- Author:
- Alan Garny <agarny@hellix.com>
- Date:
- 2021-06-11 09:51:39+12:00
- Desc:
- Removed CSV that can be regenerated.
Figure1.csv and Figure2.csv can be generated by running Figure1.sedml and Figure2.sedml, respectively, and then exporting the simulation results to CSV. So, no need for those CSV files to be tracked.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/648/rawfile/4e662cb87f8569d10d40251b876798d0d92f68f7/Figure4.cellml
<?xml version='1.0' encoding='UTF-8'?>
<!--
This CellML file was generated on 24/01/2017 at 12:48:23 using:
COR (0.9.31.1409)
Copyright 2002-2017 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model cmeta:id="Human_SAN_Fabbri_Fantini_Wilders_Severi_2017" name="Human_SAN_Fabbri_Fantini_Wilders_Severi_2017" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="per_second">
<unit exponent="-1" units="second"/>
</units>
<units name="millisecond">
<unit prefix="milli" units="second"/>
</units>
<units name="per_millisecond">
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_millivolt">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="per_millivolt_second">
<unit exponent="-1" units="millivolt"/>
<unit exponent="-1" units="second"/>
</units>
<units name="millivolt_second">
<unit units="millivolt"/>
<unit units="second"/>
</units>
<units name="microS">
<unit prefix="micro" units="siemens"/>
</units>
<units name="microF">
<unit prefix="micro" units="farad"/>
</units>
<units name="nanoA">
<unit prefix="nano" units="ampere"/>
</units>
<units name="mA_nA">
<unit prefix="milli" units="ampere"/>
<unit exponent="-1" units="nanoA"/>
</units>
<units name="millimolar">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="per_millimolar">
<unit exponent="-1" units="millimolar"/>
</units>
<units name="millimolar4">
<unit exponent="4" units="millimolar"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="per_millimolar2_second">
<unit exponent="-2" units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="per_millimolar_second">
<unit exponent="-1" units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="nanoA"/>
<unit exponent="-1" units="millimolar"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit exponent="-1" prefix="kilo" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="millimetre">
<unit prefix="milli" units="metre"/>
</units>
<units name="micrometre">
<unit prefix="micro" units="metre"/>
</units>
<units name="millimetre3">
<unit exponent="3" prefix="milli" units="metre"/>
</units>
<units name="litre_millimetre3">
<unit units="litre"/>
<unit exponent="-1" units="millimetre3"/>
</units>
<units name="micrometre_per_femtometre">
<unit units="micrometre"/>
<unit exponent="-1" prefix="femto" units="metre"/>
</units>
<units name="nanoS">
<unit prefix="nano" units="siemens"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="Membrane">
<variable initial_value="8314.472" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485.3415" name="F" public_interface="out" units="coulomb_per_mole"/>
<variable initial_value="5.7e-5" name="C" units="microF"/>
<variable name="RTONF" public_interface="out" units="millivolt"/>
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<variable name="i_NaK" public_interface="in" units="nanoA"/>
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<variable name="i_CaT" public_interface="in" units="nanoA"/>
<variable name="i_KACh" public_interface="in" units="nanoA"/>
<variable name="i_Kur" public_interface="in" units="nanoA"/>
<variable name="V" public_interface="out" units="millivolt"/>
<variable initial_value="0" name="clamp_mode" units="dimensionless"/>
<variable name="V_clamp" private_interface="in" units="millivolt"/>
<variable initial_value="-48.46347336046628" name="V_ode" units="millivolt"/>
<variable name="i_tot" units="nanoA"/>
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<eq/>
<ci>i_tot</ci>
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<plus/>
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<ci>i_NaCa</ci>
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<ci>i_CaT</ci>
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<ci>i_Kur</ci>
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<eq/>
<apply>
<diff/>
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</bvar>
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<apply>
<divide/>
<apply>
<minus/>
<ci>i_tot</ci>
</apply>
<ci>C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RTONF</ci>
<apply>
<divide/>
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<times/>
<ci>R</ci>
<ci>T</ci>
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<ci>F</ci>
</apply>
</apply>
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<eq/>
<ci>V</ci>
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<ci>V_clamp</ci>
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<geq/>
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</piece>
<otherwise>
<ci>V_ode</ci>
</otherwise>
</piecewise>
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</math>
</component>
<component name="Voltage_clamp">
<variable initial_value="0.5" name="t_holding" units="second"/>
<variable initial_value="0.5" name="t_test" units="second"/>
<variable name="V_clamp" public_interface="out" units="millivolt"/>
<variable initial_value="-35" name="V_test" units="millivolt"/>
<variable initial_value="-45" name="V_holding" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<piecewise>
<piece>
<ci>V_test</ci>
<apply>
<and/>
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<gt/>
<ci>time</ci>
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<lt/>
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<plus/>
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</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>V_holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Rate_modulation_experiments">
<variable initial_value="0" name="ACh" public_interface="out" units="millimolar"/>
<variable initial_value="0" name="Iso_1_uM" public_interface="out" units="dimensionless"/>
</component>
<component name="Ionic_values">
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable initial_value="140" name="Nao" public_interface="out" units="millimolar"/>
<variable initial_value="140" name="Ki" public_interface="out" units="millimolar"/>
<variable initial_value="5.4" name="Ko" public_interface="out" units="millimolar"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable initial_value="1.8" name="Cao" public_interface="out" units="millimolar"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable name="E_Na" public_interface="out" units="millivolt"/>
