- Author:
- Michael Clerx <michael.clerx@cs.ox.ac.uk>
- Date:
- 2019-09-09 12:43:26+01:00
- Desc:
- Added Ni model.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/5b0/rawfile/8daa4c215b21675eabed1c6e5c2e32ab0a25de68/ni_2017.cellml
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<article>
<title>ni-2017</title>
</article>
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<ci>KdSLhigh</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>BCa</ci>
<ci>KdBCa</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_ss</ci>
<ci>KdBCa</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cell">
<variable initial_value=" 2.49232441199999994e+03" name="Aj_nj" public_interface="out" units="um2"/>
<variable cmeta:id="Cm" initial_value="100.0" name="Cm" public_interface="out" units="pF"/>
<variable initial_value="0.000114" name="VSR3" public_interface="out" units="um3"/>
<variable initial_value="0.00016" name="VSR4" public_interface="out" units="um3"/>
<variable initial_value=" 1.51859999999999981e-02" name="Vnonjunct3" public_interface="out" units="um3"/>
<variable initial_value=" 9.98463999999999933e-05" name="Vss" public_interface="out" units="um3"/>
<variable initial_value="1.625" name="dx" units="um"/>
<variable name="dx2" public_interface="out" units="um2"/>
<variable initial_value="13668.0" name="vi" public_interface="out" units="um3"/>
<variable initial_value="0.8225" name="xj_nj" public_interface="out" units="um"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dx2</ci>
<apply>
<times/>
<ci>dx</ci>
<ci>dx</ci>
</apply>
</apply>
</math>
</component>
<component name="engine">
<variable cmeta:id="time" name="time" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML"/>
</component>
<component name="ibca">
<variable cmeta:id="IbCa" name="IbCa" public_interface="out" units="pA"/>
<variable cmeta:id="gbCa" initial_value="0.0015834" name="gbCa" units="mS_per_uF"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ECa" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IbCa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Cm</ci>
</apply>
<ci>gbCa</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ibna">
<variable cmeta:id="IbNa" name="IbNa" public_interface="out" units="pA"/>
<variable cmeta:id="gbNa" initial_value=" 5.39550000000000077e-04" name="gbNa" units="mS_per_uF"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ENa" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IbNa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.7</cn>
<ci>Cm</ci>
</apply>
<ci>gbNa</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ical">
<variable initial_value="65.0" name="ErL" units="mV"/>
<variable cmeta:id="ICaL" name="ICaL" public_interface="out" units="pA"/>
<variable initial_value=" 2.26716127700000005e-04" name="d" units="dimensionless"/>
<variable initial_value=" 9.35421288100000026e-01" name="f" units="dimensionless"/>
<variable initial_value=" 7.27082366600000030e-01" name="fca" units="dimensionless"/>
<variable cmeta:id="gCaL" initial_value="0.09705" name="gCaL" units="mS_per_uF"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="ical_d_inf" public_interface="in" units="dimensionless"/>
<variable name="ical_d_tau" public_interface="in" units="ms"/>
<variable name="ical_f_inf" public_interface="in" units="dimensionless"/>
<variable name="ical_f_tau" public_interface="in" units="ms"/>
<variable name="ical_fca_inf" public_interface="in" units="dimensionless"/>
<variable name="ical_fca_tau" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICaL</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.333333</cn>
<ci>Cm</ci>
</apply>
<ci>gCaL</ci>
</apply>
<ci>d</ci>
</apply>
<ci>f</ci>
</apply>
<ci>fca</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ErL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ical_d_inf</ci>
<ci>d</ci>
</apply>
<ci>ical_d_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ical_f_inf</ci>
<ci>f</ci>
</apply>
<ci>ical_f_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fca</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ical_fca_inf</ci>
<ci>fca</ci>
</apply>
<ci>ical_fca_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="ical_d">
<variable name="ical_d_a" units="ms"/>
<variable name="ical_d_inf" public_interface="out" units="dimensionless"/>
<variable name="ical_d_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ical_d_a</ci>
<apply>
<divide/>
<cn cellml:units="ms">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_d_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">8.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_d_tau</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>ical_d_a</ci>
<cn cellml:units="dimensionless">4.579</cn>
</apply>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
<cn cellml:units="mV">1e-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>ical_d_a</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_mV">0.035</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="ical_f">
<variable name="ical_f_inf" public_interface="out" units="dimensionless"/>
<variable name="ical_f_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ical_f_inf</ci>
<apply>
<divide/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">28.0</cn>
</apply>
</apply>
<cn cellml:units="mV">6.9</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">28.0</cn>
</apply>
</apply>
<cn cellml:units="mV">6.9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_f_tau</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="ms">1.5</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0197</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="per_mV">0.0337</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ical_fca">
<variable name="ical_fca_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="2.0" name="ical_fca_tau" public_interface="out" units="ms"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ical_fca_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Ca_ss</ci>
<cn cellml:units="mM">0.00035</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="icap">
<variable cmeta:id="ICap" name="ICap" public_interface="out" units="pA"/>
<variable cmeta:id="icapbar" initial_value="0.275" name="icapbar" units="A_per_F"/>
