- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-03-31 10:48:40+13:00
- Desc:
- Add open channel IV of HH models; Add simulation and plot python scripts
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/64f/rawfile/ab2962b8796666ad9938a2577611c954f006b5fd/components/INa.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="INa" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="per_ms_mV" units_ref="per_ms_mV"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
<units name="mS_per_cmsq" units_ref="mS_per_cmsq"/>
</import>
<import xlink:href="../cellLib/Components/gating-variable.cellml">
<component component_ref="hh_gating_variable" name="m_gate"/>
</import>
<import xlink:href="../cellLib/Components/gating-variable.cellml">
<component component_ref="hh_gating_variable" name="h_gate"/>
</import>
<import xlink:href="INa-gating-rates.cellml">
<component component_ref="alpha_m" name="alpha_m"/>
<component component_ref="beta_m" name="beta_m"/>
<component component_ref="alpha_h" name="alpha_h"/>
<component component_ref="beta_h" name="beta_h"/>
</import>
<component name="INa">
<variable name="INa" private_interface="out" public_interface="out" units="uA_per_cmsq"/>
<variable name="m_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="m" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="h_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="VNa" private_interface="out" public_interface="in" units="mV"/>
<variable name="gNa" private_interface="out" public_interface="out" units="mS_per_cmsq"/>
<variable name="gNa_max" private_interface="out" public_interface="in" units="mS_per_cmsq"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0Na" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10Na" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="INa_calculation">
<eq/>
<ci>INa</ci>
<apply>
<times/>
<ci>gNa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>VNa</ci>
</apply>
</apply>
</apply>
<apply id="gNa_calculation">
<eq/>
<ci>gNa</ci>
<apply>
<times/>
<ci>gNa_max</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>h</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INa">
<component_ref component="alpha_m"/>
<component_ref component="beta_m"/>
<component_ref component="alpha_h"/>
<component_ref component="beta_h"/>
<component_ref component="m_gate"/>
<component_ref component="h_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="INa" component_2="m_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="m_initial" variable_2="X_initial"/>
<map_variables variable_1="m" variable_2="X"/>
<map_variables variable_1="T0Na" variable_2="T_0"/>
<map_variables variable_1="Q10Na" variable_2="Q_10"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="INa" component_2="h_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="h_initial" variable_2="X_initial"/>
<map_variables variable_1="h" variable_2="X"/>
<map_variables variable_1="T0Na" variable_2="T_0"/>
<map_variables variable_1="Q10Na" variable_2="Q_10"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="INa" component_2="alpha_m"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="beta_m"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="alpha_h"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="beta_h"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="m_gate" component_2="alpha_m"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="m_gate" component_2="beta_m"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="h_gate" component_2="alpha_h"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="h_gate" component_2="beta_h"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
</model>