<variable name="E_K" public_interface="out" units="millivolt"/>
<variable name="E_Ca" public_interface="out" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
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<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
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<times/>
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<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Nai_concentration">
<variable name="Nai" public_interface="out" units="millimolar"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="V_sub" public_interface="in" units="millimetre3"/>
<variable name="V_i" public_interface="in" units="millimetre3"/>
<variable name="i_Na" public_interface="in" units="nanoA"/>
<variable name="i_NaCa" public_interface="in" units="nanoA"/>
<variable name="i_NaK" public_interface="in" units="nanoA"/>
<variable name="i_fNa" public_interface="in" units="nanoA"/>
<variable name="i_siNa" public_interface="in" units="nanoA"/>
<variable initial_value="5" name="Nai_" units="millimolar"/>
<variable initial_value="1" name="Nai_clamp" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
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<apply>
<divide/>
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<times/>
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<minus/>
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<ci>Nai_clamp</ci>
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<minus/>
<cn cellml:units="mA_nA">1</cn>
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<plus/>
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<ci>i_siNa</ci>
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<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
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<times/>
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<ci>i_NaCa</ci>
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</apply>
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<apply>
<times/>
<cn cellml:units="litre_millimetre3">1</cn>
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<plus/>
<ci>V_i</ci>
<ci>V_sub</ci>
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<ci>F</ci>
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</apply>
</apply>
<apply>
<eq/>
<ci>Nai</ci>
<ci>Nai_</ci>
</apply>
</math>
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<variable name="i_fNa" public_interface="out" units="nanoA"/>
<variable name="E_Na" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="i_fK" public_interface="out" units="nanoA"/>
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<variable name="g_f" public_interface="out" units="microS"/>
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<variable name="G_f_Na" units="microS"/>
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<variable name="G_f_K" units="microS"/>
<variable initial_value="45" name="Km_f" units="millimolar"/>
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<variable initial_value="0" name="blockade" units="dimensionless"/>
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<divide/>
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<minus/>
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<minus/>
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<minus/>
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<minus/>
<apply>
<minus/>
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<plus/>
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<divide/>
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<minus/>
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<minus/>
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<minus/>
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<plus/>
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<ci>ACh_shift</ci>
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<ci>Iso_shift</ci>
</apply>
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<lt/>
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<minus/>
<apply>
<minus/>
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<minus/>
<apply>
<minus/>
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<ci>ACh_shift</ci>
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<ci>Iso_shift</ci>
</apply>
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<divide/>
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<minus/>
<apply>
<minus/>
<apply>
<minus/>
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<ci>Iso_shift</ci>
</apply>
<ci>y_shift</ci>
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<diff/>
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<divide/>
<apply>
<minus/>
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<component name="i_NaK">
<variable name="i_NaK" public_interface="out" units="nanoA"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable initial_value="1.4" name="Km_Kp" units="millimolar"/>
<variable initial_value="14" name="Km_Nap" units="millimolar"/>
<variable initial_value="0.08105" name="i_NaK_max" units="nanoA"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="E_Na" public_interface="in" units="millivolt"/>
<variable name="Iso_increase" units="dimensionless"/>
<variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.2</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>Iso_increase</ci>
<ci>i_NaK_max</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Kp</ci>
<ci>Ko</ci>
</apply>
<cn cellml:units="dimensionless">1.2</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nap</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
<cn cellml:units="millivolt">110</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_NaCa">
<variable name="i_NaCa" public_interface="out" units="nanoA"/>
<variable initial_value="3.343" name="K_NaCa" units="nanoA"/>
<variable name="x1" units="dimensionless"/>
<variable name="x2" units="dimensionless"/>
<variable name="x3" units="dimensionless"/>
<variable name="x4" units="dimensionless"/>
<variable name="k41" units="dimensionless"/>
<variable name="k34" units="dimensionless"/>
<variable name="k23" units="dimensionless"/>
<variable name="k21" units="dimensionless"/>
<variable name="k32" units="dimensionless"/>
<variable name="k43" units="dimensionless"/>
<variable name="k12" units="dimensionless"/>
<variable name="k14" units="dimensionless"/>
<variable initial_value="0.1369" name="Qci" units="dimensionless"/>
<variable initial_value="0.4315" name="Qn" units="dimensionless"/>
<variable initial_value="0" name="Qco" units="dimensionless"/>
<variable initial_value="26.44" name="K3ni" units="millimolar"/>
