- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2019-04-05 14:25:01+13:00
- Desc:
- Added some semgen annotated models (AnandR)
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/584/rawfile/ade7933153a72bb89e0b02d75db92d6e4be285f5/semgen_annotated_models/owl/Yang_2006.owl
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<title>An Age-Dependent Physiologically Based Pharmokinetic Model of Methadone Distribution and Metabolism</title>
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<title>Model Status</title>
<para>This CellML version of the model has been checked in COR and PCEnv. It will recreate published results, although it only models a single organ (the liver) as well as the veins and arteries, and is based on a 5 year old boy. The model cannot replicate the population analysis described in the paper, which needs stochastic tools that are unavailable to CellML at present.</para>
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<para>Abstract: Limited pharmacokinetic (PK) and pharmacodynamic (PD) data are available to use in methadone dosing recommendations in pediatric patients for either opioid abstinence or analgesia. Considering the extreme inter-individual variability of absorption and metabolism of methadone, population-based PK would be useful to provide insight into the relationship between dose, blood concentrations, and clinical effects of methadone. To address this need, an age-dependent physiologically based pharmacokinetic (PBPK) model has been constructed to systematically study methadone metabolism and PK. The model will facilitate the design of cost-effective studies that will evaluate methadone PK and PD relationships, and may be useful to guide methadone dosing in children. The PBPK model, which includes whole-body multi-organ distribution, plasma protein binding, metabolism, and clearance, is parameterized based on a database of pediatric PK parameters and data collected from clinical experiments. The model is further tailored and verified based on PK data from individual adults, then scaled appropriately to apply to children aged 0-24 months. Based on measured variability in CYP3A enzyme expression levels and plasma orosomucoid (ORM2) concentrations, a Monte-Carlo-based simulation of methadone kinetics in a pediatric population was performed. The simulation predicts extreme variability in plasma concentrations and clearance kinetics for methadone in the pediatric population, based on standard dosing protocols. In addition, it is shown that when doses are designed for individuals based on prior protein expression information, inter-individual variability in methadone kinetics may be greatly reduced.</para>
<para>The complete original paper reference is cited below:</para>
<para>
Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model, Feng Yang, Xianping Tong, D. Gail. McCarver, Ronald N. Hines and Daniel A. Beard, 2006,
<emphasis>Journal of Pharmacokinetics and Pharmacodynamics</emphasis>
, volume 33, issue 4.
<ulink url="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&amp;Cmd=ShowDetailView&amp;TermToSearch=16758333&amp;ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">PubMed ID: 16758333</ulink>
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Schematic diagram of a PBPK model consisting of 17 compartments. The lines represent blood flow while the boxes represent organs or systems. Methadone is primarily metabolised in the liver and gastro-intestinal (GI) system, while its elimination mainly occurs through the kidneys. Organs in which methadone are not distributed include skin, adipose, thyroid, pancreas, and bone marrow are grouped together as
<emphasis>others</emphasis>
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<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_process"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
</owl:unionOf>
</owl:Class>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasInput -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasInput">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasMediator -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasMediator"/>
<!-- http://www.bhi.washington.edu/SemSim#hasOutput -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasOutput">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasParticipant -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasParticipant">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_process"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasPhysicalProperty -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasPhysicalProperty">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#physicalPropertyOf"/>
<rdfs:domain>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_process"/>
</owl:unionOf>
</owl:Class>
</rdfs:domain>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasRolePlayer -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasRolePlayer">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasSink -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasSink"/>
<!-- http://www.bhi.washington.edu/SemSim#hasSolutionDomain -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasSolutionDomain">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasSource -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasSource"/>
<!-- http://www.bhi.washington.edu/SemSim#hasUnit -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasUnit">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasUnitFactor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<!-- http://www.bhi.washington.edu/SemSim#isComputationalComponentFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#isComputationalComponentFor">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<rdfs:range>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_property"/>
</owl:unionOf>
</owl:Class>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#isDeterminedBy -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#isDeterminedBy">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#determines"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#isIndexEntityFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#isIndexEntityFor">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasIndexEntity"/>
<rdfs:domain>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_process"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
</owl:unionOf>
</owl:Class>
</rdfs:domain>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#isInputFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#isInputFor">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasInput"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#isOutputFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#isOutputFor">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasOutput"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#mappedTo -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#mappedTo"/>
<!-- http://www.bhi.washington.edu/SemSim#physicalPropertyOf -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#physicalPropertyOf">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<rdfs:range>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim#Physical_process"/>
</owl:unionOf>
</owl:Class>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#rolePlayerIn -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#rolePlayerIn">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasRolePlayer"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#solutionDomainFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#solutionDomainFor">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasSolutionDomain"/>
</owl:ObjectProperty>
<!-- http://www.bhi.washington.edu/SemSim#unitFactorFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#unitFactorFor"/>
<!-- http://www.bhi.washington.edu/SemSim#unitFor -->
