/Users/Brian/Desktop/iyer_mazhari_winslow_2004/iyer_mazhari_winslow_2004.cellml 0.2 <documentation xmlns="http://cellml.org/tmp-documentation"> <article> <articleinfo> <title>A computational model of the human left-ventricular epicardial myocyte</title> <author> <firstname>Steven</firstname> <surname>Niederer</surname> <affiliation> <shortaffil>Department of Physiology, Anatomy and Genetics, Oxford University</shortaffil> </affiliation> </author> </articleinfo> <section id="sec_status"> <title>Model Status</title> <para>This CellML model runs in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.</para> </section> <sect1 id="sec_structure"> <title>Model Structure</title> <para>ABSTRACT: A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.</para> <para>The original paper reference is cited below:</para> <para> A computational model of the human left-ventricular epicardial myocyte, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <emphasis>Biophysical Journal</emphasis> , 87, 1507-1525. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15345532">PubMed ID: 15345532</ulink> </para> <informalfigure float="0" id="fig_cell_diagram"> <mediaobject> <imageobject> <objectinfo> <title>cell diagram</title> </objectinfo> <imagedata fileref="iyer_2004.png" /> </imageobject> </mediaobject> <caption> A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis>et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte. </caption> </informalfigure> </sect1> </article> </documentation> <rdf:RDF xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:j.0="http://www.cellml.org/bqs/1.0#" xmlns:j.1="http://imc.org/vCard/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:j.2="http://purl.org/dc/terms/" xmlns:j.3="http://www.cellml.org/metadata/simulation/1.0#"> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0"> <cmeta:comment> <rdf:Description rdf:about="rdf:#53666f83-74be-4367-9ba3-e61ab647f708"> <dc:creator> <rdf:Description rdf:about="rdf:#9890a7cd-bd6f-4777-ba26-94a1c3516a62"> <FN xml:lang="en">James Lawson</FN> </rdf:Description> </dc:creator> <rdf:value xml:lang="en">This model is known to run in PCEnv 0.2 and COR and reproduces the published results. This version has been recoded by Steven Niederer and is more accurate than the previous version, but runs slower.</rdf:value> </rdf:Description> </cmeta:comment> <j.2:created> <rdf:Description rdf:about="rdf:#fc29216f-f933-4395-86ad-af87caeea93e"> <j.2:W3CDTF xml:lang="en">2007-09-11T00:00:00+00:00</j.2:W3CDTF> </rdf:Description> </j.2:created> <dc:publisher xml:lang="en">Oxford University</dc:publisher> <dc:creator> <rdf:Description rdf:about="rdf:#98283e59-0d44-4f9e-aef9-9edee42ce3e7"> <ORG> <rdf:Description rdf:about="rdf:#240869d5-d2e7-4918-b218-a10f5f2a49c0"> <Orgunit xml:lang="en">Dept of Physiology, Anatomy &amp; Genetics</Orgunit> <Orgname xml:lang="en">Oxford University</Orgname> </rdf:Description> </ORG> <EMAIL> <j.1:internet rdf:about="rdf:#a9ab6f8f-e029-4e60-8241-15b9316961f1"> <rdf:value xml:lang="en">sn@dpag.ox.ac.uk</rdf:value> </j.1:internet> </EMAIL> <N> <rdf:Description rdf:about="rdf:#b2b64ab3-337e-4460-b879-2fc16448db9e"> <Other xml:lang="en"></Other> <Given xml:lang="en">Steven</Given> <Family xml:lang="en">Niederer</Family> </rdf:Description> </N> </rdf:Description> </dc:creator> </rdf:Description> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#iyer_2004"> <j.3:simulation> <rdf:Description rdf:about="rdf:#$vhGBC2"> <j.3:boundIntervals> <rdf:Description rdf:about="rdf:#$whGBC2"> <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/> <rdf:first> <rdf:Description rdf:about="rdf:#$xhGBC2"> <j.3:nonstandard-pointDensity xml:lang="en">10000</j.3:nonstandard-pointDensity> <j.3:endingValue xml:lang="en">5000</j.3:endingValue> <j.3:nonstandard-algorithm xml:lang="en">bdf15</j.3:nonstandard-algorithm> </rdf:Description> </rdf:first> </rdf:Description> </j.3:boundIntervals> </rdf:Description> </j.3:simulation> <j.0:reference> <rdf:Description rdf:about="rdf:#192d07ed-67a8-4279-8c15-f81eb1d183ee"> <j.0:JournalArticle> <rdf:Description rdf:about="rdf:#6c3f5e45-cb7a-458d-b7fd-b69f5918bee1"> <j.0:Journal> <rdf:Description rdf:about="rdf:#ef6b366c-a1f4-465a-b261-834b05b14571"> <dc:title xml:lang="en">Biophysical Journal</dc:title> </rdf:Description> </j.0:Journal> <j.0:last_page xml:lang="en">1525</j.0:last_page> <j.0:first_page xml:lang="en">1507</j.0:first_page> <j.2:issued> <rdf:Description rdf:about="rdf:#b8cc8eac-7587-4657-accb-cb3ae8ff0976"> <j.2:W3CDTF xml:lang="en">2004-09-00 00:00</j.2:W3CDTF> </rdf:Description> </j.2:issued> <dc:title xml:lang="en">A computational model of the human left-ventricular epicardial myocyte</dc:title> <dc:creator> <rdf:Seq rdf:about="rdf:#0746c562-31fc-4b36-87d5-fa1c50fa84c3"> <rdf:li> <j.0:Person rdf:about="rdf:#87301142-03b1-46cc-93e5-9146a7272163"> <N> <rdf:Description rdf:about="rdf:#1281d5b9-4562-4c97-b2e9-9c30fcd6f310"> <Given xml:lang="en">V</Given> <Family xml:lang="en">Iyer</Family> </rdf:Description> </N> </j.0:Person> </rdf:li> <rdf:li> <j.0:Person rdf:about="rdf:#6a9b6c17-ec4c-4c47-91c1-a8fa632be6db"> <N> <rdf:Description rdf:about="rdf:#9cede4cc-268a-40cf-a26b-0196da9da6f3"> <Given xml:lang="en">R</Given> <Family xml:lang="en">Mazhari</Family> </rdf:Description> </N> </j.0:Person> </rdf:li> <rdf:li> <j.0:Person rdf:about="rdf:#3107eb69-84ad-4ad3-aead-e7325d54ac65"> <N> <rdf:Description rdf:about="rdf:#243b0e77-7c3a-4a09-8370-4a35e254c30c"> <Other xml:lang="en">L</Other> <Given xml:lang="en">R</Given> <Family xml:lang="en">Winslow</Family> </rdf:Description> </N> </j.0:Person> </rdf:li> </rdf:Seq> </dc:creator> <j.0:volume xml:lang="en">87(3)</j.0:volume> </rdf:Description> </j.0:JournalArticle> <j.0:Pubmed_id xml:lang="en">15345532</j.0:Pubmed_id> </rdf:Description> </j.0:reference> <j.0:reference rdf:parseType="Resource"> <dc:subject rdf:parseType="Resource"> <j.0:subject_type xml:lang="en">keyword</j.0:subject_type> <rdf:value> <rdf:Bag> <rdf:li xml:lang="en">excitation-contraction coupling</rdf:li> <rdf:li xml:lang="en">Ventricular Myocyte</rdf:li> <rdf:li xml:lang="en">epicardial myocyte</rdf:li> <rdf:li xml:lang="en">calcium dynamics</rdf:li> <rdf:li xml:lang="en">ventricular myocyte</rdf:li> <rdf:li xml:lang="en">electrophysiology</rdf:li> <rdf:li xml:lang="en">cardiac</rdf:li> </rdf:Bag> </rdf:value> </dc:subject> </j.0:reference> <cmeta:comment> <rdf:Description rdf:about="rdf:#73fb1875-f318-4cd4-86fc-222de5abca92"> <dc:creator> <rdf:Description rdf:about="rdf:#c63b0f0f-35d2-45d4-98a7-969320ffee8f"> <FN xml:lang="en">James Lawson</FN> </rdf:Description> </dc:creator> <rdf:value xml:lang="en">This file is a CellML description of Iyer et al's model of the human left ventricular epicardial myocyte as described in the paper "A Computational model of the human left-ventricular epicardial myocyte"</rdf:value> </rdf:Description> </cmeta:comment> </rdf:Description> </rdf:RDF> Brian Carlson Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Human Cardiomyocyte Electrophysiology with Ion Handling Iyer Mazhari and Winslow 2004 iyer_2004 Fluid volume http://bhi.washington.edu/OPB#OPB_00154 Temperature http://bhi.washington.edu/OPB#OPB_00293 Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 Electrical potential http://bhi.washington.edu/OPB#OPB_00506 Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 Nernst potential http://bhi.washington.edu/OPB#OPB_01581 sodium(1+) http://purl.obolibrary.org/obo/CHEBI_29101 potassium(1+) http://purl.obolibrary.org/obo/CHEBI_29103 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium ion http://purl.obolibrary.org/obo/CHEBI_39124 Cardiac myocyte http://purl.org/sig/ont/fma/fma14067 Cytoplasmic organelle matrix http://purl.org/sig/ont/fma/fma72444 Plasma membrane http://purl.org/sig/ont/fma/fma63841 Portion of cytosol http://purl.org/sig/ont/fma/fma66836 Portion of extracellular matrix http://purl.org/sig/ont/fma/fma9672 Sarcomere http://purl.org/sig/ont/fma/fma67895 A physical entity that is defined by linking multiple physical entity terms with structural relations. A mathematical and/or logical expression that determines the value of a data structure. An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities. A physical dependency defined in a specific SemSim model. A physical entity defined in a specific SemSim model. A physical process defined in a specific SemSim model. A physical property defined in a specific SemSim model. A computational element that stores numerical and/or logical information related to the model. A data structure whose value is limited to decimals. A data structure whose value is limited to the whole numbers. A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime. A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process. A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants. A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element. A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process. A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values. A data structure whose value is limited to the real numbers. A physical dependency that is defined using a term in an external knowledge resource. A physical entity that is defined using a term from an external knowledge resource. A physical process that is defined using a term in an external knowledge resource. A physical property that is defined using a term in an external knowledge resource. A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0. A computational or physical element of a SemSim model. A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel. A physical quantity chosen as a standard in terms of which other physical quantities may be expressed. Backgound sodium channel current Total current through background sodium channel 1.0 1.0 Background calcium channel calcium current Calcium current through background calcium channel 1.0 1.0 sodium(1+) http://purl.obolibrary.org/obo/CHEBI_29101 sodium(1+) http://purl.obolibrary.org/obo/CHEBI_29101 sodium(1+) http://purl.obolibrary.org/obo/CHEBI_29101 potassium(1+) http://purl.obolibrary.org/obo/CHEBI_29103 potassium(1+) http://purl.obolibrary.org/obo/CHEBI_29103 potassium(1+) http://purl.obolibrary.org/obo/CHEBI_29103 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium(2+) http://purl.obolibrary.org/obo/CHEBI_29108 calcium ion http://purl.obolibrary.org/obo/CHEBI_39124 calcium ion http://purl.obolibrary.org/obo/CHEBI_39124 COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES 1.534e-4 false false true false false true 0.2852239446 COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaJSR false false out true Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.2855294915 COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaNSR false false out true Calcium concentration in the network regions of the sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.1420215245e-3 false false out true Calcium concentration in diadic space Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.8601192016e-4 false false out true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 2 false false out true Calcium concentration outside the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 Faraday constant 96.5 false false 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false in true Background sodium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 false false in true Sarcolemmal calcium pump current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 false false in true false false in true Calcium release from sarcoplasmic reticulum Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 false false in true Calcium flux between junctional and network sarcoplasmic reticulum Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 false false in true Flux of calcium binding to both low and high affinity sites on troponin C Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 