<variable initial_value="0.0207" name="Kci" units="millimolar"/>
<variable initial_value="395.3" name="K1ni" units="millimolar"/>
<variable initial_value="2.289" name="K2ni" units="millimolar"/>
<variable initial_value="26.44" name="Kcni" units="millimolar"/>
<variable initial_value="4.663" name="K3no" units="millimolar"/>
<variable initial_value="1628" name="K1no" units="millimolar"/>
<variable initial_value="561.4" name="K2no" units="millimolar"/>
<variable initial_value="3.663" name="Kco" units="millimolar"/>
<variable name="do" units="dimensionless"/>
<variable name="di" units="dimensionless"/>
<variable name="Cao" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable initial_value="0" name="blockade_NaCa" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>blockade_NaCa</ci>
</apply>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>x2</ci>
<ci>k21</ci>
</apply>
<apply>
<times/>
<ci>x1</ci>
<ci>k12</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>x1</ci>
<ci>x2</ci>
<ci>x3</ci>
<ci>x4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k41</ci>
<ci>k34</ci>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k21</ci>
<ci>k32</ci>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k32</ci>
<ci>k43</ci>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k41</ci>
<ci>k12</ci>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k14</ci>
<ci>k43</ci>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k12</ci>
<ci>k23</ci>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k23</ci>
<ci>k34</ci>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k14</ci>
<ci>k21</ci>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k43</ci>
<apply>
<divide/>
<ci>Nai</ci>
<apply>
<plus/>
<ci>K3ni</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k12</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k14</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<ci>Nai</ci>
</apply>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k41</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>di</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Kcni</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k34</ci>
<apply>
<divide/>
<ci>Nao</ci>
<apply>
<plus/>
<ci>K3no</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k21</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k23</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<ci>Nao</ci>
</apply>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k32</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>do</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Na">
<variable name="i_Na_" public_interface="out" units="nanoA"/>
<variable name="i_Na_L" public_interface="out" units="nanoA"/>
<variable name="i_Na" public_interface="out" units="nanoA"/>
<variable initial_value="0.0223" name="g_Na" units="microS"/>
<variable initial_value="0" name="g_Na_L" units="microS"/>
<variable name="E_mh" units="millivolt"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_mh</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Nao</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Nai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_L</ci>
<apply>
<times/>
<ci>g_Na_L</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<plus/>
<ci>i_Na_</ci>
<ci>i_Na_L</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Na_m_gate">
<variable initial_value="0.447724" name="m" public_interface="out" units="dimensionless"/>
<variable name="alpha_m" units="per_second"/>
<variable name="beta_m" units="per_second"/>
<variable name="m_infinity" units="dimensionless"/>
<variable name="tau_m" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="1e-5" name="delta_m" units="millivolt"/>
<variable name="E0_m" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">42.0504</cn>
</apply>
</apply>
<cn cellml:units="millivolt">8.3106</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E0_m</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">41</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">2000</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">200</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_second">8000</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.056</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Na_h_gate">
<variable initial_value="0.003058" name="h" public_interface="out" units="dimensionless"/>
<variable name="alpha_h" units="per_second"/>
<variable name="beta_h" units="per_second"/>
<variable name="h_infinity" units="dimensionless"/>
<variable name="tau_h" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">69.804</cn>
</apply>
<cn cellml:units="millivolt">4.4565</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_second">20</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_second">2000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">320</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_infinity</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL">
<variable name="i_CaL" public_interface="out" units="nanoA"/>
<variable name="i_siCa" public_interface="out" units="nanoA"/>
<variable name="i_siK" public_interface="out" units="nanoA"/>
<variable name="i_siNa" public_interface="out" units="nanoA"/>
<variable name="ACh_block" units="dimensionless"/>
<variable name="ACh" public_interface="in" units="millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable initial_value="0.4578" name="P_CaL" units="nanoA_per_millimolar"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="Cao" public_interface="in" units="millimolar"/>
<variable name="Ca_sub" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="dL" private_interface="in" units="dimensionless"/>
<variable name="fL" private_interface="in" units="dimensionless"/>
<variable name="fCa" private_interface="in" units="dimensionless"/>
<variable name="Iso_increase" units="dimensionless"/>
<variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.23</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_siCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siK</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000365</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>Ko</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siNa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0000185</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Nai</ci>
<apply>
<times/>
<ci>Nao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ACh_block</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.31</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0.00009</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_siK</ci>
