- Author:
- Cristian Trovato <cristian.trovato@gmail.com>
- Date:
- 2020-04-07 19:26:00+01:00
- Desc:
- Model files upload
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/5d7/rawfile/95cadd4d554e8be258cf49a92eaf6c7fc4d66b96/Matlab/Main_file_Matlab.m
clc, clear all, close all
%%%%%%%%%%%%%% Main File to run the Trovato2020 model %%%%%%%%%%%%%%%%%%%%%
% The following code simulates 1 beat at 1 Hz with %
% the human cardiac Purkinje Trovato2020 model %
% - %
% Model description and validation in: %
% C. Trovato, E. Passini, N. Nagy, et al., Human Purkinje in %
% silico model enables mechanistic investigations into automaticity %
% and pro-arrhythmic abnormalities, Journal of Molecular and Cellular %
% Cardiology (2019), https://doi.org/10.1016/j.yjmcc.2020.04.001 . %
% [open-access] %
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
model=@modTrovato2020;
tsim= 1000; %Simulation time (ms)
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
%% Initial condition from Steady State [1000 beats at 1Hz]
v= -86.550102957989600;
nai= 8.231857731510893; nasl= 8.231553454361393; nass= 8.231561539013950;
ki= 1.437673447706863e+02; ksl= 1.437677771226899e+02; kss= 1.437677533510394e+02;
cai= 4.360080908582633e-05; casl= 1.020101597047671e-04; cass= 1.017658486729359e-04;
cansr= 1.263525645841406; cajsr= 1.248146625349512; cacsr = 1.265185617721750;
m= 0.006341207769833; hf= 0.788541761218318; hs= 0.788474863764949;
j= 0.790412100577539; hsp= 0.579594138981772; jp= 0.790885181877794;
mL= 0.0; hL= 0.463478975643765; hLp= 0.240123148015689;
a= 0.0; i= 0.649386868151536; i2= 0.989963717273401;
d= 0.0; ff= 0.999999963501871; fs= 0.926598485399264;
fcaf= 0.999999963493016; fcas= 0.999834100785052; jca= 0.999979200703676;
nca= 0.005470852996192; ffp= 0.999999963494571; fcafp= 0.999999963612862;
b= 0.0; g= 0.994211562437775; xrf= 0.0;
xrs= 0.568856244015729; xs1= 0.191294664752654; xs2= 0.0;
xk1= 0.997085416662044; y= 0.233014639857230; CaMKt= 0.005060490773142;
u= 0.466232550741101; Jrel1= 0; Jrel2= 0;
X0=[v nai nasl nass ki...
ksl kss cai casl cass...
cansr cajsr cacsr m hf...
hs j hsp jp mL...
hL hLp a i i2...
d ff fs fcaf fcas...
jca nca ffp fcafp b...
g xrf xrs xs1 xs2...
y xk1 CaMKt u Jrel1...
Jrel2]';
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
%% Simulation and AP Plot
[t,y] = ode15s(model,[0 tsim],X0);
figure(); plot(t,y(:,1)); xlabel('Time (ms)'); ylabel('V_{m} (mV)');
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