<variable initial_value="0.0005" name="kmcap" units="mM"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="Cm" public_interface="in" units="pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICap</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.26</cn>
<ci>Cm</ci>
</apply>
<ci>icapbar</ci>
</apply>
<ci>Ca_ss</ci>
</apply>
<apply>
<plus/>
<ci>Ca_ss</ci>
<ci>kmcap</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ik1">
<variable cmeta:id="IK1" name="IK1" public_interface="out" units="pA"/>
<variable cmeta:id="gK1" initial_value="0.09" name="gK1" units="mS_per_uF"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="EK" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IK1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<ci>Cm</ci>
<ci>gK1</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.07</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">80.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ikr">
<variable cmeta:id="IKr" name="IKr" public_interface="out" units="pA"/>
<variable cmeta:id="gKr" initial_value=" 2.35294119999999995e-02" name="gKr" units="mS_per_uF"/>
<variable initial_value=" 1.57418133000000000e-03" name="xr" units="dimensionless"/>
<variable name="fKr" public_interface="in" units="dimensionless"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="EK" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="ikr_xr_inf" public_interface="in" units="dimensionless"/>
<variable name="ikr_xr_tau" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IKr</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>Cm</ci>
<ci>fKr</ci>
</apply>
<ci>gKr</ci>
</apply>
<ci>xr</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">15.0</cn>
</apply>
<cn cellml:units="mV">22.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xr</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ikr_xr_inf</ci>
<ci>xr</ci>
</apply>
<ci>ikr_xr_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="ikr_xr">
<variable name="ikr_xr_a" units="mS_per_uF"/>
<variable name="ikr_xr_b" units="mS_per_uF"/>
<variable name="ikr_xr_inf" public_interface="out" units="dimensionless"/>
<variable name="ikr_xr_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ikr_xr_a</ci>
<piecewise>
<piece>
<cn cellml:units="mS_per_uF">0.0015</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">14.1</cn>
</apply>
</apply>
<cn cellml:units="mV">1e-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_per_ms">0.0003</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">14.1</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">14.1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">5.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ikr_xr_b</ci>
<piecewise>
<piece>
<cn cellml:units="mS_per_uF"> 3.78361180000000004e-04</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">3.3328</cn>
</apply>
</apply>
<cn cellml:units="mV">1e-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_per_ms"> 7.38980000000000030e-05</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">3.3328</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">3.3328</cn>
</apply>
<cn cellml:units="mV">5.1237</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ikr_xr_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">14.1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">6.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ikr_xr_tau</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>ikr_xr_a</ci>
<ci>ikr_xr_b</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="iks">
<variable cmeta:id="IKs" name="IKs" public_interface="out" units="pA"/>
<variable cmeta:id="gKs" initial_value=" 1.03529407999999989e-01" name="gKs" units="mS_per_uF"/>
<variable initial_value=" 2.22597964100000011e-02" name="xs" units="dimensionless"/>
<variable name="fKs" public_interface="in" units="dimensionless"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="EK" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="iks_xs_inf" public_interface="in" units="dimensionless"/>
<variable name="iks_xs_tau" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IKs</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>Cm</ci>
<ci>fKs</ci>
</apply>
<ci>gKs</ci>
</apply>
<ci>xs</ci>
</apply>
<ci>xs</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>iks_xs_inf</ci>
<ci>xs</ci>
</apply>
<ci>iks_xs_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="iks_xs">
<variable name="iks_xs_a" units="mS_per_uF"/>
<variable name="iks_xs_b" units="mS_per_uF"/>
<variable name="iks_xs_inf" public_interface="out" units="dimensionless"/>
<variable name="iks_xs_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>iks_xs_a</ci>
<piecewise>
<piece>
<cn cellml:units="mS_per_uF">0.00068</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">19.9</cn>
</apply>
</apply>
<cn cellml:units="mV">1e-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_per_ms">4e-05</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">19.9</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">19.9</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">17.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
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</piecewise>
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<root/>
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<ci>iks_xs_tau</ci>
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<plus/>
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<ci>iks_xs_b</ci>
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<minus/>
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<times/>
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<times/>
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<minus/>
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<ci>V</ci>
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<ci>IKur</ci>
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<times/>
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<times/>
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<times/>
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<times/>
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<minus/>
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<apply>
<minus/>
