- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2013-05-04 07:38:15+12:00
- Desc:
- adding initial raw import of all the models from my 2008 practical application of CellML 1.1 paper.
- Permanent Source URI:
- https://staging.physiomeproject.org/w/andre/nickerson-2008/rawfile/240f8797a5aa86cc265df8c04d65514de45bfda6/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="ten_tusscher_model_2004_ion_fluxes"
cmeta:id="ten_tusscher_model_2004_ion_fluxes"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nickerson</vCard:Family>
<vCard:Given>David</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>david.nickerson@nus.edu.sg</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>National University of Singapore</vCard:Orgname>
<vCard:Orgunit>Division of Bioengineering</vCard:Orgunit>
</vCard:ORG>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2007-05-15</dcterms:W3CDTF>
</dcterms:created>
<dc:publisher>
Division of Bioengineering, National University of Singapore
</dc:publisher>
</rdf:Description>
<rdf:Description rdf:about="#ten_tusscher_model_2004_ion_fluxes">
<dc:title>
The membrane ion fluxes of the ten Tusscher et al.
2004 human ventricular AP model.
</dc:title>
</rdf:Description>
<cmeta:modification rdf:parseType="Resource">
<rdf:value>
Moving to using ion-specific additional currents.
</rdf:value>
<cmeta:modifier rdf:parseType="Resource">
<vCard:FN>David Nickerson</vCard:FN>
</cmeta:modifier>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2007-05-23</dcterms:W3CDTF>
</dcterms:modified>
</cmeta:modification>
<cmeta:modification rdf:parseType="Resource">
<rdf:value>
Adding in an additional calcium SR flux for use in extending the model.
</rdf:value>
<cmeta:modifier rdf:parseType="Resource">
<vCard:FN>David Nickerson</vCard:FN>
</cmeta:modifier>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2007-06-22</dcterms:W3CDTF>
</dcterms:modified>
</cmeta:modification>
</rdf:RDF>
<import xlink:href="../../common/units.xml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="uA_per_mmsq" units_ref="uA_per_mmsq"/>
<units name="mM_per_ms" units_ref="mM_per_ms"/>
<units name="per_mm" units_ref="per_mm"/>
<units name="uF_per_mmsq" units_ref="uF_per_mmsq"/>
<units name="mmcu" units_ref="mmcu"/>
<units name="mS_per_mmsq" units_ref="mS_per_mmsq"/>
<units name="K" units_ref="K"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="faradays_constant" units_ref="faradays_constant"/>
</import>
<component name="K_flux" cmeta:id="K_flux">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#K_flux">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
A component which sums the provided potassium fluxes.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="K_flux" name="K_flux" public_interface="out" private_interface="out" units="mM_per_ms"/>
<variable name="vC" public_interface="in" units="dimensionless"/>
<variable name="Am" public_interface="in" units="per_mm"/>
<variable name="F" public_interface="in" units="faradays_constant"/>
<variable name="IK_additional" public_interface="in" units="uA_per_mmsq"/>
<variable name="IK1" public_interface="in" units="uA_per_mmsq"/>
<variable name="Ito" public_interface="in" units="uA_per_mmsq"/>
<variable name="IKr" public_interface="in" units="uA_per_mmsq"/>
<variable name="IKs" public_interface="in" units="uA_per_mmsq"/>
<variable name="INaK" public_interface="in" units="uA_per_mmsq"/>
<variable name="IpK" public_interface="in" units="uA_per_mmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="K_flux_total_calculation"><eq />
<ci> K_flux </ci>
<apply><times/>
<apply><divide/>
<ci>Am</ci>
<apply><times />
<ci> vC </ci>
<ci> F </ci>
</apply>
</apply>
<apply><minus/>
<apply><plus />
<ci> IK_additional </ci>
<ci> IK1 </ci>
<ci> Ito </ci>
<ci> IKr </ci>
<ci> IKs </ci>
<ci> IpK </ci>
</apply>
<apply><times />
<ci> INaK </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_flux" cmeta:id="Na_flux">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#Na_flux">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
