- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-05-10 19:18:00+12:00
- Desc:
- Edit documentation
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/64f/rawfile/48827c0892194dd9f203f81fe892afe824da6122/doc/periodic-stimulus.rst
Membrane action potential
--------------------------
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../sed-ml/periodic-stimulus.sedml>`__ into OpenCOR and executing the simulation.
You can change the parameters of stimulation amplitude, duration and period in the component ``stimulus_protocol_params``.
The following figure shows the action potentials with different initial displacement of membrane potential (The parameter setting is in the component ``initial_conditions``).
.. image:: ../sed-ml/originalFig12.png
:width: 85%
:align: center
:alt: originalFig12
Membrane potentials for initial depolarizations of -90, -15, -7 and -6 mV at 6 :math:`^{\circ}`
Subthreshold responses
----------------------
When the displacement of membrane potential was less than the threshold for setting up a spike, characteristic subthreshold responses were seen.
.. image:: ../sed-ml/originalFig21.png
:width: 85%
:align: center
:alt: originalFig21
Responses to stimuli during positive phase
------------------------------------------
The depolarization stimulation can be applied at various times during the positive phases of the membrane action potential. The following figure shows the responses of the membrane when it was depolarized by -90 mv at :math:`t=0, 4.7284, 5.7302, 7.7352 s`
.. image:: ../sed-ml/originalFig20.png
:width: 85%
:align: center
:alt: originalFig20
You can change the temperature T in the component ``parameters``.
The following figure shows the action potential at 18.5 :math:`^{\circ}` with initial depolarization of -15 mV.
Form of action potential at 18.5 :math:`^{\circ}`.
----------------------
.. image:: ../sed-ml/originalFig14.png
:width: 85%
:align: center
:alt: originalFig14
Membrane potentials for initial depolarizations of -15 mV at 18.5 :math:`^{\circ}`
Anode break excitation
----------------------
To simulate anode break responses where current was made to flow inward through the membrane, we set the initial potential value to be 30 mV. Meanwhile, the m, n and h gate have the steady state values for :math:`V=30 mV` when :math:`t=0`. That is, we set :math:`V_b=0` in the component ``boundary_conditions``.
.. image:: ../sed-ml/originalFig22.png
:width: 85%
:align: center
:alt: originalFig22