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<minus/>
<ci>ikur_a_inf</ci>
<ci>ikur_a</ci>
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<ci>ikur_a_tau</ci>
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<ci>i</ci>
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<apply>
<minus/>
<ci>ikur_i_inf</ci>
<ci>i</ci>
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<ci>ikur_i_tau</ci>
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<component name="ikur_ikur_a">
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<variable name="ikur_a_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<times/>
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<variable name="ikur_i_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<minus/>
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<variable name="V" public_interface="in" units="mV"/>
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<variable name="ina_h_alpha" public_interface="in" units="mS_per_uF"/>
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<variable name="ina_j_alpha" public_interface="in" units="mS_per_uF"/>
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<times/>
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<times/>
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<times/>
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<minus/>
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<times/>
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<times/>
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<times/>
<apply>
<times/>
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<times/>
<apply>
<times/>
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<minus/>
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<ci>ina_j_alpha</ci>
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<minus/>
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<variable name="ina_h_beta" public_interface="out" units="mS_per_uF"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
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<plus/>
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<apply>
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<plus/>
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<minus/>
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<minus/>
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<plus/>
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<cn cellml:units="per_mV">0.079</cn>
<ci>V</ci>
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<apply>
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<component name="ina_j">
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<variable name="ina_j_beta" public_interface="out" units="mS_per_uF"/>
<variable name="V" public_interface="in" units="mV"/>
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<times/>
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<cn cellml:units="per_mV">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">37.78</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ina_j_beta</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">2.535e-07</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">32.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="ina_m">
<variable name="ina_m_alpha" public_interface="out" units="mS_per_uF"/>
<variable name="ina_m_beta" public_interface="out" units="mS_per_uF"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ina_m_alpha</ci>
<piecewise>
<piece>
<cn cellml:units="mS_per_uF">3.2</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
<cn cellml:units="mV">1e-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_mV_per_ms">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ina_m_beta</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">11.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inaca">
<variable cmeta:id="INaCa" name="INaCa" public_interface="out" units="pA"/>
<variable initial_value="0.35" name="gammalr" units="dimensionless"/>
<variable initial_value="1.38" name="kmcalr" units="mM"/>
<variable initial_value="87.5" name="kmnalr" units="mM"/>
<variable cmeta:id="knacalr" initial_value="1600.0" name="knacalr" units="A_per_F"/>
<variable initial_value="0.1" name="ksatlr" units="dimensionless"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="FRT" public_interface="in" units="per_mV"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.4</cn>
<ci>Cm</ci>
</apply>
<ci>knacalr</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>kmnalr</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>kmcalr</ci>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<ci>ksatlr</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>gammalr</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>V</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<ci>V</ci>
<ci>gammalr</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>Ca_ss</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<ci>V</ci>
<apply>
<minus/>
<ci>gammalr</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inak">
<variable cmeta:id="INaK" name="INaK" public_interface="out" units="pA"/>
<variable cmeta:id="I_bar" initial_value=" 8.39074235999999973e-01" name="I_bar" units="A_per_F"/>
<variable name="fnak" units="dimensionless"/>
<variable initial_value="1.5" name="kmko" units="mM"/>
<variable name="sigma" units="dimensionless"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="FRT" public_interface="in" units="per_mV"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.28</cn>
<ci>Cm</ci>
</apply>
<ci>I_bar</ci>
</apply>
<ci>fnak</ci>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>kmko</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="mM">10.0</cn>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fnak</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<cn cellml:units="dimensionless">7.0</cn>
</apply>
</apply>
</math>
</component>
<component name="ion">
<variable cmeta:id="Ca_o" initial_value="1.8" name="Ca_o" public_interface="out" units="mM"/>
<variable cmeta:id="K_o" initial_value="5.4" name="K_o" public_interface="out" units="mM"/>
<variable cmeta:id="Na_o" initial_value="140.0" name="Na_o" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML"/>
