/Users/max_neal/Dropbox/Semantic Project/Annotated CellML models/cooling_hunter_crampin_2007/cooling_hunter_crampin_2007.cellml 0.2 <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:j.0="http://www.cellml.org/bqs/1.0#" xmlns:j.1="http://imc.org/vCard/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:j.2="http://purl.org/dc/terms/" xmlns:j.3="http://www.cellml.org/metadata/simulation/1.0#"> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0"> <dc:creator rdf:parseType="Resource"> <ORG rdf:parseType="Resource"> <Orgunit xml:lang="en">Auckland Bioengineering Institute</Orgunit> <Orgname xml:lang="en">The University of Auckland</Orgname> </ORG> <EMAIL> <j.1:internet> <rdf:value xml:lang="en">m.cooling@auckland.ac.nz</rdf:value> </j.1:internet> </EMAIL> <N rdf:parseType="Resource"> <Given xml:lang="en">Mike</Given> <Family xml:lang="en">Cooling</Family> </N> </dc:creator> </rdf:Description> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#cooling_2007"> <j.0:reference rdf:parseType="Resource"> <j.0:JournalArticle rdf:parseType="Resource"> <j.0:last_page xml:lang="en">3433</j.0:last_page> <j.0:first_page xml:lang="en">3421</j.0:first_page> <j.2:issued rdf:parseType="Resource"> <j.2:W3CDTF xml:lang="en">2007-00-00 00:00</j.2:W3CDTF> </j.2:issued> <j.0:Journal rdf:parseType="Resource"> <dc:title xml:lang="en">Biophysical Journal</dc:title> </j.0:Journal> <dc:title xml:lang="en">Modeling hypertrophic IP3 transients in the cardiac myocyte</dc:title> <j.0:volume xml:lang="en">93</j.0:volume> <dc:creator> <rdf:Seq> <rdf:li rdf:parseType="Resource"> <ORG rdf:parseType="Resource"> <Orgunit xml:lang="en">University of Auckland</Orgunit> <Orgname xml:lang="en">Auckland Bioengineering Institute</Orgname> </ORG> <EMAIL> <j.1:internet> <rdf:value xml:lang="en">m.cooling@auckland.ac.nz</rdf:value> </j.1:internet> </EMAIL> <N rdf:parseType="Resource"> <Given xml:lang="en">Mike</Given> <Family xml:lang="en">Cooling</Family> </N> </rdf:li> <rdf:li rdf:parseType="Resource"> <ORG rdf:parseType="Resource"> <Orgunit xml:lang="en">University of Auckland</Orgunit> <Orgname xml:lang="en">Auckland Bioengineering Institute</Orgname> </ORG> <EMAIL> <j.1:internet> <rdf:value xml:lang="en">p.hunter@auckland.ac.nz</rdf:value> </j.1:internet> </EMAIL> <N rdf:parseType="Resource"> <Given xml:lang="en">Peter</Given> <Family xml:lang="en">Hunter</Family> </N> </rdf:li> <rdf:li rdf:parseType="Resource"> <ORG rdf:parseType="Resource"> <Orgunit xml:lang="en">University of Auckland</Orgunit> <Orgname xml:lang="en">Auckland Bioengineering Institute</Orgname> </ORG> <EMAIL> <j.1:internet> <rdf:value xml:lang="en">e.crampin@auckland.ac.nz</rdf:value> </j.1:internet> </EMAIL> <N rdf:parseType="Resource"> <Given xml:lang="en">Edmund</Given> <Family xml:lang="en">Crampin</Family> </N> </rdf:li> </rdf:Seq> </dc:creator> </j.0:JournalArticle> </j.0:reference> <j.0:reference rdf:parseType="Resource"> <dc:subject rdf:parseType="Resource"> <j.0:subject_type xml:lang="en">keyword</j.0:subject_type> <rdf:value> <rdf:Bag> <rdf:li xml:lang="en">Signal Transduction</rdf:li> </rdf:Bag> </rdf:value> </dc:subject> </j.0:reference> <j.3:simulation rdf:parseType="Resource"> <j.3:boundIntervals rdf:parseType="Collection"> <rdf:Description> <j.3:endingValue xml:lang="en">100</j.3:endingValue> <j.3:nonstandard-pointDensity xml:lang="en">10000</j.3:nonstandard-pointDensity> <j.3:maximumStepSize xml:lang="en">.1</j.3:maximumStepSize> </rdf:Description> </j.3:boundIntervals> </j.3:simulation> </rdf:Description> </rdf:RDF> cooling_2007 cooling_2007 Fluid volume http://bhi.washington.edu/OPB#OPB_00154 Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-beta-1) (PLC-beta-1) http://identifiers.org/uniprot/Q9Z1B3 1D-myo-inositol 1,4,5-trisphosphate http://purl.obolibrary.org/obo/CHEBI_16595 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate