https://staging.physiomeproject.org/workspace/3e0 en-us A simple model of pacemaking using ion transport at the neuronal membrane that would help to analyse the implied energy usage is presented. The model has been used to study the association between repetitive firing pattern of Substantia nigra neurons and cytosolic calcium. With the help of detailed mechanism to describe the functioning of pumps and exchangers at the membrane, this model is capable of describing energy expenditure of these neurons due to the activity at its membrane. The model can also be used to simulate the response of these neurons to channel blockers such as TTX and dihydropyridines.  The original reference is cited below: Francis F, Garcia MR, Middleton RH (2012) Energetics of ion transport in dopaminergic substantia nigra neurons. In: Wellstead P, Cloutier M, editors, Systems Biology of Parkinson's Disease, Springer New York. pp. 81-109 https://staging.physiomeproject.org/workspace/3e0/@@file/f8ea60406d407d11e087f33bf8501be26442d285 Added a SEDML file Mathieu Deneux 2016-08-12 https://staging.physiomeproject.org/workspace/3e0/@@file/39ee8962504e78d2fa7bf93b4631b41ca65bdff0 Merge Febey 2012-06-13 https://staging.physiomeproject.org/workspace/3e0/@@file/9ef475d7d158e9015336a1e098265089285d2ab1 Metadata included Febey 2012-06-13 https://staging.physiomeproject.org/workspace/3e0/@@file/1ef93822dad9aeb2cf312fb27ad1cbd711e4412c Added documentation file for exposure. Dougal Cowan 2012-06-13 https://staging.physiomeproject.org/workspace/3e0/@@file/029a31a0cc4dd7f7d1b325bb775033c829eb3af9 Figures added Febey 2012-05-30 https://staging.physiomeproject.org/workspace/3e0/@@file/0f43a6c093118581b5185066da7c11142eaa8770 Adding the cellml file Febey 2012-05-30