</component>
<component name="ito">
<variable cmeta:id="Ito" name="Ito" public_interface="out" units="pA"/>
<variable cmeta:id="gto" initial_value=" 1.48074102000000013e-01" name="gto" units="mS_per_uF"/>
<variable initial_value=" 1.22370601099999997e-02" name="r" units="dimensionless"/>
<variable initial_value=" 8.84913984200000003e-01" name="s" units="dimensionless"/>
<variable name="fto" public_interface="in" units="dimensionless"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="EK" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="ito_r_inf" public_interface="in" units="dimensionless"/>
<variable name="ito_r_tau" public_interface="in" units="ms"/>
<variable name="ito_s_inf" public_interface="in" units="dimensionless"/>
<variable name="ito_s_tau" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ito</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.05</cn>
<ci>fto</ci>
</apply>
<ci>Cm</ci>
</apply>
<ci>gto</ci>
</apply>
<ci>r</ci>
</apply>
<ci>s</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ito_r_inf</ci>
<ci>r</ci>
</apply>
<ci>ito_r_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ito_s_inf</ci>
<ci>s</ci>
</apply>
<ci>ito_s_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="ito_r">
<variable name="ito_r_inf" public_interface="out" units="dimensionless"/>
<variable name="ito_r_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ito_r_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">1.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">11.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ito_r_tau</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">3.5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<cn cellml:units="ms">1.5</cn>
</apply>
</apply>
</math>
</component>
<component name="ito_s">
<variable name="ito_s_inf" public_interface="out" units="dimensionless"/>
<variable name="ito_s_tau" public_interface="out" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ito_s_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">40.5</cn>
</apply>
<cn cellml:units="mV">11.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ito_s_tau</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">25.635</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">52.45</cn>
</apply>
<cn cellml:units="mV">15.8827</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<cn cellml:units="ms">14.14</cn>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable name="Itotal" units="pA"/>
<variable cmeta:id="V" initial_value="-7.71325583600000044e+01" name="V" public_interface="out" units="mV"/>
<variable name="IbCa" public_interface="in" units="pA"/>
<variable name="IbNa" public_interface="in" units="pA"/>
<variable name="ICaL" public_interface="in" units="pA"/>
<variable name="ICap" public_interface="in" units="pA"/>
<variable name="IK1" public_interface="in" units="pA"/>
<variable name="IKr" public_interface="in" units="pA"/>
<variable name="IKs" public_interface="in" units="pA"/>
<variable name="IKur" public_interface="in" units="pA"/>
<variable name="INa" public_interface="in" units="pA"/>
<variable name="INaCa" public_interface="in" units="pA"/>
<variable name="INaK" public_interface="in" units="pA"/>
<variable name="Ito" public_interface="in" units="pA"/>
<variable name="Istim" public_interface="in" units="pA"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Itotal</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>Istim</ci>
</apply>
<ci>INa</ci>
</apply>
<ci>Ito</ci>
</apply>
<ci>IKur</ci>
</apply>
<ci>IKr</ci>
</apply>
<ci>IKs</ci>
</apply>
<ci>ICaL</ci>
</apply>
<ci>IK1</ci>
</apply>
<ci>IbNa</ci>
</apply>
<ci>IbCa</ci>
</apply>
<ci>INaCa</ci>
</apply>
<ci>INaK</ci>
</apply>
<ci>ICap</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Itotal</ci>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="nernst">
<variable cmeta:id="ECa" name="ECa" public_interface="out" units="mV"/>
<variable cmeta:id="EK" name="EK" public_interface="out" units="mV"/>
<variable cmeta:id="ENa" name="ENa" public_interface="out" units="mV"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ECa</ci>
<apply>
<times/>
<cn cellml:units="mV">13.35</cn>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<cn cellml:units="mV">26.71</cn>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<cn cellml:units="mV">26.71</cn>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phys">
<variable initial_value="96.4867" name="F" public_interface="out" units="C_per_mmol"/>
<variable name="FRT" public_interface="out" units="per_mV"/>
<variable initial_value="8.3143" name="R" units="J_per_mol_per_K"/>
<variable initial_value="310.0" name="T" units="kelvin"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FRT</ci>
<apply>
<divide/>
<apply>
<divide/>
<ci>F</ci>
<ci>R</ci>
</apply>
<ci>T</ci>
</apply>
</apply>
</math>
</component>
<component name="potassium">
<variable cmeta:id="K_i" initial_value=" 1.31867138000000011e+02" name="K_i" public_interface="out" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<cn cellml:units="mM_per_ms">0.0</cn>
</apply>
</math>
</component>
<component name="ryr">
<variable name="Jrel3" public_interface="out" units="kat_times_1e_minus_15"/>
<variable name="Jrelss" public_interface="out" units="kat_times_1e_minus_15"/>
<variable name="RyRSRCa3" units="dimensionless"/>
<variable name="RyRSRCass" units="dimensionless"/>
<variable initial_value=" 2.97721944299999985e-01" name="a_3" public_interface="out" units="dimensionless"/>
<variable initial_value=" 1.41927157299999995e-01" name="a_ss" public_interface="out" units="dimensionless"/>
<variable initial_value=" 9.79023869800000002e-01" name="c_3" units="dimensionless"/>
<variable initial_value=" 9.57197650200000028e-01" name="c_ss" units="dimensionless"/>
<variable name="nu3" units="um3"/>
<variable name="nuss" units="um3"/>
<variable initial_value=" 3.66799927299999980e-04" name="o_3" units="dimensionless"/>
<variable initial_value=" 4.56694440999999974e-04" name="o_ss" units="dimensionless"/>
<variable name="Ca_SR1" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_SR2" public_interface="in" units="mM"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="ryr_a_3_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_a_3_tau" public_interface="in" units="ms"/>
