- Author:
- James Lawson <j.lawson@auckland.ac.nz>
- Date:
- 2009-07-20 16:04:18+12:00
- Desc:
- fixed diagram in tmp documentation, added keywords to b and c
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/605/rawfile/2d7fa3586f4af9d80980f7f970aaec2dfd8afdad/tentusscher_noble_noble_panfilov_2004_a.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 05/11/2007 at 17:03:04 using:
COR (0.9.31.801)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" cmeta:id="tentusscher_2004_m_cell" name="tentusscher_2004_mcell">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Model For Human Ventricular Tissue - M-cell variant</title>
<author>
<firstname>Penny</firstname>
<surname>Noble</surname>
<affiliation>
<shortaffil>Oxford University</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This variant of the model was created by Penny Noble of Oxford University, and represents the parameters given for the M-cell variant in Ten Tusscher et al. 2004. A stimulus protocol component has been added to the model to allow simulation of trains of action potentials. This file is known to run in OpenCell and COR. This model is also associated with a OpenCell session file.
</para>
<para> This model is valid CellML and has full unit consistency.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Cardiac arrhythmias and sudden cardiac death are amongst the most common causes of premature death in the devloped world. However despite their prevalance, they remain relatively poorly understood. Mathematical models, which capture the function of the beating human heart, play an important role in cardiac research. In part this is because practical experiments on human hearts are limited, and animal hearts may differ significantly in their anatomy and physiology relative to the human heart. In addition, cardiac arrhythmias are three dimensional phenomena, while experimental observations are mainly limited to surface recordings.
</para>
<para>
Existing mathematical models of human ventricular cells include:
</para>
<itemizedlist>
<listitem>
<para>
Priebe and Beuckelmann, Electrophysiological Model of the Human Ventricular Myocyte, 1998; and</para>
</listitem>
<listitem>
<para>
Bernus <emphasis>et al.</emphasis> A Computationally Efficient Electrophysiological Model of Human Ventricular Cells, 2002.</para>
</listitem>
</itemizedlist>
<para>
However, these models have their limitations, such as the fact that several of the equations are based on animal data. The aim of the 2004 study by ten Tusscher <emphasis>et al.</emphasis>, is to develop a new model for human ventricular cells that is based on recent experimental data and that is computationally efficient for large-scale spatial simulations. A schematic diagram of the model can be seen in the figure below.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
A model for human ventricular tissue, K.H.W.J. ten Tusscher, D. Noble, P.J. Noble, and A.V. Panfilov, 2004,
<emphasis>American Journal of Physiology</emphasis>
, 286, H1573-H1589. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14656705&dopt=Abstract">PubMed ID: 14656705</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="tentusscher_2004.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Ten Tusscher <emphasis>et al.</emphasis> 2004 mathematical model of the human ventricular myocyte.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="micrometre3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units name="litre_micrometre3">
<unit units="litre"/>
<unit units="micrometre3" exponent="-1"/>
</units>
<units name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units name="per_millisecond">
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="millivolt_square">
<unit units="volt" prefix="milli" exponent="+2"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="nanoS_per_picoF">
<unit units="siemens" prefix="nano"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="picoA">
<unit units="ampere" prefix="pico"/>
</units>
<units name="mA_pA">
<unit units="ampere" prefix="milli"/>
<unit units="picoA" exponent="-1"/>
</units>
<units name="picoA_per_picoF">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="cm2">
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units name="microF_per_cm2">
<unit units="microF"/>
<unit units="cm2" exponent="-1"/>
</units>
<units name="litre_per_farad_second">
<unit units="litre"/>
<unit units="farad" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<component name="environment">
<variable units="millisecond" public_interface="out" cmeta:id="environment_time" name="time"/>
</component>
<component name="membrane">
<variable units="millivolt" public_interface="out" cmeta:id="membrane_V" name="V" initial_value="-86.2"/>
<variable units="joule_per_mole_kelvin" public_interface="out" name="R" initial_value="8314.472"/>
<variable units="kelvin" public_interface="out" name="T" initial_value="310"/>
<variable units="coulomb_per_millimole" public_interface="out" name="F" initial_value="96485.3415"/>
<variable units="microF" public_interface="out" name="Cm" initial_value="0.185"/>
<variable units="micrometre3" public_interface="out" name="V_c" initial_value="0.016404"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_K1"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_to"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kr"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ks"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_CaL"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_b_Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_b_Ca"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_p_K"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_p_Ca"/>
<variable units="picoA_per_picoF" public_interface="out" name="i_Stim"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>i_K1</ci>
<ci>i_to</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_CaL</ci>
<ci>i_NaK</ci>
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<ci>i_NaCa</ci>
<ci>i_b_Ca</ci>
<ci>i_p_K</ci>
<ci>i_p_Ca</ci>
<ci>i_Stim</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Stim</ci>
<ci>Istim</ci>
</apply>
</math>
<variable units="picoA_per_picoF" public_interface="in" name="Istim"/>
</component>
<component name="reversal_potentials">
<variable units="millivolt" public_interface="out" name="E_Na"/>
<variable units="millivolt" public_interface="out" name="E_K"/>
<variable units="millivolt" public_interface="out" name="E_Ks"/>
<variable units="millivolt" public_interface="out" name="E_Ca"/>
<variable units="dimensionless" name="P_kna" initial_value="0.03"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="joule_per_mole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<ci>P_kna</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="inward_rectifier_potassium_current_i_K1" name="i_K1"/>
<variable units="nanoS_per_picoF" name="g_K1" initial_value="5.405"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="xK1_inf"/>
<variable units="dimensionless" name="alpha_K1"/>