<ci>i_siNa</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ACh_block</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
<ci>Iso_increase</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_dL_gate">
<variable initial_value="0.001921" name="dL" public_interface="out" units="dimensionless"/>
<variable name="dL_infinity" units="dimensionless"/>
<variable name="tau_dL" units="second"/>
<variable name="alpha_dL" units="per_second"/>
<variable name="beta_dL" units="per_second"/>
<variable name="adVm" units="millivolt"/>
<variable name="bdVm" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable initial_value="4.3371" name="k_dL" units="millivolt"/>
<variable initial_value="-16.4508" name="V_dL" units="millivolt"/>
<variable name="Iso_shift_dL" units="millivolt"/>
<variable name="Iso_slope_dL" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_shift_dL</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">8</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Iso_slope_dL</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="dimensionless">27</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>dL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_dL</ci>
</apply>
<ci>Iso_shift_dL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_dL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Iso_slope_dL</ci>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_dL</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<ci>alpha_dL</ci>
<ci>beta_dL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_dL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt_second">0.02839</cn>
</apply>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">41.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">41.8</cn>
</apply>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">0.0849</cn>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
<cn cellml:units="millivolt">4.8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>adVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">41.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">41.8</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="millivolt">0</cn>
<apply>
<eq/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">6.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_dL</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">0.01143</cn>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="millivolt">1.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="millivolt">1.8</cn>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>bdVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">1.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">1.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dL_infinity</ci>
<ci>dL</ci>
</apply>
<ci>tau_dL</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fL_gate">
<variable initial_value="0.846702" name="fL" public_interface="out" units="dimensionless"/>
<variable name="fL_infinity" units="dimensionless"/>
<variable name="tau_fL" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="0" name="shift_fL" units="millivolt"/>
<variable initial_value="0" name="k_fL" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.4</cn>
<ci>shift_fL</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="millivolt">5.3</cn>
<ci>k_fL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn cellml:units="second">44.3</cn>
<apply>
<times/>
<cn cellml:units="second">230</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">36</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fL_infinity</ci>
<ci>fL</ci>
</apply>
<ci>tau_fL</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fCa_gate">
<variable initial_value="0.844449" name="fCa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0075" name="alpha_fCa" units="per_second"/>
<variable name="fCa_infinity" units="dimensionless"/>
<variable name="tau_fCa" units="second"/>
<variable initial_value="0.000338" name="Km_fCa" units="millimolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fCa_infinity</ci>
<apply>
<divide/>
<ci>Km_fCa</ci>
<apply>
<plus/>
<ci>Km_fCa</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fCa</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<ci>fCa_infinity</ci>
</apply>
<ci>alpha_fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fCa_infinity</ci>
<ci>fCa</ci>
</apply>
<ci>tau_fCa</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT">
<variable name="i_CaT" public_interface="out" units="nanoA"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable initial_value="0.04132" name="P_CaT" units="nanoA_per_millimolar"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable name="Cao" public_interface="in" units="millimolar"/>
<variable name="Ca_sub" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="dT" private_interface="in" units="dimensionless"/>
<variable name="fT" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaT</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>P_CaT</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dT</ci>
<ci>fT</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_dT_gate">
<variable initial_value="0.268909" name="dT" public_interface="out" units="dimensionless"/>
<variable name="dT_infinity" units="dimensionless"/>
<variable name="tau_dT" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_dT</ci>
<apply>
<divide/>
<cn cellml:units="second">0.001</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dT_infinity</ci>
<ci>dT</ci>
</apply>
<ci>tau_dT</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_fT_gate">
<variable initial_value="0.020484" name="fT" public_interface="out" units="dimensionless"/>
<variable name="fT_infinity" units="dimensionless"/>
<variable name="tau_fT" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="0" name="offset_fT" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">58.7</cn>
</apply>
<cn cellml:units="millivolt">3.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fT</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
<cn cellml:units="millivolt">83.3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">15.38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>offset_fT</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fT_infinity</ci>
<ci>fT</ci>
</apply>
<ci>tau_fT</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_SR_release">
<variable name="j_SRCarel" public_interface="out" units="millimolar_per_second"/>
<variable initial_value="0.9308" name="R" units="dimensionless"/>
<variable initial_value="6.181512e-9" name="O" units="dimensionless"/>
<variable initial_value="4.595622e-10" name="I" units="dimensionless"/>