<variable name="ryr_a_ss_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_a_ss_tau" public_interface="in" units="ms"/>
<variable name="ryr_c_3_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_c_3_tau" public_interface="in" units="ms"/>
<variable name="ryr_c_ss_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_c_ss_tau" public_interface="in" units="ms"/>
<variable name="Vnonjunct3" public_interface="in" units="um3"/>
<variable name="Vss" public_interface="in" units="um3"/>
<variable name="ryr_o_3_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_o_3_tau" public_interface="in" units="ms"/>
<variable name="ryr_o_ss_inf" public_interface="in" units="dimensionless"/>
<variable name="ryr_o_ss_tau" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jrel3</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nu3</ci>
<ci>o_3</ci>
</apply>
<ci>c_3</ci>
</apply>
<ci>RyRSRCa3</ci>
</apply>
<apply>
<minus/>
<ci>Ca_SR1</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<cn cellml:units="mS_per_uF">1.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>Jrelss</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nuss</ci>
<ci>o_ss</ci>
</apply>
<ci>c_ss</ci>
</apply>
<ci>RyRSRCass</ci>
</apply>
<apply>
<minus/>
<ci>Ca_SR2</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
<cn cellml:units="mS_per_uF">1.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>RyRSRCa3</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_SR1</ci>
<cn cellml:units="mM">0.3</cn>
</apply>
<cn cellml:units="mM">0.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RyRSRCass</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_SR2</ci>
<cn cellml:units="mM">0.3</cn>
</apply>
<cn cellml:units="mM">0.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a_3</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_a_3_inf</ci>
<ci>a_3</ci>
</apply>
<ci>ryr_a_3_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_a_ss_inf</ci>
<ci>a_ss</ci>
</apply>
<ci>ryr_a_ss_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>c_3</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_c_3_inf</ci>
<ci>c_3</ci>
</apply>
<ci>ryr_c_3_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>c_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_c_ss_inf</ci>
<ci>c_ss</ci>
</apply>
<ci>ryr_c_ss_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nu3</ci>
<ci>Vnonjunct3</ci>
</apply>
<apply>
<eq/>
<ci>nuss</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">625.0</cn>
<ci>Vss</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>o_3</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_o_3_inf</ci>
<ci>o_3</ci>
</apply>
<ci>ryr_o_3_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>o_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ryr_o_ss_inf</ci>
<ci>o_ss</ci>
</apply>
<ci>ryr_o_ss_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="ryr_a_3">
<variable name="ryr_a_3_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="250.0" name="ryr_a_3_tau" public_interface="out" units="ms"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_a_3_inf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.505</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.427</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">2000.0</cn>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">0.29</cn>
</apply>
<cn cellml:units="dimensionless">0.082</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryr_a_ss">
<variable name="ryr_a_ss_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="250.0" name="ryr_a_ss_tau" public_interface="out" units="ms"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_a_ss_inf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.505</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.427</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1000.0</cn>
<ci>Ca_ss</ci>
</apply>
<cn cellml:units="dimensionless">0.29</cn>
</apply>
<cn cellml:units="dimensionless">0.082</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryr_c_3">
<variable name="ryr_c_3_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="30.0" name="ryr_c_3_tau" public_interface="out" units="ms"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="a_3" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_c_3_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">2000.0</cn>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>a_3</ci>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">0.01</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryr_c_ss">
<variable name="ryr_c_ss_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="15.0" name="ryr_c_ss_tau" public_interface="out" units="ms"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="a_ss" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_c_ss_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1000.0</cn>
<ci>Ca_ss</ci>
</apply>
<apply>
<plus/>
<ci>a_ss</ci>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">0.01</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryr_o_3">
<variable name="ryr_o_3_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="5.0" name="ryr_o_3_tau" public_interface="out" units="ms"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="a_3" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_o_3_inf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">2000.0</cn>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>a_3</ci>
<cn cellml:units="dimensionless">0.22</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">0.03</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryr_o_ss">
<variable name="ryr_o_ss_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="5.0" name="ryr_o_ss_tau" public_interface="out" units="ms"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="a_ss" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ryr_o_ss_inf</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1000.0</cn>
<ci>Ca_ss</ci>
</apply>
<apply>
<plus/>
<ci>a_ss</ci>
<cn cellml:units="dimensionless">0.22</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">0.03</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="serca">