<variable units="dimensionless" name="beta_K1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.06</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">200</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0002</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.5</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xK1_inf</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>xK1_inf</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>K_o</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="rapid_time_dependent_potassium_current_i_Kr" name="i_Kr"/>
<variable units="nanoS_per_picoF" name="g_Kr" initial_value="0.096"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="Xr1"/>
<variable units="dimensionless" private_interface="in" name="Xr2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>K_o</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
<ci>Xr1</ci>
<ci>Xr2</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_Xr1_gate">
<variable units="dimensionless" public_interface="out" name="Xr1" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="xr1_inf"/>
<variable units="dimensionless" name="alpha_xr1"/>
<variable units="dimensionless" name="beta_xr1"/>
<variable units="millisecond" name="tau_xr1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>xr1_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">26</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_xr1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">450</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">45</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xr1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="millivolt">11.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_xr1</ci>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>alpha_xr1</ci>
<ci>beta_xr1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xr1_inf</ci>
<ci>Xr1</ci>
</apply>
<ci>tau_xr1</ci>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_Xr2_gate">
<variable units="dimensionless" public_interface="out" name="Xr2" initial_value="1"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="xr2_inf"/>
<variable units="dimensionless" name="alpha_xr2"/>
<variable units="dimensionless" name="beta_xr2"/>
<variable units="millisecond" name="tau_xr2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>xr2_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">88</cn>
</apply>
<cn cellml:units="millivolt">24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_xr2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xr2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.12</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_xr2</ci>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>alpha_xr2</ci>
<ci>beta_xr2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr2</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xr2_inf</ci>
<ci>Xr2</ci>
</apply>
<ci>tau_xr2</ci>
</apply>
</apply>
</math>
</component>
<component name="slow_time_dependent_potassium_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="slow_time_dependent_potassium_current_i_Ks" name="i_Ks"/>
<variable units="nanoS_per_picoF" name="g_Ks" initial_value="0.062"/>
<variable units="millivolt" public_interface="in" name="E_Ks"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="Xs"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_time_dependent_potassium_current_Xs_gate">
<variable units="dimensionless" public_interface="out" name="Xs" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="xs_inf"/>
<variable units="dimensionless" name="alpha_xs"/>
<variable units="dimensionless" name="beta_xs"/>
<variable units="millisecond" name="tau_xs"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>xs_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_xs</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1100</cn>
<apply>
<root/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xs</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_xs</ci>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>alpha_xs</ci>
<ci>beta_xs</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xs_inf</ci>
<ci>Xs</ci>
</apply>
<ci>tau_xs</ci>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="fast_sodium_current_i_Na" name="i_Na"/>
<variable units="nanoS_per_picoF" name="g_Na" initial_value="14.838"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="m"/>
<variable units="dimensionless" private_interface="in" name="h"/>
<variable units="dimensionless" private_interface="in" name="j"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
<variable units="dimensionless" public_interface="out" name="m" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="m_inf"/>
<variable units="dimensionless" name="alpha_m"/>
<variable units="dimensionless" name="beta_m"/>
<variable units="millisecond" name="tau_m"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">56.86</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">9.03</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
<cn cellml:units="millivolt">200</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_inf</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_h_gate">
<variable units="dimensionless" public_interface="out" name="h" initial_value="0.75"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="h_inf"/>
<variable units="per_millisecond" name="alpha_h"/>
<variable units="per_millisecond" name="beta_h"/>
<variable units="millisecond" name="tau_h"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71.55</cn>
</apply>
<cn cellml:units="millivolt">7.43</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.057</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">2.7</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">310000</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.3485</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="per_millisecond">0.77</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_inf</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_j_gate">
<variable units="dimensionless" public_interface="out" name="j" initial_value="0.75"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="j_inf"/>
<variable units="per_millisecond" name="alpha_j"/>
<variable units="per_millisecond" name="beta_j"/>
<variable units="millisecond" name="tau_j"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71.55</cn>
</apply>
<cn cellml:units="millivolt">7.43</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millisecond">25428</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond" type="e-notation">6.948<sep/>-6</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.78</cn>
</apply>
</apply>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.02424</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.6</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.057</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_j</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>j_inf</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="sodium_background_current_i_b_Na" name="i_b_Na"/>