<owl:ObjectProperty rdf:about="http://www.bhi.washington.edu/SemSim#unitFor">
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<owl:inverseOf rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnit"/>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#contained_in -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#contained_in">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<owl:inverseOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#contains"/>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#contains -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#contains">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#has_part -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#has_part">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
</owl:ObjectProperty>
<!-- http://www.obofoundry.org/ro/ro.owl#part_of -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#part_of">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:range rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<owl:inverseOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#has_part"/>
</owl:ObjectProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Data properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://www.bhi.washington.edu/SemSim#hasCellMLpublicInterface -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasCellMLpublicInterface"/>
<!-- http://www.bhi.washington.edu/SemSim#hasComputationalCode -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasComputationalCode">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasCustomDeclaration -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasCustomDeclaration">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#hasMathML -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasMathML"/>
<!-- http://www.bhi.washington.edu/SemSim#hasStartValue -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#hasStartValue">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#importedFrom -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#importedFrom">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#isDeclared -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#isDeclared">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#boolean"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#isDiscrete -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#isDiscrete">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#boolean"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#isFundamentalUnit -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#isFundamentalUnit">
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#boolean"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#isSolutionDomain -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#isSolutionDomain">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:domain rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#boolean"/>
</owl:DatatypeProperty>
<!-- http://www.bhi.washington.edu/SemSim#metadataID -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#metadataID"/>
<!-- http://www.bhi.washington.edu/SemSim#name -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#name"/>
<!-- http://www.bhi.washington.edu/SemSim#refersTo -->
<owl:DatatypeProperty rdf:about="http://www.bhi.washington.edu/SemSim#refersTo">
<rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
<rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#string"/>
</owl:DatatypeProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://bhi.washington.edu/OPB#OPB_00040 -->
<owl:Class rdf:about="http://bhi.washington.edu/OPB#OPB_00040">
<rdfs:label xml:lang="en">Total volume of shape</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_property"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00040</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://bhi.washington.edu/OPB#OPB_00154 -->
<owl:Class rdf:about="http://bhi.washington.edu/OPB#OPB_00154">
<rdfs:label xml:lang="en">Fluid volume</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_property"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00154</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://bhi.washington.edu/OPB#OPB_00340 -->
<owl:Class rdf:about="http://bhi.washington.edu/OPB#OPB_00340">
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_property"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://bhi.washington.edu/OPB#OPB_00593 -->
<owl:Class rdf:about="http://bhi.washington.edu/OPB#OPB_00593">
<rdfs:label xml:lang="en">Chemical concentration flow rate</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_property"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00593</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_6807 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_6807">
<rdfs:label xml:lang="en">methadone</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_6807</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_80645 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_80645">
<rdfs:label xml:lang="en">2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_80645</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/CHEBI_80646 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_80646">
<rdfs:label xml:lang="en">2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_80646</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.org/sig/ont/fma/fma62970 -->
<owl:Class rdf:about="http://purl.org/sig/ont/fma/fma62970">
<rdfs:label xml:lang="en">Portion of plasma</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/sig/ont/fma/fma62970</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.org/sig/ont/fma/fma67498 -->
<owl:Class rdf:about="http://purl.org/sig/ont/fma/fma67498">
<rdfs:label xml:lang="en">Organ</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/sig/ont/fma/fma67498</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.org/sig/ont/fma/fma83066 -->
<owl:Class rdf:about="http://purl.org/sig/ont/fma/fma83066">
<rdfs:label xml:lang="en">Portion of arterial blood</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/sig/ont/fma/fma83066</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.org/sig/ont/fma/fma83067 -->
<owl:Class rdf:about="http://purl.org/sig/ont/fma/fma83067">
<rdfs:label xml:lang="en">Portion of venous blood</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/sig/ont/fma/fma83067</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.org/sig/ont/fma/fma9670 -->
<owl:Class rdf:about="http://purl.org/sig/ont/fma/fma9670">
<rdfs:label xml:lang="en">Portion of blood</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bhi.washington.edu/SemSim#refersTo"/>
<owl:hasValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.org/sig/ont/fma/fma9670</owl:hasValue>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Composite_physical_entity -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Composite_physical_entity">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_entity"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical entity that is defined by linking multiple physical entity terms with structural relations.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Computation -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Computation">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mathematical and/or logical expression that determines the value of a data structure.