# Size of variable arrays: sizeAlgebraic = 2 sizeStates = 3 sizeConstants = 13 from math import * from numpy import * def createLegends(): legend_states = [""] * sizeStates legend_rates = [""] * sizeStates legend_algebraic = [""] * sizeAlgebraic legend_voi = "" legend_constants = [""] * sizeConstants legend_voi = "time in component environment (day)" legend_states[0] = "x1 in component x1 (cell)" legend_constants[0] = "alpha1 in component model_parameters (flux)" legend_constants[1] = "beta1 in component model_parameters (first_order_rate_constant)" legend_constants[2] = "g11 in component model_parameters (dimensionless)" legend_constants[3] = "g21 in component model_parameters (dimensionless)" legend_states[1] = "x2 in component x2 (cell)" legend_constants[4] = "alpha2 in component model_parameters (first_order_rate_constant)" legend_constants[5] = "beta2 in component model_parameters (first_order_rate_constant)" legend_constants[6] = "g12 in component model_parameters (dimensionless)" legend_constants[7] = "g22 in component model_parameters (dimensionless)" legend_states[2] = "z in component z (percent)" legend_constants[8] = "k1 in component model_parameters (percent_per_cell_per_day)" legend_constants[9] = "k2 in component model_parameters (percent_per_cell_per_day)" legend_algebraic[0] = "y1 in component y1 (cell)" legend_algebraic[1] = "y2 in component y2 (cell)" legend_constants[11] = "x1_bar in component x1_bar (cell)" legend_constants[12] = "x2_bar in component x2_bar (cell)" legend_constants[10] = "gamma in component model_parameters (dimensionless)" legend_rates[0] = "d/dt x1 in component x1 (cell)" legend_rates[1] = "d/dt x2 in component x2 (cell)" legend_rates[2] = "d/dt z in component z (percent)" return (legend_states, legend_algebraic, legend_voi, legend_constants) def initConsts(): constants = [0.0] * sizeConstants; states = [0.0] * sizeStates; states[0] = 10.06066 constants[0] = 3 constants[1] = 0.2 constants[2] = 0.5 constants[3] = -0.5 states[1] = 212.132 constants[4] = 4 constants[5] = 0.02 constants[6] = 1 constants[7] = 0 states[2] = 100.0 constants[8] = 0.24 constants[9] = 0.0017 constants[10] = constants[6]*constants[3]-(1.00000-constants[2])*(1.00000-constants[7]) constants[11] = (power(constants[1]/constants[0], (1.00000-constants[7])/constants[10]))*(power(constants[5]/constants[4], constants[3]/constants[10])) constants[12] = (power(constants[1]/constants[0], constants[6]/constants[10]))*(power(constants[5]/constants[4], (1.00000-constants[2])/constants[10])) return (states, constants) def computeRates(voi, states, constants): rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic rates[0] = constants[0]*(power(states[0], constants[2]))*(power(states[1], constants[3]))-constants[1]*states[0] rates[1] = constants[4]*(power(states[0], constants[6]))*(power(states[1], constants[7]))-constants[5]*states[1] algebraic[0] = custom_piecewise([greater(states[0] , constants[11]), states[0]-constants[11] , True, 0.00000]) algebraic[1] = custom_piecewise([greater(states[1] , constants[12]), states[1]-constants[12] , True, 0.00000]) rates[2] = constants[9]*algebraic[1]-constants[8]*algebraic[0] return(rates) def computeAlgebraic(constants, states, voi): algebraic = array([[0.0] * len(voi)] * sizeAlgebraic) states = array(states) voi = array(voi) algebraic[0] = custom_piecewise([greater(states[0] , constants[11]), states[0]-constants[11] , True, 0.00000]) algebraic[1] = custom_piecewise([greater(states[1] , constants[12]), states[1]-constants[12] , True, 0.00000]) return algebraic def custom_piecewise(cases): """Compute result of a piecewise function""" return select(cases[0::2],cases[1::2]) def solve_model(): """Solve model with ODE solver""" from scipy.integrate import ode # Initialise constants and state variables (init_states, constants) = initConsts() # Set timespan to solve over voi = linspace(0, 10, 500) # Construct ODE object to solve r = ode(computeRates) r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1) r.set_initial_value(init_states, voi[0]) r.set_f_params(constants) # Solve model states = array([[0.0] * len(voi)] * sizeStates) states[:,0] = init_states for (i,t) in enumerate(voi[1:]): if r.successful(): r.integrate(t) states[:,i+1] = r.y else: break # Compute algebraic variables algebraic = computeAlgebraic(constants, states, voi) return (voi, states, algebraic) def plot_model(voi, states, algebraic): """Plot variables against variable of integration""" import pylab (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends() pylab.figure(1) pylab.plot(voi,vstack((states,algebraic)).T) pylab.xlabel(legend_voi) pylab.legend(legend_states + legend_algebraic, loc='best') pylab.show() if __name__ == "__main__": (voi, states, algebraic) = solve_model() plot_model(voi, states, algebraic)