<variable units="nanoS_per_picoF" name="g_bna" initial_value="0.00029"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Na</ci>
<apply>
<times/>
<ci>g_bna</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="L_type_Ca_current_i_CaL" name="i_CaL"/>
<variable units="litre_per_farad_second" name="g_CaL" initial_value="0.000175"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_i"/>
<variable units="joule_per_mole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" public_interface="out" private_interface="in" name="d"/>
<variable units="dimensionless" private_interface="in" name="f"/>
<variable units="dimensionless" private_interface="in" name="fCa"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_CaL</ci>
<ci>d</ci>
<ci>f</ci>
<ci>fCa</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Ca_o</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_current_d_gate">
<variable units="dimensionless" public_interface="out" name="d" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="d_inf"/>
<variable units="dimensionless" name="alpha_d"/>
<variable units="dimensionless" name="beta_d"/>
<variable units="millisecond" name="gamma_d"/>
<variable units="millisecond" name="tau_d"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.4</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">35</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_d</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.4</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_d</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">50</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>alpha_d</ci>
<ci>beta_d</ci>
</apply>
<ci>gamma_d</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_current_f_gate">
<variable units="dimensionless" public_interface="out" name="f" initial_value="1"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="f_inf"/>
<variable units="millisecond" name="tau_f"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">1125</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">27</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt_square">240</cn>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">80</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">165</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">25</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf</ci>
<ci>f</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_current_fCa_gate">
<variable units="dimensionless" public_interface="out" name="fCa" initial_value="1"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="alpha_fCa"/>
<variable units="dimensionless" name="beta_fCa"/>
<variable units="dimensionless" name="gama_fCa"/>
<variable units="dimensionless" name="fCa_inf"/>
<variable units="millisecond" name="tau_fCa"/>
<variable units="per_millisecond" name="d_fCa"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.000325</cn>
</apply>
<cn cellml:units="dimensionless">8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0005</cn>
</apply>
<cn cellml:units="millimolar">0.0001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gama_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.00075</cn>
</apply>
<cn cellml:units="millimolar">0.0008</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fCa_inf</ci>
<apply>
<divide/>
<apply>
<plus/>
<ci>alpha_fCa</ci>
<ci>beta_fCa</ci>
<ci>gama_fCa</ci>
<cn cellml:units="dimensionless">0.23</cn>
</apply>
<cn cellml:units="dimensionless">1.46</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fCa</ci>
<cn cellml:units="millisecond">2</cn>
</apply>
<apply>
<eq/>
<ci>d_fCa</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>fCa_inf</ci>
<ci>fCa</ci>
</apply>
<ci>tau_fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCa</ci>
</apply>
<piecewise>
<piece>
<cn cellml:units="per_millisecond">0</cn>
<apply>
<and/>
<apply>
<gt/>
<apply>
<times/>
<cn cellml:units="millisecond">0.01</cn>
<ci>d_fCa</ci>
</apply>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<gt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>d_fCa</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="calcium_background_current_i_b_Ca" name="i_b_Ca"/>
<variable units="nanoS_per_picoF" name="g_bca" initial_value="0.000592"/>
<variable units="millivolt" public_interface="in" name="E_Ca"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Ca</ci>
<apply>
<times/>
<ci>g_bca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="transient_outward_current_i_to" name="i_to"/>
<variable units="nanoS_per_picoF" name="g_to" initial_value="0.294"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="millisecond" public_interface="in" private_interface="out" name="time"/>
<variable units="dimensionless" private_interface="in" name="s"/>
<variable units="dimensionless" private_interface="in" name="r"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<ci>r</ci>
<ci>s</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_s_gate">
<variable units="dimensionless" public_interface="out" name="s" initial_value="1"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="s_inf"/>
<variable units="millisecond" name="tau_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">85</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt_square">320</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="millisecond">5</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">3</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_inf</ci>
<ci>s</ci>
</apply>
<ci>tau_s</ci>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_r_gate">
<variable units="dimensionless" public_interface="out" name="r" initial_value="0"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" name="r_inf"/>
<variable units="millisecond" name="tau_r"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">20</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">9.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt_square">1800</cn>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">0.8</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_inf</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="sodium_potassium_pump_current_i_NaK" name="i_NaK"/>
<variable units="picoA_per_picoF" name="P_NaK" initial_value="1.362"/>
<variable units="millimolar" name="K_mk" initial_value="1"/>
<variable units="millimolar" name="K_mNa" initial_value="40"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="joule_per_mole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_mk</ci>
</apply>
</apply>
<ci>Na_i</ci>
</apply>
<apply>
<plus/>
<ci>Na_i</ci>
<ci>K_mNa</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0353</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="sodium_calcium_exchanger_current_i_NaCa" name="i_NaCa"/>
<variable units="picoA_per_picoF" name="K_NaCa" initial_value="1000"/>
<variable units="dimensionless" name="K_sat" initial_value="0.1"/>
<variable units="dimensionless" name="alpha" initial_value="2.5"/>
<variable units="dimensionless" name="gamma" initial_value="0.35"/>
<variable units="millimolar" name="Km_Ca" initial_value="1.38"/>