<variable initial_value="0.069199" name="RI" units="dimensionless"/>
<variable initial_value="148041085.1" name="ks" units="per_second"/>
<variable initial_value="15" name="MaxSR" units="dimensionless"/>
<variable initial_value="1" name="MinSR" units="dimensionless"/>
<variable initial_value="0.45" name="EC50_SR" units="millimolar"/>
<variable initial_value="2.5" name="HSR" units="dimensionless"/>
<variable name="koSRCa" units="per_millimolar2_second"/>
<variable name="kiSRCa" units="per_millimolar_second"/>
<variable initial_value="10000" name="koCa" units="per_millimolar2_second"/>
<variable initial_value="500" name="kiCa" units="per_millimolar_second"/>
<variable name="kCaSR" units="dimensionless"/>
<variable initial_value="5" name="kim" units="per_second"/>
<variable initial_value="660" name="kom" units="per_second"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable name="Ca_jsr" public_interface="in" units="millimolar"/>
<variable name="diff" units="millimolar"/>
<variable name="P_tot" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<ci>ks</ci>
<ci>O</ci>
<apply>
<minus/>
<ci>Ca_jsr</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>diff</ci>
<apply>
<minus/>
<ci>Ca_jsr</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kCaSR</ci>
<apply>
<minus/>
<ci>MaxSR</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>MaxSR</ci>
<ci>MinSR</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SR</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>HSR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>koSRCa</ci>
<apply>
<divide/>
<ci>koCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kiSRCa</ci>
<apply>
<times/>
<ci>kiCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>R</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RI</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>R</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_tot</ci>
<apply>
<plus/>
<ci>R</ci>
<ci>O</ci>
<ci>I</ci>
<ci>RI</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_intracellular_fluxes">
<variable name="j_Ca_dif" public_interface="out" units="millimolar_per_second"/>
<variable name="j_up" public_interface="out" units="millimolar_per_second"/>
<variable name="j_tr" public_interface="out" units="millimolar_per_second"/>
<variable initial_value="5.469e-5" name="tau_dif_Ca" units="second"/>
<variable initial_value="0.04" name="tau_tr" units="second"/>
<variable name="P_up" units="millimolar_per_second"/>
<variable initial_value="5" name="P_up_basal" units="millimolar_per_second"/>
<variable name="b_up" units="dimensionless"/>
<variable name="ACh" public_interface="in" units="millimolar"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable initial_value="0.000286113" name="K_up" units="millimolar"/>
<variable name="Ca_nsr" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable name="Ca_jsr" public_interface="in" units="millimolar"/>
<variable initial_value="5e-5" name="slope_up" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>b_up</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.7</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="millimolar">0.00009</cn>
<ci>ACh</ci>
</apply>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>P_up</ci>
<apply>
<times/>
<ci>P_up_basal</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>b_up</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Ca_dif</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_sub</ci>
<ci>Cai</ci>
</apply>
<ci>tau_dif_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_up</ci>
<apply>
<divide/>
<ci>P_up</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>Cai</ci>
</apply>
<ci>K_up</ci>
</apply>
<ci>slope_up</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_nsr</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_buffering">
<variable initial_value="0.031" name="TC_tot" public_interface="out" units="millimolar"/>
<variable initial_value="0.062" name="TMC_tot" public_interface="out" units="millimolar"/>
<variable initial_value="0.045" name="CM_tot" public_interface="out" units="millimolar"/>
<variable initial_value="10" name="CQ_tot" public_interface="out" units="millimolar"/>
<variable name="delta_fTC" public_interface="out" units="per_second"/>
<variable name="delta_fTMC" public_interface="out" units="per_second"/>
<variable name="delta_fCMs" public_interface="out" units="per_second"/>
<variable name="delta_fCMi" public_interface="out" units="per_second"/>
<variable name="delta_fCQ" public_interface="out" units="per_second"/>
<variable name="delta_fTMM" units="per_second"/>
<variable initial_value="0.653777" name="fTMM" units="dimensionless"/>
<variable initial_value="0.217311" name="fCMi" units="dimensionless"/>
<variable initial_value="0.158521" name="fCMs" units="dimensionless"/>
<variable initial_value="0.017929" name="fTC" units="dimensionless"/>
<variable initial_value="0.259947" name="fTMC" units="dimensionless"/>
<variable initial_value="0.138975" name="fCQ" units="dimensionless"/>
<variable initial_value="88800" name="kf_TC" units="per_millimolar_second"/>
<variable initial_value="2277" name="kf_TMM" units="per_millimolar_second"/>
<variable initial_value="227700" name="kf_TMC" units="per_millimolar_second"/>
<variable initial_value="1.642e6" name="kf_CM" units="per_millimolar_second"/>
<variable initial_value="175.4" name="kf_CQ" units="per_millimolar_second"/>
<variable initial_value="446" name="kb_TC" units="per_second"/>
<variable initial_value="7.51" name="kb_TMC" units="per_second"/>
<variable initial_value="751" name="kb_TMM" units="per_second"/>
<variable initial_value="542" name="kb_CM" units="per_second"/>
<variable initial_value="445" name="kb_CQ" units="per_second"/>
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="2.5" name="Mgi" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Ca_sub" public_interface="in" units="millimolar"/>
<variable name="Ca_jsr" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTC</ci>
</apply>
<ci>delta_fTC</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fTC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TC</ci>
<ci>fTC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMC</ci>
</apply>
<ci>delta_fTMC</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTMC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TMC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMC</ci>
<ci>fTMC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMM</ci>
</apply>
<ci>delta_fTMM</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTMM</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TMM</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMM</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMi</ci>
