- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2017-05-29 20:00:33+12:00
- Desc:
-
investigating the units
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/483/rawfile/a0757dcd23f6b53b6dfcf5c35c62e38797903460/SI/Parameters.cellml
<?xml version='1.0'?>
<model name="Parameters" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="param1">
<!-- V_G: distribution volume of Glucose
V_I: distribution volume of Insulin
k_abs: rate of intestinal absorption
k_gri: rate of grinding
f: fraction of intestinal absorption appears in plasma
k_p1: extrapolated EGP at zero Glucose and Insulin
k_p2: liver Glucose effectiveness
k_p3: amplitude of Insulin action on liver
k_p4: amplitude of portal Insulin action on liver
k_i: delay between Insulin signal and Insulin action
U_ii: Glucose Insulin independent utilisation
p_2U: rate constant of Insulin action on the peripheral Glucose utilisation
K: pancreatic responsivity to Glucose rate of change
alpha: delay between Glucose signal & Insulin secretion
beta: pancreatic responsivity to Glucose
gamma: transfer rate constant between portalvein & liver
BW: body weight
D: ingested Glucose mass-->
<variable initial_value="0.000188" name="V_G" public_interface="out" units="m3_per_kg"/>
<variable initial_value="0.001083" name="k_1" public_interface="out" units="per_s"/>
<variable initial_value="0.001316" name="k_2" public_interface="out" units="per_s"/>
<variable initial_value="5e-5" name="V_I" public_interface="out" units="m3_per_kg"/>
<variable initial_value="0.00316" name="m_1" public_interface="out" units="per_s"/>
<variable initial_value="0.00806" name="m_2" public_interface="out" units="per_s"/>
<variable initial_value="0.0032" name="m_4" public_interface="out" units="per_s"/>
<variable initial_value="1824" name="m_5" public_interface="out" units="kg_s_per_mol"/>
<variable initial_value="0.6471" name="m_6" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6" name="HE_b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00093" name="k_max" public_interface="out" units="per_s"/>
<variable initial_value="0.00013" name="k_min" public_interface="out" units="per_s"/>
<variable initial_value="0.00095" name="k_abs" public_interface="out" units="per_s"/>
<variable initial_value="0.00093" name="k_gri" public_interface="out" units="per_s"/>
<variable initial_value="0.9" name="f" public_interface="out" units="dimensionless"/>
<variable initial_value="0.82" name="b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="d" public_interface="out" units="dimensionless"/>
<variable initial_value="4.5e-08" name="k_p1" public_interface="out" units="per_s"/>
<variable initial_value="3.5e-05" name="k_p2" public_interface="out" units="per_s"/>
<variable initial_value="0.15" name="k_p3" public_interface="out" units="m3_per_mol_s"/>
<variable initial_value="1030" name="k_p4" public_interface="out" units="kg_per_mol_s"/>
<variable initial_value="0.0001316" name="k_i" public_interface="out" units="per_s"/>
<variable initial_value="1.66e-8" name="U_ii" public_interface="out" units="per_s"/>
<variable initial_value="4.166e-8" name="V_m0" public_interface="out" units="per_s"/>
<variable initial_value="0.783" name="V_mX" public_interface="out" units="m3_per_mol_s"/>
<variable initial_value="0.0002256" name="K_m0" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0005516" name="p_2U" public_interface="out" units="per_s"/>
<variable initial_value="0.2" name="part" public_interface="out" units="dimensionless"/>
<variable initial_value="2.3e-10" name="K" public_interface="out" units="m3_mol_per_kg2"/>
<variable initial_value="0.00083" name="alpha" public_interface="out" units="per_s"/>
<variable initial_value="1.833e-13" name="beta" public_interface="out" units="m3_mol_per_kg2_s"/>
<variable initial_value="0.00833" name="gamma" public_interface="out" units="per_s"/>
<variable initial_value="78" name="BW" public_interface="out" units="kilogram"/>