<variable units="millimolar" name="Km_Nai" initial_value="87.5"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="joule_per_mole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="millisecond" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<ci>alpha</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>Km_Ca</ci>
<ci>Ca_o</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>K_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="calcium_pump_current_i_p_Ca" name="i_p_Ca"/>
<variable units="picoA_per_picoF" name="g_pCa" initial_value="0.825"/>
<variable units="millimolar" name="K_pCa" initial_value="0.0005"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_pCa</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_pCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_pump_current">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="potassium_pump_current_i_p_K" name="i_p_K"/>
<variable units="nanoS_per_picoF" name="g_pK" initial_value="0.0146"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_pK</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">25</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">5.98</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_dynamics">
<variable units="millimolar" public_interface="out" name="Ca_i" initial_value="0.0002"/>
<variable units="millimolar" public_interface="out" name="Ca_o" initial_value="2"/>
<variable units="millimolar" name="Ca_SR" initial_value="0.2"/>
<variable units="millimolar_per_millisecond" cmeta:id="calcium_dynamics_i_rel" name="i_rel"/>
<variable units="millimolar_per_millisecond" cmeta:id="calcium_dynamics_i_up" name="i_up"/>
<variable units="millimolar_per_millisecond" cmeta:id="calcium_dynamics_i_leak" name="i_leak"/>
<variable units="dimensionless" name="g" initial_value="1"/>
<variable units="millisecond" name="tau_g" initial_value="2"/>
<variable units="dimensionless" name="g_inf"/>
<variable units="millimolar_per_millisecond" name="a_rel" initial_value="0.016464"/>
<variable units="millimolar" name="b_rel" initial_value="0.25"/>
<variable units="millimolar_per_millisecond" name="c_rel" initial_value="0.008232"/>
<variable units="millimolar" name="K_up" initial_value="0.00025"/>
<variable units="per_millisecond" name="V_leak" initial_value="8e-5"/>
<variable units="millimolar_per_millisecond" name="Vmax_up" initial_value="0.000425"/>
<variable units="dimensionless" name="Ca_i_bufc"/>
<variable units="dimensionless" name="Ca_sr_bufsr"/>
<variable units="millimolar" name="Buf_c" initial_value="0.15"/>
<variable units="millimolar" name="K_buf_c" initial_value="0.001"/>
<variable units="millimolar" name="Buf_sr" initial_value="10"/>
<variable units="millimolar" name="K_buf_sr" initial_value="0.3"/>
<variable units="micrometre3" name="V_sr" initial_value="0.001094"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="micrometre3" public_interface="in" name="V_c"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="d"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_CaL"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_p_Ca"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_b_Ca"/>
<variable units="per_millisecond" name="d_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>a_rel</ci>
<apply>
<power/>
<ci>Ca_SR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>b_rel</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_SR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<ci>c_rel</ci>
</apply>
<ci>d</ci>
<ci>g</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_up</ci>
<apply>
<divide/>
<ci>Vmax_up</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>K_up</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_leak</ci>
<apply>
<times/>
<ci>V_leak</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>g_inf</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
<cn cellml:units="dimensionless">16</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>d_g</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>g_inf</ci>
<ci>g</ci>
</apply>
<ci>tau_g</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>g</ci>
</apply>
<piecewise>
<piece>
<cn cellml:units="per_millisecond">0</cn>
<apply>
<and/>
<apply>
<gt/>
<apply>
<times/>
<cn cellml:units="millisecond">0.01</cn>
<ci>d_g</ci>
</apply>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<gt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>d_g</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Ca_i_bufc</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Buf_c</ci>
<ci>K_buf_c</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_buf_c</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_sr_bufsr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Buf_sr</ci>
<ci>K_buf_sr</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_SR</ci>
<ci>K_buf_sr</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>Ca_i_bufc</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_leak</ci>
<ci>i_up</ci>
</apply>
<ci>i_rel</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mA_pA">1</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaL</ci>
<ci>i_b_Ca</ci>
<ci>i_p_Ca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_c</ci>
<ci>F</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_sr_bufsr</ci>
<ci>V_c</ci>
</apply>
<ci>V_sr</ci>
</apply>
<apply>
<minus/>
<ci>i_up</ci>
<apply>
<plus/>
<ci>i_rel</ci>
<ci>i_leak</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_dynamics">
<variable units="millimolar" public_interface="out" name="Na_i" initial_value="11.6"/>
<variable units="millimolar" public_interface="out" name="Na_o" initial_value="140"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="micrometre3" public_interface="in" name="V_c"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Na"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaCa"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_b_Na"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mA_pA">1</cn>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_c</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_dynamics">
<variable units="millimolar" public_interface="out" name="K_i" initial_value="138.3"/>
<variable units="millimolar" public_interface="out" name="K_o" initial_value="5.4"/>
<variable units="millisecond" public_interface="in" name="time"/>
<variable units="coulomb_per_millimole" public_interface="in" name="F"/>
<variable units="microF" public_interface="in" name="Cm"/>
<variable units="micrometre3" public_interface="in" name="V_c"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_K1"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_to"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_NaK"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Kr"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Ks"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_p_K"/>
<variable units="picoA_per_picoF" public_interface="in" name="i_Stim"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mA_pA">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_K1</ci>
<ci>i_to</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_p_K</ci>