</apply>
<ci>delta_fCMi</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMi</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCMi</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMi</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMs</ci>
</apply>
<ci>delta_fCMs</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMs</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Ca_sub</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCMs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCQ</ci>
</apply>
<ci>delta_fCQ</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCQ</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CQ</ci>
<ci>Ca_jsr</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCQ</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CQ</ci>
<ci>fCQ</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_dynamics">
<variable initial_value="9.15641e-05" name="Cai" public_interface="out" units="millimolar"/>
<variable initial_value="0.40758460316336464" name="Ca_nsr" public_interface="out" units="millimolar"/>
<variable initial_value="0.3704741444853376" name="Ca_jsr" public_interface="out" units="millimolar"/>
<variable initial_value="5.9426453173741103e-05" name="Ca_sub" public_interface="out" units="millimolar"/>
<variable name="V_i" public_interface="in" units="millimetre3"/>
<variable name="V_jsr" public_interface="in" units="millimetre3"/>
<variable name="V_nsr" public_interface="in" units="millimetre3"/>
<variable name="V_sub" public_interface="in" units="millimetre3"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="i_siCa" public_interface="in" units="nanoA"/>
<variable name="i_CaT" public_interface="in" units="nanoA"/>
<variable name="i_NaCa" public_interface="in" units="nanoA"/>
<variable name="j_SRCarel" public_interface="in" units="millimolar_per_second"/>
<variable name="j_Ca_dif" public_interface="in" units="millimolar_per_second"/>
<variable name="j_tr" public_interface="in" units="millimolar_per_second"/>
<variable name="j_up" public_interface="in" units="millimolar_per_second"/>
<variable name="TMC_tot" public_interface="in" units="millimolar"/>
<variable name="CM_tot" public_interface="in" units="millimolar"/>
<variable name="TC_tot" public_interface="in" units="millimolar"/>
<variable name="CQ_tot" public_interface="in" units="millimolar"/>
<variable name="delta_fTMC" public_interface="in" units="per_second"/>
<variable name="delta_fCMi" public_interface="in" units="per_second"/>
<variable name="delta_fCMs" public_interface="in" units="per_second"/>
<variable name="delta_fTC" public_interface="in" units="per_second"/>
<variable name="delta_fCQ" public_interface="in" units="per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>j_Ca_dif</ci>
<ci>V_sub</ci>
</apply>
<apply>
<times/>
<ci>j_up</ci>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<ci>V_i</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMi</ci>
</apply>
<apply>
<times/>
<ci>TC_tot</ci>
<ci>delta_fTC</ci>
</apply>
<apply>
<times/>
<ci>TMC_tot</ci>
<ci>delta_fTMC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_sub</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>j_SRCarel</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_sub</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_CaT</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_sub</ci>
</apply>
</apply>
<ci>j_Ca_dif</ci>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMs</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_nsr</ci>
</apply>
<apply>
<minus/>
<ci>j_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>j_tr</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_jsr</ci>
</apply>
<apply>
<minus/>
<ci>j_tr</ci>
<apply>
<plus/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<ci>CQ_tot</ci>
<ci>delta_fCQ</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cell_parameters">
<variable name="V_sub" public_interface="out" units="millimetre3"/>
<variable name="V_jsr" public_interface="out" units="millimetre3"/>
<variable name="V_nsr" public_interface="out" units="millimetre3"/>
<variable name="V_i" public_interface="out" units="millimetre3"/>
<variable name="V_cell" units="millimetre3"/>
<variable initial_value="0.0012" name="V_jsr_part" units="dimensionless"/>
<variable initial_value="0.46" name="V_i_part" units="dimensionless"/>
<variable initial_value="0.0116" name="V_nsr_part" units="dimensionless"/>
<variable initial_value="3.9" name="R_cell" units="micrometre"/>
<variable initial_value="67" name="L_cell" units="micrometre"/>
<variable initial_value="0.02" name="L_sub" units="micrometre"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_cell</ci>
<apply>
<times/>
<cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
<pi/>
<apply>
<power/>
<ci>R_cell</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_sub</ci>
<apply>
<times/>
<cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
<cn cellml:units="dimensionless">2</cn>
<pi/>
<ci>L_sub</ci>
<apply>
<minus/>
<ci>R_cell</ci>
<apply>
<divide/>
<ci>L_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_jsr</ci>
<apply>
<times/>
<ci>V_jsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>V_i_part</ci>
<ci>V_cell</ci>
</apply>
<ci>V_sub</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_nsr</ci>
<apply>
<times/>
<ci>V_nsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kur">
<variable name="i_Kur" public_interface="out" units="nanoA"/>
<variable initial_value="0.1539e-3" name="g_Kur" units="microS"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="r_Kur" private_interface="in" units="dimensionless"/>
<variable name="s_Kur" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kur</ci>
<apply>
<times/>
<ci>g_Kur</ci>
<ci>r_Kur</ci>
<ci>s_Kur</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Kur_rKur_gate">
<variable initial_value="0.011845" name="r_Kur" public_interface="out" units="dimensionless"/>
<variable name="tau_r_Kur" units="second"/>
<variable name="r_Kur_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_Kur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_Kur_infinity</ci>
<ci>r_Kur</ci>
</apply>
<ci>tau_r_Kur</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>r_Kur_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">6</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">8.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_Kur</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.009</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0005</cn>
</apply>
</apply>
</math>
</component>