<variable name="J_SERCASR" public_interface="out" units="kat_times_1e_minus_15"/>
<variable name="J_SERCASRss" public_interface="out" units="kat_times_1e_minus_15"/>
<variable name="J_bulkSERCA" public_interface="out" units="kat_times_1e_minus_15"/>
<variable name="J_bulkSERCAss" public_interface="out" units="kat_times_1e_minus_15"/>
<variable initial_value=" 9.58584701999999969e-03" name="SERCACa" units="mM"/>
<variable initial_value=" 9.38694111799999974e-03" name="SERCACass" units="mM"/>
<variable initial_value="0.04" name="cpumps" units="mM"/>
<variable initial_value="7500000.0" name="k1" units="per_mM2_per_ms"/>
<variable initial_value="0.46875" name="k2" units="mS_per_uF"/>
<variable initial_value="2.314815" name="k3" units="per_mM2_per_ms"/>
<variable initial_value="7.5" name="k4" units="mS_per_uF"/>
<variable name="Ca_SR1" public_interface="in" units="mM"/>
<variable name="Vnonjunct3" public_interface="in" units="um3"/>
<variable name="Ca_SR2" public_interface="in" units="mM"/>
<variable name="Vss" public_interface="in" units="um3"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_ss" public_interface="in" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_SERCASR</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>Ca_SR1</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>SERCACa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>SERCACa</ci>
</apply>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_SERCASRss</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>Ca_SR2</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>SERCACass</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>SERCACass</ci>
</apply>
</apply>
</apply>
<ci>Vss</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCA</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>SERCACa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>SERCACa</ci>
</apply>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCAss</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>SERCACass</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>SERCACass</ci>
</apply>
</apply>
</apply>
<ci>Vss</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SERCACa</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASR</ci>
</apply>
<ci>J_bulkSERCA</ci>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SERCACass</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASRss</ci>
</apply>
<ci>J_bulkSERCAss</ci>
</apply>
</apply>
<ci>Vss</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium">
<variable cmeta:id="Na_i" initial_value=" 1.03039701200000007e+01" name="Na_i" public_interface="out" units="mM"/>
<variable name="vi" public_interface="in" units="um3"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="IbNa" public_interface="in" units="pA"/>
<variable name="INa" public_interface="in" units="pA"/>
<variable name="INaCa" public_interface="in" units="pA"/>
<variable name="INaK" public_interface="in" units="pA"/>
<variable name="F" public_interface="in" units="C_per_mmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>INaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>INaCa</ci>
</apply>
</apply>
<ci>IbNa</ci>
</apply>
<ci>INa</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>vi</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="stimulus">
<variable cmeta:id="Istim" name="Istim" public_interface="out" units="pA"/>
<variable cmeta:id="amplitude" initial_value="-80.0" name="amplitude" units="A_per_F"/>
<variable cmeta:id="duration" initial_value="0.5" name="duration" units="ms"/>
<variable cmeta:id="offset" initial_value="10.0" name="offset" units="ms"/>
<variable name="pace" units="dimensionless"/>
<variable cmeta:id="period" initial_value="1000.0" name="period" units="ms"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Istim</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Cm</ci>
<ci>amplitude</ci>
</apply>
<ci>pace</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>pace</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<lt/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>offset</ci>
</apply>
<apply>
<times/>
<ci>period</ci>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>offset</ci>
</apply>
<ci>period</ci>
</apply>
</apply>
</apply>
</apply>
<ci>duration</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_1="calcium" component_2="calcium_Ca_SR1"/>
<map_variables variable_1="JSRCa1" variable_2="JSRCa1"/>
<map_variables variable_1="betaSR1" variable_2="betaSR1"/>
<map_variables variable_1="JSRCaleak3" variable_2="JSRCaleak3"/>
<map_variables variable_1="CSQN" variable_2="CSQN"/>
<map_variables variable_1="Ca_SR1" variable_2="Ca_SR1"/>
<map_variables variable_1="KdCSQN" variable_2="KdCSQN"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="cell"/>
<map_variables variable_1="VSR3" variable_2="VSR3"/>
<map_variables variable_1="dx2" variable_2="dx2"/>
<map_variables variable_1="VSR4" variable_2="VSR4"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="Aj_nj" variable_2="Aj_nj"/>
<map_variables variable_1="xj_nj" variable_2="xj_nj"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="engine"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_SR1" component_2="ryr"/>
<map_variables variable_1="Jrel3" variable_2="Jrel3"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_SR1" component_2="serca"/>
<map_variables variable_1="J_SERCASR" variable_2="J_SERCASR"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="calcium_Ca_SR2"/>
<map_variables variable_1="JSRCa2" variable_2="JSRCa2"/>
<map_variables variable_1="betaSR2" variable_2="betaSR2"/>
<map_variables variable_1="JSRCaleakss" variable_2="JSRCaleakss"/>
<map_variables variable_1="CSQN" variable_2="CSQN"/>
<map_variables variable_1="Ca_SR2" variable_2="Ca_SR2"/>
<map_variables variable_1="KdCSQN" variable_2="KdCSQN"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_SR2" component_2="ryr"/>
<map_variables variable_1="Jrelss" variable_2="Jrelss"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_SR2" component_2="serca"/>
<map_variables variable_1="J_SERCASRss" variable_2="J_SERCASRss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="calcium_Ca_i"/>
<map_variables variable_1="JCa" variable_2="JCa"/>
