3) = 0.0700000.*exp((25.0000 - ALGEBRAIC(:,1))./20.0000); ALGEBRAIC(:,7) = 1.00000./(exp((55.0000 - ALGEBRAIC(:,1))./10.0000)+1.00000); ALGEBRAIC(:,10) = ALGEBRAIC(:,3)./(ALGEBRAIC(:,3)+ALGEBRAIC(:,7)); ALGEBRAIC(:,12) = 12.5000./(ALGEBRAIC(:,3)+ALGEBRAIC(:,7)); ALGEBRAIC(:,5) = ( 0.0100000.*(55.0000 - ALGEBRAIC(:,1)))./(exp((55.0000 - ALGEBRAIC(:,1))./10.0000) - 1.00000); ALGEBRAIC(:,8) = 0.125000.*exp((45.0000 - ALGEBRAIC(:,1))./80.0000); ALGEBRAIC(:,13) = 12.5000./(ALGEBRAIC(:,5)+ALGEBRAIC(:,8)); ALGEBRAIC(:,11) = ALGEBRAIC(:,5)./(ALGEBRAIC(:,5)+ALGEBRAIC(:,8)); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end