false false in true Calcium uptake from cytosol to network SR through SERCA2a Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 false false in true Calcium flux between the diadic subspace and blulk cytosol Chemical concentration flow rate 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false true Volume of matrix of the junctional sarcoplasmic reticulum Fluid volume http://bhi.washington.edu/OPB#OPB_00154 2.1e-6 false false true Volume of the matrix of the network sarcoplasmic reticulum Fluid volume http://bhi.washington.edu/OPB#OPB_00154 1.2e-9 false false true Volume of the cytosolic fluid in the diadic space Fluid volume http://bhi.washington.edu/OPB#OPB_00154 Electrical potential http://bhi.washington.edu/OPB#OPB_00506 25.84e-6 false false true Volume of the cytosol of the cardiac myocyte Fluid volume http://bhi.washington.edu/OPB#OPB_00154 false false true false false true false false in true false false in true false false in true false false in true false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>RT_over_F</ci> <apply> <divide /> <apply> <times /> <ci>Rgas</ci> <ci>Temp</ci> </apply> <ci>Faraday</ci> </apply> </apply> <apply> <eq /> 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<ci>Ki</ci> </apply> <apply> <times /> <apply> <minus /> <apply> <plus /> <apply> <minus /> <apply> <plus /> <ci>IKr</ci> <ci>IKs</ci> <ci>IK1</ci> <ci>ICaK</ci> <ci>i_Stim</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>INaK</ci> </apply> </apply> <ci>IKv43</ci> <ci>IKv14_K</ci> </apply> </apply> <ci>a1</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Cai</ci> </apply> <apply> <times /> <ci>beta_i</ci> <apply> <minus /> <apply> <minus /> <apply> <minus /> <ci>Jxfer</ci> <ci>Jup</ci> </apply> <ci>Jtrpn</ci> </apply> <apply> <times /> <apply> <plus /> <apply> <minus /> <ci>ICab</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>INaCa</ci> </apply> </apply> <ci>IpCa</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <ci>a1</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CaSS</ci> </apply> <apply> <times /> <ci>beta_SS</ci> <apply> <minus /> <apply> <minus /> <apply> <divide /> <apply> <times /> <ci>Jrel</ci> <ci>VJSR</ci> </apply> <ci>VSS</ci> </apply> <apply> <divide /> <apply> <times /> <ci>Jxfer</ci> <ci>Vmyo</ci> </apply> <ci>VSS</ci> </apply> </apply> <apply> <times /> <ci>ICa</ci> <ci>a2</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CaJSR</ci> </apply> <apply> <times /> <ci>beta_JSR</ci> <apply> <minus /> <ci>Jtr</ci> <ci>Jrel</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CaNSR</ci> </apply> <apply> <minus /> <apply> <divide /> <apply> <times /> <ci>Jup</ci> <ci>Vmyo</ci> </apply> <ci>VNSR</ci> </apply> <apply> <divide /> <apply> <times /> <ci>Jtr</ci> <ci>VJSR</ci> </apply> <ci>VNSR</ci> </apply> </apply> </apply> <apply> <eq /> <ci>i_tot</ci> <apply> <plus /> <ci>INa</ci> <ci>ICa</ci> <ci>ICaK</ci> <ci>IKr</ci> <ci>IKs</ci> <ci>IK1</ci> <ci>INaCa</ci> <ci>INaK</ci> <ci>Ito1</ci> <ci>IpCa</ci> <ci>ICab</ci> <ci>INab</ci> <ci>i_Stim</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>V</ci> </apply> <apply> <minus /> <ci>i_tot</ci> </apply> </apply> </math> COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES 0.5977099765 false false out true false false true false false true 0.1730990528 false false out true false false true false false true false false true 0.01881072386 false false out true false false true false false true false false true 9.16070135e-4 false false out true false false true false false true false false true 0.03539084346 false false out true false false true false false true 0.005428824353 false false out true false false true false false true false false true 0.02287858869 false false out true false false true false false true false false true 0.03233800003 false false out true false false true false false true false false true 0.1134082058 false false out true false false true false false true 1.975541357e-5 false false out true false false true false false true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true 0.00768548031 false false true false false true false false true 1.84002414554 false false true 0.00305767916 false false true 1.00947847105 false false true 1.17100540567 false false true 0.63902768758 false false true 2.12035379095 false false true 0.07793378174 false false true false false true false false true 0.0108174834 false false true 0.00000244936 false false true 0.52465073996 false false true 17.51885408639 false false true 938.58764534556 false false true 54749.19473332601 false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>alpha_act14</ci> <apply> <times /> <ci>alphaa0Kv14</ci> <apply> <exp /> <apply> <times /> <ci>aaKv14</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_act14</ci> <apply> <times /> <ci>betaa0Kv14</ci> <apply> <exp /> <apply> <times /> <apply> <minus /> <ci>baKv14</ci> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>alpha_inact14</ci> <ci>alphai0Kv14</ci> </apply> <apply> <eq /> <ci>beta_inact14</ci> <ci>betai0Kv14</ci> </apply> <apply> <eq /> <ci>C0Kv14_to_C1Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>alpha_act14</ci> </apply> </apply> <apply> <eq /> <ci>C1Kv14_to_C2Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>alpha_act14</ci> </apply> </apply> <apply> <eq /> <ci>C2Kv14_to_C3Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>alpha_act14</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv14_to_OKv14</ci> <ci>alpha_act14</ci> </apply> <apply> <eq /> <ci>CI0Kv14_to_CI1Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>b1Kv14</ci> <ci>alpha_act14</ci> </apply> </apply> <apply> <eq /> <ci>CI1Kv14_to_CI2Kv14</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>b2Kv14</ci> <ci>alpha_act14</ci> </apply> <ci>b1Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv14_to_CI3Kv14</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>b3Kv14</ci> <ci>alpha_act14</ci> </apply> <ci>b2Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv14_to_OIKv14</ci> <apply> <divide /> <apply> <times /> <ci>b4Kv14</ci> <ci>alpha_act14</ci> </apply> <ci>b3Kv14</ci> </apply> </apply> <apply> <eq /> <ci>C1Kv14_to_C0Kv14</ci> <ci>beta_act14</ci> </apply> <apply> <eq /> <ci>C2Kv14_to_C1Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>beta_act14</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv14_to_C2Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>beta_act14</ci> </apply> </apply> <apply> <eq /> <ci>OKv14_to_C3Kv14</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>beta_act14</ci> </apply> </apply> <apply> <eq /> <ci>CI1Kv14_to_CI0Kv14</ci> <apply> <divide /> <ci>beta_act14</ci> <ci>f1Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv14_to_CI1Kv14</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>f1Kv14</ci> <ci>beta_act14</ci> </apply> <ci>f2Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv14_to_CI2Kv14</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>f2Kv14</ci> <ci>beta_act14</ci> </apply> <ci>f3Kv14</ci> </apply> </apply> <apply> <eq /> <ci>OIKv14_to_CI3Kv14</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>f3Kv14</ci> <ci>beta_act14</ci> </apply> <ci>f4Kv14</ci> </apply> </apply> <apply> <eq /> <ci>C0Kv14_to_CI0Kv14</ci> <ci>beta_inact14</ci> </apply> <apply> <eq /> <ci>C1Kv14_to_CI1Kv14</ci> <apply> <times /> <ci>f1Kv14</ci> <ci>beta_inact14</ci> </apply> </apply> <apply> <eq /> <ci>C2Kv14_to_CI2Kv14</ci> <apply> <times /> <ci>f2Kv14</ci> <ci>beta_inact14</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv14_to_CI3Kv14</ci> <apply> <times /> <ci>f3Kv14</ci> <ci>beta_inact14</ci> </apply> </apply> <apply> <eq /> <ci>OKv14_to_OIKv14</ci> <apply> <times /> <ci>f4Kv14</ci> <ci>beta_inact14</ci> </apply> </apply> <apply> <eq /> <ci>CI0Kv14_to_C0Kv14</ci> <ci>alpha_inact14</ci> </apply> <apply> <eq /> <ci>CI1Kv14_to_C1Kv14</ci> <apply> <divide /> <ci>alpha_inact14</ci> <ci>b1Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv14_to_C2Kv14</ci> <apply> <divide /> <ci>alpha_inact14</ci> <ci>b2Kv14</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv14_to_C3Kv14</ci> <apply> <divide /> <ci>alpha_inact14</ci> <ci>b3Kv14</ci> </apply> </apply> <apply> <eq /> <ci>OIKv14_to_OKv14</ci> <apply> <divide /> <ci>alpha_inact14</ci> <ci>b4Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a1_C0</ci> <apply> <times /> <apply> <plus /> <ci>C0Kv14_to_C1Kv14</ci> <ci>C0Kv14_to_CI0Kv14</ci> </apply> <ci>C0Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_C0</ci> <apply> <plus /> <apply> <times /> <ci>C1Kv14_to_C0Kv14</ci> <ci>C1Kv14</ci> </apply> <apply> <times /> <ci>CI0Kv14_to_C0Kv14</ci> <ci>CI0Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C0Kv14</ci> </apply> <apply> <minus /> <ci>a2_C0</ci> <ci>a1_C0</ci> </apply> </apply> <apply> <eq /> <ci>a1_C1</ci> <apply> <times /> <apply> <plus /> <ci>C1Kv14_to_C2Kv14</ci> <ci>C1Kv14_to_C0Kv14</ci> <ci>C1Kv14_to_CI1Kv14</ci> </apply> <ci>C1Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_C1</ci> <apply> <plus /> <apply> <times /> <ci>C2Kv14_to_C1Kv14</ci> <ci>C2Kv14</ci> </apply> <apply> <times /> <ci>CI1Kv14_to_C1Kv14</ci> <ci>CI1Kv14</ci> </apply> <apply> <times /> <ci>C0Kv14_to_C1Kv14</ci> <ci>C0Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1Kv14</ci> </apply> <apply> <minus /> <ci>a2_C1</ci> <ci>a1_C1</ci> </apply> </apply> <apply> <eq /> <ci>a1_C2</ci> <apply> <times /> <apply> <plus /> <ci>C2Kv14_to_C3Kv14</ci> <ci>C2Kv14_to_C1Kv14</ci> <ci>C2Kv14_to_CI2Kv14</ci> </apply> <ci>C2Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_C2</ci> <apply> <plus /> <apply> <times /> <ci>C3Kv14_to_C2Kv14</ci> <ci>C3Kv14</ci> </apply> <apply> <times /> <ci>CI2Kv14_to_C2Kv14</ci> <ci>CI2Kv14</ci> </apply> <apply> <times /> <ci>C1Kv14_to_C2Kv14</ci> <ci>C1Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C2Kv14</ci> </apply> <apply> <minus /> <ci>a2_C2</ci> <ci>a1_C2</ci> </apply> </apply> <apply> <eq /> <ci>a1_C3</ci> <apply> <times /> <apply> <plus /> <ci>C3Kv14_to_OKv14</ci> <ci>C3Kv14_to_C2Kv14</ci> <ci>C3Kv14_to_CI3Kv14</ci> </apply> <ci>C3Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_C3</ci> <apply> <plus /> <apply> <times /> <ci>OKv14_to_C3Kv14</ci> <ci>OKv14</ci> </apply> <apply> <times /> <ci>CI3Kv14_to_C3Kv14</ci> <ci>CI3Kv14</ci> </apply> <apply> <times /> <ci>C2Kv14_to_C3Kv14</ci> <ci>C2Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C3Kv14</ci> </apply> <apply> <minus /> <ci>a2_C3</ci> <ci>a1_C3</ci> </apply> </apply> <apply> <eq /> <ci>a1_O</ci> <apply> <times /> <apply> <plus /> <ci>OKv14_to_C3Kv14</ci> <ci>OKv14_to_OIKv14</ci> </apply> <ci>OKv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_O</ci> <apply> <plus /> <apply> <times /> <ci>C3Kv14_to_OKv14</ci> <ci>C3Kv14</ci> </apply> <apply> <times /> <ci>OIKv14_to_OKv14</ci> <ci>OIKv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>OKv14</ci> </apply> <apply> <minus /> <ci>a2_O</ci> <ci>a1_O</ci> </apply> </apply> <apply> <eq /> <ci>a1_CI0</ci> <apply> <times /> <apply> <plus /> <ci>CI0Kv14_to_C0Kv14</ci> <ci>CI0Kv14_to_CI1Kv14</ci> </apply> <ci>CI0Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_CI0</ci> <apply> <plus /> <apply> <times /> <ci>C0Kv14_to_CI0Kv14</ci> <ci>C0Kv14</ci> </apply> <apply> <times /> <ci>CI1Kv14_to_CI0Kv14</ci> <ci>CI1Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI0Kv14</ci> </apply> <apply> <minus /> <ci>a2_CI0</ci> <ci>a1_CI0</ci> </apply> </apply> <apply> <eq /> <ci>a1_CI1</ci> <apply> <times /> <apply> <plus /> <ci>CI1Kv14_to_CI2Kv14</ci> <ci>CI1Kv14_to_C1Kv14</ci> <ci>CI1Kv14_to_CI0Kv14</ci> </apply> <ci>CI1Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_CI1</ci> <apply> <plus /> <apply> <times /> <ci>CI2Kv14_to_CI1Kv14</ci> <ci>CI2Kv14</ci> </apply> <apply> <times /> <ci>C1Kv14_to_CI1Kv14</ci> <ci>C1Kv14</ci> </apply> <apply> <times /> <ci>CI0Kv14_to_CI1Kv14</ci> <ci>CI0Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI1Kv14</ci> </apply> <apply> <minus /> <ci>a2_CI1</ci> <ci>a1_CI1</ci> </apply> </apply> <apply> <eq /> <ci>a1_CI2</ci> <apply> <times /> <apply> <plus /> <ci>CI2Kv14_to_CI3Kv14</ci> <ci>CI2Kv14_to_C2Kv14</ci> <ci>CI2Kv14_to_CI1Kv14</ci> </apply> <ci>CI2Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_CI2</ci> <apply> <plus /> <apply> <times /> <ci>CI3Kv14_to_CI2Kv14</ci> <ci>CI3Kv14</ci> </apply> <apply> <times /> <ci>C2Kv14_to_CI2Kv14</ci> <ci>C2Kv14</ci> </apply> <apply> <times /> <ci>CI1Kv14_to_CI2Kv14</ci> <ci>CI1Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI2Kv14</ci> </apply> <apply> <minus /> <ci>a2_CI2</ci> <ci>a1_CI2</ci> </apply> </apply> <apply> <eq /> <ci>a1_CI3</ci> <apply> <times /> <apply> <plus /> <ci>CI3Kv14_to_OIKv14</ci> <ci>CI3Kv14_to_C3Kv14</ci> <ci>CI3Kv14_to_CI2Kv14</ci> </apply> <ci>CI3Kv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_CI3</ci> <apply> <plus /> <apply> <times /> <ci>OIKv14_to_CI3Kv14</ci> <ci>OIKv14</ci> </apply> <apply> <times /> <ci>C3Kv14_to_CI3Kv14</ci> <ci>C3Kv14</ci> </apply> <apply> <times /> <ci>CI2Kv14_to_CI3Kv14</ci> <ci>CI2Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI3Kv14</ci> </apply> <apply> <minus /> <ci>a2_CI3</ci> <ci>a1_CI3</ci> </apply> </apply> <apply> <eq /> <ci>a1_OI</ci> <apply> <times /> <apply> <plus /> <ci>OIKv14_to_OKv14</ci> <ci>OIKv14_to_CI3Kv14</ci> </apply> <ci>OIKv14</ci> </apply> </apply> <apply> <eq /> <ci>a2_OI</ci> <apply> <plus /> <apply> <times /> <ci>OKv14_to_OIKv14</ci> <ci>OKv14</ci> </apply> <apply> <times /> <ci>CI3Kv14_to_OIKv14</ci> <ci>CI3Kv14</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>OIKv14</ci> </apply> <apply> <minus /> <ci>a2_OI</ci> <ci>a1_OI</ci> </apply> </apply> </math> COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES 0.9513721351 false false out true false false true false false true 0.02668288089 false false out true false false true false false true false false true 2.806380358e-4 false false out true false false true false false true false false true 1.311837579e-6 false false out true false false true false false true false false true 0.01513025204 false false out true false false true false false true 0.005442964601 false false out true false false true false false true false false true 9.918373359000001e-4 false false out true false false true false false true false false true 9.514386057000001e-5 false false out true false false true false false true false false true 2.742677382e-6 false false out true false false true false false true 2.29955624e-9 false false out true false false true false false true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true 0.028983 false false true 0.000373016 false false true false false true false false true 0.543708 false false true 0.0498424 false false true 6.77348 false false true 15.6212705152 false false true 28.7532603313 false false true 524.576206679 false false true 0.0468437 false false true false false true false false true 0.080185 false false true 0.000819482 false false true 0.00000005374 false false true 1.8936 false false true 14.224647456 false false true 158.574378389 false false true 142.936645351 false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>alpha_act43</ci> <apply> <times /> <ci>alphaa0Kv43</ci> <apply> <exp /> <apply> <times /> <ci>aaKv43</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_act43</ci> <apply> <times /> <ci>betaa0Kv43</ci> <apply> <exp /> <apply> <times /> <apply> <minus /> <ci>baKv43</ci> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>alpha_inact43</ci> <apply> <times /> <ci>alphai0Kv43</ci> <apply> <exp /> <apply> <times /> <apply> <minus /> <ci>aiKv43</ci> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_inact43</ci> <apply> <times /> <ci>betai0Kv43</ci> <apply> <exp /> <apply> <times /> <ci>biKv43</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>C0Kv43_to_C1Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>alpha_act43</ci> </apply> </apply> <apply> <eq /> <ci>C1Kv43_to_C2Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>alpha_act43</ci> </apply> </apply> <apply> <eq /> <ci>C2Kv43_to_C3Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>alpha_act43</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv43_to_OKv43</ci> <ci>alpha_act43</ci> </apply> <apply> <eq /> <ci>CI0Kv43_to_CI1Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>b1Kv43</ci> <ci>alpha_act43</ci> </apply> </apply> <apply> <eq /> <ci>CI1Kv43_to_CI2Kv43</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>b2Kv43</ci> <ci>alpha_act43</ci> </apply> <ci>b1Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv43_to_CI3Kv43</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>b3Kv43</ci> <ci>alpha_act43</ci> </apply> <ci>b2Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv43_to_OIKv43</ci> <apply> <divide /> <apply> <times /> <ci>b4Kv43</ci> <ci>alpha_act43</ci> </apply> <ci>b3Kv43</ci> </apply> </apply> <apply> <eq /> <ci>C1Kv43_to_C0Kv43</ci> <ci>beta_act43</ci> </apply> <apply> <eq /> <ci>C2Kv43_to_C1Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>beta_act43</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv43_to_C2Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>beta_act43</ci> </apply> </apply> <apply> <eq /> <ci>OKv43_to_C3Kv43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>beta_act43</ci> </apply> </apply> <apply> <eq /> <ci>CI1Kv43_to_CI0Kv43</ci> <apply> <divide /> <ci>beta_act43</ci> <ci>f1Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv43_to_CI1Kv43</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>f1Kv43</ci> <ci>beta_act43</ci> </apply> <ci>f2Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv43_to_CI2Kv43</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>f2Kv43</ci> <ci>beta_act43</ci> </apply> <ci>f3Kv43</ci> </apply> </apply> <apply> <eq /> <ci>OIKv43_to_CI3Kv43</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>f3Kv43</ci> <ci>beta_act43</ci> </apply> <ci>f4Kv43</ci> </apply> </apply> <apply> <eq /> <ci>C0Kv43_to_CI0Kv43</ci> <ci>beta_inact43</ci> </apply> <apply> <eq /> <ci>C1Kv43_to_CI1Kv43</ci> <apply> <times /> <ci>f1Kv43</ci> <ci>beta_inact43</ci> </apply> </apply> <apply> <eq /> <ci>C2Kv43_to_CI2Kv43</ci> <apply> <times /> <ci>f2Kv43</ci> <ci>beta_inact43</ci> </apply> </apply> <apply> <eq /> <ci>C3Kv43_to_CI3Kv43</ci> <apply> <times /> <ci>f3Kv43</ci> <ci>beta_inact43</ci> </apply> </apply> <apply> <eq /> <ci>OKv43_to_OIKv43</ci> <apply> <times /> <ci>f4Kv43</ci> <ci>beta_inact43</ci> </apply> </apply> <apply> <eq /> <ci>CI0Kv43_to_C0Kv43</ci> <ci>alpha_inact43</ci> </apply> <apply> <eq /> <ci>CI1Kv43_to_C1Kv43</ci> <apply> <divide /> <ci>alpha_inact43</ci> <ci>b1Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI2Kv43_to_C2Kv43</ci> <apply> <divide /> <ci>alpha_inact43</ci> <ci>b2Kv43</ci> </apply> </apply> <apply> <eq /> <ci>CI3Kv43_to_C3Kv43</ci> <apply> <divide /> <ci>alpha_inact43</ci> <ci>b3Kv43</ci> </apply> </apply> <apply> <eq /> <ci>OIKv43_to_OKv43</ci> <apply> <divide /> <ci>alpha_inact43</ci> <ci>b4Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a1_C043</ci> <apply> <times /> <apply> <plus /> <ci>C0Kv43_to_C1Kv43</ci> <ci>C0Kv43_to_CI0Kv43</ci> </apply> <ci>C0Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_C043</ci> <apply> <plus /> <apply> <times /> <ci>C1Kv43_to_C0Kv43</ci> <ci>C1Kv43</ci> </apply> <apply> <times /> <ci>CI0Kv43_to_C0Kv43</ci> <ci>CI0Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C0Kv43</ci> </apply> <apply> <minus /> <ci>a2_C043</ci> <ci>a1_C043</ci> </apply> </apply> <apply> <eq /> <ci>a1_C143</ci> <apply> <times /> <apply> <plus /> <ci>C1Kv43_to_C2Kv43</ci> <ci>C1Kv43_to_C0Kv43</ci> <ci>C1Kv43_to_CI1Kv43</ci> </apply> <ci>C1Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_C143</ci> <apply> <plus /> <apply> <times /> <ci>C2Kv43_to_C1Kv43</ci> <ci>C2Kv43</ci> </apply> <apply> <times /> <ci>CI1Kv43_to_C1Kv43</ci> <ci>CI1Kv43</ci> </apply> <apply> <times /> <ci>C0Kv43_to_C1Kv43</ci> <ci>C0Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1Kv43</ci> </apply> <apply> <minus /> <ci>a2_C143</ci> <ci>a1_C143</ci> </apply> </apply> <apply> <eq /> <ci>a1_C243</ci> <apply> <times /> <apply> <plus /> <ci>C2Kv43_to_C3Kv43</ci> <ci>C2Kv43_to_C1Kv43</ci> <ci>C2Kv43_to_CI2Kv43</ci> </apply> <ci>C2Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_C243</ci> <apply> <plus /> <apply> <times /> <ci>C3Kv43_to_C2Kv43</ci> <ci>C3Kv43</ci> </apply> <apply> <times /> <ci>CI2Kv43_to_C2Kv43</ci> <ci>CI2Kv43</ci> </apply> <apply> <times /> <ci>C1Kv43_to_C2Kv43</ci> <ci>C1Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C2Kv43</ci> </apply> <apply> <minus /> <ci>a2_C243</ci> <ci>a1_C243</ci> </apply> </apply> <apply> <eq /> <ci>a1_C343</ci> <apply> <times /> <apply> <plus /> <ci>C3Kv43_to_OKv43</ci> <ci>C3Kv43_to_C2Kv43</ci> <ci>C3Kv43_to_CI3Kv43</ci> </apply> <ci>C3Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_C343</ci> <apply> <plus /> <apply> <times /> <ci>OKv43_to_C3Kv43</ci> <ci>OKv43</ci> </apply> <apply> <times /> <ci>CI3Kv43_to_C3Kv43</ci> <ci>CI3Kv43</ci> </apply> <apply> <times /> <ci>C2Kv43_to_C3Kv43</ci> <ci>C2Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C3Kv43</ci> </apply> <apply> <minus /> <ci>a2_C343</ci> <ci>a1_C343</ci> </apply> </apply> <apply> <eq /> <ci>a1_O43</ci> <apply> <times /> <apply> <plus /> <ci>OKv43_to_C3Kv43</ci> <ci>OKv43_to_OIKv43</ci> </apply> <ci>OKv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_O43</ci> <apply> <plus /> <apply> <times /> <ci>C3Kv43_to_OKv43</ci> <ci>C3Kv43</ci> </apply> <apply> <times /> <ci>OIKv43_to_OKv43</ci> <ci>OIKv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>OKv43</ci> </apply> <apply> <minus /> <ci>a2_O43</ci> <ci>a1_O43</ci> </apply> </apply> <apply> <eq /> <ci>a1_I043</ci> <apply> <times /> <apply> <plus /> <ci>CI0Kv43_to_C0Kv43</ci> <ci>CI0Kv43_to_CI1Kv43</ci> </apply> <ci>CI0Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_I043</ci> <apply> <plus /> <apply> <times /> <ci>C0Kv43_to_CI0Kv43</ci> <ci>C0Kv43</ci> </apply> <apply> <times /> <ci>CI1Kv43_to_CI0Kv43</ci> <ci>CI1Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI0Kv43</ci> </apply> <apply> <minus /> <ci>a2_I043</ci> <ci>a1_I043</ci> </apply> </apply> <apply> <eq /> <ci>a1_I143</ci> <apply> <times /> <apply> <plus /> <ci>CI1Kv43_to_CI2Kv43</ci> <ci>CI1Kv43_to_C1Kv43</ci> <ci>CI1Kv43_to_CI0Kv43</ci> </apply> <ci>CI1Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_I143</ci> <apply> <plus /> <apply> <times /> <ci>CI2Kv43_to_CI1Kv43</ci> <ci>CI2Kv43</ci> </apply> <apply> <times /> <ci>C1Kv43_to_CI1Kv43</ci> <ci>C1Kv43</ci> </apply> <apply> <times /> <ci>CI0Kv43_to_CI1Kv43</ci> <ci>CI0Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI1Kv43</ci> </apply> <apply> <minus /> <ci>a2_I143</ci> <ci>a1_I143</ci> </apply> </apply> <apply> <eq /> <ci>a1_I243</ci> <apply> <times /> <apply> <plus /> <ci>CI2Kv43_to_CI3Kv43</ci> <ci>CI2Kv43_to_C2Kv43</ci> <ci>CI2Kv43_to_CI1Kv43</ci> </apply> <ci>CI2Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_I243</ci> <apply> <plus /> <apply> <times /> <ci>CI3Kv43_to_CI2Kv43</ci> <ci>CI3Kv43</ci> </apply> <apply> <times /> <ci>C2Kv43_to_CI2Kv43</ci> <ci>C2Kv43</ci> </apply> <apply> <times /> <ci>CI1Kv43_to_CI2Kv43</ci> <ci>CI1Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI2Kv43</ci> </apply> <apply> <minus /> <ci>a2_I243</ci> <ci>a1_I243</ci> </apply> </apply> <apply> <eq /> <ci>a1_I343</ci> <apply> <times /> <apply> <plus /> <ci>CI3Kv43_to_OIKv43</ci> <ci>CI3Kv43_to_C3Kv43</ci> <ci>CI3Kv43_to_CI2Kv43</ci> </apply> <ci>CI3Kv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_I343</ci> <apply> <plus /> <apply> <times /> <ci>OIKv43_to_CI3Kv43</ci> <ci>OIKv43</ci> </apply> <apply> <times /> <ci>C3Kv43_to_CI3Kv43</ci> <ci>C3Kv43</ci> </apply> <apply> <times /> <ci>CI2Kv43_to_CI3Kv43</ci> <ci>CI2Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CI3Kv43</ci> </apply> <apply> <minus /> <ci>a2_I343</ci> <ci>a1_I343</ci> </apply> </apply> <apply> <eq /> <ci>a1_OI43</ci> <apply> <times /> <apply> <plus /> <ci>OIKv43_to_OKv43</ci> <ci>OIKv43_to_CI3Kv43</ci> </apply> <ci>OIKv43</ci> </apply> </apply> <apply> <eq /> <ci>a2_OI43</ci> <apply> <plus /> <apply> <times /> <ci>OKv43_to_OIKv43</ci> <ci>OKv43</ci> </apply> <apply> <times /> <ci>CI3Kv43_to_OIKv43</ci> <ci>CI3Kv43</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>OIKv43</ci> </apply> <apply> <minus /> <ci>a2_OI43</ci> <ci>a1_OI43</ci> </apply> </apply> </math> COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES 0.8621934054 false false true false false true false false true 0.01141398211 false false true false false true false false true false false true 5.666325225e-5 false false true false false true false false true false false true 1.25021357e-7 false false true false false true false false true false false true 1.034426748e-10 false false true false false true false false true 0.1198547081 false false true false false true false false true 0.006346794302 false false true false false true false false true false false true 1.260326488e-4 false false true false false true false false true false false true 1.112315238e-6 false false true false false true false false true false false true 3.681315892e-9 false false true false false true false false true false false in true Calcium concentration in diadic space Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 7.757981563e-12 false false out true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true 2 false false true false false true false false true 2 false false true false false true false false true 0.3 false false true 4 false false true false false true false false true false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain 0.9997157074 false false out true false false true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>alpha</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.416</cn> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.012</cn> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">35</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.45</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.049</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.065</cn> </apply> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">22</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>alpha_prime</ci> <apply> <times /> <ci>aL</ci> <ci>alpha</ci> </apply> </apply> <apply> <eq /> <ci>beta_prime</ci> <apply> <divide /> <ci>beta</ci> <ci>bL</ci> </apply> </apply> <apply> <eq /> <ci>gamma</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.6</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mM">0.09233</cn> <ci>CaSS</ci> </apply> </apply> <apply> <eq /> <ci>omega</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.25</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn> </apply> </apply> <apply> <eq /> <ci>C0_to_C1</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>alpha</ci> </apply> </apply> <apply> <eq /> <ci>C1_to_C2</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>alpha</ci> </apply> </apply> <apply> <eq /> <ci>C2_to_C3</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>alpha</ci> </apply> </apply> <apply> <eq /> <ci>C3_to_C4</ci> <ci>alpha</ci> </apply> <apply> <eq /> <ci>CCa0_to_CCa1</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>alpha_prime</ci> </apply> </apply> <apply> <eq /> <ci>CCa1_to_CCa2</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>alpha_prime</ci> </apply> </apply> <apply> <eq /> <ci>CCa2_to_CCa3</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>alpha_prime</ci> </apply> </apply> <apply> <eq /> <ci>CCa3_to_CCa4</ci> <ci>alpha_prime</ci> </apply> <apply> <eq /> <ci>C1_to_C0</ci> <ci>beta</ci> </apply> <apply> <eq /> <ci>C2_to_C1</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>beta</ci> </apply> </apply> <apply> <eq /> <ci>C3_to_C2</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>beta</ci> </apply> </apply> <apply> <eq /> <ci>C4_to_C3</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>beta</ci> </apply> </apply> <apply> <eq /> <ci>CCa1_to_CCa0</ci> <ci>beta_prime</ci> </apply> <apply> <eq /> <ci>CCa2_to_CCa1</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>beta_prime</ci> </apply> </apply> <apply> <eq /> <ci>CCa3_to_CCa2</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>beta_prime</ci> </apply> </apply> <apply> <eq /> <ci>CCa4_to_CCa3</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>beta_prime</ci> </apply> </apply> <apply> <eq /> <ci>C0_to_CCa0</ci> <ci>gamma</ci> </apply> <apply> <eq /> <ci>C1_to_CCa1</ci> <apply> <times /> <ci>aL</ci> <ci>C0_to_CCa0</ci> </apply> </apply> <apply> <eq /> <ci>C2_to_CCa2</ci> <apply> <times /> <ci>aL</ci> <ci>C1_to_CCa1</ci> </apply> </apply> <apply> <eq /> <ci>C3_to_CCa3</ci> <apply> <times /> <ci>aL</ci> <ci>C2_to_CCa2</ci> </apply> </apply> <apply> <eq /> <ci>C4_to_CCa4</ci> <apply> <times /> <ci>aL</ci> <ci>C3_to_CCa3</ci> </apply> </apply> <apply> <eq /> <ci>CCa0_to_C0</ci> <ci>omega</ci> </apply> <apply> <eq /> <ci>CCa1_to_C1</ci> <apply> <divide /> <ci>CCa0_to_C0</ci> <ci>bL</ci> </apply> </apply> <apply> <eq /> <ci>CCa2_to_C2</ci> <apply> <divide /> <ci>CCa1_to_C1</ci> <ci>bL</ci> </apply> </apply> <apply> <eq /> <ci>CCa3_to_C3</ci> <apply> <divide /> <ci>CCa2_to_C2</ci> <ci>bL</ci> </apply> </apply> <apply> <eq /> <ci>CCa4_to_C4</ci> <apply> <divide /> <ci>CCa3_to_C3</ci> <ci>bL</ci> </apply> </apply> <apply> <eq /> <ci>a1_C0</ci> <apply> <times /> <apply> <plus /> <ci>C0_to_C1</ci> <ci>C0_to_CCa0</ci> </apply> <ci>C0</ci> </apply> </apply> <apply> <eq /> <ci>a2_C0</ci> <apply> <plus /> <apply> <times /> <ci>C1_to_C0</ci> <ci>C1</ci> </apply> <apply> <times /> <ci>CCa0_to_C0</ci> <ci>CCa0</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C0</ci> </apply> <apply> <minus /> <ci>a2_C0</ci> <ci>a1_C0</ci> </apply> </apply> <apply> <eq /> <ci>a1_C1</ci> <apply> <times /> <apply> <plus /> <ci>C1_to_C0</ci> <ci>C1_to_C2</ci> <ci>C1_to_CCa1</ci> </apply> <ci>C1</ci> </apply> </apply> <apply> <eq /> <ci>a2_C1</ci> <apply> <plus /> <apply> <times /> <ci>C0_to_C1</ci> <ci>C0</ci> </apply> <apply> <times /> <ci>C2_to_C1</ci> <ci>C2</ci> </apply> <apply> <times /> <ci>CCa1_to_C1</ci> <ci>CCa1</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1</ci> </apply> <apply> <minus /> <ci>a2_C1</ci> <ci>a1_C1</ci> </apply> </apply> <apply> <eq /> <ci>a1_C2</ci> <apply> <times /> <apply> <plus /> <ci>C2_to_C1</ci> <ci>C2_to_C3</ci> <ci>C2_to_CCa2</ci> </apply> <ci>C2</ci> </apply> </apply> <apply> <eq /> <ci>a2_C2</ci> <apply> <plus /> <apply> <times /> <ci>C1_to_C2</ci> <ci>C1</ci> </apply> <apply> <times /> <ci>C3_to_C2</ci> <ci>C3</ci> </apply> <apply> <times /> <ci>CCa2_to_C2</ci> <ci>CCa2</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C2</ci> </apply> <apply> <minus /> <ci>a2_C2</ci> <ci>a1_C2</ci> </apply> </apply> <apply> <eq /> <ci>a1_C3</ci> <apply> <times /> <apply> <plus /> <ci>C3_to_C2</ci> <ci>C3_to_C4</ci> <ci>C3_to_CCa3</ci> </apply> <ci>C3</ci> </apply> </apply> <apply> <eq /> <ci>a2_C3</ci> <apply> <plus /> <apply> <times /> <ci>C2_to_C3</ci> <ci>C2</ci> </apply> <apply> <times /> <ci>C4_to_C3</ci> <ci>C4</ci> </apply> <apply> <times /> <ci>CCa3_to_C3</ci> <ci>CCa3</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C3</ci> </apply> <apply> <minus /> <ci>a2_C3</ci> <ci>a1_C3</ci> </apply> </apply> <apply> <eq /> <ci>a1_C4</ci> <apply> <times /> <apply> <plus /> <ci>C4_to_C3</ci> <ci>fL</ci> <ci>C4_to_CCa4</ci> </apply> <ci>C4</ci> </apply> </apply> <apply> <eq /> <ci>a2_C4</ci> <apply> <plus /> <apply> <times /> <ci>C3_to_C4</ci> <ci>C3</ci> </apply> <apply> <times /> <ci>gL</ci> <ci>Open</ci> </apply> <apply> <times /> <ci>CCa4_to_C4</ci> <ci>CCa4</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C4</ci> </apply> <apply> <minus /> <ci>a2_C4</ci> <ci>a1_C4</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Open</ci> </apply> <apply> <minus /> <apply> <times /> <ci>fL</ci> <ci>C4</ci> </apply> <apply> <times /> <ci>gL</ci> <ci>Open</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a1_Ca0</ci> <apply> <times /> <apply> <plus /> <ci>CCa0_to_CCa1</ci> <ci>CCa0_to_C0</ci> </apply> <ci>CCa0</ci> </apply> </apply> <apply> <eq /> <ci>a2_Ca0</ci> <apply> <plus /> <apply> <times /> <ci>CCa1_to_CCa0</ci> <ci>CCa1</ci> </apply> <apply> <times /> <ci>C0_to_CCa0</ci> <ci>C0</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CCa0</ci> </apply> <apply> <minus /> <ci>a2_Ca0</ci> <ci>a1_Ca0</ci> </apply> </apply> <apply> <eq /> <ci>a1_Ca1</ci> <apply> <times /> <apply> <plus /> <ci>CCa1_to_CCa0</ci> <ci>CCa1_to_CCa2</ci> <ci>CCa1_to_C1</ci> </apply> <ci>CCa1</ci> </apply> </apply> <apply> <eq /> <ci>a2_Ca1</ci> <apply> <plus /> <apply> <times /> <ci>CCa0_to_CCa1</ci> <ci>CCa0</ci> </apply> <apply> <times /> <ci>CCa2_to_CCa1</ci> <ci>CCa2</ci> </apply> <apply> <times /> <ci>C1_to_CCa1</ci> <ci>C1</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CCa1</ci> </apply> <apply> <minus /> <ci>a2_Ca1</ci> <ci>a1_Ca1</ci> </apply> </apply> <apply> <eq /> <ci>a1_Ca2</ci> <apply> <times /> <apply> <plus /> <ci>CCa2_to_CCa1</ci> <ci>CCa2_to_CCa3</ci> <ci>CCa2_to_C2</ci> </apply> <ci>CCa2</ci> </apply> </apply> <apply> <eq /> <ci>a2_Ca2</ci> <apply> <plus /> <apply> <times /> <ci>CCa1_to_CCa2</ci> <ci>CCa1</ci> </apply> <apply> <times /> <ci>CCa3_to_CCa2</ci> <ci>CCa3</ci> </apply> <apply> <times /> <ci>C2_to_CCa2</ci> <ci>C2</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CCa2</ci> </apply> <apply> <minus /> <ci>a2_Ca2</ci> <ci>a1_Ca2</ci> </apply> </apply> <apply> <eq /> <ci>a1_Ca3</ci> <apply> <times /> <apply> <plus /> <ci>CCa3_to_CCa2</ci> <ci>CCa3_to_CCa4</ci> <ci>CCa3_to_C3</ci> </apply> <ci>CCa3</ci> </apply> </apply> <apply> <eq /> <ci>a2_Ca3</ci> <apply> <plus /> <apply> <times /> <ci>CCa2_to_CCa3</ci> <ci>CCa2</ci> </apply> <apply> <times /> <ci>CCa4_to_CCa3</ci> <ci>CCa4</ci> </apply> <apply> <times /> <ci>C3_to_CCa3</ci> <ci>C3</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CCa3</ci> </apply> <apply> <minus /> <ci>a2_Ca3</ci> <ci>a1_Ca3</ci> </apply> </apply> <apply> <eq /> <ci>a1_Ca4</ci> <apply> <times /> <apply> <plus /> <ci>CCa4_to_CCa3</ci> <ci>CCa4_to_C4</ci> </apply> <ci>CCa4</ci> </apply> </apply> <apply> <eq /> <ci>a2_Ca4</ci> <apply> <plus /> <apply> <times /> <ci>CCa3_to_CCa4</ci> <ci>CCa3</ci> </apply> <apply> <times /> <ci>C4_to_CCa4</ci> <ci>C4</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>CCa4</ci> </apply> <apply> <minus /> <ci>a2_Ca4</ci> <ci>a1_Ca4</ci> </apply> </apply> <apply> <eq /> <ci>a1_Cainf</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn> </apply> <apply> <eq /> <ci>yCa_inf</ci> <apply> <minus /> <apply> <plus /> <apply> <divide /> <ci>a1_Cainf</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">28.5</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">7.8</cn> </apply> </apply> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <ci>a1_Cainf</ci> </apply> </apply> <apply> <eq /> <ci>tau_yCa</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn> <apply> <plus /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00336336209452</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <apply> <exp /> <apply> <divide /> <ci>V</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">5.53899874036055</cn> </apply> </apply> </apply> </apply> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00779046570737</cn> <apply> <exp /> <apply> <divide /> <ci>V</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">49.51039631160386</cn> </apply> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>yCa</ci> </apply> <apply> <divide /> <apply> <minus /> <ci>yCa_inf</ci> <ci>yCa</ci> </apply> <ci>tau_yCa</ci> </apply> </apply> </math> COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES 0.4448038946 false false out true 0.554535924 false false out true false false in true Calcium concentration in diadic space Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.6601783287e-3 false false out true 0.397392006e-8 false false out true false false true false false true false false true false false true 0.576 false false true 0.01215 false false true 1.93 false false true 0.00405 false false true 0.0008 false false true 0.1 false false true 3 false false true 4 false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>dC1_RyR</ci> <apply> <plus /> <apply> <times /> <apply> <minus /> <ci>kaplus</ci> </apply> <apply> <power /> <apply> <times /> <ci>CaSS</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn> </apply> <ci>ncoop</ci> </apply> <ci>C1_RyR</ci> </apply> <apply> <times /> <ci>kaminus</ci> <ci>O1_RyR</ci> </apply> </apply> </apply> <apply> <eq /> <ci>dO2_RyR</ci> <apply> <minus /> <apply> <times /> <ci>kbplus</ci> <apply> <power /> <apply> <times /> <ci>CaSS</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn> </apply> <ci>mcoop</ci> </apply> <ci>O1_RyR</ci> </apply> <apply> <times /> <ci>kbminus</ci> <ci>O2_RyR</ci> </apply> </apply> </apply> <apply> <eq /> <ci>dC2_RyR</ci> <apply> <minus /> <apply> <times /> <ci>kcplus</ci> <ci>O1_RyR</ci> </apply> <apply> <times /> <ci>kcminus</ci> <ci>C2_RyR</ci> </apply> </apply> </apply> <apply> <eq /> <ci>dO1_RyR</ci> <apply> <minus /> <apply> <plus /> <ci>dC1_RyR</ci> <ci>dO2_RyR</ci> <ci>dC2_RyR</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1_RyR</ci> </apply> <ci>dC1_RyR</ci> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>O2_RyR</ci> </apply> <ci>dO2_RyR</ci> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C2_RyR</ci> </apply> <ci>dC2_RyR</ci> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>O1_RyR</ci> </apply> <ci>dO1_RyR</ci> </apply> </math> COMPUTE_ICa_ICaK false false in true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration outside the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 Faraday constant false false http://bhi.washington.edu/OPB#OPB_00089 in true Faraday constant false false out true Calcium current through L-type calcium channel false false out true Potassium current through L-type calcium channel Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 -0.265 false false true false false true false false true false false in true Potassium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Concentration of potassium external to the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true false false true false false true false false true 7 false false true false false in true false false in true Membrane potential false false true false false true Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false in true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>PK</ci> <apply> <times /> <ci>Pscale</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second"> 4.574 <sep /> -7 </cn> </apply> </apply> <apply> <eq /> <ci>PCa</ci> <apply> <times /> <ci>Pscale</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second"> 2.469 <sep /> -4 </cn> </apply> </apply> <apply> <eq /> <ci>VF_over_RT</ci> <apply> <divide /> <ci>V</ci> <ci>RT_over_F</ci> </apply> </apply> <apply> <eq /> <ci>VFsq_over_RT</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn> <ci>Faraday</ci> <ci>VF_over_RT</ci> </apply> </apply> <apply> <eq /> <ci>a1_Ca</ci> <apply> <minus /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM"> 1.0 <sep /> -3 </cn> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>VF_over_RT</ci> </apply> </apply> </apply> <apply> <times /> <ci>Cao</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn> </apply> </apply> </apply> <apply> <eq /> <ci>a2_Ca</ci> <apply> <minus /> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>VF_over_RT</ci> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> <apply> <eq /> <ci>ICamax</ci> <apply> <divide /> <apply> <times /> <ci>PCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>VFsq_over_RT</ci> <ci>a1_Ca</ci> </apply> <ci>a2_Ca</ci> </apply> </apply> <apply> <eq /> <ci>ICa</ci> <apply> <times /> <ci>ICamax</ci> <ci>yCa</ci> <ci>Open</ci> </apply> </apply> <apply> <eq /> <ci>Icabar</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn> <apply> <geq /> <ci>ICamax</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn> </apply> </piece> <otherwise> <ci>ICamax</ci> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>PKprime</ci> <apply> <divide /> <ci>PK</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <ci>Icabar</ci> <ci>ICahalf</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>a1_K</ci> <apply> <minus /> <apply> <times /> <ci>Ki</ci> <apply> <exp /> <ci>VF_over_RT</ci> </apply> </apply> <ci>Ko</ci> </apply> </apply> <apply> <eq /> <ci>a2_K</ci> <apply> <minus /> <apply> <exp /> <ci>VF_over_RT</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> <apply> <eq /> <ci>ICaK</ci> <apply> <divide /> <apply> <times /> <ci>PKprime</ci> <ci>Open</ci> <ci>yCa</ci> <ci>VFsq_over_RT</ci> <ci>a1_K</ci> </apply> <ci>a2_K</ci> </apply> </apply> </math> COMPUTE_INTRACELLULAR_CALCIUM_FLUXES false false in true Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration in the network regions of the sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration in diadic space Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jrel false false out true Calcium release from sarcoplasmic reticulum Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jtr false false out true Calcium flux between junctional and network sarcoplasmic reticulum Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jup false false out true Calcium uptake from cytosol to network SR through SERCA2a Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jxfer false false out true Calcium flux between the diadic subspace and blulk cytosol Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 1.2 false false true 0.000168 false false true 3.29 false false true 1.2 false false true 1 false false true false false in true false false in true false false true false false true 0.5747 false false true 26.7 false false true 1.8 false false true 0.0748e-3 false false true 0.318e-3 false false true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>fb</ci> <apply> <power /> <apply> <divide /> <ci>Cai</ci> <ci>Kfb</ci> </apply> <ci>Nfb</ci> </apply> </apply> <apply> <eq /> <ci>rb</ci> <apply> <power /> <apply> <divide /> <ci>CaNSR</ci> <ci>Krb</ci> </apply> <ci>Nrb</ci> </apply> </apply> <apply> <eq /> <ci>Jup</ci> <apply> <divide /> <apply> <times /> <ci>KSR</ci> <apply> <minus /> <apply> <times /> <ci>vmaxf</ci> <ci>fb</ci> </apply> <apply> <times /> <ci>vmaxr</ci> <ci>rb</ci> </apply> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>fb</ci> <ci>rb</ci> </apply> </apply> </apply> <apply> <eq /> <ci>Jrel</ci> <apply> <times /> <ci>v1</ci> <apply> <plus /> <ci>O1_RyR</ci> <ci>O2_RyR</ci> </apply> <apply> <minus /> <ci>CaJSR</ci> <ci>CaSS</ci> </apply> </apply> </apply> <apply> <eq /> <ci>Jtr</ci> <apply> <divide /> <apply> <minus /> <ci>CaNSR</ci> <ci>CaJSR</ci> </apply> <ci>tautr</ci> </apply> </apply> <apply> <eq /> <ci>Jxfer</ci> <apply> <divide /> <apply> <minus /> <ci>CaSS</ci> <ci>Cai</ci> </apply> <ci>tauxfer</ci> </apply> </apply> </math> COMPUTE_INaK_INaCa_ICab_IpCa false false in true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration outside the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Nernst potential of calcium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 7.684e-5 false false true COMPUTE_INaK_INaCa_ICab_IpCa_ICab false false out true Calcium current through background calcium channel Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INaK_INaCa_ICab_IpCa_INaCa false false out true Sodium/calcium exchanger current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INaK_INaCa_ICab_IpCa_INaK false false out true Sodium/potassium pump current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 2.387 false false true COMPUTE_INaK_INaCa_ICab_IpCa_IpCa false false out true Sarcolemmal calcium pump current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 0.05 false false true 1.38 false false true 1.5 false false true 87.5 false false true 20 false false true 0.0005 false false true false false in true Concentration of potassium external to the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Concentration of sodium in cytosol of cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Sodium concentration external to cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true false false in true Membrane potential false false true Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true false false true 0.35 false false true false false true 0.44 false false true 0.2 false false true false false true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>ICab</ci> <apply> <times /> <ci>GCab</ci> <apply> <minus /> <ci>V</ci> <ci>ECa</ci> </apply> </apply> </apply> <apply> <eq /> <ci>IpCa</ci> <apply> <divide /> <apply> <times /> <ci>IpCamax</ci> <ci>Cai</ci> </apply> <apply> <plus /> <ci>KmpCa</ci> <ci>Cai</ci> </apply> </apply> </apply> <apply> <eq /> <ci>VF_over_RT</ci> <apply> <divide /> <ci>V</ci> <ci>RT_over_F</ci> </apply> </apply> <apply> <eq /> <ci>sigma</ci> <apply> <divide /> <apply> <minus /> <apply> <exp /> <apply> <divide /> <ci>Nao</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn> </apply> </apply> <apply> <eq /> <ci>a1_Na</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn> </apply> <ci>VF_over_RT</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>a2_Na</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn> <ci>sigma</ci> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.33</cn> </apply> <ci>VF_over_RT</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>fNaK</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <plus /> <ci>a1_Na</ci> <ci>a2_Na</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a1_K</ci> <apply> <divide /> <ci>Ko</ci> <apply> <plus /> <ci>Ko</ci> <ci>KmKo</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2_K</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <power /> <apply> <divide /> <ci>KmNai</ci> <ci>Nai</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn> </apply> </apply> </apply> <apply> <eq /> <ci>INaK</ci> <apply> <divide /> <apply> <times /> <ci>INaKmax</ci> <ci>fNaK</ci> <ci>a1_K</ci> </apply> <ci>a2_K</ci> </apply> </apply> <apply> <eq /> <ci>a1_ncx</ci> <apply> <times /> <apply> <exp /> <apply> <times /> <ci>eta</ci> <ci>VF_over_RT</ci> </apply> </apply> <apply> <power /> <ci>Nai</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <ci>Cao</ci> </apply> </apply> <apply> <eq /> <ci>a2_ncx</ci> <apply> <times /> <apply> <exp /> <apply> <times /> <apply> <minus /> <ci>eta</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <ci>VF_over_RT</ci> </apply> </apply> <apply> <power /> <ci>Nao</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <ci>Cai</ci> </apply> </apply> <apply> <eq /> <ci>a3_ncx</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <times /> <ci>ksat</ci> <apply> <exp /> <apply> <times /> <apply> <minus /> <ci>eta</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <ci>VF_over_RT</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>a4_ncx</ci> <apply> <plus /> <ci>KmCa</ci> <ci>Cao</ci> </apply> </apply> <apply> <eq /> <ci>a5_ncx</ci> <apply> <divide /> <apply> <plus /> <apply> <power /> <ci>KmNa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <apply> <power /> <ci>Nao</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5000</cn> </apply> </apply> <apply> <eq /> <ci>INaCa</ci> <apply> <divide /> <apply> <times /> <ci>kNaCa</ci> <apply> <minus /> <ci>a1_ncx</ci> <ci>a2_ncx</ci> </apply> </apply> <apply> <times /> <ci>a4_ncx</ci> <ci>a3_ncx</ci> <ci>a5_ncx</ci> </apply> </apply> </apply> </math> COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp false false in true Nernst potential of potassium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 false false in true Nernst potential of sodium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 Faraday constant false false http://bhi.washington.edu/OPB#OPB_00089 in true Faraday constant 0.1253051261188079722568586886469e0 false false true 0.0186e0 false false true 0.0035e0 false false true false false true 56.32e0 false false true 0.001e0 false false true COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1 false false out true Inward rectifier potassium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr false false out true Rapid delayed rectifier potassium current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs false false out true Slow delayed rectifier potassium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 false false out true false false out true false false out true false false out true COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa false false out true Fast sodium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INab false false out true Background sodium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1 false false out true Transient outward potassium channel current Charge flow rate http://bhi.washington.edu/OPB#OPB_00318 false false true false false in true Potassium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Concentration of potassium external to the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.889 false false true 0.872 false false true false false in true Concentration of sodium in cytosol of cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Sodium concentration external to cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true false false in true false false in true false false in true false false in true false false true false false in true false false in true Membrane potential false false true false false true Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false in true false false in true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>PKv14</ci> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>Kv43Frac</ci> </apply> <ci>KvScale</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second"> 4.2986 <sep /> -7 </cn> </apply> </apply> <apply> <eq /> <ci>GKv43</ci> <apply> <times /> <ci>Kv43Frac</ci> <ci>KvScale</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mS_per_uF">0.1</cn> </apply> </apply> <apply> <eq /> <ci>INa</ci> <apply> <times /> <ci>GNa</ci> <apply> <plus /> <ci>na6</ci> <ci>na7</ci> </apply> <apply> <minus /> <ci>V</ci> <ci>ENa</ci> </apply> </apply> </apply> <apply> <eq /> <ci>fKo</ci> <apply> <root /> <apply> <divide /> <ci>Ko</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">4</cn> </apply> </apply> </apply> <apply> <eq /> <ci>IKr</ci> <apply> <times /> <ci>GKr</ci> <ci>fKo</ci> <ci>OHerg</ci> <apply> <minus /> <ci>V</ci> <ci>EK</ci> </apply> </apply> </apply> <apply> <eq /> <ci>IKs</ci> <apply> <times /> <ci>GKs</ci> <apply> <plus /> <ci>O1ks</ci> <ci>O2ks</ci> </apply> <apply> <minus /> <ci>V</ci> <ci>EK</ci> </apply> </apply> </apply> <apply> <eq /> <ci>IKv43</ci> <apply> <times /> <ci>GKv43</ci> <ci>OKv43</ci> <apply> <minus /> <ci>V</ci> <ci>EK</ci> </apply> </apply> </apply> <apply> <eq /> <ci>VF_over_RT</ci> <apply> <divide /> <ci>V</ci> <ci>RT_over_F</ci> </apply> </apply> <apply> <eq /> <ci>VFsq_over_RT</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn> <ci>Faraday</ci> <ci>VF_over_RT</ci> </apply> </apply> <apply> <eq /> <ci>a1_K</ci> <apply> <minus /> <apply> <times /> <ci>Ki</ci> <apply> <exp /> <ci>VF_over_RT</ci> </apply> </apply> <ci>Ko</ci> </apply> </apply> <apply> <eq /> <ci>a2</ci> <apply> <minus /> <apply> <exp /> <ci>VF_over_RT</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> <apply> <eq /> <ci>IKv14_K</ci> <apply> <divide /> <apply> <times /> <ci>PKv14</ci> <ci>OKv14</ci> <ci>VFsq_over_RT</ci> <ci>a1_K</ci> </apply> <ci>a2</ci> </apply> </apply> <apply> <eq /> <ci>a1_Na</ci> <apply> <minus /> <apply> <times /> <ci>Nai</ci> <apply> <exp /> <ci>VF_over_RT</ci> </apply> </apply> <ci>Nao</ci> </apply> </apply> <apply> <eq /> <ci>IKv14_Na</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn> <ci>PKv14</ci> <ci>OKv14</ci> <ci>VFsq_over_RT</ci> <ci>a1_Na</ci> </apply> <ci>a2</ci> </apply> </apply> <apply> <eq /> <ci>IKv14</ci> <apply> <plus /> <ci>IKv14_K</ci> <ci>IKv14_Na</ci> </apply> </apply> <apply> <eq /> <ci>Ito1</ci> <apply> <plus /> <ci>IKv43</ci> <ci>IKv14</ci> </apply> </apply> <apply> <eq /> <ci>K1_inf</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.94</cn> <apply> <exp /> <apply> <times /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.26</cn> <ci>RT_over_F</ci> </apply> <apply> <minus /> <ci>V</ci> <ci>EK</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>IK1</ci> <apply> <times /> <ci>GK1</ci> <apply> <root /> <apply> <divide /> <ci>Ko</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn> </apply> </apply> <ci>K1_inf</ci> <apply> <minus /> <ci>V</ci> <ci>EK</ci> </apply> </apply> </apply> <apply> <eq /> <ci>INab</ci> <apply> <times /> <ci>GNab</ci> <apply> <minus /> <ci>V</ci> <ci>ENa</ci> </apply> </apply> </apply> </math> COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS 50e-3 COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CMDNtot false false true Total concentration of calmodulin in cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 15e0 COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CSQNtot false false true Total concentration of calmodulin in junctional sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration of fluid inside the junctional region of the sarcoplasmic reticulum Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration in diadic space Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0e0 false false true Total concentration of EGTA in cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 0.9772152481 false false out true Concentration of calcium bound to high affinity troponin C binding sites Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 140e-3 false false true Total concentration of high affinity troponin binding sites Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_Jtrpn false false out true Flux of calcium binding to both low and high affinity sites on troponin C Chemical concentration flow rate http://bhi.washington.edu/OPB#OPB_00593 2.38e-3 false false true 0.8e0 false false true 1.5e-4 false false true 0.8046584973e-1 false false out true Concentration of calcium bound to low affinity troponin C binding sites Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 70e-3 false false true Total concentration of low affinity troponin binding sites Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false out true false false out true false false out true false false true false false true 0.066e-3 false false true 20e0 false false true 40e-3 false false true 40e0 false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>dLTRPNCa</ci> <apply> <minus /> <apply> <times /> <ci>kltrpn_plus</ci> <ci>Cai</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>LTRPNCa</ci> </apply> </apply> <apply> <times /> <ci>kltrpn_minus</ci> <ci>LTRPNCa</ci> </apply> </apply> </apply> <apply> <eq /> <ci>dHTRPNCa</ci> <apply> <minus /> <apply> <times /> <ci>khtrpn_plus</ci> <ci>Cai</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>HTRPNCa</ci> </apply> </apply> <apply> <times /> <ci>khtrpn_minus</ci> <ci>HTRPNCa</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>LTRPNCa</ci> </apply> <ci>dLTRPNCa</ci> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>HTRPNCa</ci> </apply> <ci>dHTRPNCa</ci> </apply> <apply> <eq /> <ci>Jtrpn</ci> <apply> <plus /> <apply> <times /> <ci>LTRPNtot</ci> <ci>dLTRPNCa</ci> </apply> <apply> <times /> <ci>HTRPNtot</ci> <ci>dHTRPNCa</ci> </apply> </apply> </apply> <apply> <eq /> <ci>beta_SS</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <apply> <times /> <ci>CMDNtot</ci> <ci>KmCMDN</ci> </apply> <apply> <power /> <apply> <plus /> <ci>CaSS</ci> <ci>KmCMDN</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> <apply> <divide /> <apply> <times /> <ci>EGTAtot</ci> <ci>KmEGTA</ci> </apply> <apply> <power /> <apply> <plus /> <ci>CaSS</ci> <ci>KmEGTA</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_JSR</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <apply> <times /> <ci>CSQNtot</ci> <ci>KmCSQN</ci> </apply> <apply> <power /> <apply> <plus /> <ci>CaJSR</ci> <ci>KmCSQN</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_i</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <apply> <times /> <ci>CMDNtot</ci> <ci>KmCMDN</ci> </apply> <apply> <power /> <apply> <plus /> <ci>Cai</ci> <ci>KmCMDN</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> <apply> <divide /> <apply> <times /> <ci>EGTAtot</ci> <ci>KmEGTA</ci> </apply> <apply> <power /> <apply> <plus /> <ci>Cai</ci> <ci>KmEGTA</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> </apply> </math> COMPUTE_REVERSAL_POTENTIALS false false in true Calcium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Calcium concentration outside the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false out true Nernst potential of calcium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 false false out true Nernst potential of potassium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 false false out true false false out true Nernst potential of sodium across the plasma membrane of the cardiac myocyte Nernst potential http://bhi.washington.edu/OPB#OPB_01581 false false in true Potassium concentration in bulk cytosol Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Concentration of potassium external to the cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Concentration of sodium in cytosol of cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true Sodium concentration external to cardiac myocyte Chemical concentration http://bhi.washington.edu/OPB#OPB_00340 false false in true false false true false false true <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>ENa</ci> <apply> <times /> <ci>RT_over_F</ci> <apply> <ln /> <apply> <divide /> <ci>Nao</ci> <ci>Nai</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>EK</ci> <apply> <times /> <ci>RT_over_F</ci> <apply> <ln /> <apply> <divide /> <ci>Ko</ci> <ci>Ki</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>a1</ci> <apply> <plus /> <ci>Ko</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn> <ci>Nao</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2</ci> <apply> <plus /> <ci>Ki</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn> <ci>Nai</ci> </apply> </apply> </apply> <apply> <eq /> <ci>EKs</ci> <apply> <times /> <ci>RT_over_F</ci> <apply> <ln /> <apply> <divide /> <ci>a1</ci> <ci>a2</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>ECa</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <ci>RT_over_F</ci> <apply> <ln /> <apply> <divide /> <ci>Cao</ci> <ci>Cai</ci> </apply> </apply> </apply> </apply> </math> Calcium/troponin buffering Buffering uptake of calcium by both high and low affinity troponin 1.0 1.0 1.0 Calcium bound to high affinity troponin C binding sites Calcium bound to low affinity troponin C binding site Cardiac myocyte http://purl.org/sig/ont/fma/fma14067 Cytoplasmic organelle matrix http://purl.org/sig/ont/fma/fma72444 Cytoplasmic organelle matrix http://purl.org/sig/ont/fma/fma72444 Diadic space Space between t-tubule and junctional sarcoplasmic reticulum IKr 0.017147641733086 false false true 0.03969328381141 false false true 0.02057448605977 false false true 0.00134366604423 false false true 0.10666316491288 false false true 0.00646393910049 false false true 0.00008039374403 false false true 0.03304608038835 