- Author:
- aram148 <42922407+aram148@users.noreply.github.com>
- Date:
- 2020-11-12 19:37:18+13:00
- Desc:
- Added semantic annotations
Added semantic annotations using semgen V 4.2.3
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/486/rawfile/5038f17afed04818c655ffbced375515d6d29855/README.rtf
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README\
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HumanSAN_Fabbri_Fantini_Wilders_Severi_2017.cellml\
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This is the source code for the sino-atrial node (SAN) action potential (AP) mathematical model presented in :\
\
\'93Computational analysis of the human sinus node action potential: model development and effects of mutations\'94\
Fabbri A., Fantini M., Wilders R., Severi S.\
\
The model can be run directly on COR [1] (for Windows Only)/OpenCOR [2] (for all platforms \expnd0\expndtw0\kerning0
Windows/Mac/Linux) or can be automatically exported in other computational languages (matlab, c, java, python, etc.) through tools provided by COR/OpenCoR.\
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********************************************************************************************************************************\
Running simulations in OpenCOR :\
\
Seconds are the OpenCOR default time unit.\
To run a simulation set the \'93Point interval\'94 value to 0.001 s (but you can chose also lower values) ,\
otherwise a \'93at t = xxxx, mxstep steps taken before reaching out\'94 will occur. \
********************************************************************************************************************************\
\
For more details don\'92t hesitate to contact us: \
\
Alan Fabbri : alan.fabbri3@unibo.it\
Stefano Severi : stefano.severi@unibo.it \
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References for COR/OpenCOR\
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[1] Garny A, Noble D, Hunter PJ & Kohl P (2009).\
Cellular Open Resource (COR): current status and future directions. \
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\i \cf0 Philos Trans R Soc Lond Math Phys Eng Sci
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\b 367,
\b0 1885\'961905.\
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[2] \cf0 \kerning1\expnd0\expndtw0 Garny A & Hunter PJ (2015). \
OpenCOR: a modular and interoperable approach to computational biology. \
\i Front Physiol
\i0 ; DOI: 10.3389/fphys.2015.00026.\
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Web sources \
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OpenCOR is downloadable from:\
\
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{\field{\*\fldinst{HYPERLINK "http://opencor.ws/downloads/index.html"}}{\fldrslt \cf0 http://opencor.ws}} (home page) \
{\field{\*\fldinst{HYPERLINK "http://opencor.ws/downloads/index.html"}}{\fldrslt http://opencor.ws/downloads/index.html}} (downloads)\
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Cite us\
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\f1 \cf0 Fabbri A, Fantini M, Wilders R & Severi S (2017). Computational analysis of the human sinus node action potential: model development and effects of mutations.
\i J Physiol
\i0
\b 595,
\b0 2365\'962396.\
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