<component name="i_Kur_sKur_gate">
<variable initial_value="0.845304" name="s_Kur" public_interface="out" units="dimensionless"/>
<variable name="tau_s_Kur" units="second"/>
<variable name="s_Kur_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_Kur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_Kur_infinity</ci>
<ci>s_Kur</ci>
</apply>
<ci>tau_s_Kur</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>s_Kur_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_Kur</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.59</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">3.05</cn>
</apply>
</apply>
</math>
</component>
<component name="i_to">
<variable name="i_to" public_interface="out" units="nanoA"/>
<variable initial_value="3.5e-3" name="g_to" units="microS"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="q" private_interface="in" units="dimensionless"/>
<variable name="r" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<ci>q</ci>
<ci>r</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to_q_gate">
<variable initial_value="0.430836" name="q" public_interface="out" units="dimensionless"/>
<variable name="q_infinity" units="dimensionless"/>
<variable name="tau_q" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">49</cn>
</apply>
<cn cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_q</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">65.17</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_second">0.57</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.08</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">44</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">0.065</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.93</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">10.1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>q_infinity</ci>
<ci>q</ci>
</apply>
<ci>tau_q</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to_r_gate">
<variable initial_value="0.014523" name="r" public_interface="out" units="dimensionless"/>
<variable name="r_infinity" units="dimensionless"/>
<variable name="tau_r" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.66</cn>
<cn cellml:units="dimensionless">1.4</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">15.59</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.09</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.12</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">2.98</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr">
<variable name="i_Kr" public_interface="out" units="nanoA"/>
<variable initial_value="0.00424" name="g_Kr" units="microS"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="paS" private_interface="in" units="dimensionless"/>
<variable name="paF" private_interface="in" units="dimensionless"/>
<variable name="piy" private_interface="in" units="dimensionless"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>paF</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>paS</ci>
</apply>
</apply>
<ci>piy</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pa_gate">
<variable initial_value="0.283185" name="paS" public_interface="out" units="dimensionless"/>
<variable initial_value="0.011068" name="paF" public_interface="out" units="dimensionless"/>
<variable name="pa_infinity" units="dimensionless"/>
<variable name="alfapaF" units="per_second"/>
<variable name="betapaF" units="per_second"/>
<variable name="tau_paS" units="second"/>
<variable name="tau_paF" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alfapaF</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">11.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">18.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betapaF</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.84655354</cn>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pa_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.0144</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7.6607</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paS</ci>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">21.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paF</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">30</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paS</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paS</ci>
</apply>
<ci>tau_paS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paF</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paF</ci>
</apply>
<ci>tau_paF</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pi_gate">
<variable initial_value="0.709051" name="piy" public_interface="out" units="dimensionless"/>
<variable name="pi_infinity" units="dimensionless"/>
<variable name="tau_pi" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_pi</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">100</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">54.645</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">656</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">106.157</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pi_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.6</cn>
</apply>
<cn cellml:units="millivolt">17.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>piy</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pi_infinity</ci>
<ci>piy</ci>
</apply>
<ci>tau_pi</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Ks">
<variable name="i_Ks" public_interface="out" units="nanoA"/>
<variable name="g_Ks" public_interface="out" units="microS"/>
<variable initial_value="0.00065" name="g_Ks_" units="microS"/>
<variable name="E_Ks" units="millivolt"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="RTONF" public_interface="in" units="millivolt"/>
<variable name="n" private_interface="in" units="dimensionless"/>
<variable name="Iso_1_uM" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ks</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">1.2</cn>
<ci>g_Ks_</ci>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<ci>g_Ks_</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Ks_n_gate">
<variable initial_value="0.1162" name="n" public_interface="out" units="dimensionless"/>
<variable name="n_infinity" units="dimensionless"/>
<variable name="tau_n" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="Iso_shift" units="millivolt"/>
<variable name="alpha_n" units="per_second"/>
<variable name="beta_n" units="per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">14</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>n_infinity</ci>
<apply>