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Computational_model_component -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Computational_model_component">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#SemSim_component"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Custom_physical_dependency -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_dependency">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_dependency"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical dependency defined in a specific SemSim model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Custom_physical_entity -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_entity">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical entity defined in a specific SemSim model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Custom_physical_process -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_process">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_process"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical process defined in a specific SemSim model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Custom_physical_property -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Custom_physical_property">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Reference_physical_property"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical property defined in a specific SemSim model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Data_structure -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Data_structure">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A computational element that stores numerical and/or logical information related to the model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Decimal -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Decimal">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Real"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Integer"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data structure whose value is limited to decimals.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Integer -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Integer">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Real"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data structure whose value is limited to the whole numbers.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#MMLchoice -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#MMLchoice">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Real"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Physical_dependency -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Physical_dependency">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_process"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Physical_entity -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Physical_entity">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_process"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Physical_model_component -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Physical_model_component">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#SemSim_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element. </rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Physical_process -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Physical_process">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<owl:disjointWith rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Physical_property -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Physical_property">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Real -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Real">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Data_structure"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data structure whose value is limited to the real numbers.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Reference_physical_dependency -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_dependency">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_dependency"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical dependency that is defined using a term in an external knowledge resource.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Reference_physical_entity -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_entity">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_entity"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical entity that is defined using a term from an external knowledge resource.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Reference_physical_process -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_process">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_process"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical process that is defined using a term in an external knowledge resource.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Reference_physical_property -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Reference_physical_property">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical property that is defined using a term in an external knowledge resource.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Relational_constraint -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Relational_constraint">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#SemSim_component -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#SemSim_component">
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A computational or physical element of a SemSim model.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Submodel -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Submodel">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel.</rdfs:comment>
</owl:Class>
<!-- http://www.bhi.washington.edu/SemSim#Unit_of_measurement -->
<owl:Class rdf:about="http://www.bhi.washington.edu/SemSim#Unit_of_measurement">
<rdfs:subClassOf rdf:resource="http://www.bhi.washington.edu/SemSim#Computational_model_component"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical quantity chosen as a standard in terms of which other physical quantities may be expressed.</rdfs:comment>
</owl:Class>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Individuals
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<SemSim:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">B</SemSim:name>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B_computation"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">B_B</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Bound concentration of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B_property"/>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Arterial blood concentration of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_1"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0.48</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">B_F</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Free methadone concentration in plasma</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F_property"/>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0.8532</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">B_K2</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Binding Constant</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_per_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.K2"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">B_n2</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Number of non-competitive binding sites on the protein molecule</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.n2"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B_computation -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B_computation">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<SemSim:hasMathML rdf:datatype="http://www.w3.org/2001/XMLSchema#string"><math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>B</ci>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>n2</ci>
<ci>K2</ci>
