https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003 en-us Many different agonists use calcium as a second messenger. Despite intensive research in intracellular calcium signalling it is an unsolved riddle how the different types of information represented by the different agonists, is encoded using the universal carrier calcium. It is also still not clear how the information encoded is decoded again into the intracellular specific information at the site of enzymes and genes. After the discovery of calcium oscillations, one likely mechanism is that information is encoded in the frequency, amplitude and waveform of the oscillations. This hypothesis has received some experimental support. However, the mechanism of decoding of oscillatory signals is still not known. Here, we study a mechanistic model of calcium oscillations, which is able to reproduce both spiking and bursting calcium oscillations. We use the model to study the decoding of calcium signals on the basis of co-operativity of calcium binding to various proteins. We show that this co-operativity offers a simple way to decode different calcium dynamics into different enzyme activities. https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/bdb5e309844ed8cdd65fe9cf3ed5456310b87d37 Added images in ai svg and png format. Added xul file and clickable session files. Zoom is currently broken. Hanne Nielsen 2011-09-12 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/683c12736e417a79e6f60951e34f61d14090ab95 Added HTML file to workspace Hanne Nielsen 2011-08-03 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/0964b0d8e410794be0a60616e97b793add142e2c Corrected the fifth term in larsen_olsen_kummer_2003a Hanne Nielsen 2011-08-03 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/2b82cddf3ddf0a1dcd5149280edd3ca3700a8809 Added third CellML file to recreate Figure 4. This is the c file. Hanne Nielsen 2011-08-01 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/5c04b8cfa2cc8733812d709278698e1c91d7e2c4 Removed previus versions of cellML Hanne Nielsen 2011-07-29 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/401c29e8001d9bd561b67747e3efca53039f6f4e Added cellML and session files for a - figure2 graphc and b- figure3 graphc. b does not recreate published results Hanne Nielsen 2011-07-29 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/131179e594027378987022a869f281d4188ab64b Fixed session file Hanne Nielsen 2011-07-28 https://staging.physiomeproject.org/w/hnielsen/larsen_olsen_kummer_2003/@@file/f2accee3e2af0b6b38841e26358a1b4cab80838f Added CellML file and session file using parameters for figure 2, eqns 1-5 Hanne Nielsen 2011-07-27