<root/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">0.6383</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">10.7071</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_n</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_n</ci>
<ci>beta_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<cn cellml:units="per_second">28</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>Iso_shift</ci>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
</math>
</component>
<component name="i_KACh">
<variable name="ACh" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="i_KACh" public_interface="out" units="nanoA"/>
<variable initial_value="0.00345" name="g_KACh" units="microS"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="a" private_interface="in" units="dimensionless"/>
<variable initial_value="1" name="ACh_on" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KACh</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>ACh_on</ci>
<ci>g_KACh</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<ci>a</ci>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="i_KACh_a_gate">
<variable initial_value="0.00277" name="a" public_interface="out" units="dimensionless"/>
<variable name="alpha_a" units="per_second"/>
<variable name="beta_a" units="per_second"/>
<variable name="a_infinity" units="dimensionless"/>
<variable name="tau_a" units="second"/>
<variable name="ACh" public_interface="in" units="millimolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_a</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="per_second">3.5988</cn>
<cn cellml:units="per_second">0.025641</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.0000012155</cn>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">1.6951</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="per_second">0.025641</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a</ci>
<apply>
<times/>
<cn cellml:units="per_second">10</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0133</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a_infinity</ci>
<apply>
<divide/>
<ci>alpha_a</ci>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_a</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>a_infinity</ci>
<ci>a</ci>
</apply>
<ci>tau_a</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="Membrane">
<component_ref component="Ionic_values"/>
<component_ref component="Voltage_clamp"/>
<component_ref component="i_NaK"/>
<component_ref component="i_NaCa"/>
<component_ref component="Ca_SR_release"/>
<component_ref component="Ca_intracellular_fluxes"/>
<component_ref component="Ca_buffering"/>
<component_ref component="Ca_dynamics"/>
<component_ref component="Cell_parameters"/>
<component_ref component="Nai_concentration"/>
<component_ref component="Rate_modulation_experiments"/>
<component_ref component="i_f">
<component_ref component="i_f_y_gate"/>
</component_ref>
<component_ref component="i_Na">
<component_ref component="i_Na_m_gate"/>
<component_ref component="i_Na_h_gate"/>
</component_ref>
<component_ref component="i_Kur">
<component_ref component="i_Kur_rKur_gate"/>
<component_ref component="i_Kur_sKur_gate"/>
</component_ref>
<component_ref component="i_CaL">
<component_ref component="i_CaL_dL_gate"/>
<component_ref component="i_CaL_fL_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
</component_ref>
<component_ref component="i_CaT">
<component_ref component="i_CaT_dT_gate"/>
<component_ref component="i_CaT_fT_gate"/>
</component_ref>
<component_ref component="i_to">
<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
</component_ref>
<component_ref component="i_Kr">
<component_ref component="i_Kr_pa_gate"/>
<component_ref component="i_Kr_pi_gate"/>
</component_ref>
<component_ref component="i_Ks">
<component_ref component="i_Ks_n_gate"/>
</component_ref>
<component_ref component="i_KACh">
<component_ref component="i_KACh_a_gate"/>
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="Membrane">
<component_ref component="Voltage_clamp"/>
</component_ref>
<component_ref component="i_f">
<component_ref component="i_f_y_gate"/>
</component_ref>
<component_ref component="i_Na">
<component_ref component="i_Na_m_gate"/>
<component_ref component="i_Na_h_gate"/>
</component_ref>
<component_ref component="i_Kur">
<component_ref component="i_Kur_rKur_gate"/>
<component_ref component="i_Kur_sKur_gate"/>
</component_ref>
<component_ref component="i_CaL">
<component_ref component="i_CaL_dL_gate"/>
<component_ref component="i_CaL_fL_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
</component_ref>
<component_ref component="i_CaT">
<component_ref component="i_CaT_dT_gate"/>
<component_ref component="i_CaT_fT_gate"/>
</component_ref>
<component_ref component="i_to">
<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
</component_ref>
<component_ref component="i_Kr">
<component_ref component="i_Kr_pa_gate"/>
<component_ref component="i_Kr_pi_gate"/>
</component_ref>
<component_ref component="i_Ks">
<component_ref component="i_Ks_n_gate"/>
</component_ref>
<component_ref component="i_KACh">
<component_ref component="i_KACh_a_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="Membrane" component_2="Voltage_clamp"/>
<map_variables variable_1="V_clamp" variable_2="V_clamp"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="Ionic_values"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_SR_release" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_buffering" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_KACh" variable_2="i_KACh"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Ionic_values"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="Ionic_values"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="Ionic_values"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="Ionic_values"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Ionic_values"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Ionic_values"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="Ionic_values"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="Ionic_values"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="Ionic_values"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="Ionic_values"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="i_f_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="i_Kur_rKur_gate"/>
<map_variables variable_1="r_Kur" variable_2="r_Kur"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="i_Kur_sKur_gate"/>
<map_variables variable_1="s_Kur" variable_2="s_Kur"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="dL" variable_2="dL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
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