<ci>i_Stim</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="litre_micrometre3">1</cn>
<ci>V_c</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="stimulus_protocol">
<variable units="picoA_per_picoF" public_interface="out" cmeta:id="stimulus_protocol_Istim" name="Istim"/>
<variable units="millisecond" cmeta:id="stimulus_protocol_IstimStart" name="IstimStart" initial_value="100"/>
<variable units="millisecond" cmeta:id="stimulus_protocol_IstimEnd" name="IstimEnd" initial_value="50000"/>
<variable units="picoA_per_picoF" cmeta:id="stimulus_protocol_IstimAmplitude" name="IstimAmplitude" initial_value="-52"/>
<variable units="millisecond" cmeta:id="stimulus_protocol_IstimPeriod" name="IstimPeriod" initial_value="1000"/>
<variable units="millisecond" cmeta:id="stimulus_protocol_IstimPulseDuration" name="IstimPulseDuration" initial_value="1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="Stimulus_Current_Equation">
<apply>
<eq/>
<ci>Istim</ci>
<piecewise>
<piece>
<ci>IstimAmplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>IstimStart</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>IstimEnd</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>IstimStart</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>IstimStart</ci>
</apply>
<ci>IstimPeriod</ci>
</apply>
</apply>
<ci>IstimPeriod</ci>
</apply>
</apply>
<ci>IstimPulseDuration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="picoA_per_picoF">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<variable units="millisecond" public_interface="in" name="time"/>
</component>
<connection>
<map_components component_2="stimulus_protocol" component_1="membrane"/>
<map_variables variable_2="Istim" variable_1="Istim"/>
</connection>
<connection>
<map_components component_2="stimulus_protocol" component_1="environment"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_current">
<component_ref component="L_type_Ca_current_d_gate"/>
<component_ref component="L_type_Ca_current_f_gate"/>
<component_ref component="L_type_Ca_current_fCa_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_Xr1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_Xr2_gate"/>
</component_ref>
<component_ref component="slow_time_dependent_potassium_current">
<component_ref component="slow_time_dependent_potassium_current_Xs_gate"/>
</component_ref>
<component_ref component="sodium_background_current"/>
<component_ref component="calcium_background_current"/>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump_current"/>
<component_ref component="sodium_calcium_exchanger_current"/>
<component_ref component="calcium_pump_current"/>
<component_ref component="potassium_pump_current"/>
<component_ref component="calcium_dynamics"/>
<component_ref component="sodium_dynamics"/>
<component_ref component="potassium_dynamics"/>
<component_ref component="reversal_potentials"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_current">
<component_ref component="L_type_Ca_current_d_gate"/>
<component_ref component="L_type_Ca_current_f_gate"/>
<component_ref component="L_type_Ca_current_fCa_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_Xr1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_Xr2_gate"/>
</component_ref>
<component_ref component="slow_time_dependent_potassium_current">
<component_ref component="slow_time_dependent_potassium_current_Xs_gate"/>
</component_ref>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_s_gate"/>
<component_ref component="transient_outward_current_r_gate"/>
</component_ref>
</group>
<connection>
<map_components component_2="environment" component_1="membrane"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="reversal_potentials"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="fast_sodium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="L_type_Ca_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="rapid_time_dependent_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="slow_time_dependent_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="inward_rectifier_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_background_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_background_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="transient_outward_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_potassium_pump_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_calcium_exchanger_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="calcium_dynamics"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_dynamics"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="potassium_dynamics"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="reversal_potentials" component_1="membrane"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_CaL" variable_1="i_CaL"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="rapid_time_dependent_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Kr" variable_1="i_Kr"/>
</connection>
<connection>
<map_components component_2="slow_time_dependent_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_Ks" variable_1="i_Ks"/>
</connection>
<connection>
<map_components component_2="transient_outward_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_to" variable_1="i_to"/>
</connection>
<connection>
<map_components component_2="inward_rectifier_potassium_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_K1" variable_1="i_K1"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Na" variable_1="i_b_Na"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Ca" variable_1="i_b_Ca"/>
</connection>
<connection>
<map_components component_2="sodium_potassium_pump_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="sodium_calcium_exchanger_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="calcium_pump_current" component_1="membrane"/>
<map_variables variable_2="i_p_Ca" variable_1="i_p_Ca"/>
</connection>
<connection>
<map_components component_2="potassium_pump_current" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_p_K" variable_1="i_p_K"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="membrane"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="V_c" variable_1="V_c"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="membrane"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="V_c" variable_1="V_c"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="membrane"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="V_c" variable_1="V_c"/>
<map_variables variable_2="Cm" variable_1="Cm"/>
<map_variables variable_2="i_Stim" variable_1="i_Stim"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="inward_rectifier_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="rapid_time_dependent_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="transient_outward_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="potassium_pump_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="slow_time_dependent_potassium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Ks" variable_1="E_Ks"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Ca" variable_1="E_Ca"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current" component_1="reversal_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="reversal_potentials"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="reversal_potentials"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="reversal_potentials"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="inward_rectifier_potassium_current"/>