A component which sums the provided sodium fluxes.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Na_flux" name="Na_flux" public_interface="out" private_interface="out" units="mM_per_ms"/>
<variable name="vC" public_interface="in" units="dimensionless"/>
<variable name="Am" public_interface="in" units="per_mm"/>
<variable name="F" public_interface="in" units="faradays_constant"/>
<variable name="INa_additional" public_interface="in" units="uA_per_mmsq"/>
<variable name="INa" public_interface="in" units="uA_per_mmsq"/>
<variable name="IbNa" public_interface="in" units="uA_per_mmsq"/>
<variable name="INaK" public_interface="in" units="uA_per_mmsq"/>
<variable name="INaCa" public_interface="in" units="uA_per_mmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Na_flux_total_calculation"><eq />
<ci> Na_flux </ci>
<apply><times/>
<apply><divide/>
<ci>Am</ci>
<apply><times />
<ci> vC </ci>
<ci> F </ci>
</apply>
</apply>
<apply><plus />
<ci> INa </ci>
<ci> INa_additional </ci>
<ci> IbNa </ci>
<apply><times />
<ci> INaK </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
<apply><times />
<ci> INaCa </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_flux" cmeta:id="Ca_flux">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#Ca_flux">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
A component which sums the provided calcium membrane fluxes. Gives the
rate of change of intracellular concentration due to sarcolemmal
calcium fluxes.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Ca_flux" name="Ca_flux" public_interface="out" private_interface="out" units="mM_per_ms"/>
<variable name="vC" public_interface="in" units="dimensionless"/>
<variable name="Am" public_interface="in" units="per_mm"/>
<variable name="F" public_interface="in" units="faradays_constant"/>
<variable name="ICa_additional" public_interface="in" units="uA_per_mmsq"/>
<variable name="ICaL" public_interface="in" units="uA_per_mmsq"/>
<variable name="IbCa" public_interface="in" units="uA_per_mmsq"/>
<variable name="IpCa" public_interface="in" units="uA_per_mmsq"/>
<variable name="INaCa" public_interface="in" units="uA_per_mmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Ca_flux_total_calculation"><eq />
<ci> Ca_flux </ci>
<apply><times/>
<apply><divide/>
<ci>Am</ci>
<apply><times />
<cn cellml:units="dimensionless">2.0</cn>
<ci> vC </ci>
<ci> F </ci>
</apply>
</apply>
<apply><minus/>
<apply><times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>INaCa</ci>
</apply>
<apply><plus />
<ci>ICa_additional</ci>
<ci>ICaL</ci>
<ci>IbCa</ci>
<ci>IpCa</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_SR_flux" cmeta:id="Ca_SR_flux">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#Ca_SR_flux">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
A component which sums the provided calcium fluxes. Gives the
rate of change of intracellular concentration due to SR
calcium fluxes.
</rdf:value>
</cmeta:comment>
</rdf:Description>
<rdf:Description rdf:about="#JCaSR_additional">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
An additional calcium flux which can be used by higher level components to
modify or extend the base TNNP Ca fluxes into and/or out of the SR.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="Ca_SR_flux" name="Ca_SR_flux" public_interface="out" private_interface="out" units="mM_per_ms"/>
<variable name="Jleak" public_interface="in" units="mM_per_ms"/>
<variable name="Jup" public_interface="in" units="mM_per_ms"/>
<variable name="Jrel" public_interface="in" units="mM_per_ms"/>
<variable cmeta:id="JCaSR_additional" name="JCaSR_additional" public_interface="in" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Ca_SR_flux_total_calculation"><eq />
<ci> Ca_SR_flux </ci>
<apply><minus/>
<apply><plus/>
<ci>Jleak</ci>
<ci>Jrel</ci>
<ci>JCaSR_additional</ci>
</apply>
<ci>Jup</ci>
</apply>
</apply>
</math>
</component>
</model>
