Location: Na+/K+-ATPase (sodium-potassium pump) @ c0a79feceb0b / BG-full / NaK_BG.cellml

Author:
Soroush Safaei <Soroush@Soroushs-MacBook-Pro-2.local>
Date:
2017-01-13 00:30:02+13:00
Desc:
evaluating the parameters
Permanent Source URI:
https://staging.physiomeproject.org/workspace/294/rawfile/c0a79feceb0bae983bc25be33120e6d11c0d26e9/BG-full/NaK_BG.cellml

<?xml version='1.0'?>
<model name="NaK_BG" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="Units.cellml">
        <units name="per_mol" units_ref="per_mol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="mol_per_s" units_ref="mol_per_s"/>
        <units name="per_C" units_ref="per_C"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="C_per_s" units_ref="C_per_s"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
    </import>
    <import xlink:href="StateDiagram.cellml">
        <component component_ref="state" name="state"/>
    </import>
    <import xlink:href="Parameters.cellml">
        <component component_ref="param" name="param"/>
    </import>
    <component name="module">
        <variable name="time" private_interface="out" units="second"/>
        <variable initial_value="2494.34" name="RT" private_interface="out" units="J_per_mol"/>
        <variable initial_value="1" name="z" private_interface="out" units="dimensionless"/>
        <variable initial_value="96485" name="F" private_interface="out" units="C_per_mol"/>
        <!-- State variables-->
        <variable initial_value="1.0e-6" name="q_0_Na1_o" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Na1_i" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Na2_o" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Na2_i" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Na3_o" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Na3_i" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_K1_o" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_K1_i" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_K2_o" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_K2_i" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_ATP" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_ADP" private_interface="out" units="mole"/>
        <variable initial_value="1.0e-6" name="q_0_Pi" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PE_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PEK_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PE2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_E2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPE2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPE2K_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPEK_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPE_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPENa_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPE2Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_ATPE3Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PE3Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PE3Na_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PE2Na_o" private_interface="out" units="mole"/>
        <variable initial_value="0.06667" name="q_0_PENa_o" private_interface="out" units="mole"/>
        <variable name="q_Na1_o" private_interface="in" units="mole"/>
        <variable name="q_Na1_i" private_interface="in" units="mole"/>
        <variable name="q_Na2_o" private_interface="in" units="mole"/>
        <variable name="q_Na2_i" private_interface="in" units="mole"/>
        <variable name="q_Na3_o" private_interface="in" units="mole"/>
        <variable name="q_Na3_i" private_interface="in" units="mole"/>
        <variable name="q_K1_o" private_interface="in" units="mole"/>
        <variable name="q_K1_i" private_interface="in" units="mole"/>
        <variable name="q_K2_o" private_interface="in" units="mole"/>
        <variable name="q_K2_i" private_interface="in" units="mole"/>
        <variable name="q_ATP" private_interface="in" units="mole"/>
        <variable name="q_ADP" private_interface="in" units="mole"/>
        <variable name="q_Pi" private_interface="in" units="mole"/>
        <variable name="q_PE_o" private_interface="in" units="mole"/>
        <variable name="q_PEK_o" private_interface="in" units="mole"/>
        <variable name="q_PE2K_o" private_interface="in" units="mole"/>
        <variable name="q_E2K_o" private_interface="in" units="mole"/>
        <variable name="q_ATPE2K_o" private_interface="in" units="mole"/>
        <variable name="q_ATPE2K_i" private_interface="in" units="mole"/>
        <variable name="q_ATPEK_i" private_interface="in" units="mole"/>
        <variable name="q_ATPE_i" private_interface="in" units="mole"/>
        <variable name="q_ATPENa_i" private_interface="in" units="mole"/>
        <variable name="q_ATPE2Na_i" private_interface="in" units="mole"/>