<map_variables variable_2="i_K1" variable_1="i_K1"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="rapid_time_dependent_potassium_current"/>
<map_variables variable_2="i_Kr" variable_1="i_Kr"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="slow_time_dependent_potassium_current"/>
<map_variables variable_2="i_Ks" variable_1="i_Ks"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="fast_sodium_current"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="sodium_background_current"/>
<map_variables variable_2="i_b_Na" variable_1="i_b_Na"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="L_type_Ca_current"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="d" variable_1="d"/>
<map_variables variable_2="i_CaL" variable_1="i_CaL"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="calcium_pump_current"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="i_p_Ca" variable_1="i_p_Ca"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="calcium_background_current"/>
<map_variables variable_2="i_b_Ca" variable_1="i_b_Ca"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="sodium_potassium_pump_current"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="sodium_potassium_pump_current"/>
<map_variables variable_2="i_NaK" variable_1="i_NaK"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
</connection>
<connection>
<map_components component_2="calcium_dynamics" component_1="sodium_calcium_exchanger_current"/>
<map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
</connection>
<connection>
<map_components component_2="sodium_dynamics" component_1="sodium_calcium_exchanger_current"/>
<map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="rapid_time_dependent_potassium_current_Xr1_gate" component_1="rapid_time_dependent_potassium_current"/>
<map_variables variable_2="Xr1" variable_1="Xr1"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="rapid_time_dependent_potassium_current_Xr2_gate" component_1="rapid_time_dependent_potassium_current"/>
<map_variables variable_2="Xr2" variable_1="Xr2"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="slow_time_dependent_potassium_current_Xs_gate" component_1="slow_time_dependent_potassium_current"/>
<map_variables variable_2="Xs" variable_1="Xs"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current_m_gate" component_1="fast_sodium_current"/>
<map_variables variable_2="m" variable_1="m"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current_h_gate" component_1="fast_sodium_current"/>
<map_variables variable_2="h" variable_1="h"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="fast_sodium_current_j_gate" component_1="fast_sodium_current"/>
<map_variables variable_2="j" variable_1="j"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_current_d_gate" component_1="L_type_Ca_current"/>
<map_variables variable_2="d" variable_1="d"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_current_f_gate" component_1="L_type_Ca_current"/>
<map_variables variable_2="f" variable_1="f"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_current_fCa_gate" component_1="L_type_Ca_current"/>
<map_variables variable_2="fCa" variable_1="fCa"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="transient_outward_current_s_gate" component_1="transient_outward_current"/>
<map_variables variable_2="s" variable_1="s"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="transient_outward_current_r_gate" component_1="transient_outward_current"/>
<map_variables variable_2="r" variable_1="r"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="transient_outward_current"/>
<map_variables variable_2="i_to" variable_1="i_to"/>
</connection>
<connection>
<map_components component_2="potassium_dynamics" component_1="potassium_pump_current"/>
<map_variables variable_2="i_p_K" variable_1="i_p_K"/>
</connection>
<rdf:RDF>
<rdf:Bag rdf:about="rdf:#8fc9f990-0f48-460b-8074-2cd2d341a3c6">
<rdf:li>cardiac</rdf:li>
<rdf:li>ventricular myocyte</rdf:li>
<rdf:li>electrophysiology</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#fa33b0c4-05b8-48fa-9451-5be23dc285d9">
<rdf:li rdf:resource="rdf:#347ed4e4-c0d2-41c2-b879-8be8d12e5e16"/>
<rdf:li rdf:resource="rdf:#df6a1893-9e56-471c-a6d4-bfd30a797236"/>
<rdf:li rdf:resource="rdf:#e9158930-f3cc-4627-b1cf-56a27ddc3d90"/>
<rdf:li rdf:resource="rdf:#2b8577d9-d937-40c6-a8dd-82abe6abaa3d"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#5d1bfb7d-722c-42ea-adf6-16114a7a22e9">
<vCard:Orgname>Oxford University</vCard:Orgname>
<vCard:Orgunit>Department of Physiology, Anatomy & Genetics</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e1fea502-dc59-494f-8e92-90618056b4b7">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>Department of Physiology, Anatomy & Genetics, University of Oxford</dc:publisher>
<cmeta:comment rdf:resource="rdf:#9c176e4c-ffb7-4213-ac54-263c2ebf24da"/>
<dcterms:created rdf:resource="rdf:#70475844-b324-4544-b9cb-2eb27abe6f3c"/>
<dc:creator rdf:resource="rdf:#d2f88c1a-9aab-4a6f-a522-2897e4ccebe7"/>
<cmeta:modification rdf:resource="rdf:#760e3921-49f3-4d3d-a8ae-110c71fde1d1"/>
<cmeta:modification rdf:resource="rdf:#10dc27e0-3958-478a-98b3-ce62d8bda228"/>
<cmeta:modification rdf:resource="rdf:#39ca2adc-1a09-481c-870d-5124f6612865"/>
<cmeta:modification rdf:resource="rdf:#5aedc532-7f3b-4d9f-8ff2-d454ad8d6636"/>
<cmeta:modification rdf:resource="rdf:#82ac3ca4-6f4e-4311-96cc-49270a8a8cb8"/>
<cmeta:modification rdf:resource="rdf:#94a0a365-1658-459c-9bc3-9b6a533e0f3e"/>
<cmeta:modification rdf:resource="rdf:#c169a7d6-0345-481e-9ff7-5bd3f483618b"/>
<cmeta:modification rdf:resource="rdf:#cbd50196-8588-4d67-9757-f2c15b5cf202"/>
<cmeta:modification rdf:resource="rdf:#f1b4908a-a3fd-48d4-ab85-9e9cda6fe858"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f9e0a27f-cc1f-4cfa-ae1d-d06dda594542">
<dc:creator rdf:resource="rdf:#3d8cf7c6-1329-4a64-ab8f-53022d1f5432"/>
<rdf:value>This variant describes the human cardiac M-cell, as described in ten Tusscher et al. 2004</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#94a0a365-1658-459c-9bc3-9b6a533e0f3e">
<dcterms:modified rdf:resource="rdf:#2758a0ce-a078-4aa3-8f3a-d7a47e96c46c"/>
<rdf:value>Units checked, curated.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#3627c33f-29c2-4990-a24f-64ef4cc4c7f1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$+k1WL">
<ns7:boundIntervals rdf:resource="rdf:#$0l1WL"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f0f13b80-4c6c-4b4c-b32d-6930c4d46367">
<dc:creator rdf:resource="rdf:#fa33b0c4-05b8-48fa-9451-5be23dc285d9"/>
<dc:title>A model for human ventricular tissue</dc:title>
<bqs:volume>286 4</bqs:volume>
