https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009 en-us Drug biotransformation is one of the most important parameters of preclinical screening tests for the registration of new drug candidates. Conventional existing tests rely on nonhuman models which deliver an incomplete metabolic profile of drugs due to the lack of proper CYP450 expression as seen in human liver in vivo. In order to overcome this limitation, we used an organotypical model of human primary hepatocytes for the biotransformation of the drug diazepam with special reference to metabolites in both the cell matrix phase and supernatant and its interaction of three inducers (phenobarbital, dexamethasone, aroclor 1254) in different time responses (1, 2, 4, 8, 24 h). This model runs in OpenCell to reproduce the results in figure 3 of the published paper. There are four model versions: control (a), aroclor (b), dexamethasone (c) and phenobarbital (d). Initial values were taken from the published graphs. https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/c8631a184845350321b2956d4df7b5c1e2f3809c Added image to HTMl file Hanne Nielsen 2011-08-23 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/5d1a96dabd9c670b63f04b192f8d9b664c4460a0 Added HTML file Hanne Nielsen 2011-08-03 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/7036149d16693287d7c50f538a48bca5ce85cb1f Edited image documentation in CellML files Hanne Nielsen 2011-03-29 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/c8172e3db1b61393b89b1cc878ef2cc6d319736c Updated images and SVG in session files Hanne Nielsen 2011-02-02 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/590a005d2f62e7874e2d686b639e1c6c80ec84f2 Added hepatocyte as keyword to cellml files Hanne Nielsen 2011-01-28 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/027a92da219aba55ac3402f5c48e229a0a9be9ce Added three sessions and updated xul Hanne Nielsen 2011-01-27 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/3ef0f90de065ae0c6ce252078cd6dc81ec69063b Session file for a has clickable SVG Hanne Nielsen 2011-01-27 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/fef2620eff29565a3b1537216f4d461782239863 Added three other variants of cellml model Hanne Nielsen 2011-01-27 https://staging.physiomeproject.org/w/hnielsen/acikgoz_2009/@@file/9329f89ea20da07f0d0b3a679afaee0de20e27a9 Added cellml file and session file for control expriment Hanne Nielsen 2011-01-26