<ci>Cp</ci>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>K2</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</math></SemSim:hasMathML>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_0">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<rdfs:label xml:lang="en">Bound Methadone</rdfs:label>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B_property"/>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_part_of_fma62970_part_of_fma9670"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B_property"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma62970_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_part_of_fma62970_part_of_fma9670 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_part_of_fma62970_part_of_fma9670">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<SemSim:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C</SemSim:name>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C_computation"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C_C</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Total methadone concentration in the organ's metabolizing tissue</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C_property"/>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C"/>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Arterial blood concentration of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_1"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Partition coefficient of organ</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.P"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Volumetric blood flow of organ</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Metabolic rate of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00593"/>
<rdfs:label xml:lang="en">Chemical concentration flow rate</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00593</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1454</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">C_V</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Volume of organ</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00040"/>
<rdfs:label xml:lang="en">Total volume of shape</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00040</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma67498_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Time domain</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdfs:label xml:lang="en">methadone</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_6807</SemSim:refersTo>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C_property"/>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_Metabolizing_Tissue_of_Organ"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C_property"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolizing_Tissue_of_Organ_0"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_1 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_1">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdfs:label xml:lang="en">methadone</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_6807</SemSim:refersTo>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83067"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv_property"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv_property"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma83067_0"/>
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<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_2 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_2">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdfs:label xml:lang="en">methadone</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_6807</SemSim:refersTo>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83066"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca_property"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma83066_0"/>
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<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_Metabolizing_Tissue_of_Organ -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_Metabolizing_Tissue_of_Organ">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
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</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83066 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83066">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
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</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83067 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_part_of_fma83067">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_1"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_80645"/>
<rdfs:label xml:lang="en">2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_80645</SemSim:refersTo>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_part_of_Metabolizing_Tissue_of_Organ"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolizing_Tissue_of_Organ_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_part_of_Metabolizing_Tissue_of_Organ -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_part_of_Metabolizing_Tissue_of_Organ">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_80646"/>
<rdfs:label xml:lang="en">2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://purl.obolibrary.org/obo/CHEBI_80646</SemSim:refersTo>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_part_of_Metabolizing_Tissue_of_Organ"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolizing_Tissue_of_Organ_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_part_of_Metabolizing_Tissue_of_Organ -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_part_of_Metabolizing_Tissue_of_Organ">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C_computation -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C_computation">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<SemSim:hasMathML rdf:datatype="http://www.w3.org/2001/XMLSchema#string"><math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<times />
<ci>Q</ci>
<apply>
<minus />
<ci>Ca</ci>
<apply>
<divide />
<ci>C</ci>
<ci>P</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>R</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ml">1</cn>
</apply>
</apply>
<ci>V</ci>
</apply>
</apply>
</math></SemSim:hasMathML>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<SemSim:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ca</SemSim:name>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca_computation"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6.6685</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ca_Ca</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Arterial blood concentration of methadone</rdfs:comment>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp"/>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca"/>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_2"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Mixed venous concentration of drug</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_1"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Total cardiac output</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2148</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ca_Va</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Arterial blood volume</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00154"/>
<rdfs:label xml:lang="en">Fluid volume</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00154</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma83066_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">3431</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ca_Vv</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Venous blood volume</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00154"/>
<rdfs:label xml:lang="en">Fluid volume</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00154</SemSim:refersTo>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv"/>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma83067_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Time domain</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca_computation -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca_computation">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<SemSim:hasMathML rdf:datatype="http://www.w3.org/2001/XMLSchema#string"><math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>Qc</ci>