<bqs:first_page>1573</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#37bdac01-0411-4c42-9f51-ab05680ed96a"/>
<dcterms:issued rdf:resource="rdf:#cfa84a7b-c4be-4e0a-ba1b-d52df81f2c5e"/>
<bqs:last_page>1589</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$nZnH.1">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$oZnH.1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#70475844-b324-4544-b9cb-2eb27abe6f3c">
<dcterms:W3CDTF>2006-11-08T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3627c33f-29c2-4990-a24f-64ef4cc4c7f1">
<vCard:N rdf:resource="rdf:#2736b5a1-e26d-4618-9dfc-e73fa1983ee4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e9c3ab69-fab6-4385-8b7e-3260b8831680">
<dcterms:W3CDTF>2007-06-18T12:39:04+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#adeabb62-186d-4839-822a-4bbf905e60e8">
<dcterms:W3CDTF>2008-04-01T14:14:36+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e9d6e6c0-ab8a-435b-a771-288c2c87271f">
<dcterms:W3CDTF>2008-05-27T12:41:26+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$4qYgz1">
<ns7:boundIntervals rdf:resource="rdf:#$5qYgz1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$1l1WL">
<ns7:nonstandard-abseps>1E-8</ns7:nonstandard-abseps>
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>50000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9d357c8e-9504-49be-966b-ac0b2438fd91">
<vCard:N rdf:resource="rdf:#28d7fb05-cfa0-4080-91da-a9c4bfb9806c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f1b4908a-a3fd-48d4-ab85-9e9cda6fe858">
<dcterms:modified rdf:resource="rdf:#adeabb62-186d-4839-822a-4bbf905e60e8"/>
<cmeta:modifier rdf:resource="rdf:#45442339-ea6c-4461-9baf-527e257edbd0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#77c66de4-59bc-4ba1-a406-2b1d53d17987">
<vCard:N rdf:resource="rdf:#59077e6d-87c8-4130-ae35-8dc503093e5e"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39ca2adc-1a09-481c-870d-5124f6612865">
<dcterms:modified rdf:resource="rdf:#bd2eef02-8b67-49c5-85af-e2a1787eafc3"/>
<rdf:value>Penny's file was modified to allow it to run in PCEnv. This required rearrangement of some differential equations such that the differential was on the left hand side. This modification produces a mathematically equivalent model and the output of the pre-modified model has not been altered in any way.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#77c66de4-59bc-4ba1-a406-2b1d53d17987"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$d02cI3">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$e02cI3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#023e0b51-279e-4b21-89cc-d5bf68ebaa1a">
<vCard:Given>D</vCard:Given>
<vCard:Family>Noble</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#760e3921-49f3-4d3d-a8ae-110c71fde1d1">
<dcterms:modified rdf:resource="rdf:#e9d6e6c0-ab8a-435b-a771-288c2c87271f"/>
<rdf:value>replaced illegal - in model cmeta:id with _</rdf:value>
<cmeta:modifier rdf:resource="rdf:#84764963-8896-4139-b2e5-e01831dd3fa9"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5aedc532-7f3b-4d9f-8ff2-d454ad8d6636">
<dcterms:modified rdf:resource="rdf:#e93617f8-1c81-4193-8c1e-fec90d70a8f1"/>
<rdf:value>Version 03 Variant 01 duplicated as version 04 to allow repository main page listing to point straight to latest TT04 version. v3v1 session also duplicated.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#8b4426fc-e7b6-4b56-8ae1-6dbccb5d5e47"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ba0fde41-e133-499f-9e22-d89c780c0587">
<vCard:Given>A</vCard:Given>
<vCard:Family>Panfilov</vCard:Family>
<vCard:Other>V</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#57066891-a6c1-4691-8cbd-96958e8232ca">
<dc:subject rdf:resource="rdf:#3766f7d9-d2ea-4c50-a1ab-da9abd92c72b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3d8cf7c6-1329-4a64-ab8f-53022d1f5432">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$STbci">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$TTbci"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cbd50196-8588-4d67-9757-f2c15b5cf202">
<dcterms:modified rdf:resource="rdf:#f8140607-0935-4c49-89c7-8c70eee275e2"/>
<rdf:value>added cmeta:id's to some variables to allow referencing by a PCEnv session file</rdf:value>
<cmeta:modifier rdf:resource="rdf:#9d357c8e-9504-49be-966b-ac0b2438fd91"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#82ac3ca4-6f4e-4311-96cc-49270a8a8cb8">
<dcterms:modified rdf:resource="rdf:#e9c3ab69-fab6-4385-8b7e-3260b8831680"/>
<rdf:value>A stimulus protocol component was added to the model to allow simulation of trains of action potentials. Values for the amplitude (-52 picoA per picoF) and duration (1 ms) of the stimulus were taken from the original single stimulus in the model. The period of 1000 ms is intended to reflect beat period of the human heart, on which this model is based.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#f1d197ce-5fd3-4983-a21a-7a3a48246ff0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1e19283c-2e21-42e9-9d1a-3cb85bdd76be">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#59077e6d-87c8-4130-ae35-8dc503093e5e">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e9158930-f3cc-4627-b1cf-56a27ddc3d90">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#1ba94015-96a2-4ac7-9956-302a20a0485b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#948fcd7f-44b6-4a59-803e-d2931920e605">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>unknown</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0c416269-ddf5-48c9-ab48-916a404ff438">
<vCard:Given>Tommy</vCard:Given>
<vCard:Family>Yu</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#157954b8-18d9-4028-abb6-3050db782c35">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>unknown</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e93617f8-1c81-4193-8c1e-fec90d70a8f1">
<dcterms:W3CDTF>2007-10-18T15:39:05+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$mZnH.1">
<ns7:boundIntervals rdf:resource="rdf:#$nZnH.1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3766f7d9-d2ea-4c50-a1ab-da9abd92c72b">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value rdf:resource="rdf:#8fc9f990-0f48-460b-8074-2cd2d341a3c6"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#37bdac01-0411-4c42-9f51-ab05680ed96a">
<dc:title>American Journal of Physiology Heart and Circulatory Physiology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9dee9082-8541-48c5-8190-a559628013d9">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>penny.noble@dpag.ox.ac.uk</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$e02cI3">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.01</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#84764963-8896-4139-b2e5-e01831dd3fa9">
<vCard:N rdf:resource="rdf:#1e19283c-2e21-42e9-9d1a-3cb85bdd76be"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f1d197ce-5fd3-4983-a21a-7a3a48246ff0">
<vCard:N rdf:resource="rdf:#9f0bbf92-7466-42c5-9dc0-2f1470ff6d79"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9f0bbf92-7466-42c5-9dc0-2f1470ff6d79">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d2f88c1a-9aab-4a6f-a522-2897e4ccebe7">
