Figure 2

This is the general mathematical model for the NHE3 model with modifications to enable simulations which are capable of reproducing Figure 2 in the original paper. The simulation experiment for this model can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation. The results of which are shown below. A rendering of the mathematical model itself is available here.

In Figure 2, the zero trans Na⁺ influx is computed for a range of external pH. Model parameters are from Table I in the original paper; internal pH 6.0, internal Na⁺ = 0.0 mmol/litre, and external Na⁺ = 0.1 mmol/litre. NH₄⁺ is absent. (top) Na⁺ flux (relative to maximal zero trans flux) is plotted as a function of external pH. (bottom) Reciprocal flux is plotted as a function of the external H⁺ concentration.

A screenshot illustrating the results when the associated SED-ML document is loaded into OpenCOR and the simulation executed.

This can be reproduced directly from the repository by choosing the Launch with OpenCOR link from the Views Available.