false false true -0.0430605416398 false false true 0.02617412715118 false false true -0.02691385498399 false false true 0.00568908859717 false false true -0.04536642959543 false false true 0.00000069808924 false false true false false true 0.996697338 false false out true false false true false false true 4.340879648e-4 false false out true false false true false false true false false true 7.634099755000001e-5 false false out true false false true false false true 1.533347007e-6 false false out true false false true false false true 9.511789113e-6 false false out true 5.320000001 false false true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>C2H_to_C3H</ci> <apply> <times /> <ci>T_Const_HERG</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.02608362043337</cn> </apply> </apply> <apply> <eq /> <ci>C3H_to_C2H</ci> <apply> <times /> <ci>T_Const_HERG</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.14832978132145</cn> </apply> </apply> <apply> <eq /> <ci>C1H_to_C2H</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A0_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B0_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>C2H_to_C1H</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A1_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B1_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>C3H_to_OH</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A2_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B2_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>OH_to_C3H</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A3_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B3_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>OH_to_IH</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A4_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B4_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>IH_to_OH</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A5_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B5_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>C3H_to_IH</ci> <apply> <times /> <ci>T_Const_HERG</ci> <ci>A6_HERG</ci> <apply> <exp /> <apply> <times /> <ci>B6_HERG</ci> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>IH_to_C3H</ci> <apply> <divide /> <apply> <times /> <ci>OH_to_C3H</ci> <ci>IH_to_OH</ci> <ci>C3H_to_IH</ci> </apply> <apply> <times /> <ci>C3H_to_OH</ci> <ci>OH_to_IH</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1Herg</ci> </apply> <apply> <minus /> <apply> <times /> <ci>C2H_to_C1H</ci> <ci>C2Herg</ci> </apply> <apply> <times /> <ci>C1H_to_C2H</ci> <ci>C1Herg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a1_C2</ci> <apply> <plus /> <apply> <times /> <ci>C1H_to_C2H</ci> <ci>C1Herg</ci> </apply> <apply> <times /> <ci>C3H_to_C2H</ci> <ci>C3Herg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2_C2</ci> <apply> <times /> <apply> <plus /> <ci>C2H_to_C1H</ci> <ci>C2H_to_C3H</ci> </apply> <ci>C2Herg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C2Herg</ci> </apply> <apply> <minus /> <ci>a1_C2</ci> <ci>a2_C2</ci> </apply> </apply> <apply> <eq /> <ci>a1_C3</ci> <apply> <plus /> <apply> <times /> <ci>C2H_to_C3H</ci> <ci>C2Herg</ci> </apply> <apply> <times /> <ci>OH_to_C3H</ci> <ci>OHerg</ci> </apply> <apply> <times /> <ci>IH_to_C3H</ci> <ci>IHerg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2_C3</ci> <apply> <times /> <apply> <plus /> <ci>C3H_to_IH</ci> <ci>C3H_to_OH</ci> <ci>C3H_to_C2H</ci> </apply> <ci>C3Herg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C3Herg</ci> </apply> <apply> <minus /> <ci>a1_C3</ci> <ci>a2_C3</ci> </apply> </apply> <apply> <eq /> <ci>a1_O</ci> <apply> <plus /> <apply> <times /> <ci>C3H_to_OH</ci> <ci>C3Herg</ci> </apply> <apply> <times /> <ci>IH_to_OH</ci> <ci>IHerg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2_O</ci> <apply> <times /> <apply> <plus /> <ci>OH_to_C3H</ci> <ci>OH_to_IH</ci> </apply> <ci>OHerg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>OHerg</ci> </apply> <apply> <minus /> <ci>a1_O</ci> <ci>a2_O</ci> </apply> </apply> <apply> <eq /> <ci>a1_I</ci> <apply> <plus /> <apply> <times /> <ci>C3H_to_IH</ci> <ci>C3Herg</ci> </apply> <apply> <times /> <ci>OH_to_IH</ci> <ci>OHerg</ci> </apply> </apply> </apply> <apply> <eq /> <ci>a2_I</ci> <apply> <times /> <apply> <plus /> <ci>IH_to_C3H</ci> <ci>IH_to_OH</ci> </apply> <ci>IHerg</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>IHerg</ci> </apply> <apply> <minus /> <ci>a1_I</ci> <ci>a2_I</ci> </apply> </apply> </math> IKs 0.9645606295 false false out true false false true 0.03542613568 false false out true false false true false false true 2.491710696e-7 false false out true false false true false false true 1.298547822e-5 false false out true false false true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>C0ks_C1ks</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00795600798004</cn> </apply> <apply> <eq /> <ci>C1ks_O1ks</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.03966720676071</cn> </apply> <apply> <eq /> <ci>O1ks_O2ks</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00767254363063</cn> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.08662945914655</cn> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>O1ks_C1ks</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00700806628929</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.14999754700285</cn> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>O2ks_O1ks</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00379737998368</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.01425668126881</cn> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>C1ks_C0ks</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.2162557589585</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.00001889123021</cn> </apply> <ci>V</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C0ks</ci> </apply> <apply> <plus /> <apply> <times /> <apply> <minus /> <ci>C0ks_C1ks</ci> </apply> <ci>C0ks</ci> </apply> <apply> <times /> <ci>C1ks_C0ks</ci> <ci>C1ks</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C1ks</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>C0ks_C1ks</ci> <ci>C0ks</ci> </apply> <apply> <times /> <apply> <plus /> <ci>C1ks_C0ks</ci> <ci>C1ks_O1ks</ci> </apply> <ci>C1ks</ci> </apply> </apply> <apply> <times /> <ci>O1ks_C1ks</ci> <ci>O1ks</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>O1ks</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>C1ks_O1ks</ci> <ci>C1ks</ci> </apply> <apply> <times /> <apply> <plus /> <ci>O1ks_C1ks</ci> <ci>O1ks_O2ks</ci> </apply> <ci>O1ks</ci> </apply> </apply> <apply> <times /> <ci>O2ks_O1ks</ci> <ci>O2ks</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>O2ks</ci> </apply> <apply> <minus /> <apply> <times /> <ci>O1ks_O2ks</ci> <ci>O1ks</ci> </apply> <apply> <times /> <ci>O2ks_O1ks</ci> <ci>O2ks</ci> </apply> </apply> </apply> </math> INa false false true false false true false false true false false true Faraday constant false false http://bhi.washington.edu/OPB#OPB_00089 in true Faraday constant false false true false false true false false true false false true false false true false false true false false true false false in true Gas constant false false http://bhi.washington.edu/OPB#OPB_00410 in true Universal gas constant 294.16 false false true false false true false false in true Membrane potential Electrical potential http://bhi.washington.edu/OPB#OPB_00506 false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true false false true 0.1437575649 false false out true 0.05786120057 false false out true 0.005496292279 false false out true 1.957874519e-4 false false out true 4.17679396e-4 false false out true 0.0417776208 false false out true 0.004552898364 false false out true 2.20520743e-4 false false out true 4.005266484e-6 false false out true 1.57442749e-8 false false out true 2.856607179e-9 false false out true 0.4749950008 false false out true 0.2707214097 false false out true false false true false false true false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>FoverRT</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>RToverF</ci> </apply> </apply> <apply> <eq /> <ci>KToverH</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="joule_per_kelvin"> 1.381 <sep /> -23 </cn> <ci>TNa</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="joule_ms"> 6.626 <sep /> -31 </cn> </apply> </apply> <apply> <eq /> <ci>RTNa</ci> <apply> <times /> <ci>Rgas</ci> <ci>TNa</ci> </apply> </apply> <apply> <eq /> <ci>RTNaF</ci> <apply> <divide /> <apply> <times /> <ci>Rgas</ci> <ci>TNa</ci> </apply> <ci>Faraday</ci> </apply> </apply> <apply> <eq /> <ci>Temp_Scale</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.38862291252871</cn> </apply> <apply> <eq /> <ci>alpha1</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">114007.462700232</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">224.114</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.286374268596235</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta1</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">272470.273489681</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">708.146</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.28528417586424</cn> </apply> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>gamma1</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">196336.575735923</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">529.952</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.78084918596045</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>Delta1</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">133689.9304091</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">229.205</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.55804214553883</cn> </apply> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>On</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">62123.0784380481</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">39.295</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.288816042743232</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>Of</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">97657.8497137015</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">1.51</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0684861993100685</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>GammaGamma</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">116431.142142348</cn> <ci>RTNa</ci> </apply> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">578.317</cn> </apply> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.764126011745707</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>DeltaDelta</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">55700.6624658307</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">130.639</cn> </apply> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.64981672927078</cn> </apply> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>epsilon</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">85800.3675578326</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">70.078</cn> <ci>Rgas</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>omega_na</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121955.166154864</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">225.175</cn> <ci>Rgas</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>rho</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">147813.990005035</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">338.915</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.1360043702126</cn> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>mu</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121322.143275242</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">193.265</cn> <ci>Rgas</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.74290267020903</cn> </apply> <ci>V</ci> </apply> <ci>RTNaF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>Cn</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">287913.446530953</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">786.217</cn> <ci>Rgas</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>Cf</ci> <apply> <times /> <ci>Temp_Scale</ci> <ci>KToverH</ci> <apply> <exp /> <apply> <plus /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">59565.2236284584</cn> </apply> <ci>RTNa</ci> </apply> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">0.00711</cn> <ci>Rgas</ci> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>parameter_a</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.40042625477401</cn> </apply> <apply> <eq /> <ci>k12</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>alpha1</ci> </apply> </apply> <apply> <eq /> <ci>k23</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>alpha1</ci> </apply> </apply> <apply> <eq /> <ci>k34</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>alpha1</ci> </apply> </apply> <apply> <eq /> <ci>k45</ci> <ci>alpha1</ci> </apply> <apply> <eq /> <ci>k56</ci> <ci>gamma1</ci> </apply> <apply> <eq /> <ci>k67</ci> <ci>epsilon</ci> </apply> <apply> <eq /> <ci>k89</ci> <apply> <times /> <ci>k12</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k910</ci> <apply> <times /> <ci>k23</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1011</ci> <apply> <times /> <ci>k34</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1112</ci> <apply> <times /> <ci>k45</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1213</ci> <ci>GammaGamma</ci> </apply> <apply> <eq /> <ci>k57</ci> <ci>rho</ci> </apply> <apply> <eq /> <ci>k21</ci> <ci>beta1</ci> </apply> <apply> <eq /> <ci>k32</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>beta1</ci> </apply> </apply> <apply> <eq /> <ci>k43</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> <ci>beta1</ci> </apply> </apply> <apply> <eq /> <ci>k54</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>beta1</ci> </apply> </apply> <apply> <eq /> <ci>k65</ci> <ci>Delta1</ci> </apply> <apply> <eq /> <ci>k76</ci> <ci>omega_na</ci> </apply> <apply> <eq /> <ci>k98</ci> <apply> <divide /> <ci>k21</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k109</ci> <apply> <divide /> <ci>k32</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1110</ci> <apply> <divide /> <ci>k43</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1211</ci> <apply> <divide /> <ci>k54</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k1312</ci> <ci>DeltaDelta</ci> </apply> <apply> <eq /> <ci>k75</ci> <ci>mu</ci> </apply> <apply> <eq /> <ci>k81</ci> <ci>Cf</ci> </apply> <apply> <eq /> <ci>k92</ci> <apply> <divide /> <ci>k81</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k103</ci> <apply> <divide /> <ci>k92</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k114</ci> <apply> <divide /> <ci>k103</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k125</ci> <apply> <divide /> <ci>k114</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k136</ci> <ci>Of</ci> </apply> <apply> <eq /> <ci>k18</ci> <ci>Cn</ci> </apply> <apply> <eq /> <ci>k29</ci> <apply> <times /> <ci>k18</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k310</ci> <apply> <times /> <ci>k29</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k411</ci> <apply> <times /> <ci>k310</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k512</ci> <apply> <times /> <ci>k411</ci> <ci>parameter_a</ci> </apply> </apply> <apply> <eq /> <ci>k613</ci> <ci>On</ci> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na1</ci> </apply> <apply> <plus /> <apply> <times /> <apply> <minus /> <apply> <plus /> <ci>k18</ci> <ci>k12</ci> </apply> </apply> <ci>na1</ci> </apply> <apply> <times /> <ci>k21</ci> <ci>na2</ci> </apply> <apply> <times /> <ci>k81</ci> <ci>na8</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na2</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k12</ci> <ci>na1</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k21</ci> <ci>k23</ci> <ci>k29</ci> </apply> <ci>na2</ci> </apply> </apply> <apply> <times /> <ci>k32</ci> <ci>na3</ci> </apply> <apply> <times /> <ci>k92</ci> <ci>na9</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na3</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k23</ci> <ci>na2</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k32</ci> <ci>k34</ci> <ci>k310</ci> </apply> <ci>na3</ci> </apply> </apply> <apply> <times /> <ci>k43</ci> <ci>na4</ci> </apply> <apply> <times /> <ci>k103</ci> <ci>na10</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na4</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k34</ci> <ci>na3</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k43</ci> <ci>k45</ci> <ci>k411</ci> </apply> <ci>na4</ci> </apply> </apply> <apply> <times /> <ci>k54</ci> <ci>na5</ci> </apply> <apply> <times /> <ci>k114</ci> <ci>na11</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na5</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k45</ci> <ci>na4</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k54</ci> <ci>k56</ci> <ci>k57</ci> <ci>k512</ci> </apply> <ci>na5</ci> </apply> </apply> <apply> <times /> <ci>k65</ci> <ci>na6</ci> </apply> <apply> <times /> <ci>k75</ci> <ci>na7</ci> </apply> <apply> <times /> <ci>k125</ci> <ci>na12</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na6</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k56</ci> <ci>na5</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k65</ci> <ci>k67</ci> <ci>k613</ci> </apply> <ci>na6</ci> </apply> </apply> <apply> <times /> <ci>k76</ci> <ci>na7</ci> </apply> <apply> <times /> <ci>k136</ci> <ci>na13</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na7</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k57</ci> <ci>na5</ci> </apply> <apply> <times /> <ci>k67</ci> <ci>na6</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k75</ci> <ci>k76</ci> </apply> <ci>na7</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na8</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k18</ci> <ci>na1</ci> </apply> <apply> <times /> <apply> <plus /> <ci>k81</ci> <ci>k89</ci> </apply> <ci>na8</ci> </apply> </apply> <apply> <times /> <ci>k98</ci> <ci>na9</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na9</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k29</ci> <ci>na2</ci> </apply> <apply> <times /> <ci>k89</ci> <ci>na8</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k98</ci> <ci>k92</ci> <ci>k910</ci> </apply> <ci>na9</ci> </apply> </apply> <apply> <times /> <ci>k109</ci> <ci>na10</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na10</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k310</ci> <ci>na3</ci> </apply> <apply> <times /> <ci>k910</ci> <ci>na9</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k1011</ci> <ci>k103</ci> <ci>k109</ci> </apply> <ci>na10</ci> </apply> </apply> <apply> <times /> <ci>k1110</ci> <ci>na11</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na11</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k411</ci> <ci>na4</ci> </apply> <apply> <times /> <ci>k1011</ci> <ci>na10</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k1110</ci> <ci>k114</ci> <ci>k1112</ci> </apply> <ci>na11</ci> </apply> </apply> <apply> <times /> <ci>k1211</ci> <ci>na12</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na12</ci> </apply> <apply> <plus /> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k512</ci> <ci>na5</ci> </apply> <apply> <times /> <ci>k1112</ci> <ci>na11</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k1211</ci> <ci>k125</ci> <ci>k1213</ci> </apply> <ci>na12</ci> </apply> </apply> <apply> <times /> <ci>k1312</ci> <ci>na13</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>na13</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k613</ci> <ci>na6</ci> </apply> <apply> <times /> <ci>k1213</ci> <ci>na12</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k1312</ci> <ci>k136</ci> </apply> <ci>na13</ci> </apply> </apply> </apply> </math> I_stimulus false false out true false false true -15 false false true 3 false false true 0 false false true 1e3 false false true Time false false http://bhi.washington.edu/OPB#OPB_01023 in true Simulation time domain <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq /> <ci>past</ci> <apply> <times /> <apply> <floor /> <apply> <divide /> <ci>time</ci> <ci>stim_period</ci> </apply> </apply> <ci>stim_period</ci> </apply> </apply> <apply> <eq /> <ci>i_Stim</ci> <piecewise> <piece> <ci>stim_amplitude</ci> <apply> <and /> <apply> <geq /> <apply> <minus /> <ci>time</ci> <ci>past</ci> </apply> <ci>stim_offset</ci> </apply> <apply> <leq /> <apply> <minus /> <ci>time</ci> <ci>past</ci> </apply> <apply> <plus /> <ci>stim_offset</ci> <ci>stim_duration</ci> </apply> </apply> </apply> </piece> <otherwise> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn> </otherwise> </piecewise> </apply> </math> Internal Cytosolic Ca2+ transfer Calcium Flux from the cytosolic diadic space to the bulk cytosol by diffusion 1.0 1.0 Internal SR Ca2+ transfer Calcium flux from network SR into junctional SR by diffusion 1.0 1.0 Inward rectifier potassium channel current Total current through the inward rectifier potassium channel 1.0 1.0 Ions_n_reversal_potentials Junctional sarcoplasmic reticulum SR regions in close proximity to cytosolic diadic space L-Type calcium channel calcium current Calcium current through L-type calcium channel 1.0 1.0 L-type calcium channel potassium current Potassium current through L-type calcium channel 1.0 1.0 Network sarcoplasmic reticulum Region of the sarcoplasmic reticulum connecting the junction sarcoplasmic reticulum regions Plasma membrane http://purl.org/sig/ont/fma/fma63841 Portion of cytosol http://purl.org/sig/ont/fma/fma66836 Portion of cytosol http://purl.org/sig/ont/fma/fma66836 Portion of extracellular matrix http://purl.org/sig/ont/fma/fma9672 Rapid delayed rectifier potassium channel current Total current through rapid delayed rectifier potassium channel 1.0 1.0 SERCA2a Uptake Uptake of Calcium from the Cytosol to the Network SR by the Smooth Endoplasmic Reticulum Calcium Pump (SERCA2a) 1.0 1.0 SR RyR Ca2+ release Calcium release from junctional SR into the cytosolic subspace (Diadic space) mediated by sarcoplasmic reticulum ryanodine receptor 1.0 1.0 Sarcolemmal calcium pump current Total current through sarcolemmal calcium pump 1.0 1.0 Sarcomere http://purl.org/sig/ont/fma/fma67895 Slow delayed rectifier potassium channel current Total current through the slow delayed rectifier potassium channel 1.0 1.0 Sodium/calcium exchanger current Total current through sodium/calcium exchanger 1.0 1.0 1.0 1.0 Sodium/potassium pump current Total current through the sodium/potassium pump 1.0 1.0 1.0 1.0 Sodium channel current Total current through the fast sodium channel 1.0 1.0 Total portion of EGTA Total portion of calmodulin Total portion of calsequestrin Total portion of high affinity troponin C binding sites Total portion of low affinity troponin C binding sites Transient outward potassium channel current Total current through transient outward potassium channel 1.0 1.0 F_M_per_coulomb -1.0 cm cm2 2.0 coulomb true coulomb_per_millimole -1.0 milli farad true joule true joule_per_mole -1.0 joule_per_mole_kelvin -1.0 -1.0 kelvin true litre true litre_per_farad_second -1.0 -1.0 mF milli mM -1.0 milli mM3 3.0 mM4 4.0 mM_per_ms -1.0 mS mS_per_uF -1.0 mV milli molar -1.0 mole true ms milli per_mM_per_ms -1.0 -1.0 per_mV -1.0 milli per_ms -1.0 per_uM3_per_ms -3.0 -1.0 per_uM4_per_ms -1.0 -4.0 second true uA uA_per_uF -1.0 uF micro uL micro uM -1.0 micro true volt cell environment Time environment_time false false http://bhi.washington.edu/OPB#OPB_01023 out true Simulation time domain intracellular_currents transmembrane_currents