<vCard:ORG rdf:resource="rdf:#5d1bfb7d-722c-42ea-adf6-16114a7a22e9"/>
<vCard:EMAIL rdf:resource="rdf:#9dee9082-8541-48c5-8190-a559628013d9"/>
<vCard:N rdf:resource="rdf:#e1fea502-dc59-494f-8e92-90618056b4b7"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2736b5a1-e26d-4618-9dfc-e73fa1983ee4">
<vCard:Given>Penny</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4ff62832-a95d-4a53-b0e5-0fe8a7e94e0c">
<vCard:N rdf:resource="rdf:#0c416269-ddf5-48c9-ab48-916a404ff438"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3630fa95-f900-4a5a-a70e-2e1f0afc2fc5">
<vCard:N rdf:resource="rdf:#afe98b15-bc5d-4624-a72a-72be6ca1b507"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d4afc7e3-b69b-48bc-b422-9a3979e48c6f">
<dcterms:W3CDTF>2007-06-22T15:51:38+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f51be818-d44e-4d90-861d-833f77889d2c">
<vCard:ORG rdf:resource="rdf:#e73e76f4-5e33-46cc-9ebf-3c80b685c5d3"/>
<vCard:EMAIL rdf:resource="rdf:#948fcd7f-44b6-4a59-803e-d2931920e605"/>
<vCard:N rdf:resource="rdf:#157954b8-18d9-4028-abb6-3050db782c35"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9c176e4c-ffb7-4213-ac54-263c2ebf24da">
<dc:creator rdf:resource="rdf:#8564ffeb-76b6-4b96-ab64-438b59853105"/>
<rdf:value>This variant of the model was created by Penny Noble of Oxford University, and represents the parameters given for the M-cell variant in Ten Tusscher et al. 2004. A stimulus protocol component has been added to the model to allow simulation of trains of action potentials (JL, 18/06/07). This file is known to run in PCEnv and COR.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8b4426fc-e7b6-4b56-8ae1-6dbccb5d5e47">
<vCard:N rdf:resource="rdf:#f466f81f-77a6-495a-ad6f-5f56ddc3214d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#28d7fb05-cfa0-4080-91da-a9c4bfb9806c">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1ba94015-96a2-4ac7-9956-302a20a0485b">
<vCard:Given>P</vCard:Given>
<vCard:Family>Noble</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#41d307c2-a4ae-4000-9179-d17c9604da8f">
<dcterms:W3CDTF>2007-11-26T12:38:03+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2758a0ce-a078-4aa3-8f3a-d7a47e96c46c">
<dcterms:W3CDTF>2007-12-06T15:13:38+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$5qYgz1">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$6qYgz1"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#afe98b15-bc5d-4624-a72a-72be6ca1b507">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$TTbci">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>100000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.01</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$ozQGz">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>50000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#df6a1893-9e56-471c-a6d4-bfd30a797236">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#023e0b51-279e-4b21-89cc-d5bf68ebaa1a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$nzQGz">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$ozQGz"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ee4f9c1e-f859-4dd4-95f0-25a6c1de83ba">
<vCard:Given>K</vCard:Given>
<vCard:Family>Ten Tusscher</vCard:Family>
<vCard:Other>H</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#347ed4e4-c0d2-41c2-b879-8be8d12e5e16">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#ee4f9c1e-f859-4dd4-95f0-25a6c1de83ba"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bd2eef02-8b67-49c5-85af-e2a1787eafc3">
<dcterms:W3CDTF>2007-05-06T12:35:00+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$oZnH.1">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$RTbci">
<ns7:boundIntervals rdf:resource="rdf:#$STbci"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cfa84a7b-c4be-4e0a-ba1b-d52df81f2c5e">
<dcterms:W3CDTF>2004-04-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="#tentusscher_2004_m_cell">
<ns7:simulation rdf:resource="rdf:#$+k1WL"/>
<ns7:simulation rdf:resource="rdf:#$4qYgz1"/>
<ns7:simulation rdf:resource="rdf:#$RTbci"/>
<ns7:simulation rdf:resource="rdf:#$c02cI3"/>
<ns7:simulation rdf:resource="rdf:#$mZnH.1"/>
<ns7:simulation rdf:resource="rdf:#$mzQGz"/>
<dc:title>unknown</dc:title>
<cmeta:comment rdf:resource="rdf:#f9e0a27f-cc1f-4cfa-ae1d-d06dda594542"/>
<bqs:reference rdf:resource="rdf:#31d2c8d3-9e0f-4390-a0dd-49ffbb1b3e7f"/>
<bqs:reference rdf:resource="rdf:#57066891-a6c1-4691-8cbd-96958e8232ca"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f8140607-0935-4c49-89c7-8c70eee275e2">
<dcterms:W3CDTF>2008-01-25T09:54:15+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="">
<dcterms:created rdf:resource="rdf:#62e7f227-da71-4eb6-bc5d-fce425307859"/>
<dc:creator rdf:resource="rdf:#f51be818-d44e-4d90-861d-833f77889d2c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$0l1WL">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$1l1WL"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c169a7d6-0345-481e-9ff7-5bd3f483618b">
<dcterms:modified rdf:resource="rdf:#41d307c2-a4ae-4000-9179-d17c9604da8f"/>
<rdf:value>Tommy hand-fixed the RDF to get the repository to save the simulation metadata.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#4ff62832-a95d-4a53-b0e5-0fe8a7e94e0c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8564ffeb-76b6-4b96-ab64-438b59853105">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#31d2c8d3-9e0f-4390-a0dd-49ffbb1b3e7f">
<bqs:Pubmed_id>14656705</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#f0f13b80-4c6c-4b4c-b32d-6930c4d46367"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$6qYgz1">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>100000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize>0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f466f81f-77a6-495a-ad6f-5f56ddc3214d">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#62e7f227-da71-4eb6-bc5d-fce425307859">
<dcterms:W3CDTF>2006-01-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#10dc27e0-3958-478a-98b3-ce62d8bda228">
<dcterms:modified rdf:resource="rdf:#d4afc7e3-b69b-48bc-b422-9a3979e48c6f"/>
<rdf:value>Some variables have been given cmeta:id's to allow a PCEnv session to be created.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#3630fa95-f900-4a5a-a70e-2e1f0afc2fc5"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$c02cI3">
<ns7:boundIntervals rdf:resource="rdf:#$d02cI3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2b8577d9-d937-40c6-a8dd-82abe6abaa3d">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#ba0fde41-e133-499f-9e22-d89c780c0587"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$mzQGz">
<ns7:boundIntervals rdf:resource="rdf:#$nzQGz"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#45442339-ea6c-4461-9baf-527e257edbd0">
<vCard:N rdf:resource="rdf:#148c20f0-6fed-44c0-85cd-b92d245e0823"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e73e76f4-5e33-46cc-9ebf-3c80b685c5d3">
<vCard:Orgname>Oxford University</vCard:Orgname>
<vCard:Orgunit>unknown</vCard:Orgunit>
</rdf:Description>
</rdf:RDF>
</model>