        <variable name="q_ATPE3Na_i" private_interface="in" units="mole"/>
        <variable name="q_PE3Na_i" private_interface="in" units="mole"/>
        <variable name="q_PE3Na_o" private_interface="in" units="mole"/>
        <variable name="q_PE2Na_o" private_interface="in" units="mole"/>
        <variable name="q_PENa_o" private_interface="in" units="mole"/>
        <variable name="v_Re1" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re2" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re3" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re4" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re5" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re6" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re7" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re8" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re9" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re10" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re11" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re12" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re13" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re14" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re15" private_interface="in" units="mol_per_s"/>
        <variable name="u_Na1_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na1_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na2_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na2_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na3_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na3_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_K1_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_K1_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_K2_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_K2_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATP" private_interface="in" units="J_per_mol"/>
        <variable name="u_ADP" private_interface="in" units="J_per_mol"/>
        <variable name="u_Pi" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_PEK_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_E2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE2K_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPEK_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPENa_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE2Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE3Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE3Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE3Na_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE2Na_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_PENa_o" private_interface="in" units="J_per_mol"/>
        <variable name="u29" private_interface="in" units="J_per_mol"/>
        <variable name="u30" private_interface="in" units="J_per_mol"/>
        <variable name="u31" private_interface="in" units="J_per_mol"/>
        <variable name="u32" private_interface="in" units="J_per_mol"/>
        <variable name="u33" private_interface="in" units="J_per_mol"/>
        <variable name="u34" private_interface="in" units="J_per_mol"/>
        <variable name="u35" private_interface="in" units="J_per_mol"/>
        <variable name="u36" private_interface="in" units="J_per_mol"/>
        <variable name="u37" private_interface="in" units="J_per_mol"/>
        <variable name="u38" private_interface="in" units="J_per_mol"/>
        <variable name="u39" private_interface="in" units="J_per_mol"/>
        <variable name="u40" private_interface="in" units="J_per_mol"/>
        <variable name="u41" private_interface="in" units="J_per_mol"/>
        <!--        ode(q_0_Na_o, time) = 0.005{mol_per_s};
        ode(q_0_E, time) = 0.001{coulomb};-->
    </component>
    <!-- Mapping to the BG state diagram-->
    <connection>
        <map_components component_1="module" component_2="state"/>
        <map_variables variable_1="time" variable_2="t"/>
        <map_variables variable_1="RT" variable_2="RT"/>
        <map_variables variable_1="z" variable_2="z"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="q_0_Na1_o" variable_2="q1_init"/>
        <map_variables variable_1="q_0_Na1_i" variable_2="q2_init"/>
        <map_variables variable_1="q_0_Na2_o" variable_2="q3_init"/>
        <map_variables variable_1="q_0_Na2_i" variable_2="q4_init"/>
        <map_variables variable_1="q_0_Na3_o" variable_2="q5_init"/>
        <map_variables variable_1="q_0_Na3_i" variable_2="q6_init"/>
        <map_variables variable_1="q_0_K1_o" variable_2="q7_init"/>
        <map_variables variable_1="q_0_K1_i" variable_2="q8_init"/>
        <map_variables variable_1="q_0_K2_o" variable_2="q9_init"/>
        <map_variables variable_1="q_0_K2_i" variable_2="q10_init"/>
        <map_variables variable_1="q_0_ATP" variable_2="q11_init"/>
