Annotations
- Described by
- A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule, A.M. Weinstein, 1995, The Journal of General Physiology, 105, 617-641. DOI: 10.1085/jgp.105.5.617
- Protein
- Sodium/hydrogen exchanger 3
- Located in
- Proximal convoluted tubule
- Apical plasma membrane
- Epithelial cell of proximal tubule
Workspace Status
This workspace contains several verisons of the Weinstein (1995) NHE3 model, the mathematical model and then a version of the model to reproduce each figure in the original paper. These models can be browsed via the Navigation panel in the right hand column.
- Figure 2 illustrates the effect of external pH on Na+ influx.
- Figure 3 illustrates the effect of external pH on the Michaelis constant of Na+ flux.
- Figure 4 illustrates the effect of external pH on competitive inhibition by NH4+.