<apply>
<minus />
<ci>Cv</ci>
<ci>Ca</ci>
</apply>
</apply>
<apply>
<plus />
<ci>Va</ci>
<ci>Vv</ci>
</apply>
</apply>
</apply>
</math></SemSim:hasMathML>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<SemSim:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cv</SemSim:name>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv_computation"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Total methadone concentration in the organ's metabolizing tissue</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cv_Cv</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Mixed venous concentration of drug</rdfs:comment>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv"/>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_1"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Partition coefficient of organ</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.P"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Volumetric blood flow of organ</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Total cardiac output</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv_computation -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv_computation">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<SemSim:hasMathML rdf:datatype="http://www.w3.org/2001/XMLSchema#string"><math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Cv</ci>
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<ci>Q</ci>
<ci>C</ci>
</apply>
<ci>P</ci>
</apply>
<ci>Qc</ci>
</apply>
</apply>
</math></SemSim:hasMathML>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_0">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<rdfs:label xml:lang="en">Free Methadone</rdfs:label>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F_property"/>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma62970"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F_property"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma62970_1"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_1 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_1">
<rdf:type rdf:resource="http://purl.obolibrary.org/obo/CHEBI_6807"/>
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<rdfs:label xml:lang="en">Free Methadone</rdfs:label>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp_property"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca_property"/>
<SemSim:isIndexEntityFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma83066"/>
<ro:part_of rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma83066_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma62970 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma62970">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma83066 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_part_of_fma83066">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Composite_physical_entity"/>
<SemSim:hasIndexEntity rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_1"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_process"/>
<rdfs:label xml:lang="en">Metabolism of Methadone in Organ</rdfs:label>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R_property"/>
<SemSim:hasSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
<SemSim:hasSink rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0"/>
<SemSim:hasSink rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0"/>
<SemSim:hasPhysicalProperty rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R_property"/>
<SemSim:hasMediator rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma67498_0"/>
</owl:NamedIndividual>
<owl:Axiom>
<SemSim:hasMultiplier rdf:datatype="http://www.w3.org/2001/XMLSchema#double">1.0</SemSim:hasMultiplier>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasSource"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
</owl:Axiom>
<owl:Axiom>
<SemSim:hasMultiplier rdf:datatype="http://www.w3.org/2001/XMLSchema#double">1.0</SemSim:hasMultiplier>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasSink"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
</owl:Axiom>
<owl:Axiom>
<SemSim:hasMultiplier rdf:datatype="http://www.w3.org/2001/XMLSchema#double">1.0</SemSim:hasMultiplier>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasSink"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
</owl:Axiom>
<owl:Axiom>
<SemSim:hasMultiplier rdf:datatype="http://www.w3.org/2001/XMLSchema#double">1.0</SemSim:hasMultiplier>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasMediator"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#fma67498_0"/>
</owl:Axiom>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolizing_Tissue_of_Organ_0 -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolizing_Tissue_of_Organ_0">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Custom_physical_entity"/>
<rdfs:label xml:lang="en">Metabolizing Tissue of Organ</rdfs:label>
<ro:has_part rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
<ro:has_part rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80645_0"/>
<ro:has_part rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_80646_0"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Submodel"/>
<SemSim:name rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R</SemSim:name>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age"/>
<SemSim:hasAssociatedDataStructure rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R_computation"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Bound concentration of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Bound_Methadone_0"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Total methadone concentration in the organ's metabolizing tissue</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#CHEBI_6807_0"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Free methadone concentration in plasma</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00340"/>
<rdfs:label xml:lang="en">Chemical concentration</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00340</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Free_Methadone_0"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_ISF</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Scaling factor for scaling adult Vmax to infant Vmax</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.ISF"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">198</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_Km</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Michaelis-Menten constant</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_R</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:hasCellMLpublicInterface rdf:datatype="http://www.w3.org/2001/XMLSchema#string">out</SemSim:hasCellMLpublicInterface>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Metabolic rate of methadone</rdfs:comment>
<SemSim:mappedTo rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R"/>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R_property">
<rdf:type rdf:resource="http://bhi.washington.edu/OPB#OPB_00593"/>
<rdfs:label xml:lang="en">Chemical concentration flow rate</rdfs:label>
<SemSim:refersTo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://bhi.washington.edu/OPB#OPB_00593</SemSim:refersTo>
<SemSim:physicalPropertyOf rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Metabolism_of_Methadone_in_Organ"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9.433e-3</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_Vmax</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Michaelis-Menten constant</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax_property"/>