        <map_variables variable_1="q_0_ADP" variable_2="q12_init"/>
        <map_variables variable_1="q_0_Pi" variable_2="q13_init"/>
        <map_variables variable_1="q_0_PE_o" variable_2="q14_init"/>
        <map_variables variable_1="q_0_PEK_o" variable_2="q15_init"/>
        <map_variables variable_1="q_0_PE2K_o" variable_2="q16_init"/>
        <map_variables variable_1="q_0_E2K_o" variable_2="q17_init"/>
        <map_variables variable_1="q_0_ATPE2K_o" variable_2="q18_init"/>
        <map_variables variable_1="q_0_ATPE2K_i" variable_2="q19_init"/>
        <map_variables variable_1="q_0_ATPEK_i" variable_2="q20_init"/>
        <map_variables variable_1="q_0_ATPE_i" variable_2="q21_init"/>
        <map_variables variable_1="q_0_ATPENa_i" variable_2="q22_init"/>
        <map_variables variable_1="q_0_ATPE2Na_i" variable_2="q23_init"/>
        <map_variables variable_1="q_0_ATPE3Na_i" variable_2="q24_init"/>
        <map_variables variable_1="q_0_PE3Na_i" variable_2="q25_init"/>
        <map_variables variable_1="q_0_PE3Na_o" variable_2="q26_init"/>
        <map_variables variable_1="q_0_PE2Na_o" variable_2="q27_init"/>
        <map_variables variable_1="q_0_PENa_o" variable_2="q28_init"/>
        <map_variables variable_1="q_Na1_o" variable_2="q1"/>
        <map_variables variable_1="q_Na1_i" variable_2="q2"/>
        <map_variables variable_1="q_Na2_o" variable_2="q3"/>
        <map_variables variable_1="q_Na2_i" variable_2="q4"/>
        <map_variables variable_1="q_Na3_o" variable_2="q5"/>
        <map_variables variable_1="q_Na3_i" variable_2="q6"/>
        <map_variables variable_1="q_K1_o" variable_2="q7"/>
        <map_variables variable_1="q_K1_i" variable_2="q8"/>
        <map_variables variable_1="q_K2_o" variable_2="q9"/>
        <map_variables variable_1="q_K2_i" variable_2="q10"/>
        <map_variables variable_1="q_ATP" variable_2="q11"/>
        <map_variables variable_1="q_ADP" variable_2="q12"/>
        <map_variables variable_1="q_Pi" variable_2="q13"/>
        <map_variables variable_1="q_PE_o" variable_2="q14"/>
        <map_variables variable_1="q_PEK_o" variable_2="q15"/>
        <map_variables variable_1="q_PE2K_o" variable_2="q16"/>
        <map_variables variable_1="q_E2K_o" variable_2="q17"/>
        <map_variables variable_1="q_ATPE2K_o" variable_2="q18"/>
        <map_variables variable_1="q_ATPE2K_i" variable_2="q19"/>
        <map_variables variable_1="q_ATPEK_i" variable_2="q20"/>
        <map_variables variable_1="q_ATPE_i" variable_2="q21"/>
        <map_variables variable_1="q_ATPENa_i" variable_2="q22"/>
        <map_variables variable_1="q_ATPE2Na_i" variable_2="q23"/>
        <map_variables variable_1="q_ATPE3Na_i" variable_2="q24"/>
        <map_variables variable_1="q_PE3Na_i" variable_2="q25"/>
        <map_variables variable_1="q_PE3Na_o" variable_2="q26"/>
        <map_variables variable_1="q_PE2Na_o" variable_2="q27"/>
        <map_variables variable_1="q_PENa_o" variable_2="q28"/>
        <map_variables variable_1="v_Re1" variable_2="v_Re1"/>
        <map_variables variable_1="v_Re2" variable_2="v_Re2"/>
        <map_variables variable_1="v_Re3" variable_2="v_Re3"/>
        <map_variables variable_1="v_Re4" variable_2="v_Re4"/>
        <map_variables variable_1="v_Re5" variable_2="v_Re5"/>
        <map_variables variable_1="v_Re6" variable_2="v_Re6"/>
        <map_variables variable_1="v_Re7" variable_2="v_Re7"/>
        <map_variables variable_1="v_Re8" variable_2="v_Re8"/>
        <map_variables variable_1="v_Re9" variable_2="v_Re9"/>
        <map_variables variable_1="v_Re10" variable_2="v_Re10"/>
        <map_variables variable_1="v_Re11" variable_2="v_Re11"/>
        <map_variables variable_1="v_Re12" variable_2="v_Re12"/>
        <map_variables variable_1="v_Re13" variable_2="v_Re13"/>
        <map_variables variable_1="v_Re14" variable_2="v_Re14"/>
        <map_variables variable_1="v_Re15" variable_2="v_Re15"/>
        <map_variables variable_1="u_Na1_o" variable_2="u1"/>
        <map_variables variable_1="u_Na1_i" variable_2="u2"/>
        <map_variables variable_1="u_Na2_o" variable_2="u3"/>
        <map_variables variable_1="u_Na2_i" variable_2="u4"/>
        <map_variables variable_1="u_Na3_o" variable_2="u5"/>
        <map_variables variable_1="u_Na3_i" variable_2="u6"/>
        <map_variables variable_1="u_K1_o" variable_2="u7"/>
        <map_variables variable_1="u_K1_i" variable_2="u8"/>
        <map_variables variable_1="u_K2_o" variable_2="u9"/>
        <map_variables variable_1="u_K2_i" variable_2="u10"/>
        <map_variables variable_1="u_ATP" variable_2="u11"/>
        <map_variables variable_1="u_ADP" variable_2="u12"/>
        <map_variables variable_1="u_Pi" variable_2="u13"/>
        <map_variables variable_1="u_PE_o" variable_2="u14"/>