<map_variables variable_1="calcium_Ca_i_beta" variable_2="calcium_Ca_i_beta"/>
<map_variables variable_1="JSRCaleak3" variable_2="JSRCaleak3"/>
<map_variables variable_1="Jj_nj" variable_2="Jj_nj"/>
<map_variables variable_1="BCa" variable_2="BCa"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="KdBCa" variable_2="KdBCa"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_i" component_2="ryr"/>
<map_variables variable_1="Jrel3" variable_2="Jrel3"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_i" component_2="serca"/>
<map_variables variable_1="J_bulkSERCA" variable_2="J_bulkSERCA"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="calcium_Ca_ss"/>
<map_variables variable_1="I_tot" variable_2="I_tot"/>
<map_variables variable_1="JCass" variable_2="JCass"/>
<map_variables variable_1="calcium_Ca_ss_beta" variable_2="calcium_Ca_ss_beta"/>
<map_variables variable_1="JSRCaleakss" variable_2="JSRCaleakss"/>
<map_variables variable_1="Jj_nj" variable_2="Jj_nj"/>
<map_variables variable_1="BCa" variable_2="BCa"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
<map_variables variable_1="KdBCa" variable_2="KdBCa"/>
<map_variables variable_1="KdSLhigh" variable_2="KdSLhigh"/>
<map_variables variable_1="KdSLlow" variable_2="KdSLlow"/>
<map_variables variable_1="SLhigh" variable_2="SLhigh"/>
<map_variables variable_1="SLlow" variable_2="SLlow"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="ibca"/>
<map_variables variable_1="IbCa" variable_2="IbCa"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="ical"/>
<map_variables variable_1="ICaL" variable_2="ICaL"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="icap"/>
<map_variables variable_1="ICap" variable_2="ICap"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="inaca"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="ryr"/>
<map_variables variable_1="Jrelss" variable_2="Jrelss"/>
</connection>
<connection>
<map_components component_1="calcium_Ca_ss" component_2="serca"/>
<map_variables variable_1="J_bulkSERCAss" variable_2="J_bulkSERCAss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ibca"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ibca" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IbCa" variable_2="IbCa"/>
</connection>
<connection>
<map_components component_1="ibca" component_2="nernst"/>
<map_variables variable_1="ECa" variable_2="ECa"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ibna"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ibna" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IbNa" variable_2="IbNa"/>
</connection>
<connection>
<map_components component_1="ibna" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ical"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ical" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="ICaL" variable_2="ICaL"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ical"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ical" component_2="ical_d"/>
<map_variables variable_1="ical_d_inf" variable_2="ical_d_inf"/>
<map_variables variable_1="ical_d_tau" variable_2="ical_d_tau"/>
</connection>
<connection>
<map_components component_1="ical_d" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ical" component_2="ical_f"/>
<map_variables variable_1="ical_f_inf" variable_2="ical_f_inf"/>
<map_variables variable_1="ical_f_tau" variable_2="ical_f_tau"/>
</connection>
<connection>
<map_components component_1="ical_f" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ical" component_2="ical_fca"/>
<map_variables variable_1="ical_fca_inf" variable_2="ical_fca_inf"/>
<map_variables variable_1="ical_fca_tau" variable_2="ical_fca_tau"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ical_fca"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="icap"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="icap"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ik1"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="acacetin" component_2="ikr"/>
<map_variables variable_1="fKr" variable_2="fKr"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ikr"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="ikr_xr"/>
<map_variables variable_1="ikr_xr_inf" variable_2="ikr_xr_inf"/>
<map_variables variable_1="ikr_xr_tau" variable_2="ikr_xr_tau"/>
</connection>
<connection>
<map_components component_1="ikr_xr" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="acacetin" component_2="iks"/>
<map_variables variable_1="fKs" variable_2="fKs"/>
</connection>
<connection>
<map_components component_1="cell" component_2="iks"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="iks" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
</connection>
<connection>
<map_components component_1="iks" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="engine" component_2="iks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="iks" component_2="iks_xs"/>
<map_variables variable_1="iks_xs_inf" variable_2="iks_xs_inf"/>
<map_variables variable_1="iks_xs_tau" variable_2="iks_xs_tau"/>
</connection>
<connection>
<map_components component_1="iks_xs" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="acacetin" component_2="ikur"/>
<map_variables variable_1="conc" variable_2="conc"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikur"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IKur" variable_2="IKur"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ikur"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="ikur_ikur_a"/>
<map_variables variable_1="ikur_a_inf" variable_2="ikur_a_inf"/>
<map_variables variable_1="ikur_a_tau" variable_2="ikur_a_tau"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="ikur_ikur_a" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="ikur_i"/>
<map_variables variable_1="ikur_i_inf" variable_2="ikur_i_inf"/>
<map_variables variable_1="ikur_i_tau" variable_2="ikur_i_tau"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="ikur_i" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ina"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ina"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ina" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="INa" variable_2="INa"/>
</connection>
<connection>
