Location: Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model @ d6328d18c94e / cellml / models / 2004_tenTusscher-version-2 / components / total_current.xml

Author:

David Nickerson <nickerso@users.sourceforge.net>

Date:

2013-05-04 07:40:04+12:00

Desc:

adding initial TODO list to keep track of what I need to do to get things working with more recent tools than my original CellMLSimulator that I used in this paper

Permanent Source URI:

https://staging.physiomeproject.org/w/andre/nickerson-2008/rawfile/d6328d18c94e9dad70f4d0e4b250e89429773b62/cellml/models/2004_tenTusscher-version-2/components/total_current.xml

<?xml version="1.0" encoding="iso-8859-1"?>

<model
    name="ten_tusscher_model_2004_Itotal"
    cmeta:id="ten_tusscher_model_2004_Itotal"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:xlink="http://www.w3.org/1999/xlink">
  <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
      xmlns:bqs="http://www.cellml.org/bqs/1.0#"
      xmlns:dc="http://purl.org/dc/elements/1.1/"
      xmlns:dcterms="http://purl.org/dc/terms/"
      xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
    <rdf:Description rdf:about="">
      <dc:creator rdf:parseType="Resource">
        <vCard:N rdf:parseType="Resource">
          <vCard:Family>Nickerson</vCard:Family>
          <vCard:Given>David</vCard:Given>
        </vCard:N>
        <vCard:EMAIL rdf:parseType="Resource">
          <rdf:value>david.nickerson@nus.edu.sg</rdf:value>
          <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
        </vCard:EMAIL>
        <vCard:ORG rdf:parseType="Resource">
          <vCard:Orgname>National University of Singapore</vCard:Orgname>
          <vCard:Orgunit>Division of Bioengineering</vCard:Orgunit>
        </vCard:ORG>
      </dc:creator>
      <dcterms:created rdf:parseType="Resource">
        <dcterms:W3CDTF>2007-05-14</dcterms:W3CDTF>
      </dcterms:created>
      <dc:publisher>
        Division of Bioengineering, National University of Singapore
      </dc:publisher>
    </rdf:Description>
    <rdf:Description rdf:about="#ten_tusscher_model_2004_Itotal">
      <dc:title>
        The total membrane current of the ten Tusscher et al.
        2004 human ventricular AP model.
      </dc:title>
    </rdf:Description>
    <cmeta:modification rdf:parseType="Resource">
      <rdf:value>
        Moving to using ion-specific additional currents.
      </rdf:value>
      <cmeta:modifier rdf:parseType="Resource">
        <vCard:FN>David Nickerson</vCard:FN>
      </cmeta:modifier>
      <dcterms:modified rdf:parseType="Resource">
        <dcterms:W3CDTF>2007-05-23</dcterms:W3CDTF>
      </dcterms:modified>
    </cmeta:modification>
  </rdf:RDF>
  
  <import xlink:href="../../common/units.xml">
    <units name="uA_per_mmsq" units_ref="uA_per_mmsq"/>
  </import>
  
  <component name="total_membrane_current" cmeta:id="total_membrane_current">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#total_membrane_current">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            A component which sums the provided membrane currents.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    
    <variable cmeta:id="Itotal" name="Itotal" public_interface="out" private_interface="out" units="uA_per_mmsq"/>
    
    <variable name="ICa_additional" public_interface="in" units="uA_per_mmsq"/>
    <variable name="INa_additional" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IK_additional" public_interface="in" units="uA_per_mmsq"/>

    <variable name="INa" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IK1" public_interface="in" units="uA_per_mmsq"/>
    <variable name="Ito" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IKr" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IKs" public_interface="in" units="uA_per_mmsq"/>
    <variable name="ICaL" public_interface="in" units="uA_per_mmsq"/>
    <variable name="INaCa" public_interface="in" units="uA_per_mmsq"/>
    <variable name="INaK" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IpCa" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IpK" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IbCa" public_interface="in" units="uA_per_mmsq"/>
    <variable name="IbNa" public_interface="in" units="uA_per_mmsq"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="Itotal_eq"><eq/>
        <ci>Itotal</ci>
        <apply><plus/>
          <ci>ICa_additional</ci>
          <ci>INa_additional</ci>
          <ci>IK_additional</ci>
          <ci>INa</ci>
          <ci>IK1</ci>
          <ci>Ito</ci>
          <ci>IKr</ci>
          <ci>IKs</ci>
          <ci>ICaL</ci>
          <ci>INaCa</ci>
          <ci>INaK</ci>
          <ci>IbNa</ci>
          <ci>IbCa</ci>
          <ci>IpCa</ci>
          <ci>IpK</ci>
        </apply>
      </apply>
    </math>
  </component>
  
</model>