        <map_variables variable_1="u_PEK_o" variable_2="u15"/>
        <map_variables variable_1="u_PE2K_o" variable_2="u16"/>
        <map_variables variable_1="u_E2K_o" variable_2="u17"/>
        <map_variables variable_1="u_ATPE2K_o" variable_2="u18"/>
        <map_variables variable_1="u_ATPE2K_i" variable_2="u19"/>
        <map_variables variable_1="u_ATPEK_i" variable_2="u20"/>
        <map_variables variable_1="u_ATPE_i" variable_2="u21"/>
        <map_variables variable_1="u_ATPENa_i" variable_2="u22"/>
        <map_variables variable_1="u_ATPE2Na_i" variable_2="u23"/>
        <map_variables variable_1="u_ATPE3Na_i" variable_2="u24"/>
        <map_variables variable_1="u_PE3Na_i" variable_2="u25"/>
        <map_variables variable_1="u_PE3Na_o" variable_2="u26"/>
        <map_variables variable_1="u_PE2Na_o" variable_2="u27"/>
        <map_variables variable_1="u_PENa_o" variable_2="u28"/>
        <map_variables variable_1="u29" variable_2="u29"/>
        <map_variables variable_1="u30" variable_2="u30"/>
        <map_variables variable_1="u31" variable_2="u31"/>
        <map_variables variable_1="u32" variable_2="u32"/>
        <map_variables variable_1="u33" variable_2="u33"/>
        <map_variables variable_1="u34" variable_2="u34"/>
        <map_variables variable_1="u35" variable_2="u35"/>
        <map_variables variable_1="u36" variable_2="u36"/>
        <map_variables variable_1="u37" variable_2="u37"/>
        <map_variables variable_1="u38" variable_2="u38"/>
        <map_variables variable_1="u39" variable_2="u39"/>
        <map_variables variable_1="u40" variable_2="u40"/>
        <map_variables variable_1="u41" variable_2="u41"/>
    </connection>
    <!-- Mapping to the Parameters module-->
    <connection>
        <map_components component_1="param" component_2="state"/>
        <map_variables variable_1="K_Na1_o" variable_2="K_q1"/>
        <map_variables variable_1="K_Na1_i" variable_2="K_q2"/>
        <map_variables variable_1="K_Na2_o" variable_2="K_q3"/>
        <map_variables variable_1="K_Na2_i" variable_2="K_q4"/>
        <map_variables variable_1="K_Na3_o" variable_2="K_q5"/>
        <map_variables variable_1="K_Na3_i" variable_2="K_q6"/>
        <map_variables variable_1="K_K1_o" variable_2="K_q7"/>
        <map_variables variable_1="K_K1_i" variable_2="K_q8"/>
        <map_variables variable_1="K_K2_o" variable_2="K_q9"/>
        <map_variables variable_1="K_K2_i" variable_2="K_q10"/>
        <map_variables variable_1="K_ATP" variable_2="K_q11"/>
        <map_variables variable_1="K_ADP" variable_2="K_q12"/>
        <map_variables variable_1="K_Pi" variable_2="K_q13"/>
        <map_variables variable_1="K_PE_o" variable_2="K_q14"/>
        <map_variables variable_1="K_PEK_o" variable_2="K_q15"/>
        <map_variables variable_1="K_PE2K_o" variable_2="K_q16"/>
        <map_variables variable_1="K_E2K_o" variable_2="K_q17"/>
        <map_variables variable_1="K_ATPE2K_o" variable_2="K_q18"/>
        <map_variables variable_1="K_ATPE2K_i" variable_2="K_q19"/>
        <map_variables variable_1="K_ATPEK_i" variable_2="K_q20"/>
        <map_variables variable_1="K_ATPE_i" variable_2="K_q21"/>
        <map_variables variable_1="K_ATPENa_i" variable_2="K_q22"/>
        <map_variables variable_1="K_ATPE2Na_i" variable_2="K_q23"/>
        <map_variables variable_1="K_ATPE3Na_i" variable_2="K_q24"/>
        <map_variables variable_1="K_PE3Na_i" variable_2="K_q25"/>
        <map_variables variable_1="K_PE3Na_o" variable_2="K_q26"/>
        <map_variables variable_1="K_PE2Na_o" variable_2="K_q27"/>
        <map_variables variable_1="K_PENa_o" variable_2="K_q28"/>
        <map_variables variable_1="K_Re1" variable_2="K_Re1"/>
        <map_variables variable_1="K_Re2" variable_2="K_Re2"/>
        <map_variables variable_1="K_Re3" variable_2="K_Re3"/>
        <map_variables variable_1="K_Re4" variable_2="K_Re4"/>
        <map_variables variable_1="K_Re5" variable_2="K_Re5"/>
        <map_variables variable_1="K_Re6" variable_2="K_Re6"/>
        <map_variables variable_1="K_Re7" variable_2="K_Re7"/>
        <map_variables variable_1="K_Re8" variable_2="K_Re8"/>
        <map_variables variable_1="K_Re9" variable_2="K_Re9"/>
        <map_variables variable_1="K_Re10" variable_2="K_Re10"/>
        <map_variables variable_1="K_Re11" variable_2="K_Re11"/>
        <map_variables variable_1="K_Re12" variable_2="K_Re12"/>
        <map_variables variable_1="K_Re13" variable_2="K_Re13"/>
        <map_variables variable_1="K_Re14" variable_2="K_Re14"/>
        <map_variables variable_1="K_Re15" variable_2="K_Re15"/>
    </connection>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="module">
            <component_ref component="state"/>
            <component_ref component="param"/>
        </component_ref>
    </group>
</model>