<SemSim:hasUnit rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:hasStartValue rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5</SemSim:hasStartValue>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_age</SemSim:metadataID>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.age"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Decimal"/>
<SemSim:metadataID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">R_fu</SemSim:metadataID>
<SemSim:isDiscrete rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isDiscrete>
<SemSim:isSolutionDomain rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</SemSim:isSolutionDomain>
<SemSim:isDeclared rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isDeclared>
<rdfs:comment xml:lang="en">Unbound fraction of methadone</rdfs:comment>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu_property"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu_property -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu_property">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Physical_property"/>
<SemSim:hasComputationalComponent rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.fu"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R_computation -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R_computation">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Computation"/>
<SemSim:hasMathML rdf:datatype="http://www.w3.org/2001/XMLSchema#string"><math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R</ci>
<apply>
<divide />
<apply>
<times />
<ci>ISF</ci>
<ci>Vmax</ci>
<ci>fu</ci>
<ci>C</ci>
</apply>
<apply>
<plus />
<ci>Km</ci>
<apply>
<times />
<ci>fu</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>fu</ci>
<apply>
<divide />
<ci>F</ci>
<apply>
<plus />
<ci>F</ci>
<ci>B</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>ISF</ci>
<apply>
<plus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8.3212</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0401</cn>
<ci>age</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.1962</cn>
<apply>
<log />
<apply>
<times />
<ci>age</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">365</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math></SemSim:hasMathML>
<SemSim:isComputationalComponentFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">flow</SemSim:hasComputationalCode>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Q"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Qc"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Q"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Qc"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#model_constants.Q"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#model_constants.Qc"/>
</owl:NamedIndividual>
<owl:Axiom>
<SemSim:hasUnitFactorPrefix rdf:datatype="http://www.w3.org/2001/XMLSchema#string">milli</SemSim:hasUnitFactorPrefix>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
</owl:Axiom>
<owl:Axiom>
<SemSim:hasUnitFactorExponent rdf:datatype="http://www.w3.org/2001/XMLSchema#double">-1.0</SemSim:hasUnitFactorExponent>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
</owl:Axiom>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">flux</SemSim:hasComputationalCode>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.R"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.R"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Vmax"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
</owl:NamedIndividual>
<owl:Axiom>
<SemSim:hasUnitFactorExponent rdf:datatype="http://www.w3.org/2001/XMLSchema#double">-1.0</SemSim:hasUnitFactorExponent>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute"/>
</owl:Axiom>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">litre</SemSim:hasComputationalCode>
<SemSim:isFundamentalUnit rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</SemSim:isFundamentalUnit>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">micromolar</SemSim:hasComputationalCode>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.B"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.Cp"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#B.F"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.C"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.Ca"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Ca"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Cv"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.C"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Cv.Cv"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.B"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.C"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.F"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#R.Km"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_mole"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_per_micromolar"/>
</owl:NamedIndividual>
<owl:Axiom>
<SemSim:hasUnitFactorExponent rdf:datatype="http://www.w3.org/2001/XMLSchema#double">-1.0</SemSim:hasUnitFactorExponent>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:Axiom>
<owl:Axiom>
<SemSim:hasUnitFactorPrefix rdf:datatype="http://www.w3.org/2001/XMLSchema#string">micro</SemSim:hasUnitFactorPrefix>
<owl:annotatedProperty rdf:resource="http://www.bhi.washington.edu/SemSim#hasUnitFactor"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_mole"/>
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<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_minute">
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<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">minute</SemSim:hasComputationalCode>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.time"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.time"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flow"/>
<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_flux"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_second"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#environment.time"/>
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<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
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<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#C.V"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Va"/>
<SemSim:unitFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#Ca.Vv"/>
<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
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<owl:Axiom>
<SemSim:hasUnitFactorPrefix rdf:datatype="http://www.w3.org/2001/XMLSchema#string">milli</SemSim:hasUnitFactorPrefix>
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<owl:annotatedTarget rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_litre"/>
<owl:annotatedSource rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_ml"/>
</owl:Axiom>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_mole -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_mole">
<rdf:type rdf:resource="http://www.bhi.washington.edu/SemSim#Unit_of_measurement"/>
<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mole</SemSim:hasComputationalCode>
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<SemSim:unitFactorFor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
</owl:NamedIndividual>
<!-- http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_per_micromolar -->
<owl:NamedIndividual rdf:about="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_per_micromolar">
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<SemSim:hasComputationalCode rdf:datatype="http://www.w3.org/2001/XMLSchema#string">per_micromolar</SemSim:hasComputationalCode>
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<SemSim:hasUnitFactor rdf:resource="http://www.bhi.washington.edu/SemSim/23032015175934459m0500#UNIT_micromolar"/>
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