http://purl.obolibrary.org/obo/CHEBI_18348 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 Extracellular space http://purl.org/sig/ont/fma/fma70022 Plasma membrane http://purl.org/sig/ont/fma/fma63841 Portion of cytosol http://purl.org/sig/ont/fma/fma66836 Regular atrial cardiac myocyte http://purl.org/sig/ont/fma/fma83108 A physical entity that is defined by linking multiple physical entity terms with structural relations. A mathematical and/or logical expression that determines the value of a data structure. An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities. A physical dependency defined in a specific SemSim model. A physical entity defined in a specific SemSim model. A physical process defined in a specific SemSim model. A physical property defined in a specific SemSim model. A computational element that stores numerical and/or logical information related to the model. A data structure whose value is limited to decimals. A data structure whose value is limited to the whole numbers. A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime. A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process. A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants. A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element. A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process. A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values. A data structure whose value is limited to the real numbers. A physical dependency that is defined using a term in an external knowledge resource. A physical entity that is defined using a term from an external knowledge resource. A physical process that is defined using a term in an external knowledge resource. A physical property that is defined using a term in an external knowledge resource. A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0. A computational or physical element of a SemSim model. A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel. A physical quantity chosen as a standard in terms of which other physical quantities may be expressed. Binding of G-alpha-GDP to receptor 1.0 1.0 1.0 Binding of G-alpha-GTP to calcium-bound PLC-beta 1.0 1.0 1.0 Binding of PLC-beta to G-alpha-GTP 1.0 1.0 1.0 Binding of calcium to G-alpha-GTP-bound PLC-beta 1.0 1.0 1.0 Binding of calcium to PLC-beta 1.0 1.0 1.0 Binding of ligand and receptor to G-alpha-GDP 1.0 1.0 1.0 Binding of ligand to receptor 1.0 1.0 1.0 Binding of ligand to receptor and G-alpha-GDP 1.0 1.0 1.0 1D-myo-inositol 1,4,5-trisphosphate http://purl.obolibrary.org/obo/CHEBI_16595 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate http://purl.obolibrary.org/obo/CHEBI_18348 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 Degradation of G-alpha-GTP 1.0 1.0 Degradation of free IP3 1.0 Dissociation of G-alpha-GTP from PLC-beta and degradation 1.0 1.0 1.0 Dissociation of G-alpha-GTP from activated receptor 1.0 1.0 1.0 Dissociation of G-alpha-GTP from calcium-bound PLC-beta and degradation 1.0 1.0 1.0 Extracellular space http://purl.org/sig/ont/fma/fma70022 G-alpha-GDP G-alpha-GTP Hydrolysis of PIP2 by calcium-bound PLC-beta 1.0 1.0 1.0 Hydrolysis of PIP2 by calcium-bound PLC-beta and G-alpha-GTP complex 1.0 1.0 1.0 Ligand Ligand bound to phosphorylated receptor and G-alpha-GDP Ligand bound to receptor Ligand bound to receptor and G-alpha-GDP PLC-beta bound to G-alpha-GTP PLC-beta bound to calcium (2+) PLC-beta bound to calcium (2+) and G-alpha-GTP Phosphorylation of ligand-bound receptor 1.0 1.0 Plasma membrane http://purl.org/sig/ont/fma/fma63841 Portion of cytosol http://purl.org/sig/ont/fma/fma66836 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-beta-1) (PLC-beta-1) http://identifiers.org/uniprot/Q9Z1B3 Receptor bound to G-alpha-GDP Receptor not bound to G-alpha-GDP Regular atrial cardiac myocyte http://purl.org/sig/ont/fma/fma83108 liter true meter true mole true