Generated Code

# Size of variable arrays:
sizeAlgebraic = 3
sizeStates = 3
sizeConstants = 20
from math import *
from numpy import *

def createLegends():
    legend_states = [""] * sizeStates
    legend_rates = [""] * sizeStates
    legend_algebraic = [""] * sizeAlgebraic
    legend_voi = ""
    legend_constants = [""] * sizeConstants
    legend_voi = "time in component environment (minute)"
    legend_constants[0] = "V_0 in component Vin (micromolar_per_minute)"
    legend_constants[1] = "V_1 in component Vin (micromolar_per_minute)"
    legend_constants[2] = "beta in component Vin (dimensionless)"
    legend_constants[19] = "V_in in component Vin (micromolar_per_minute)"
    legend_constants[3] = "V_M2 in component V2 (micromolar_per_minute)"
    legend_states[0] = "Z in component cytosol (micromolar)"
    legend_constants[4] = "K_2 in component V2 (micromolar)"
    legend_algebraic[0] = "V_2 in component V2 (micromolar_per_minute)"
    legend_constants[5] = "V_M3 in component V3 (micromolar_per_minute)"
    legend_constants[6] = "K_Z in component V3 (micromolar)"
    legend_constants[7] = "K_A in component V3 (micromolar)"
    legend_constants[8] = "K_Y in component V3 (micromolar)"
    legend_constants[9] = "m in component V3 (dimensionless)"
    legend_states[1] = "Y in component internal_pool (micromolar)"
    legend_states[2] = "A in component InsP3_conc (micromolar)"
    legend_algebraic[2] = "V_3 in component V3 (micromolar_per_minute)"
    legend_constants[10] = "V_M5 in component V5 (micromolar_per_minute)"
    legend_constants[11] = "K_5 in component V5 (micromolar)"
    legend_constants[12] = "K_d in component V5 (micromolar)"
    legend_constants[13] = "p in component V5 (dimensionless)"
    legend_constants[14] = "n in component V5 (dimensionless)"
    legend_algebraic[1] = "V_5 in component V5 (micromolar_per_minute)"
    legend_constants[15] = "k in component cytosol (per_minute)"
    legend_constants[16] = "k_f in component cytosol (per_minute)"
    legend_constants[17] = "epsilon in component InsP3_conc (per_minute)"
    legend_constants[18] = "V_4 in component InsP3_conc (micromolar_per_minute)"
    legend_rates[0] = "d/dt Z in component cytosol (micromolar)"
    legend_rates[1] = "d/dt Y in component internal_pool (micromolar)"
    legend_rates[2] = "d/dt A in component InsP3_conc (micromolar)"
    return (legend_states, legend_algebraic, legend_voi, legend_constants)

def initConsts():
    constants = [0.0] * sizeConstants; states = [0.0] * sizeStates;
    constants[0] = 2
    constants[1] = 2
    constants[2] = 0.6
    constants[3] = 6
    states[0] = 0.15
    constants[4] = 0.1
    constants[5] = 20
    constants[6] = 0.5
    constants[7] = 0.2
    constants[8] = 0.2
    constants[9] = 2
    states[1] = 1
    states[2] = 0.42
    constants[10] = 5
    constants[11] = 1
    constants[12] = 0.4
    constants[13] = 2
    constants[14] = 4
    constants[15] = 10
    constants[16] = 1
    constants[17] = 0.1
    constants[18] = 2
    constants[19] = constants[0]+constants[1]*constants[2]
    return (states, constants)

def computeRates(voi, states, constants):
    rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic
    algebraic[1] = (((constants[10]*(power(states[2], constants[13])))/(power(constants[11], constants[13])+power(states[2], constants[13])))*(power(states[0], constants[14])))/(power(constants[12], constants[14])+power(states[0], constants[14]))
    rates[2] = (constants[2]*constants[18]-algebraic[1])-constants[17]*states[2]
    algebraic[0] = (constants[3]*(power(states[0], 2.00000)))/(power(constants[4], 2.00000)+power(states[0], 2.00000))
    algebraic[2] = (((((constants[5]*(power(states[0], constants[9])))/(power(constants[6], constants[9])+power(states[0], constants[9])))*(power(states[1], 2.00000)))/(power(constants[8], 2.00000)+power(states[1], 2.00000)))*(power(states[2], 4.00000)))/(power(constants[7], 4.00000)+power(states[2], 4.00000))
    rates[0] = ((constants[19]-algebraic[0])+algebraic[2]+constants[16]*states[1])-constants[15]*states[0]
    rates[1] = (algebraic[0]-algebraic[2])-constants[16]*states[1]
    return(rates)

def computeAlgebraic(constants, states, voi):
    algebraic = array([[0.0] * len(voi)] * sizeAlgebraic)
    states = array(states)
    voi = array(voi)
    algebraic[1] = (((constants[10]*(power(states[2], constants[13])))/(power(constants[11], constants[13])+power(states[2], constants[13])))*(power(states[0], constants[14])))/(power(constants[12], constants[14])+power(states[0], constants[14]))
    algebraic[0] = (constants[3]*(power(states[0], 2.00000)))/(power(constants[4], 2.00000)+power(states[0], 2.00000))
    algebraic[2] = (((((constants[5]*(power(states[0], constants[9])))/(power(constants[6], constants[9])+power(states[0], constants[9])))*(power(states[1], 2.00000)))/(power(constants[8], 2.00000)+power(states[1], 2.00000)))*(power(states[2], 4.00000)))/(power(constants[7], 4.00000)+power(states[2], 4.00000))
    return algebraic

def solve_model():
    """Solve model with ODE solver"""
    from scipy.integrate import ode
    # Initialise constants and state variables
    (init_states, constants) = initConsts()

    # Set timespan to solve over
    voi = linspace(0, 10, 500)

    # Construct ODE object to solve
    r = ode(computeRates)
    r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1)
    r.set_initial_value(init_states, voi[0])
    r.set_f_params(constants)

    # Solve model
    states = array([[0.0] * len(voi)] * sizeStates)
    states[:,0] = init_states
    for (i,t) in enumerate(voi[1:]):
        if r.successful():
            r.integrate(t)
            states[:,i+1] = r.y
        else:
            break

    # Compute algebraic variables
    algebraic = computeAlgebraic(constants, states, voi)
    return (voi, states, algebraic)

def plot_model(voi, states, algebraic):
    """Plot variables against variable of integration"""
    import pylab
    (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends()
    pylab.figure(1)
    pylab.plot(voi,vstack((states,algebraic)).T)
    pylab.xlabel(legend_voi)
    pylab.legend(legend_states + legend_algebraic, loc='best')
    pylab.show()

if __name__ == "__main__":
    (voi, states, algebraic) = solve_model()
    plot_model(voi, states, algebraic)