<variable initial_value="0.078" name="D" public_interface="out" units="kilogram"/>
<variable initial_value="0.95" name="G_b" public_interface="out" units="kg_per_m3"/>
<variable initial_value="2.5e-8" name="I_b" public_interface="out" units="mol_per_m3"/>
<variable initial_value="3e-14" name="S_b" public_interface="out" units="mol_per_kg_s"/>
</component>
<component name="param2">
<variable initial_value="0.000161" name="k21" public_interface="out" units="per_s"/>
<variable initial_value="39.58295" name="k22" public_interface="out" units="per_s"/>
<variable initial_value="0.0019983" name="k23" public_interface="out" units="per_s"/>
<variable initial_value="0.0157183" name="k24" public_interface="out" units="per_s"/>
<variable initial_value="10.14306" name="k2b" public_interface="out" units="per_s"/>
<variable initial_value="0.135198" name="k3f" public_interface="out" units="per_s"/>
<variable initial_value="0.003158" name="k3b" public_interface="out" units="per_s"/>
<variable initial_value="6414.76146" name="k4f" public_interface="out" units="per_s"/>
<variable initial_value="468.951166" name="k4b" public_interface="out" units="per_s"/>
<variable initial_value="1071.66785" name="k5f" public_interface="out" units="per_s"/>
<variable initial_value="167.541806" name="k5b" public_interface="out" units="per_s"/>
<variable initial_value="268236.6965" name="k6f" public_interface="out" units="per_s"/>
<variable initial_value="1.2961868" name="k6b" public_interface="out" units="per_s"/>
<variable initial_value="69.577166" name="k7f" public_interface="out" units="per_s"/>
<variable initial_value="9422.36936" name="k7b" public_interface="out" units="per_s"/>
<variable initial_value="25262.707" name="k8f" public_interface="out" units="per_s"/>
<variable initial_value="5.0125166" name="k8b" public_interface="out" units="per_s"/>
<variable initial_value="1.3566e-09" name="k91" public_interface="out" units="per_s"/>
<variable initial_value="0.0004683" name="k92" public_interface="out" units="per_s"/>
<variable initial_value="0.0671626" name="k9b" public_interface="out" units="per_s"/>
<variable initial_value="3.9e-10" name="k5BasicWb" public_interface="out" units="per_s"/>
<variable initial_value="4.9433e-9" name="k_glut1" public_interface="out" units="per_s"/>
<variable initial_value="5.2366e-7" name="k_glut4" public_interface="out" units="per_s"/>
<variable initial_value="0.00013277" name="KmG1" public_interface="out" units="dimensionless"/>
<variable initial_value="7.04032e-5" name="KmG4" public_interface="out" units="dimensionless"/>
<variable initial_value="5.2e-5" name="kbf" public_interface="out" units="m3_per_mol_s"/>
</component>
<component name="param3">
<variable initial_value="7470.86" name="a1" public_interface="out" units="m3_per_mol_s"/>
<variable initial_value="72.03" name="a2" public_interface="out" units="m3_per_mol_s"/>
<variable initial_value="0.0129" name="d1" public_interface="out" units="per_s"/>
<variable initial_value="0.0002" name="d2" public_interface="out" units="per_s"/>
<variable initial_value="2.273e-5" name="K_cr" public_interface="out" units="per_s"/>
<variable initial_value="0.618" name="K_ex" public_interface="out" units="per_s"/>
<variable initial_value="0.5114" name="K_end" public_interface="out" units="per_s"/>
<variable initial_value="1.583e-5" name="K_dp" public_interface="out" units="per_s"/>
<variable initial_value="3.959" name="K_cat" public_interface="out" units="per_s"/>
<variable initial_value="0.0503" name="K_m" public_interface="out" units="per_s"/>
<variable initial_value="0.0083" name="kfbasal" public_interface="out" units="per_s"/>
<variable initial_value="2134.05" name="krbasal" public_interface="out" units="per_s"/>
<variable initial_value="0.0233" name="K4" public_interface="out" units="m3_per_mol_s"/>
<variable initial_value="0.000167" name="K8" public_interface="out" units="per_s"/>
</component>
</model>