<map_components component_1="ina" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="ina" component_2="ina_h"/>
<map_variables variable_1="ina_h_alpha" variable_2="ina_h_alpha"/>
<map_variables variable_1="ina_h_beta" variable_2="ina_h_beta"/>
</connection>
<connection>
<map_components component_1="ina_h" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ina" component_2="ina_j"/>
<map_variables variable_1="ina_j_alpha" variable_2="ina_j_alpha"/>
<map_variables variable_1="ina_j_beta" variable_2="ina_j_beta"/>
</connection>
<connection>
<map_components component_1="ina_j" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ina" component_2="ina_m"/>
<map_variables variable_1="ina_m_alpha" variable_2="ina_m_alpha"/>
<map_variables variable_1="ina_m_beta" variable_2="ina_m_beta"/>
</connection>
<connection>
<map_components component_1="ina_m" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="inaca"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="inaca"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="ion"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="sodium"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="cell" component_2="inak"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="inak" component_2="ion"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="inak" component_2="sodium"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="acacetin" component_2="ito"/>
<map_variables variable_1="fto" variable_2="fto"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ito"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="ito" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ito" variable_2="Ito"/>
</connection>
<connection>
<map_components component_1="ito" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ito"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ito" component_2="ito_r"/>
<map_variables variable_1="ito_r_inf" variable_2="ito_r_inf"/>
<map_variables variable_1="ito_r_tau" variable_2="ito_r_tau"/>
</connection>
<connection>
<map_components component_1="ito_r" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ito" component_2="ito_s"/>
<map_variables variable_1="ito_s_inf" variable_2="ito_s_inf"/>
<map_variables variable_1="ito_s_tau" variable_2="ito_s_tau"/>
</connection>
<connection>
<map_components component_1="ito_s" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="icap" component_2="membrane"/>
<map_variables variable_1="ICap" variable_2="ICap"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="stimulus"/>
<map_variables variable_1="Istim" variable_2="Istim"/>
</connection>
<connection>
<map_components component_1="cell" component_2="membrane"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="engine" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="nernst"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ion" component_2="nernst"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="potassium"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="sodium"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="engine" component_2="potassium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr"/>
<map_variables variable_1="Ca_SR1" variable_2="Ca_SR1"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR2" variable_2="Ca_SR2"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ryr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_a_3"/>
<map_variables variable_1="ryr_a_3_inf" variable_2="ryr_a_3_inf"/>
<map_variables variable_1="ryr_a_3_tau" variable_2="ryr_a_3_tau"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_a_3"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_a_ss"/>
<map_variables variable_1="ryr_a_ss_inf" variable_2="ryr_a_ss_inf"/>
<map_variables variable_1="ryr_a_ss_tau" variable_2="ryr_a_ss_tau"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_a_ss"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_c_3"/>
<map_variables variable_1="ryr_c_3_inf" variable_2="ryr_c_3_inf"/>
<map_variables variable_1="ryr_c_3_tau" variable_2="ryr_c_3_tau"/>
<map_variables variable_1="a_3" variable_2="a_3"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_c_3"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_c_ss"/>
<map_variables variable_1="ryr_c_ss_inf" variable_2="ryr_c_ss_inf"/>
<map_variables variable_1="ryr_c_ss_tau" variable_2="ryr_c_ss_tau"/>
<map_variables variable_1="a_ss" variable_2="a_ss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_c_ss"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ryr"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_o_3"/>
<map_variables variable_1="ryr_o_3_inf" variable_2="ryr_o_3_inf"/>
<map_variables variable_1="ryr_o_3_tau" variable_2="ryr_o_3_tau"/>
<map_variables variable_1="a_3" variable_2="a_3"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_o_3"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ryr" component_2="ryr_o_ss"/>
<map_variables variable_1="ryr_o_ss_inf" variable_2="ryr_o_ss_inf"/>
<map_variables variable_1="ryr_o_ss_tau" variable_2="ryr_o_ss_tau"/>
<map_variables variable_1="a_ss" variable_2="a_ss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr_o_ss"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="serca"/>
<map_variables variable_1="Ca_SR1" variable_2="Ca_SR1"/>
<map_variables variable_1="Ca_SR2" variable_2="Ca_SR2"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="serca"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
</connection>
<connection>
<map_components component_1="engine" component_2="serca"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="cell" component_2="sodium"/>
<map_variables variable_1="vi" variable_2="vi"/>
</connection>
<connection>
<map_components component_1="engine" component_2="sodium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ibna" component_2="sodium"/>
<map_variables variable_1="IbNa" variable_2="IbNa"/>
</connection>
<connection>
<map_components component_1="ina" component_2="sodium"/>
<map_variables variable_1="INa" variable_2="INa"/>
</connection>
<connection>
<map_components component_1="phys" component_2="sodium"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell" component_2="stimulus"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
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</model>