per_s -1.0 per_uM_per_s -1.0 -1.0 per_um -1.0 micro per_um2 -1.0 per_um2_per_s -1.0 -1.0 s second true uM micro -1.0 uM_per_s -1.0 uM_um2 um2 2.0 micro um2_per_s -1.0 um3 3.0 micro all 0.1 all_Ca false false true Cytosolic calcium (2+) concentration Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false true Factor for converting from number of particles to cytosolic concentration false false true Factor for converting number of particles to a density on the cell’s plasma membrane false false true Factor for converting between density fluxes and concentration fluxes 10000 all_Gd false false true Area density of free inactive G-protein. "...represents the densities of a species required to form that mobile messenger—the amount of free G-alpha-GDP." Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Gt false false true G-alpha-GTP density Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.015 all_IP3 false false true IP3 concentration in cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false true Reaction R1 flux false false out true Reaction R10 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false out true Reaction R11 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R12 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R13 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R14 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R15 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R16 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R2 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R3 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R4 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R5 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R6 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R7 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R8 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 false false true Reaction R9 flux Chemical flow rate http://bhi.washington.edu/OPB#OPB_00237 3e-5 false false true Dissociation constant for the binding of ligand to the receptor with no attached G-protein 0.1 false false true Reaction R11 dissociation rate constant 27500 false false true Dissociation constant for the binding of unbound receptor to G-protein 3e-5 false false true Dissociation constant for the binding of ligand to the receptor with attached G-protein 19.8 false false true Reaction R14 Km value 5 false false true Reaction R15 Km value all_L false false true Extracellular ligand concentration for unstimulated condition Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.1 false false true Full-strength ligand concentration during stimulation Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 90.9 all_P false false true PLC-beta density 4000 all_PIP2 false false true PIP2 density Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 9.09 all_Pc false false out true Density of PLC-beta bound to calcium (2+) Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Pcg false false out true Density of PLC-beta bound to calcium (2+) and G-alpha-GTP Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Pg false false true Density of PLC-beta bound to G-alpha-GTP Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 13.9 all_R false false true Area density of noncoupled receptors Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 5.06 all_Rg false false true Density of receptors coupled with G-proteins Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Rl false false true Ligand-bound receptor density Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Rlg false false true Active receptor density Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0 all_Rlgp false false true Phosphorylated receptor density Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 4.61 false false true Ratio of plasma membrane surface area to cytosolic volume 2550 false