- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2019-09-16 16:04:50+12:00
- Desc:
- added annotations and curated model
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/5b7/rawfile/547382087780419f3046e1b7b01b2c7e9cc7d606/Weinstein_2000.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" >
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_2">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_6">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Jb_influx">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>flux of bicarbonate from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_6">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_4">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Pb_p">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of bicarbonate from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_4">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_0"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_1">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_1"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_1"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_1"/>
<semsim:name>velocity of chloride from cytosol to tissue fluid across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_2">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_70982"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_0">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_5">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_5"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_5"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_5"/>
<semsim:name>Cl- flow from across basolateral plasma membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_1">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Pc_pp">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_1"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of chloride from portion of cytoosl in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_5">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_0">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_5"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_1">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_7">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_84669"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_5">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_5"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#Concentrations.HCO3_i">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of biocarbonate in the portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_3">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17544"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_5">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_1">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_5"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#Concentrations.HCO3_e">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of bicarbonate in the portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_2">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_2"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_2"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_2"/>
<semsim:name>velocity of HCO3- from tissue fluid to cytosol across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.J_Cl">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>net flux (efflux) of chloride from portion of cytoosl in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Pb_pp">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of bicarbonate from portion of cytosol in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#Concentrations.Cl_e">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of chlordie in the portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_6">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_6"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_6"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_6"/>
<semsim:name>HCO3- flow from across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_0">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#Concentrations.Cl_i">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of chloride in the portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_4">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.HCO3_e">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of bicarbonate in the portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.HCO3_i">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of biocarbonate in the portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Jc_influx">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>flux of chloride from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1_rate_constants.Pb_p">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of bicarbonate from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_0">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17544"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#weinstein_2000_AE1">
<semsim:unknown>10894785</semsim:unknown>
<bqmodel:isDescribedBy>10894785</bqmodel:isDescribedBy>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A mathematical model of the outer medullary collecting duct of the rat</title>
<author>
<firstname>Jonna</firstname>
<surname>Terkildsen</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<sect1 id="sec_status">
<title>Model Status</title>
<para>This CellML model represents the renal AE1 (Cl/HCO3) exchanger. It has been curated, the units are consistent and the model runs in COR and PCEnv to replicate the published results.</para>
</sect1>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Abstract: A mathematical model of the outer medullary collecting duct (OMCD) has been developed, consisting of a-intercalated cells and a paracellular pathway, and which includes Na, K, Cl, HCO3, CO2, H2CO3, phosphate, ammonia, and urea. Proton secretion across the luminal cell membrane is mediated by both H-ATPase and H-K-ATPase, with fluxes through the H-K-ATPase given by a previously developed kinetic model (Weinstein AM. Am J Physiol Renal Physiol 274: F856-F867, 1998). The flux across each ATPase is substantial, and variation in abundance of either pump can be used to control OMCD proton secretion. In comparison with the H-ATPase, flux through the H-K-ATPase is relatively insensitive to changes in lumen pH, so as luminal acidification proceeds, proton secretion shifts toward this pathway. Peritubular HCO3 exit is via a conductive pathway and via the Cl/HCO3 exchanger, AE1. To represent AE1, a kinetic model has been developed based on transport studies obtained at 38 degrees celcius in red blood cells. (Gasbjerg PK, Knauf PA, and Brahm J. J Gen Physiol 108: 565-575, 1996; Knauf PA, Gasbjerg PK, and Brahm J. J Gen Physiol 108: 577-589, 1996). Model calculations indicate that if all of the chloride entry via AE1 recycles across a peritubular chloride channel and if this channel is anything other than highly selective for chloride, then it should conduct a substantial fraction of the bicarbonate exit. Since both luminal membrane proton pumps are sensitive to small changes in cytosolic pH, variation in density of either AE1 or peritubular anion conductance can modulate OMCD proton secretory rate. With respect to the OMCD in situ, available buffer is predicted to be abundant, including delivered HCO3 and HPO4, as well as peritubular NH3. Thus, buffer availability is unlikely to exert a regulatory role in total proton secretion by this tubule segment.</para>
<para>The original paper reference is cited below:</para>
<para>
A mathematical model of the outer medullary collecting duct of the rat, A.M. Weinstein, 2000,
<emphasis>American Journal of Physiology (Renal Physiology)</emphasis>
, 279, F24-F45.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10894785">PubMed ID: 10894785</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="weinstein_2000.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the Weinstein 2000 AE1 transporter model (Cl/HCO3 exchanger).</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
<semsim:modelName>Weinstein_2000</semsim:modelName>
<semsim:modelName>weinstein_2000_AE1</semsim:modelName>
<semsim:unknown>weinstein_2000_AE1</semsim:unknown>
<semsim:unknown>The Weinstein 2000 quantitative model of AE1 (Cl/HCO3 exchanger).</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Pc_p">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation vealocity of chloride from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_2">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_0"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_6">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_3">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_3"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_3"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_3"/>
<semsim:name>velocity of HCO3- from cytosol to tissue fluid across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_4">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_9673"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_6">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_0"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_2">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_7">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_7"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_7"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_7"/>
<semsim:name>Cl- flow from tissue fluid to cytosol across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.J_HCO3">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>net flux (efflux) of bicarbonate from portion of cytoosl in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_3">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#mediator_7">
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1_rate_constants.Pc_p">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation vealocity of chloride from portion of tissue fluid in epithelial cell of collecting duct of renal tubule to portion of cytoosl in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_7">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Cl_i">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of chloride in the portion of cytoosl in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_0">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_0"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_0"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_0"/>
<semsim:name>velocity of chloride from tissue fluid to cytosol across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1_rate_constants.Pb_pp">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of bicarbonate from portion of cytosol in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_5">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_1"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:17996"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_3">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#source_3">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_0"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#process_4">
<semsim:hasMediatorParticipant rdf:resource="./Weinstein_2000.cellml#mediator_4"/>
<semsim:hasSinkParticipant rdf:resource="./Weinstein_2000.cellml#sink_4"/>
<semsim:hasSourceParticipant rdf:resource="./Weinstein_2000.cellml#source_4"/>
<semsim:name>HCO3- flow across basolateral membrane</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1.Cl_e">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of chlordie in the portion of tissue fluid in epithelial cell of collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#sink_7">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./Weinstein_2000.cellml#entity_5"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#entity_1">
<bqbiol:isPartOf rdf:resource="./Weinstein_2000.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_66836"/>
</rdf:Description>
<rdf:Description rdf:about="./Weinstein_2000.cellml#AE1_rate_constants.Pc_pp">
<bqbiol:isPropertyOf rdf:resource="./Weinstein_2000.cellml#process_1"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00299"/>
<dcterms:description>permeation velocity of chloride from portion of cytoosl in epithelial cell of collecting duct of renal tubule to portion of tissue fluid in epithelial cell of collecting duct of renal tubule across basolateral plasma membrane</dcterms:description>
</rdf:Description>
</rdf:RDF>