false true Cytosolic volume Fluid volume http://bhi.washington.edu/OPB#OPB_00154 0.0003 false false true Reaction R1 forward rate constant 0.042 false false true Reaction R10 forward rate constant 0.0334 false false true Reaction R11 forward rate constant 6 false false true Reaction R12 forward rate constant 6 false false true Reaction R13 forward rate constant 0.444 false false true Rate constant for the nonstimulated IP3 production reaction 3.8 false false true Reaction R15 forward rate constant 1.25 false false true Rate constant for the degradation of IP3 2.75e-4 false false true Reaction R2 forward rate constant 1 false false true Reaction R3 forward rate constant 0.3 false false true Forward rate for the binding of ligand to precoupled receptor 0.0004 false false true Rate constant for the phosphorylation of active receptor 1 false false true G-protein dissociation rate from the activated receptor 0.15 false false true Reaction R7 forward rate constant 0.0167 false false true Forward rate constant for the binding of calcium to PLC-beta 0.0042 false false true Reaction R9 forward rate constant false false true Reaction R1 reverse rate constant 1 false false true Reaction R10 reverse rate constant false false true Reaction R11 reverse rate constant false false true Reaction R2 reverse rate constant 0.001 false false true Reaction R3 reverse rate constant false false true Reaction R2 reverse rate constant 0.0167 false false true Reverse rate constant for the binding of calcium to PLC-beta 1 false false true Reaction R9 forward rate constant Time all_t false false http://bhi.washington.edu/OPB#OPB_01023 true Time domain 10 false false true Time of ligand stimulation <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>Cc</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <times /> <ci>Vc</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_uM_per_um3"> 6.022 <sep /> 2 </cn> </apply> </apply> </apply> <apply> <eq /> <ci>Cp</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <times /> <ci>Vc</ci> <ci>Rpc</ci> </apply> </apply> </apply> <apply> <eq /> <ci>Cpc</ci> <apply> <divide /> <ci>Cc</ci> <ci>Cp</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>P</ci> </apply> <apply> <minus /> <ci>J13</ci> <apply> <plus /> <ci>J9</ci> <ci>J8</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Pg</ci> </apply> <apply> <minus /> <ci>J9</ci> <apply> <plus /> <ci>J11</ci> <ci>J13</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Pc</ci> </apply> <apply> <minus /> <apply> <plus /> <ci>J8</ci> <ci>J12</ci> </apply> <ci>J10</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Pcg</ci> </apply> <apply> <minus /> <apply> <plus /> <ci>J10</ci> <ci>J11</ci> </apply> <ci>J12</ci> </apply> </apply> <apply> <eq /> <ci>J13</ci> <apply> <times /> <ci>kf13</ci> <ci>Pg</ci> </apply> </apply> <apply> <eq /> <ci>J12</ci> <apply> <times /> <ci>kf12</ci> <ci>Pcg</ci> </apply> </apply> <apply> <eq /> <ci>kr11</ci> <apply> <times /> <ci>kf11</ci> <ci>Kd11</ci> </apply> </apply> <apply> <eq /> <ci>J11</ci> <apply> <minus /> <apply> <times /> <ci>kf11</ci> <ci>Pg</ci> <ci>Ca</ci> </apply> <apply> <times /> <ci>kr11</ci> <ci>Pcg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J10</ci> <apply> <minus /> <apply> <times /> <ci>kf10</ci> <ci>Pc</ci> <ci>Gt</ci> </apply> <apply> <times /> <ci>kr10</ci> <ci>Pcg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J8</ci> <apply> <minus /> <apply> <times /> <ci>kf8</ci> <ci>P</ci> <ci>Ca</ci> </apply> <apply> <times /> <ci>kr8</ci> <ci>Pc</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J9</ci> <apply> <minus /> <apply> <times /> <ci>kf9</ci> <ci>P</ci> <ci>Gt</ci> </apply> <apply> <times /> <ci>kr9</ci> <ci>Pg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J16</ci> <apply> <times /> <ci>kf16</ci> <ci>IP3</ci> </apply> </apply> <apply> <eq /> <ci>J14</ci> <apply> <divide /> <apply> <times /> <ci>kf14</ci> <ci>Pc</ci> <ci>PIP2</ci> </apply> <apply> <plus /> <apply> <divide /> <ci>Km14</ci> <ci>Cpc</ci> </apply> <ci>PIP2</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J15</ci> <apply> <divide /> <apply> <times /> <ci>kf15</ci> <ci>Pcg</ci> <ci>PIP2</ci> </apply> <apply> <plus /> <apply> <divide /> <ci>Km15</ci> <ci>Cpc</ci> </apply> <ci>PIP2</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>IP3</ci> </apply> <apply> <minus /> <apply> <times /> <ci>Cpc</ci> <apply> <plus /> <ci>J14</ci> <ci>J15</ci> </apply> </apply> <ci>J16</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Gd</ci> </apply> <apply> <minus /> <apply> <plus /> <ci>J7</ci> <ci>J13</ci> <ci>J12</ci> </apply> <apply> <plus /> <ci>J2</ci> <ci>J3</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Gt</ci> </apply> <apply> <minus /> <ci>J6</ci> <apply> <plus /> <ci>J7</ci> <ci>J9</ci> <ci>J10</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J7</ci> <apply> <times /> <ci>kf7</ci> <ci>Gt</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Ca</ci> </apply> <apply> <times /> <ci>Cpc</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <plus /> <ci>J8</ci> <ci>J11</ci> </apply> </apply> </apply> <apply> <eq /> <ci>L</ci> <piecewise> <piece> <apply> <divide /> <ci>Ls</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_s">80</cn> </apply> <apply> <minus /> <apply> <minus /> <ci>t</ci> <ci>ts</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="s">0.05</cn> </apply> </apply> </apply> </apply> </apply> <apply> <and /> <apply> <lt /> <ci>t</ci> <apply> <plus /> <ci>ts</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="s">0.15</cn> </apply> </apply> <apply> <geq /> <ci>t</ci> <ci>ts</ci> </apply> </apply> </piece> <piece> <ci>Ls</ci> <apply> <geq /> <ci>t</ci> <apply> <plus /> <ci>ts</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="s">0.15</cn> </apply> </apply> </piece> <otherwise> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uM">0</cn> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>kr1</ci> <apply> <times /> <ci>kf1</ci> <ci>Kd1</ci> </apply> </apply> <apply> <eq /> <ci>J1</ci> <apply> <minus /> <apply> <times /> <ci>kf1</ci> <ci>R</ci> <ci>L</ci> </apply> <apply> <times /> <ci>kr1</ci> <ci>Rl</ci> </apply> </apply> </apply> <apply> <eq /> <ci>kr2</ci> <apply> <times /> <ci>kf2</ci> <ci>Kd2</ci> </apply> </apply> <apply> <eq /> <ci>J2</ci> <apply> <minus /> <apply> <times /> <ci>kf2</ci> <ci>R</ci> <ci>Gd</ci> </apply> <apply> <times /> <ci>kr2</ci> <ci>Rg</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>R</ci> </apply> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <plus /> <ci>J1</ci> <ci>J2</ci> </apply> </apply> </apply> <apply> <eq /> <ci>J3</ci> <apply> <minus /> <apply> <times /> <ci>kf3</ci> <ci>Rl</ci> <ci>Gd</ci> </apply> <apply> <times /> <ci>kr3</ci> <ci>Rlg</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Rl</ci> </apply> <apply> <minus /> <apply> <plus /> <ci>J1</ci> <ci>J6</ci> </apply> <ci>J3</ci> </apply> </apply> <apply> <eq /> <ci>kr4</ci> <apply> <times /> <ci>kf4</ci> <ci>Kd4</ci> </apply> </apply> <apply> <eq /> <ci>J4</ci> <apply> <minus /> <apply> <times /> <ci>kf4</ci> <ci>L</ci> <ci>Rg</ci> </apply> <apply> <times /> <ci>kr4</ci> <ci>Rlg</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Rg</ci> </apply> <apply> <minus /> <ci>J2</ci> <ci>J4</ci> </apply> </apply> <apply> <eq /> <ci>J5</ci> <apply> <times /> <ci>kf5</ci> <ci>Rlg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Rlgp</ci> </apply> <ci>J5</ci> </apply> <apply> <eq /> <ci>J6</ci> <apply> <times /> <ci>kf6</ci> <ci>Rlg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>t</ci> </bvar> <ci>Rlg</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <minus /> <ci>J3</ci> <ci>J5</ci> </apply> <ci>J4</ci> </apply> <ci>J6</ci> </apply> </apply> </math>